Zhou, Muxing published the artcileChiral Bicyclic Imidazole-Catalyzed Acylative Dynamic Kinetic Resolution for the Synthesis of Chiral Phthalidyl Esters, Computed Properties of 52010-22-7, the main research area is acylative dynamic kinetic resolution hydroxyphthalide bicyclic imidazole catalyst; enantioselective acylation hydroxyphthalide dynamic kinetic resolution; phthalidyl ester prodrug preparation acylative dynamic kinetic resolution; bicyclic imidazole; dynamic kinetic resolution; enantioselective acylation; organocatalyst; phthalidyl ester prodrugs.
Utilizing a chiral bicyclic imidazole organocatalyst, I, and adopting a continuous injection process, an alternative route has been developed for the efficient synthesis of chiral phthalidyl ester prodrugs via dynamic kinetic resolution of 3-hydroxyphthalides through enantioselective acylation (up to 99% ee). The computational studies suggest a general base catalytic mechanism differing from the widely accepted nucleophilic catalytic mechanism. The structure anal. of the key transition states shows that the CH-π interaction, and not the previously considered cation/π-π interactions between the catalyst and substrate, is the dominant factor giving rise to the observed stereocontrol.
Angewandte Chemie, International Edition published new progress about Acylation catalysts (stereoselective, kinetic resolution). 52010-22-7 belongs to class benzofurans, name is 4-Chlorophthalide, and the molecular formula is C8H5ClO2, Computed Properties of 52010-22-7.
Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem