Recommanded Product: 1260795-42-3. The protonation of heteroatoms in aromatic heterocycles can be divided into two categories: lone pairs of electrons are in the aromatic ring conjugated system; and lone pairs of electrons do not participate. Compound: Methyl 4-bromo-2-formylbenzoate, is researched, Molecular C9H7BrO3, CAS is 1260795-42-3, about Discovery of Novel Inhibitors of LpxC Displaying Potent in Vitro Activity against Gram-Negative Bacteria. Author is Surivet, Jean-Philippe; Panchaud, Philippe; Specklin, Jean-Luc; Diethelm, Stefan; Blumstein, Anne-Catherine; Gauvin, Jean-Christophe; Jacob, Loic; Masse, Florence; Mathieu, Gaelle; Mirre, Azely; Schmitt, Christine; Lange, Roland; Tidten-Luksch, Naomi; Gnerre, Carmela; Seeland, Swen; Herrmann, Charlyse; Seiler, Peter; Enderlin-Paput, Michel; Mac Sweeney, Aengus; Wicki, Micha; Hubschwerlen, Christian; Ritz, Daniel; Rueedi, Georg.
UDP-3-O-((R)-3-hydroxymyristoyl)-N-glucosamine deacetylase (LpxC) is as an attractive target for the discovery and development of novel antibacterial drugs to address the critical medical need created by multidrug resistant Gram-neg. bacteria. By using a scaffold hopping approach on a known family of methylsulfone hydroxamate LpxC inhibitors, several hit series eliciting potent antibacterial activities against Enterobacteriaceae and Pseudomonas aeruginosa were identified. Subsequent hit-to-lead optimization, using cocrystal structures of inhibitors bound to Pseudomonas aeruginosa LpxC as guides, resulted in the discovery of multiple chem. series based on (i) isoindolin-1-ones, (ii) 4,5-dihydro-6H-thieno[2,3-c]pyrrol-6-ones, and (iii) 1,2-dihydro-3H-pyrrolo[1,2-c]imidazole-3-ones. Synthetic methods, antibacterial activities and relative binding affinities, as well as physicochem. properties that allowed compound prioritization are presented. Finally, in vivo properties of lead mols. which belong to the most promising pyrrolo-imidazolone series, such as I, are discussed.
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Reference:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem