Tag: M.W=150-200

Zhou, Muxing published the artcileChiral Bicyclic Imidazole-Catalyzed Acylative Dynamic Kinetic Resolution for the Synthesis of Chiral Phthalidyl Esters, Computed Properties of 52010-22-7, the main research area is acylative dynamic kinetic resolution hydroxyphthalide bicyclic imidazole catalyst; enantioselective acylation hydroxyphthalide dynamic kinetic resolution; phthalidyl ester prodrug preparation acylative dynamic kinetic resolution; bicyclic imidazole; dynamic kinetic resolution; enantioselective acylation; organocatalyst; phthalidyl ester prodrugs.

Utilizing a chiral bicyclic imidazole organocatalyst, I, and adopting a continuous injection process, an alternative route has been developed for the efficient synthesis of chiral phthalidyl ester prodrugs via dynamic kinetic resolution of 3-hydroxyphthalides through enantioselective acylation (up to 99% ee). The computational studies suggest a general base catalytic mechanism differing from the widely accepted nucleophilic catalytic mechanism. The structure anal. of the key transition states shows that the CH-π interaction, and not the previously considered cation/π-π interactions between the catalyst and substrate, is the dominant factor giving rise to the observed stereocontrol.

Angewandte Chemie, International Edition published new progress about Acylation catalysts (stereoselective, kinetic resolution). 52010-22-7 belongs to class benzofurans, name is 4-Chlorophthalide, and the molecular formula is C8H5ClO2, Computed Properties of 52010-22-7.

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Henry, Martyn C. published the artcileSynthesis of Benzo[b]furans by Intramolecular C-O Bond Formation Using Iron and Copper Catalysis, Category: benzofurans, the main research area is benzofuran preparation regioselective; aryl alkyl ketone halogenation arylation iron copper catalyst.

One-pot processes for the synthesis of benzo[b]furans from 1-aryl- or 1-alkylketones using nonprecious transition metal catalysts have been developed. Regioselective iron(III)-catalyzed halogenation of the aryl ring, followed by iron- or copper-catalyzed O-arylation allowed the synthesis of various structural analogs, including the benzo[b]furan-derived natural products corsifuran C, moracin F, and caleprunin B.

Organic Letters published new progress about Acetamides Role: RCT (Reactant), RACT (Reactant or Reagent). 13391-27-0 belongs to class benzofurans, name is 5-Methoxy-2-methylbenzofuran, and the molecular formula is C10H10O2, Category: benzofurans.

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Yoshida, N. published the artcileReductive dechlorination of PCBs and other chlorinated compounds by novel anaerobic bacterial species, Formula: C8H5ClO2, the main research area is anaerobic bacteria polychlorinated biphenyl chlorinated compound reductive dechlorination.

Bacteria that can reductively dechlorinate chlorinated compounds such as polychlorinated biphenyls (PCBs) and polychlorinated dibenzo-p-dioxins (PCDDs) have been receiving much attention in the field of environmental science and technol. In this study, the enrichment of bacteria that dechlorinate PCBs and PCDDs was performed by the sequentially transferred culture amended with 4,5,6,7-tetrachlorophthalide (fthalide) and single fatty acids from an uncontaminated paddy field. The enrichment cultures amended with lactate (KFL) or formate (KFF) maintained the activity to dechlorinate fthalide to 4-chlorophthalide in the sequential transfer but not the culture amended with acetate and butyrate. The only KFL-culture dechlorinated diverse chlorinated compounds including 2,3,4,5-tetrachlorobiphenyl, 2,3,4-trichlorobiphenyl, 1,2,3-trichlorodibenzo-p-dioxin. A further enrichment of KLF-culture provided an enrichment culture, KFC4A-culture, containing uniformly small short rods. Microbial community anal. based on 16S rRNA genes revealed the involvement of two phylogenetically distinct operational taxonomic units (OTUs) of Dehalobacter sp. (FTH1 and FTH2) with the dechlorination of chlorinated compounds Dehalobacter restrictus TEA was their closest relative, and had 97.5% and 97.3% of 16SrRNA gene similarities for FTH1 and FTH2, resp. These results demonstrate the capacity of uncontaminated paddy soil to dechlorinate PCBs and PCDDs, and the involvement of Dehalobacter sp.

Organohalogen Compounds published new progress about 16S rRNA Role: BSU (Biological Study, Unclassified), BIOL (Biological Study). 52010-22-7 belongs to class benzofurans, name is 4-Chlorophthalide, and the molecular formula is C8H5ClO2, Formula: C8H5ClO2.

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Yoshida, Naoko published the artcileA novel Dehalobacter species is involved in extensive 4,5,6,7-tetrachlorophthalide dechlorination, Category: benzofurans, the main research area is novel Dehalobacter tetrachlorophthalide dechlorination waste fungicide rice blast Dehalobacter.

The purpose of this study was the enrichment and phylogenetic identification of bacteria that dechlorinate 4,5,6,7-tetrachlorophthalide (com. designated “”fthalide””), an effective fungicide for rice blast disease. Sequential transfer culture of a paddy soil with lactate and fthalide produced a soil-free enrichment culture (designated the “”KFL culture””) that dechlorinated fthalide by using hydrogen, which is produced from lactate. Phylogenetic anal. based on 16S rRNA genes revealed the dominance of two novel phylotypes of the genus Dehalobacter (FTH1 and FTH2) in the KFL culture. FTH1 and FTH2 disappeared during culture transfer in medium without fthalide and increased in abundance with the dechlorination of fthalide, indicating their growth dependence on the dechlorination of fthalide. Dehalobacter restrictus TEA is their closest relative, with 97.5% and 97.3% 16S rRNA gene similarities to FTH1 and FTH2, resp.

Applied and Environmental Microbiology published new progress about Dechlorination. 52010-22-7 belongs to class benzofurans, name is 4-Chlorophthalide, and the molecular formula is C8H5ClO2, Category: benzofurans.

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Tabanca, Nurhayat published the artcileGas chromatographic-mass spectrometric analysis of essential oils from Pimpinella aurea, Pimpinella corymbosa, Pimpinella peregrina and Pimpinella puberula gathered from Eastern and Southern Turkey, Application In Synthesis of 13391-27-0, the main research area is Pimpinella essential oil terpene phenylpropanoid.

Essential oils from fruits, stems and leaves and roots of Pimpinella aurea DC., P. corymbosa Boiss., P. peregrina L. were analyzed by gas chromatog. (GC) and gas chromatog.-mass spectrometry (GC-MS) techniques. Fruits and aerial parts of P. puberula (DC.) Boiss were also evaluated. A total of 140 different compounds were identified, and significant qual. and quant. differences were observed among the samples. In fact, the main constituents of each species were different and only the oils extracted from roots shared the same principal compound, epoxy pseudoisoeugenyl-2-Me butyrate (26.8-42.8%). The other fractions were dominated by different sesquiterpene compounds although in three of them, P. aurea stem and leaves, P. puberula fruits and P. puberula stems and leaves, monoterpene constituents also appear as main ones.

Journal of Chromatography A published new progress about Gas chromatography. 13391-27-0 belongs to class benzofurans, name is 5-Methoxy-2-methylbenzofuran, and the molecular formula is C10H10O2, Application In Synthesis of 13391-27-0.

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Moock, Daniel published the artcileEnantio- and Diastereoselective, Complete Hydrogenation of Benzofurans by Cascade Catalysis, Category: benzofurans, the main research area is octahydrobenzofuran enantioselective preparation; benzofuran preparation enantioselective hydrogenation cascade catalyst; benzofuran; cascade catalysis; enantioselective hydrogenation; heterogeneous catalysis; homogeneous catalysis.

We report an enantio- and diastereoselective, complete hydrogenation of multiply substituted benzofurans in a one-pot cascade catalysis. The developed protocol facilitates the controlled installation of up to six new defined stereocenters and produces architecturally complex octahydrobenzofurans, prevalent in many bioactive mols. A unique match of a chiral homogeneous ruthenium-N-heterocyclic carbene complex and an in situ activated rhodium catalyst from a complex precursor act in sequence to enable the presented process.

Angewandte Chemie, International Edition published new progress about Diastereoselective synthesis. 13391-27-0 belongs to class benzofurans, name is 5-Methoxy-2-methylbenzofuran, and the molecular formula is C10H10O2, Category: benzofurans.

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Salom-Roig, Xavier J. published the artcilePreparation of substituted hydroquinones and benzofurans from 1,4-quinone monoketals, Related Products of benzofurans, the main research area is hydroquinone preparation; propargylhydroquinone preparation dienone phenol type rearrangement; benzofuran preparation; quinone ketal organometallic addition.

An easy procedure for the preparation of 2-substituted hydroquinones, by addition of organolithium or organomagnesium compounds to 1,4-quinone monoketals followed by acid-catalyzed dienone-phenol type rearrangement, is described. Transformation of the propargylated derivatives to benzofurans is also reported.

Synthesis published new progress about Ketals Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 13391-27-0 belongs to class benzofurans, name is 5-Methoxy-2-methylbenzofuran, and the molecular formula is C10H10O2, Related Products of benzofurans.

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Zhou, Lixin published the artcilePd-catalyzed intramolecular Heck reaction for the synthesis of 2-methylbenzofurans, COA of Formula: C10H10O2, the main research area is methylbenzofuran preparation; iodobenzene aryl bromide intramol Heck reaction palladium catalyst.

A new strategy for the synthesis of 2-methylbenzofurans I (R1 = H, 7-Me, 5-Cl, etc.; R2 = H, Me, COOEt) via the intramol. Heck reaction has been developed. This efficient palladium-catalyzed system showed good catalytic activity. Various substituted 2-methylbenzofurans could be afforded in good to excellent yields.

Tetrahedron Letters published new progress about Aryl iodides Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 13391-27-0 belongs to class benzofurans, name is 5-Methoxy-2-methylbenzofuran, and the molecular formula is C10H10O2, COA of Formula: C10H10O2.

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Shen, Yu-Dong published the artcileNatural tanshinone-like heterocyclic-fused ortho-quinones from regioselective Diels-Alder reaction: Synthesis and cytotoxicity evaluation, Computed Properties of 13391-27-0, the main research area is tanshinone analog heterocyclic fused ortho quinone preparation cytotoxicity; benzofuranol regioselective Diels Alder reaction dieneamide aminodiene; structure activity relationship tanshinone analog cytotoxicity.

A series of new natural tanshinone-like oxoheterocyclic-fused ortho-quinone derivatives I [R1 = Me, H; R2 = Ar, H; R3 = H, amide group; R4 = R5 = Me, H] were synthesized from readily available benzofuranol and N-substituted dienes via IBX oxidation-cycloaddition-aromatization procedure. The regiospecific Diels-Alder cycloaddition reactions of N-dienes were achieved efficiently with a variety of dienophiles. It is found that the amide moiety in the mol. could be preserved or eliminated by control of the aromatization conditions. Selected oxoheterocyclic-fused ortho-quinones as well as several thioheterocyclic-fused ortho-quinones we obtained before were evaluated for their cytotoxicities on different cancer cell lines and the Structure-Activity Relationship (SAR) was discussed.

European Journal of Medicinal Chemistry published new progress about Antitumor agents. 13391-27-0 belongs to class benzofurans, name is 5-Methoxy-2-methylbenzofuran, and the molecular formula is C10H10O2, Computed Properties of 13391-27-0.

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Velasco-Negueruela, A. published the artcileAnalysis by gas chromatography-mass spectrometry of the essential oil from the aerial parts of Pimpinella junoniae Ceb. & Ort., gathered in La Gomera, Canary Islands, Spain, Quality Control of 13391-27-0, the main research area is terpene arylpropanoid gas chromatog oil Pimpinella.

The essential oil from the aerial parts of Pimpinella junoniae Ceb.& Ort., growing in La Gomera, Canary Islands, Spain, was studied by gas chromatog. and gas chromatog.-mass spectrometry, and 43 constituents were identified. The major components were found to be α-zingiberene (20.6%), α-pinene (17.9%), (E)-β-farnesene (9.3%), ar-curcumene (7.4%), β-phellandrene (7.0%), β-bisabolene (6.1%) and epoxypseudoisoeugenyl 2-methylbutyrate (6.0%). The decomposition product of epoxypseudoisoeugenol derivatives, 5-methoxy-2-methylbenzofuran (5.7%), moderate amounts of other arylpropanoids with the pseudoisoeugenol skeleton (total percentage, 5.2%) and other compounds such as β-sesquiphellandrene (3.0%), cis-β-guaiene (1.5%), α-phellandrene (1.5%) and α-bisabolol (1.3%), were also found.

Journal of Chromatography A published new progress about Gas chromatography-mass spectrometry. 13391-27-0 belongs to class benzofurans, name is 5-Methoxy-2-methylbenzofuran, and the molecular formula is C10H10O2, Quality Control of 13391-27-0.

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem