Tag: M.W:200-300

Heterocyclic compounds can be divided into two categories: alicyclic heterocycles and aromatic heterocycles. Compounds whose heterocycles in the molecular skeleton cannot reflect aromaticity are called alicyclic heterocyclic compounds. Compound: 1260795-42-3, is researched, Molecular C9H7BrO3, about Synthesis of 3-Benzylphthalide Derivatives by Using a TDAE Strategy, the main research direction is benzylphthalide preparation; nitrobenzyl chloride tetrakisdimethylaminoethylene formylbenzoate nucleophilic addition.Safety of Methyl 4-bromo-2-formylbenzoate.

A one-pot synthesis of new 3-benzylphthalide derivatives I (X = CH, N; R1 = 4-NO2, 3-OMe-4-NO2, 2-NO2-4-C6H4, etc.; R2 = 4-CN, 5-Cl, 4-COOMe, etc.) was developed by using a strategy based on tetrakis(dimethylamino)ethylene (TDAE). The reactions in the presence of TDAE of substituted benzyl chlorides with Me 2-formylbenzoate or of substituted methyl-2-formylbenzoates with 4-nitrobenzyl chloride furnished the corresponding isobenzofuran-1(3H)-one products in moderate to good yields.

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Reference:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

The chemical properties of alicyclic heterocycles are similar to those of the corresponding chain compounds. Compound: Silver(I) trifluoromethanesulfonate, is researched, Molecular CAgF3O3S, CAS is 2923-28-6, about Sulfonate improves water solubility and cell selective toxicity and alters the lysozyme binding activity of half sandwich Rh(III) complexes, the main research direction is rhodium half sandwich pyridylbenzimidazole complex sulfonate substituted preparation fungicide.Product Details of 2923-28-6.

Introduction of the propyl-sulfonic acid group at N1 of the coordinated 1-R-2-(2-pyridyl)benzimidazole ligand (R-PyBzIm, R = Et, HO3SCH2CH2CH2) in [RhCl(η5-C5Me5)(R-PyBzIm)][OTf] gives rise to a water-soluble complex, which can bind to the model protein lysozyme via non-covalent interactions. The complex shows selective moderate toxicity against Cryptococcus neoformans (MIC = 21.6-43.3μM) and exhibits no cytotoxicity to healthy HEK293 cells.

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Reference:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Adrian, Rafael A.; Ibarra, Sara J.; Arman, Hadi D. published an article about the compound: Silver(I) trifluoromethanesulfonate( cas:2923-28-6,SMILESS:O=S(C(F)(F)F)([O-])=O.[Ag+] ).Recommanded Product: Silver(I) trifluoromethanesulfonate. Aromatic heterocyclic compounds can be classified according to the number of heteroatoms or the size of the ring. The authors also want to convey more information about this compound (cas:2923-28-6) through the article.

The central AgI atom of the title salt, [Ag(INAM)2](CF3SO3)·2CH3CN, where INAM is isonicotinamide (C6H6N2O), is twofold coordinated by the pyridine N atoms of two isonicotinamide ligands creating a slightly distorted linear mol. geometry. The formation of polymeric chains {[Ag(INAM)2]+}n, held together by discrete hydrogen bonds through the amide group of the INAM ligand leaves voids for non-coordinating acetonitrile mols. that interact the silver metal center via regium bonds.

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Reference:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Recommanded Product: 1260795-42-3. The protonation of heteroatoms in aromatic heterocycles can be divided into two categories: lone pairs of electrons are in the aromatic ring conjugated system; and lone pairs of electrons do not participate. Compound: Methyl 4-bromo-2-formylbenzoate, is researched, Molecular C9H7BrO3, CAS is 1260795-42-3, about Discovery of Novel Inhibitors of LpxC Displaying Potent in Vitro Activity against Gram-Negative Bacteria. Author is Surivet, Jean-Philippe; Panchaud, Philippe; Specklin, Jean-Luc; Diethelm, Stefan; Blumstein, Anne-Catherine; Gauvin, Jean-Christophe; Jacob, Loic; Masse, Florence; Mathieu, Gaelle; Mirre, Azely; Schmitt, Christine; Lange, Roland; Tidten-Luksch, Naomi; Gnerre, Carmela; Seeland, Swen; Herrmann, Charlyse; Seiler, Peter; Enderlin-Paput, Michel; Mac Sweeney, Aengus; Wicki, Micha; Hubschwerlen, Christian; Ritz, Daniel; Rueedi, Georg.

UDP-3-O-((R)-3-hydroxymyristoyl)-N-glucosamine deacetylase (LpxC) is as an attractive target for the discovery and development of novel antibacterial drugs to address the critical medical need created by multidrug resistant Gram-neg. bacteria. By using a scaffold hopping approach on a known family of methylsulfone hydroxamate LpxC inhibitors, several hit series eliciting potent antibacterial activities against Enterobacteriaceae and Pseudomonas aeruginosa were identified. Subsequent hit-to-lead optimization, using cocrystal structures of inhibitors bound to Pseudomonas aeruginosa LpxC as guides, resulted in the discovery of multiple chem. series based on (i) isoindolin-1-ones, (ii) 4,5-dihydro-6H-thieno[2,3-c]pyrrol-6-ones, and (iii) 1,2-dihydro-3H-pyrrolo[1,2-c]imidazole-3-ones. Synthetic methods, antibacterial activities and relative binding affinities, as well as physicochem. properties that allowed compound prioritization are presented. Finally, in vivo properties of lead mols. which belong to the most promising pyrrolo-imidazolone series, such as I, are discussed.

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Reference:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Liu, Yu; Taylor, Laurence J.; Argent, Stephen P.; McMaster, Jonathan; Kays, Deborah L. published the article 《Group 11 m-Terphenyl Complexes Featuring Metallophilic Interactions》. Keywords: gold silver copper terphenyl complex preparation metallophilic interaction; crystal structure mol gold silver copper terphenyl complex optimized.They researched the compound: Silver(I) trifluoromethanesulfonate( cas:2923-28-6 ).Safety of Silver(I) trifluoromethanesulfonate. Aromatic heterocyclic compounds can be divided into two categories: single heterocyclic and fused heterocyclic. In addition, there is a lot of other information about this compound (cas:2923-28-6) here.

A series of group 11 m-terphenyl complexes have been synthesized via a metathesis reaction from the Fe(II) complexes (2,6-Mes2C6H3)2Fe and (2,6-Xyl2C6H3)2Fe (Mes = 2,4,6-Me3C6H2; Xyl = 2,6-Me2C6H3). [2,6-Mes2C6H3M]2 (1 M = Cu; 2 M = Ag; 6 M = Au) and [2,6-Xyl2C6H3M]2 (3 M = Cu; 4 M = Ag) are dimeric in the solid state, although different geometries are observed depending on the ligand. These complexes feature short metal-metal distances in the expected range for metallophilic interactions. While 1-4 are readily isolated using this metathetical route, the Au complex 6 is unstable in solution at ambient temperatures and has only been obtained in low yield from the decomposition of (2,6-Mes2C6H3)Au·SMe2 (5). NMR spectroscopic measurements, including Diffusion Ordered Spectroscopy (DOSY), suggest 1-4 remain dimeric in benzene-d6 solution The metal-metal interactions have been examined computationally using the Quantum Theory of Atoms in Mols. (QTAIM) and by an energy decomposition anal. employing naturalized orbitals for chem. valence (EDA-NOCV).

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Reference:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

In organic chemistry, atoms other than carbon and hydrogen are generally referred to as heteroatoms. The most common heteroatoms are nitrogen, oxygen and sulfur. Now I present to you an article called Half-Sandwich Ru(p-cymene) Compounds with Diphosphanes: In Vitro and In Vivo Evaluation As Potential Anticancer Metallodrugs, published in 2021-03-01, which mentions a compound: 2923-28-6, mainly applied to half sandwich ruthenium cymene diphosphane anticancer metallodrug; crystal mol structure ruthenium cymene diphosphane complex, Related Products of 2923-28-6.

Ruthenium(II) complexes are currently considered attractive alternatives to the widely used platinum-based drugs. We present herein the synthesis and characterization of half-sandwich ruthenium compounds formulated as [Ru(p-cymene)(L)Cl][CF3SO3] (L = 1,1-bis(methylenediphenylphosphino)ethylene, 1; L = 1,1-bis(diphenylphosphino)ethylene, 2), which were characterized by elemental anal., mass spectrometry, 1H and 31P{1H} NMR, UV-vis and IR spectroscopy, conductivity measurements and cyclic voltammetry. The mol. structures for both complexes were determined by single-crystal X-ray diffraction. Their cytotoxic activity was evaluated using the MTT assay against human tumor cells, namely ovarian (A2780) and breast (MCF7 and MDA-MB-231). Both complexes were active against breast adenocarcinoma cells, with complex 1 exhibiting a quite remarkable cytotoxicity in the submicromolar range. Interestingly, at concentrations equivalent to the IC50 values in the MCF7 cancer cells, complexes 1 and 2 presented lower cytotoxicity in normal human primary fibroblasts. The antiproliferative effects of 1 and 2 in MCF7 cells might be associated with the induction of reactive oxygen species (ROS), leading to a combined cell death mechanism via apoptosis and autophagy. Despite the fact that in vitro a partial intercalation between complexes and DNA was observed, no MCF7 cell cycle delay or arrest was observed, indicating that DNA might not be a direct target. Complexes 1 and 2 both exhibited a moderate to strong interaction with human serum albumin, suggesting that protein targets may be involved in their mode of action. Their acute toxicity was evaluated in the zebrafish model. Complex 1 (the most toxic of the two) exhibited a lethal toxicity LC50 value about 1 order of magnitude higher than any IC50 concentrations found for the cancer cell models used, highlighting its therapeutic relevance as a drug candidate in cancer chemotherapy.

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Reference:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

COA of Formula: CAgF3O3S. The fused heterocycle is formed by combining a benzene ring with a single heterocycle, or two or more single heterocycles. Compound: Silver(I) trifluoromethanesulfonate, is researched, Molecular CAgF3O3S, CAS is 2923-28-6, about Robotic Stepwise Synthesis of Hetero-Multinuclear Metal Oxo Clusters as Single-Molecule Magnets. Author is Minato, Takuo; Salley, Daniel; Mizuno, Noritaka; Yamaguchi, Kazuya; Cronin, Leroy; Suzuki, Kosuke.

An efficient stepwise synthesis method for discovering new heteromultinuclear metal clusters using a robotic workflow is developed where numerous reaction conditions for constructing heteromultinuclear metal oxo clusters in polyoxometalates (POMs) were explored using a custom-built automated platform. As a result, new nonanuclear tetrametallic oxo clusters {FeMn4}Lu2A2 in TBA5[(A-α-SiW9O34)2FeMn4O2{Lu(acac)2}2A2] (2A; A = Ag, Na, K; TBA = Bu4N; acac = acetylacetonate) were discovered by the installation of diamagnetic metal cations A+ into a paramagnetic {FeMn4}Lu2 unit in TBA7[(A-α-SiW9O34)2FeMn4O2{Lu(acac)2}2] (1). POMs 2A exhibited single-mol. magnet properties with the higher energy barriers for magnetization reversal (2Ag, 40.0 K; 2Na, 40.3 K; 2K, 26.7 K) compared with that of the parent 1 (19.7 K). Importantly, these clusters with unique properties were constructed as designed by a step of the predictable sequential multistep reactions with the time-efficient platform.

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Reference:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

The three-dimensional configuration of the ester heterocycle is basically the same as that of the carbocycle. Compound: Silver(I) trifluoromethanesulfonate(SMILESS: O=S(C(F)(F)F)([O-])=O.[Ag+],cas:2923-28-6) is researched.HPLC of Formula: 70539-42-3. The article 《Synthesis, Structure, and Reactivity of Acid-Free Neutral Oxoborane》 in relation to this compound, is published in Angewandte Chemie, International Edition. Let’s take a look at the latest research on this compound (cas:2923-28-6).

Carborane- and NHC-stabilized oxoborane 2-(TfO)-o-C2B10H10-1-B(:O)-IDipp [IDipp = 1,3-bis(diisopropylphenyl)-2-imidazolylidene] was prepared by reaction of AgOTf with 1,2-BBr(IDipp)-o-C2B10H10; its structure was confirmed by single-crystal x-ray diffraction. An efficient synthesis of an acid-free neutral oxoborane of the type carboranyl-B(carbene):O has been developed via a serendipitous discovery from the reaction of 1,2-[BBr(carbene)]-o-carborane with AgOTf. This represents a new type of oxoborane. The stabilization of this oxoborane may be attributed to (1) kinetic stabilization provided by a bulky 3D carboranyl ligand and (2) thermodn. stabilization offered by a carbene ligand. Crystallog. analyses support the presence of the shortest terminal B:O double bond ever reported thus far. Its reactivity has also been examined

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Reference:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Safety of Methyl 4-bromo-2-formylbenzoate. The reaction of aromatic heterocyclic molecules with protons is called protonation. Aromatic heterocycles are more basic than benzene due to the participation of heteroatoms. Compound: Methyl 4-bromo-2-formylbenzoate, is researched, Molecular C9H7BrO3, CAS is 1260795-42-3, about An Efficient Entry to syn- and anti-Selective Isoindolinones via an Organocatalytic Direct Mannich/Lactamization Sequence. Author is Bisai, Vishnumaya; Unhale, Rajshekhar A.; Suneja, Arun; Dhanasekaran, Sivasankaran; Singh, Vinod K..

An organocatalytic direct Mannich-lactamization sequence for the syntheses of pharmacol. important enantioenriched isoindolinones is reported. The method utilizes simple α-amino acids to deliver syn- and anti- selective isoindolinones, e.g., I, with remarkably high enantioselectivity (up to >99% ee) in good to excellent yields and diastereomeric ratios. The overall sequence involves one C-C and two C-N bond forming events in one pot starting from inexpensive starting material.

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Reference:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Related Products of 2923-28-6. Aromatic compounds can be divided into two categories: single heterocycles and fused heterocycles. Compound: Silver(I) trifluoromethanesulfonate, is researched, Molecular CAgF3O3S, CAS is 2923-28-6, about New fluorinated manganese carbonyl complexes for light controlled carbon monoxide (CO) release and the use of bench-top 19F-NMR spectroscopy. Author is Sakla, Rahul; Amilan Jose, D..

CO is used as an essential therapeutic agent. Control delivery and tracking of CO is the important concern for using in therapeutics. The authors report fluorinated Mn(I) tricarbonyl complexes PF-DPA perfluorobenzyl-dipicolinylamine, Mn and CF-DPA·Mn (CF-DPA = trifluoromethylbenzyl-dipicolinylamine) as a new photoCORMs for photo-controlled CO release. For the 1st time, the bench-top 19F-NMR on-off signal was used to monitor light-controlled CO release along with other traditional methods. 19F-NMR signal was initially on which attenuates on irradiating with blue light due to conversion of Mn(I) to Mn(II). CO release behavior of new complexes was also supported by Myoglobin assay, time-dependent IR study and UV-visible experiments Fluorinated Mn carbonyl complexes with 19F-NMR open up vast opportunities for researchers to develop a fast and reliable technique for tracking CO release.

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Reference:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem