Tag: M.W:100-200

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.7169-34-8,Benzofuran-3(2H)-one,as a common compound, the synthetic route is as follows.,7169-34-8

General procedure: A mixture of benzofuran-3(2H)-one (2.0 mmol), benzaldehyde (2.2mmol) and water (5 mL) was stirred at reflux temperature for 6-10 h. Completion of the reaction was checked on TLC. Then the mixture was allowed to rt and stirred for 1 h. The precipitated solids were filtered, washedwith water (2 ¡Á 5 mL) and dried to give the product. (Z)-2-Benzylidenebenzofuran-3(2H)-one (4a). Pale yellow color solid (380 mg, 86%), mp 102-104 C (lit.23 mp110-111 C). 1H NMR (CDCl3): 7.93 (2H, d, J 6.8 Hz), 7.82 (1H, d, J 7.6 Hz), 7.66 (1H, t, J 8.2 Hz), 7.38-7.48 (3H,m), 7.34 (1H, d, J 8.0 Hz), 7.22 (1H, t, J 7.4 Hz), 6.90 (1H, s); 13C NMR (CDCl3): 184.7, 166.2, 146.9, 136.8, 132.4,131.5, 129.9, 128.9, 124.7, 123.5, 121.7, 113.0, 112.9; LC-MS (positive ion mode): m/z 223 (M+H)+.

As the paragraph descriping shows that 7169-34-8 is playing an increasingly important role.

Reference£º
Article; Venkateswarlu, Somepalli; Murty, Gandrotu Narasimha; Satyanarayana, Meka; Arkivoc; vol. 2017; 4; (2017); p. 303 – 314;,
Benzofuran – Wikipedia
Benzofuran | C8H6O – PubChem

496-16-2, 2,3-Dihydrobenzo[b]furan is a benzofuran compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

56 g (0.42 mol) of aluminum trichloride is added to 280 g of methylene chloride,Cool to 0¡ãC,Temperature drop below 10¡ãC45 g (0.33 mol) monoethyl oxalyl chloride,After the drop, the heat preservation reaction is 1hr,36 g (0.30 mol) of 2,3-dihydrobenzofuran (Compound 3) was added dropwise below 10¡ã C., and the reaction was allowed to proceed overnight at room temperature.After confirming the reaction,The reaction solution was poured into 300 g of ice water,Stirring liquid,Extract with dichloromethane (100g x 2)Combine the organic phase,Wash once with 200 g of saturated aqueous sodium bicarbonate,filter,The filtrate was dried over anhydrous sodium sulfate.Filtered,Concentrate to give about 73 g of oil (theoretical amount: 65.98 g).

496-16-2, As the paragraph descriping shows that 496-16-2 is playing an increasingly important role.

Reference£º
Patent; Inner Mongolia Jingdong Pharmaceutical Co., Ltd.; Guo Rongyao; Wang Xiaofeng; (9 pag.)CN107721954; (2018); A;,
Benzofuran – Wikipedia
Benzofuran | C8H6O – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.59434-19-4,4-Aminophthalide,as a common compound, the synthetic route is as follows.,59434-19-4

To a solution of 4-aminoisobenzofuran-1(3H)-one (1 g, 6.7 mmol) and 1-(4-fluorophenyl)ethanone (1.4 g, 10.1 mmol) in toluene (35 mL) was added anhydrous magnesium sulfate (8.8 g, 73.7 mmol) and acetic acid (0.2 mL) at room temperature under N2. The reaction mixture was then stirred at 120 C. for 36 hr. The reaction mixture was cooled to 90 C. and filtered. After filter cake was washed with acetonitrile, the filtrates were combined and evaporated to dryness to obtain yellow solid, which was washed by petroleum ether to obtain the title compound as a white solid (1.58 g, yield 88%). LC-MS (ESI) m/z: 270(M+1)+H-NMR (400 MHz, CDCl3) delta (ppm): 2.30 (s, 3H), 5.16 (s, 2H), 7.00-7.02 (d, J=7.6 Hz, 1H), 7.13-7.18 (m, 2H), 7.51-7.56 (t, J=7.6 Hz, 1H), 7.66-7.69 (d, J=7.6 Hz, 1H), 7.99-8.03 (m, 2H).

As the paragraph descriping shows that 59434-19-4 is playing an increasingly important role.

Reference£º
Patent; LEAD THERAPEUTICS, INC.; US2010/35883; (2010); A1;,
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166599-84-4, Benzofuran-4-carboxylic acid is a benzofuran compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

To a mixture of benzofuran-4-carboxylic acid (Eissenstat M. A. et al, J. Med. Chem. 1995, 38, 16, 3094-3105 (61 mg), PyBOP (196 mg), DIEA (0.15 mL) in dry DMF (0.5 mL), was added a solution of (2RS)-(2-aminomethyl-azetidin-1-yl)-biphenyl-2-yl-methanone (100 mg) in dry DMF (0.5 mL). The resulting reaction mixture was stirred at RT for 20 h. The reaction mixture was diluted with EA, washed with water. The aqueous phase was extracted once again with EA, the combined organic extracts were dried (MgSO4), filtered and concentrated to yield the crude product as light brown oil.FC (EA) gave 140 mg (71%) of the title compound as a light yellow oilLC-MS: rt=0.99 min, 411 [M+H]+., 166599-84-4

As the paragraph descriping shows that 166599-84-4 is playing an increasingly important role.

Reference£º
Patent; Actelion Pharmaceuticals Ltd.; US2010/222600; (2010); A1;,
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10242-08-7, 5-Methoxybenzofuran-2-carboxylic acid is a benzofuran compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Under ice-cooling,2-hydroxy-5-methoxybenzaldehyde (3.0g, 20mmol) and anhydrous K2CO3 (3.3g,23.4mmol) (50ml) was dissolved in DMF, was slowly added dropwise ethylbromoacetate (3.3g, 20mmol). After dropping Bi, 0 C was stirred for 30min,then at 60 C in an oil bath, the reaction 12h. The reaction solution waspoured into ice water, over Filtered, the solid was dissolved in chloroform,dried over anhydrous Na2SO4, filtered, and spin dry the solvent, by silica gelcolumn chromatography, To give 3.24 g of a yellow solid (75% yield), which was dissolved indioxane (30ml) was added 1N hydrogen Sodium hydroxide solution (15ml), stirredat room temperature 2h, the dioxane was evaporated to dryness, the residualliquid was poured into ice water, washed with diethyl Washed with methylenechloride, adjusting the PH value to 2, the solid was collected by filtration 2.68g (92% yield), whichwas dissolved in methylene Dioxane (50ml), was added DIC (1.51g, 11.98mmol),after stirring at room temperature 1h, was added DMAP (0.24g, 1.96 mmol) anddimethyl hydroxyethyl phosphonate (1.84g, 10.95mmol), heated to reflux after6h, water and saturated brine The reaction solution was washed with water,dried over anhydrous magnesium sulfate, filtered and evaporated to dryness,ethyl acetate – petroleum ether system recrystallized To (dimethoxyphosphoryl)ethyl 5-methoxybenzofuran-2-carboxylate 3.67g (77% yield), which was Was dissolved indichloromethane (50ml), was added trimethylsilyl bromide (9.85g, 64.8mmol) atroom temperature was stirred for 3h, with Quench with methanol, evaporated todryness to give the product 5-methoxy-benzofuran-2-carboxylic acid ethyl esterphosphono 2.38 g (yield, 74%)., 10242-08-7

As the paragraph descriping shows that 10242-08-7 is playing an increasingly important role.

Reference£º
Patent; Institute of Medicinal Biotechnology Chinese Academy of MedicalSciences; Li, Zhuorong; Liu, Zongying; Xue, Situ; He, Xiaobo; Jin, Jie; Si, Shuyi; Ye, Weidong; (43 pag.)CN103130705; (2016); B;,
Benzofuran – Wikipedia
Benzofuran | C8H6O – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.496-16-2,2,3-Dihydrobenzo[b]furan,as a common compound, the synthetic route is as follows.

Bromination using NBS has been found to be applicable for use with a wide range of aromatic starting materials or substrates, as is EPO summarized in Table 1 . For example, anisole can be brominated by use of 1 equivalent of NBS in the presence of 5 mol % of ZrCI4 at -78 0C to afford p- bromoanisole in 98% yield as sole product (Table 1 , Entry 1 ). However, in the absence of ZrCI4 the halogenation does not proceed, even at room temperature (Table 1 , Entry 1 ).[00111] All of the substrates shown in Table 1 were brominated to give the corresponding monobromo products in excellent yield and regioselectivity. In most cases, the reaction can proceed at very low temperature and no further purification is necessary. In addition. Table 1 reveals that the halogenation of the present invention is compatible with a variety of substituents.Table 1 ZrCI4 Catalyzed Bromination of Aromatic Compounds EPO (5 mol %), CH2CI2 (4d See spectroscopic data for characterization.

496-16-2, 496-16-2 2,3-Dihydrobenzo[b]furan 10329, abenzofuran compound, is more and more widely used in various fields.

Reference£º
Patent; UNIVERSITY OF CHICAGO; JAPAN SCIENCE AND TECHNOLOGY AGENCY; WO2007/27917; (2007); A2;,
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Benzofuran | C8H6O – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.496-16-2,2,3-Dihydrobenzo[b]furan,as a common compound, the synthetic route is as follows.

2,3-dihydrobenzofuran (6.0 g, 49.94 mmol) is added over 20 minutes to chlorosulfonic acid (29.09 g, 249.69 mmol) at -20¡ã C. The reaction mixture is quenched by addition of ice followed by water (20 mL). The mixture is then extracted with ethyl acetate. The combined organic estracts are washed with brine, dried (Na2 SO4), and the solvent is evaporated. The crude product is purified by silica gel chromatography (30percent ethyl acetate/hexane) to give 2,3-dihydrobenzofuran-5-sulfonyl chloride (3.3 g).

496-16-2, As the paragraph descriping shows that 496-16-2 is playing an increasingly important role.

Reference£º
Patent; Ciba-Geigy Corporation; US5455258; (1995); A;; ; Patent; Ciba-Geigy Corporation; US5552419; (1996); A;,
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Benzofuran | C8H6O – PubChem

24673-56-1, 3-Methylbenzofuran-2-carboxylic acid is a benzofuran compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

3-Methylbenzofuran-2-carboxylic acid (commercially available) was heated withcopper metal in quinoline to give compound 5. Colorlessoil, 1H-NMR (500 MHz, CDCl3) delta: 2.22 (3H, d, J=1.2 Hz),7.18-7.26 (2H,m), 7.38 (1H, dd, J=1.2, 8.0 Hz), 7.48 (1H, m),7.51 (1H, dd, J=1.2, 8.0 Hz). 13C-NMR (125 MHz, CDCl3)delta: 6.4, 110.6, 115.2, 119.0, 121.9, 123.8, 128.4, 141.4, 155.5.Its spectral data are in accordance with previously reported data.

24673-56-1, The synthetic route of 24673-56-1 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Yamaguchi, Yuki; Akimoto, Ichie; Motegi, Kyoko; Yoshimura, Teruki; Wada, Keiji; Nishizono, Naozumi; Oda, Kazuaki; Chemical and Pharmaceutical Bulletin; vol. 61; 10; (2013); p. 997 – 1001;,
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Benzofuran | C8H6O – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.69999-16-2,2,3-Dihydrobenzofuranyl-5-acetic acid,as a common compound, the synthetic route is as follows.,69999-16-2

208 g of tetrahydrofuran was added to the reaction flask.Then add 13g (0.344mol) sodium borohydride,Add with stirring26g (0.146mol)Compound 1 obtained in Example 3,Insulation does not exceed 10C during the joining process.After the addition,49 g (0.345 mol) of boron trifluoride diethyl ether complex were initially added dropwise for about 2 hours.After dropping,The temperature of the dropping process does not exceed 15C.After the addition,Remove ice salt water,Naturally warm to room temperature;Reheat to reflux,After about 2hrs,After the reaction is completed,Cool down to 15C,Methanol 60 g was added dropwise.Then add 140g concentrated hydrochloric acid solution,After stirring,Tetrahydrofuran is concentrated under reduced pressureAfter the basic concentration of tetrahydrofuran is complete,An aqueous solution containing 11 g of sodium hydroxide is added,Add 300g ethyl acetate extraction,Liquid separation,The aqueous phase is extracted with 200 g of ethyl acetate.Combine the organic phase,Dry with anhydrous sodium sulfatefilter,Concentrate under reduced pressure,Get an oil,19.2g (theoretical quantity:23.96g);Yield:80.1%.

The synthetic route of 69999-16-2 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Inner Mongolia Jingdong Pharmaceutical Co., Ltd.; Guo Rongyao; Wang Xiaofeng; (9 pag.)CN107721954; (2018); A;,
Benzofuran – Wikipedia
Benzofuran | C8H6O – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.23145-07-5,5-Bromobenzofuran,as a common compound, the synthetic route is as follows.

23145-07-5, A. Preparation of 5-Cyanobenzo(b)furan: 5-Bromobenzo(b)-furan (19.3 g., 0.098 mole) was added dropwise to a stirred mixture of cuprous cyanide (0.14 mole) and pyridine at 165¡ã C. Heating at 165¡ã C. was continued for 26 hours and the cool reaction mixture was then added to 10percent (by weight) aqueous ammonia solution. Toluene (100 ml.) was added and the resulting mixture stirred for 0.5 hours and then filtered. Ether (250 ml.) was added to the filtrate and the organic phase separated and combined with the ether extracts (2*100 ml.) of the aqueous phase. The combined organic solutions were washed in turn with 5percent aqueous ammonia (4*100 ml.), water (100 ml.), dilute hydrochloric acid (3*100 ml.) and finally water (100 ml.). Evaporation in vacuo of the dried (MgSO4) organic solution gave an oil which readily solidified. Purification was effected by column chromatography on silica gel using methylene chloride as eluent. Trituration of the product with hexane provided pure 5-cyanobenzo(b)furan as a white solid (8.2 g), m.p. 85¡ã-87¡ã C. Analysis percent: Found: C, 75.2; H, 3.5; N, 9.7; C9 H5 NO requires: C, 75.5; H, 3.5; N, 9.8.

As the paragraph descriping shows that 23145-07-5 is playing an increasingly important role.

Reference£º
Patent; Pfizer Inc.; US4341792; (1982); A;,
Benzofuran – Wikipedia
Benzofuran | C8H6O – PubChem