Tag: M.W=200-250

Wen, Chang published the artcileHighly Efficient Synthesis of 2-Substituted Benzo[ b ]furan Derivatives from the Cross-Coupling Reactions of 2-Halobenzo[ b ]furans with Organoalane Reagents, COA of Formula: C8H5IO, the publication is Synthesis (2021), 53(20), 3847-3861, database is CAplus.

A highly efficient and simple route for the synthesis of benzo[ b]furans was developed by palladium-catalyzed cross-coupling reaction of 2-halobenzo[ b]furans with aryl, alkynyl, and alkylaluminum reagents. Various 2-aryl-, 2-alkynyl-, and 2-alkyl benzo[ b]furans was obtained in 23-97% isolated yields using 2-3 mol% PdCl 2/4-6 mol% XantPhos as the catalyst under mild reaction conditions. The aryls beared electron-donating or electron-withdrawing groups in 2-halobenzo[ b]furans gave products in 40-97% isolated yields. In addition, aluminum reagents containing thienyl, furanyl, trimethylsilanyl, and benzyl groups worked efficiently with 2-halobenzo[ b]furans as well, and three bioactive mols. with benzo[ b]furans skeleton were synthesized. Furthermore, the broad substrates scope and the typical maintenance of vigorous efficiency on gram scale made this protocol a potentially practical method to synthesize benzo[ b]furans. On the basis of the exptl. results, a possible catalytic cycle was proposed.

Synthesis published new progress about 69626-75-1. 69626-75-1 belongs to benzofurans, auxiliary class Iodide,Benzofuran, name is 2-Iodobenzofuran, and the molecular formula is C22H32O2, COA of Formula: C8H5IO.

Referemce:
https://en.wikipedia.org/wiki/Benzofuran,
Benzofuran | C8H6O – PubChem

He, Xue-mei published the artcileChemical constituents from the root bark of Morus atropurpurea, Computed Properties of 56317-21-6, the publication is Xiandai Shipin Keji (2014), 30(6), 219-228, 300, database is CAplus.

Mulberry root bark (Sang Bai Pi) was a kind of traditional Chinese medicine which showed hypotensive, antiviral bacteriostatic and anti-inflammatory activities. In order to explore the material basis of pharmacol. activity of mulberry root bark, the chem. constituents of the root bark from Moms atropurpurea was studied in this paper. Fifteen compounds were isolated from the root bark by silica gel, Sephadex LH-20, ODS and PHPLC column chromatog. Their structures were identified by physicochem. properties and spectral anal. as kuwanon A (1), kuwanon B (2), kuwanon C (3), kuwanon T (4), cyclomorusin (5), moracin M (6), moracin O (7), moracin P (8), mulberrofuran L (9), albanin A (10), australone A (11), 5′-(1”’,1”’-dimethylallyl)-8-(3″,3″-dimethylallyl)-2′,4′,5,7-tetrahydroxyfla-vone (12), 5,7-dihydroxycoumarin (13), oxyresceratrol (14) and β-daucosterol (15), resp. Fifteen compounds contained eight prenylflavonoids, four 2-arylbenzofuran, one coumarin, one stilbene and one sterol. Moreover, compounds 1-4 and 7-13 were firstly found from Moms atropurpurea.

Xiandai Shipin Keji published new progress about 56317-21-6. 56317-21-6 belongs to benzofurans, auxiliary class Metabolic Enzyme,PDE,Natural product, name is 5-(6-Hydroxybenzofuran-2-yl)benzene-1,3-diol, and the molecular formula is C14H10O4, Computed Properties of 56317-21-6.

Referemce:
https://en.wikipedia.org/wiki/Benzofuran,
Benzofuran | C8H6O – PubChem

Wu, Kai published the artcileTransition-Metal-Free C(sp²)-C(sp²) Cross-Coupling of Diazo Quinones with Catechol Boronic Esters, Name: 5-(6-Hydroxybenzofuran-2-yl)benzene-1,3-diol, the publication is Angewandte Chemie, International Edition (2020), 59(37), 16202-16208, database is CAplus and MEDLINE.

A transition-metal-free C(sp²)-C(sp²) bond formation reaction by the cross-coupling of diazo quinones with catechol boronic esters was developed. With this protocol, a variety of biaryls and alkenyl phenols were obtained in good to high yields under mild conditions [e.g., ortho-diazo quinone I + catechol boronic ester II → III (94%) using K₂CO₃ as base and MeCN/DCM mixed solvent]. The reaction tolerates various functionalities and is applicable to the derivatization of pharmaceuticals and natural products. The synthetic utility of the method was demonstrated by the short synthesis of multi-substituted triphenylenes and three bioactive natural products, honokiol, moracin M, and stemofuran A. Mechanistic studies and d. functional theory (DFT) calculations revealed that the reaction involves attack of the boronic ester by a singlet quinone carbene followed by a 1,2-rearrangement through a stepwise mechanism. Safety: diazo quinones are potentially explosive.

Angewandte Chemie, International Edition published new progress about 56317-21-6. 56317-21-6 belongs to benzofurans, auxiliary class Metabolic Enzyme,PDE,Natural product, name is 5-(6-Hydroxybenzofuran-2-yl)benzene-1,3-diol, and the molecular formula is C7H8FNO2S, Name: 5-(6-Hydroxybenzofuran-2-yl)benzene-1,3-diol.

Referemce:
https://en.wikipedia.org/wiki/Benzofuran,
Benzofuran | C8H6O – PubChem

Zhang, Fuyi published the artcileGeneral and efficient one-pot synthesis of novel sugar/heterocyclic(aryl) 1,2-diketones from sugar terminal alkynes by Sonogashira/tetra-n-butylammonium permanganate oxidation, HPLC of Formula: 69626-75-1, the publication is Carbohydrate Research (2015), 41-51, database is CAplus and MEDLINE.

A new approach for one-pot synthesis of novel sugar/heterocyclic(aryl) 1,2-diketones has been achieved by the reaction of various sugar terminal alkynes with heterocyclic(aryl) iodides at room temperature This one-pot protocol includes Sonogashira coupling and mild n-Bu₄NMnO₄ oxidation reaction. This method is mild, general and efficient. Fifty-six examples have been given and the sugar/heterocyclic(aryl) 1,2-diketones were obtained in 71-94% yields. The sugar terminal alkynes include 9 structurally different sugars in pyranose, furanose, and acyclic form which have various protecting groups, sensitive groups, and sterically bulky substituents. The heterocyclic(aryl) iodides include sterically bulky heterocyclic compounds and iodobenzenes with electron-donating, electron-neutral, and electron-withdrawing substituents.

Carbohydrate Research published new progress about 69626-75-1. 69626-75-1 belongs to benzofurans, auxiliary class Iodide,Benzofuran, name is 2-Iodobenzofuran, and the molecular formula is C10H16Br3N, HPLC of Formula: 69626-75-1.

Referemce:
https://en.wikipedia.org/wiki/Benzofuran,
Benzofuran | C8H6O – PubChem

Negishi, Ei-ichi published the artcileDirect synthesis of heteroarylethynes via palladium-catalyzed coupling of heteroaryl halides with ethynylzinc halides. Its application to an efficient synthesis of a thiophenelactone from Chamaemelum nobile L, Computed Properties of 69626-75-1, the publication is Heterocycles (1997), 209-214, database is CAplus.

A variety of terminal alkynes containing a heteroaryl group can be directly and selectively synthesized by the Pd-catalyzed coupling of heteroaryl iodides or bromides with ethynylzinc halides. Various compounds of this class containing furan, thiophene, and pyridine have been prepared, and the procedure has been applied to an efficient and selective synthesis of a thiophenelactone from Chamaemelum nobile L.

Heterocycles published new progress about 69626-75-1. 69626-75-1 belongs to benzofurans, auxiliary class Iodide,Benzofuran, name is 2-Iodobenzofuran, and the molecular formula is C8H5IO, Computed Properties of 69626-75-1.

Referemce:
https://en.wikipedia.org/wiki/Benzofuran,
Benzofuran | C8H6O – PubChem

Wang, Ping published the artcilePhenylpropanoids and diphenylethene compounds from roots and rhizomes of Smilax scobinicaulis, Recommanded Product: 5-(6-Hydroxybenzofuran-2-yl)benzene-1,3-diol, the publication is Zhongguo Zhongyao Zazhi (2013), 38(10), 1531-1535, database is CAplus and MEDLINE.

The chem. constituents were separated and purified from the roots and rhizomes of Smilax scobinicaulis by various chromatog. methods including silica gel, Sephadex LH-20. Their structures were obtained and identified as resveratrol-3-O-β-D-glucopyranosyl-(1->3)-β-D-glucopyranoside(1), resveratrol(2), δ-viniferin(3), Et caffeate(4), 1-O-caffeoyl glycerol(5), 1-O-p-coumaroyl glycerol(6), 1-O-feruloyl glycerol(7), grossamide(8), moracin M(9) on the anal. of spectroscopic data. Compound 1 was a new compound and compounds 3-5, 8, 9 were separated from this plant for the first time.

Zhongguo Zhongyao Zazhi published new progress about 56317-21-6. 56317-21-6 belongs to benzofurans, auxiliary class Metabolic Enzyme,PDE,Natural product, name is 5-(6-Hydroxybenzofuran-2-yl)benzene-1,3-diol, and the molecular formula is C9H8O4, Recommanded Product: 5-(6-Hydroxybenzofuran-2-yl)benzene-1,3-diol.

Referemce:
https://en.wikipedia.org/wiki/Benzofuran,
Benzofuran | C8H6O – PubChem

He, Jiahong published the artcileInsight into the corrosion inhibition property of Artocarpus heterophyllus Lam leaves extract, Computed Properties of 56317-21-6, the publication is Journal of Industrial and Engineering Chemistry (Amsterdam, Netherlands) (2021), 260-270, database is CAplus.

In this work, the method (water extraction way) was uesd to acquire Artocarpus heterophyllus Lam leaves extract (AHLLE). We refer to the relevant references on the composition of Artocarpus heterophyllus Lam leaves and perform Fourier IR spectroscopy anal. for AHLLE. It can be concluded that AHLLE contains 2-(2,4-dihydroxyphenyl)-5,7-dihydroxy-4H-chromen-4-one (DPD), (2R,3R)-2-(2,4-dihydroxyphenyl)-3 ,5,7-trihydroxychroman-4-one (DPT), 3-(4-hydroxyphenyl)acrylic acid (HPT), and 5-(6-hydroxybenzofuran-2-yl)benzene-1,3-diol (HBB). Quantum chem. calculations (QCC) data and mol. dynamics (MD) simulations results show that DPD, DPT, HPT, and HBB all have the potential of excellent corrosion inhibitors. Scanning electron microscope (SEM) results and at. force microscope (AFM) test results show that after adding AHLLE to H2SO4 environment, the copper surface is still correspondingly flat. In addition, the results of electrochem. experiments indicate that the AHLLE is 500 ppm, the anti-corrosion efficiency obtained from electrochem. impedance spectroscopy data can reach 97.3%. With the temperature augments to 313 K, the corrosion inhibition nature of AHLLE can still be maintained to 97%. AHLLE is adsorbed onto the Cu surface and belongs to Langmuir monolayer adsorption.

Journal of Industrial and Engineering Chemistry (Amsterdam, Netherlands) published new progress about 56317-21-6. 56317-21-6 belongs to benzofurans, auxiliary class Metabolic Enzyme,PDE,Natural product, name is 5-(6-Hydroxybenzofuran-2-yl)benzene-1,3-diol, and the molecular formula is C14H10O4, Computed Properties of 56317-21-6.

Referemce:
https://en.wikipedia.org/wiki/Benzofuran,
Benzofuran | C8H6O – PubChem

Dej-adisai, Sukanya published the artcileDetermination of phytochemical compounds, and tyrosinase inhibitory and antimicrobial activities of bioactive compounds from Streblus ilicifolius (s vidal) corner, Computed Properties of 56317-21-6, the publication is Tropical Journal of Pharmaceutical Research (2016), 15(3), 497-506, database is CAplus.

Purpose: To determine the phytochem. content, and tyrosinase inhibitory and antimicrobial activities of the wood from S treblus ilicifolius (S. Vidal) Corner Methods: The dried wood of S. ilicifolius (8.70 kg) was extracted by maceration to give petroleum ether, Et acetate, ethanol and water extracts, resp. Dopachrome method was used to determine antityrosinase activity. Agar disk diffusion and modified broth microdilution methods were used to determine antimicrobial activity. Chromatog. techniques were used for phytochem. investigation. The structures elucidation of isolated compounds were identified by phys. properties and spectroscopic data including UV, IR, NMR and MS data and confirmed by comparison with previously reports. Results: The ethanol extract exhibited tyrosinase inhibition and antimicrobial activity against the Grampos. bacteria, Staphylococcus epidermidis and S. aureus. Phytochem. investigation showed five compounds, namely, (E)-2,4-dihydroxy-3-(3,7-dimethyl-2,6-octadienyl) benzaldehyde (1), phydroxybenzoic acid Me ester (2), umbelliferone (3), moracin M (4), trans-resveratrol (5). Compound 4 exhibited tyrosinase inhibition with half maximal inhibitory concentration (IC50) of 67.69 μg/mL, while compound 1 displayed strong activity against S. epidermidis, S. aureus and methicillin-resistant S. aureus (MRSA) with min. inhibitory concentration (MIC) of 8, 4 and 8 μg/mL, resp. and min. bactericidal concentration (MBC) of 32, 16 and 64 μg/mL, resp. Conclusion: This is the first report of the biol. activities and phytochem. composition of S. ilicifolius and the results indicate the high potentials of the plant for com. applications such as in facial whitening and anti-acne cream.

Tropical Journal of Pharmaceutical Research published new progress about 56317-21-6. 56317-21-6 belongs to benzofurans, auxiliary class Metabolic Enzyme,PDE,Natural product, name is 5-(6-Hydroxybenzofuran-2-yl)benzene-1,3-diol, and the molecular formula is C14H10O4, Computed Properties of 56317-21-6.

Referemce:
https://en.wikipedia.org/wiki/Benzofuran,
Benzofuran | C8H6O – PubChem

Tathe, Akash G. published the artcileLigand-Enabled Gold-Catalyzed C(sp²)-S Cross-Coupling Reactions, COA of Formula: C8H5IO, the publication is Organic Letters (2022), 24(24), 4459-4463, database is CAplus and MEDLINE.

C(sp²)-S cross-coupling reactions of aryl iodides and arylsulfonyl hydrazides under ligand-enabled, Au(I)/Au(III) redox catalysis was reported. This strategy operates under mild reaction conditions, requires no prefunctionalized aryl coupling partner and works across several aryl iodides. The reaction mechanism was supported with control experiments, mass spectrometry, and NMR studies.

Organic Letters published new progress about 69626-75-1. 69626-75-1 belongs to benzofurans, auxiliary class Iodide,Benzofuran, name is 2-Iodobenzofuran, and the molecular formula is C20H17FO4S, COA of Formula: C8H5IO.

Referemce:
https://en.wikipedia.org/wiki/Benzofuran,
Benzofuran | C8H6O – PubChem

Chen, Hong-Bin published the artcileAccessing 2-Arylbenzofurans by Cu^I₂(pip)₂-Catalyzed Tandem Coupling/Cyclization Reaction: Mechanistic Studies and Application to the Synthesis of Stemofuran A and Moracin M, Product Details of C14H10O4, the publication is Asian Journal of Organic Chemistry (2016), 5(11), 1345-1352, database is CAplus.

An asym. dinuclear copper(I) complex, Cu^I2(pip)₂ (pip = (2-picolyliminomethyl)pyrrole anion), was utilized to catalyze the tandem coupling/cyclization reaction of o-iodophenols and terminal alkynes, which led to the formation of valuable 2-arylbenzofurans I (R¹ = Ph, 4-EtC₆H₄, 1-naphthyl, etc.; R² = H, 4-MeO, 4-t-Bu, 4-Ph, 4-F, 4-Br) in good yields. DFT calculations showed that the two proximate copper atoms play cooperative roles throughout the catalytic cycle. Using this catalytic protocol, bioactive natural products stemofuran A and moracin M were concisely synthesized.

Asian Journal of Organic Chemistry published new progress about 56317-21-6. 56317-21-6 belongs to benzofurans, auxiliary class Metabolic Enzyme,PDE,Natural product, name is 5-(6-Hydroxybenzofuran-2-yl)benzene-1,3-diol, and the molecular formula is C14H10O4, Product Details of C14H10O4.

Referemce:
https://en.wikipedia.org/wiki/Benzofuran,
Benzofuran | C8H6O – PubChem