Ni, Yan; Li, Chun-Xiu; Wang, Li-Juan; Zhang, Jie; Xu, Jian-He published an article about the compound: (R)-Ethyl 4-chloro-3-hydroxybutanoate( cas:90866-33-4,SMILESS:O=C(OCC)C[C@@H](O)CCl ).Reference of (R)-Ethyl 4-chloro-3-hydroxybutanoate. Aromatic heterocyclic compounds can be classified according to the number of heteroatoms or the size of the ring. The authors also want to convey more information about this compound (cas:90866-33-4) through the article.
A carbonyl reductase gene (yueD) from Bacillus sp. ECU0013 was heterologously overexpressed in Escherichia coli, and the encoded protein (BYueD) was purified to homogeneity and characterized. The NADPH-dependent reductase showed a broad substrate spectrum towards different aromatic ketones, and α- and β-ketoesters. Although the enantioselectivity was high to moderate for the reduction of α-ketoesters, all the tested β-ketoesters and aromatic ketones were reduced to the corresponding chiral alcs. in enantiomerically pure forms. Furthermore, the practical applicability of this enzyme was evaluated for the reduction of Et 4-chloro-3-oxobutanoate (1a). Using Escherichia coli cells coexpressing BYueD and glucose dehydrogenase, 215 g L-1 (1.3 M) of 1a was stoichiometrically converted to Et (R)-4-chloro-3-hydroxybutanoate ((R)-1b) in an aqueous-toluene biphasic system by using a substrate fed-batch strategy, resulting in an overall hydroxyl product yield of 91.7% with enantiomeric purity of 99.6% ee.
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Reference:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem