Tag: M.W:100-200

Reference of 4265-16-1, The reaction rate of a catalyzed reaction is faster than the reaction rate of the uncatalyzed reaction at the same temperature.4265-16-1, Name is Benzo[b]furan-2-carboxaldehyde, molecular formula is C9H6O2. In a Article，once mentioned of 4265-16-1

Four novel series of cinnamyl-containing histone deacetylase (HDAC) inhibitors 1-4 are described, containing hydroxamate (1 and 3) or 2-aminoanilide (2 and 4) derivatives. When screened against classI (maize HD1-B and human HDAC1) and classII (maize HD1-A and human HDAC4) HDACs, most hydroxamates and 2-aminoanilides displayed potent and selective inhibition toward classI enzymes. Immunoblotting analyses performed in U937 leukemia cells generally revealed high acetyl-H3 and low acetyl-alpha-tubulin levels. Exceptions are compounds 3f-i, 3m-o, and 4k, which showed higher tubulin acetylation than SAHA. In U937 cells, cell-cycle blockade in either the G2/M or G1/S phase was observed with 1-4. Five hydroxamates (compounds 1h-l) effected a two- to greater than threefold greater percent apoptosis than SAHA, and in the CD11c cytodifferentiation test some 2-aminoanilides belonging to both series 2 and 4 were more active than MS-275. The highest-scoring derivatives in terms of apoptosis (1k, 1l) or cytodifferentiation (2c, 4n) also showed antiproliferative activity in U937 cells, thus representing valuable tools for study in other cancer contexts.

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Reference：
Benzofuran – Wikipedia,
Benzofuran | C8H1085O – PubChem

Synthetic Route of 4790-81-2, Catalysts function by providing an alternate reaction mechanism that has a lower activation energy than would be found in the absence of the catalyst. In some cases, the catalyzed mechanism may include additional steps.In a article, 4790-81-2, molcular formula is C8H6O2, introducing its new discovery.

The present invention is directed to novel nanomolar and picomolar inhibitors of HIV reverse transcriptase, pharmaceutical compositions therefrom and methods for inhibiting reverse transcriptase and treating HIV infections, especially included drug resistant strains of HIV-1 and HIV-2 and/or secondary disease states and/or conditions which occur as a consequence of HIV infection.

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Reference：
Benzofuran – Wikipedia,
Benzofuran | C8H436O – PubChem

Reference of 13196-11-7, Because a catalyst decreases the height of the energy barrier, its presence increases the reaction rates of both the forward and the reverse reactions by the same amount.13196-11-7, Name is Benzofuran-6-ol, molecular formula is C8H6O2. In a article，once mentioned of 13196-11-7

The lead identification of a novel potent selective PPARgamma agonist, DS-6930 is reported. To avoid PPARgamma-related adverse effects, a partial agonist was designed to prevent the direct interaction with helix 12 of PPARgamma-LBD. Because the TZD group is known to interact with helix 12, the TZD in efatutazone (CS-7017) was replaced to discover novel PPARgamma intermediate partial agonist 8i. The optimization of 8i yielded 13ac with high potency in vitro. Compound 13ac exhibited robust plasma glucose lowering effects comparable to those of rosiglitazone (3 mg/kg) in Zucker diabetic fatty rats. Upon toxicological evaluation, compound 13ac (300 mg/kg) induced hemodilution to a lower extent than rosiglitazone; however, 13ac elevated liver enzyme activities. X-ray crystallography revealed no direct interaction of 13ac with helix 12, and the additional lipophilic interactions are also suggested to be related to the maximum transcriptional activity of 13ac.

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Reference：
Benzofuran – Wikipedia,
Benzofuran | C8H422O – PubChem

Chemistry is traditionally divided into organic and inorganic chemistry. Product Details of 1563-38-8, The former is the study of compounds containing at least one carbon-hydrogen bonds.In a patent，Which mentioned a new discovery about 1563-38-8

A set of new aryloxy-quinones were synthesized and evaluated in vitro against the epimastigote form of Trypanosoma cruzi and their unspecific cytotoxicity was tested on murine macrophages J-774 cells. Most of these novel compounds were found to be much more potent and selective than the standard drug nifurtimox. Interestingly, 2-phenoxy-naphthoquinone 3b displayed a remarkable nanomolar inhibitory activity, IC50 = 20 nM, and a high selectivity index, SI = 625. The Epc1 was determined for the most interesting compounds and no correlation with the trypanosomicidal effect was found. Therefore, an in silico study was carried out to obtain a pharmacophoric model and quantitative structure-trypanosomicidal activity relationship. The designed pharmacophore recognized the more potent and selective molecules, exhibiting five pharmacophoric features. A correlation coefficient R2 of 0.99 of pIC50 plotted against the predicted values indicated that the 3D-QSAR equation could be applied to further predictions of newly designed trypanosomicidal compounds.

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Reference：
Benzofuran – Wikipedia,
Benzofuran | C8H2426O – PubChem

Synthetic Route of 4265-16-1, Chemistry is the experimental science by definition. We want to make observations to prove hypothesis. For this purpose, we perform experiments in the lab. 4265-16-1, Name is Benzo[b]furan-2-carboxaldehyde,introducing its new discovery.

Synthetic array technology was utilized to rapidly synthesize and analyze a diverse set of reductive alkylation analogues of daptomycin. Analysis of the array suggested the use of polar functionality such as sulfonamides or amide or polar spaces such as piperazine would beneficially affect activity.

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Reference：
Benzofuran – Wikipedia,
Benzofuran | C8H1044O – PubChem

Reference of 4265-16-1, Chemistry is the experimental science by definition. We want to make observations to prove hypothesis. For this purpose, we perform experiments in the lab. 4265-16-1, Name is Benzo[b]furan-2-carboxaldehyde,introducing its new discovery.

A series of linear benzofuran derivatives consisting of either a vinylene or a cyanovinylene were prepared in order to investigate their emission properties. The X-ray crystallography of structurally similar derivatives was also evaluated. The crystalline structures of the vinylene derivatives showed only lateral contacts that involved the benzofurans and no pi-stacking. In contrast, pi-stacking was observed for the bisbenzofuran and benzofuran-phenyl cyanovinylene derivatives. No intermolecular pi-pi stacking was observed for the extended cyanovinylene structures. Intermolecular bonding between the nitrile and a furan atom was found. The fluorescence quantum yields (fl) of the vinylene derivatives were consistently high (>50%) in both solution and the crystal state. The exception was the benzofuran-furan-vinylene-phenyl, the fl of which was <10% when in the solid state. The cyanovinylene counterparts emitted weakly in solution (fl < 2%). Their luminogenic property was demonstrated with a ca. 15-fold increase in emission in the solid state. A 6-fold emission enhancement was also found when they were aggregated in a 90 vol% methanol/water mixture. The solid-state emission enhancement of the cyanovinylene benzofurans was in part attributable to intermolecular contacts that suppressed excited-state deactivation by molecular motion. We’ll also look at important developments in the pharmaceutical industry because understanding organic chemistry is important in understanding health, medicine, the role of 4265-16-1, and how the biochemistry of the body works.Reference of 4265-16-1

Reference：
Benzofuran – Wikipedia,
Benzofuran | C8H834O – PubChem

Application of 13196-11-7, The reaction rate of a catalyzed reaction is faster than the reaction rate of the uncatalyzed reaction at the same temperature.13196-11-7, Name is Benzofuran-6-ol, molecular formula is C8H6O2. In a Article，once mentioned of 13196-11-7

Enzymatic cis-dihydroxylation of benzo[b]thiophene, benzo[b]furan and several methyl substituted derivatives was found to occur in both the carbocyclic and heterocyclic rings. Relative and absolute configurations and enantiopurities of the resulting dihydrodiols were determined. Hydrogenation of the alkene bond in carbocyclic cis-dihydrodiols and ring-opening epimerization/reduction reactions of heterocyclic cis/trans-dihydrodiols were also studied. The relatively stable heterocyclic dihydrodiols of benzo[b]thiophene and benzo[b]furan showed a strong preference for the trans configuration in aqueous solutions. The 2,3-dihydrodiol metabolite of benzo[b]thiophene was utilized as a precursor in the chemoenzymatic synthesis of the unstable arene oxide, benzo[b]thiophene 2,3-oxide.

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Reference：
Benzofuran – Wikipedia,
Benzofuran | C8H409O – PubChem

Application of 1563-38-8, Chemistry is the experimental science by definition. We want to make observations to prove hypothesis. For this purpose, we perform experiments in the lab. 1563-38-8, Name is 2,2-Dimethyl-2,3-dihydrobenzofuran-7-ol,introducing its new discovery.

The preparation of carbamates under mild conditions utilizing a new class of activated carbonates (containing chloromethyl function) is described.

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Reference：
Benzofuran – Wikipedia,
Benzofuran | C8H2396O – PubChem

4265-16-1, Name is Benzo[b]furan-2-carboxaldehyde, belongs to benzofurans compound, is a common compound. Recommanded Product: 4265-16-1In an article, once mentioned the new application about 4265-16-1.

An efficient synthesis of a novel series of twelve substituted 2-amino-3-cyano-4H-pyran derivatives was achieved by a one-pot three-component cyclocondensation reaction of heteroaryl aldehydes, malononitrile and active methylene compounds catalyzed by iodine in aqueous medium under ultrasound irradiation. In comparison with conventional methods, our protocol is convenient and offers several advantages, such as shorter reaction time, higher yields, milder conditions and environmental friendliness. We have herein successfully demonstrated the synergistic outcome of multi-component reaction (MCR) and sonication to offer a facile route for the design of these derivatives.

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Reference：
Benzofuran – Wikipedia,
Benzofuran | C8H1063O – PubChem

Chemistry is traditionally divided into organic and inorganic chemistry. Recommanded Product: Methyl benzofuran-4-carboxylate, The former is the study of compounds containing at least one carbon-hydrogen bonds.In a patent，Which mentioned a new discovery about 41019-56-1

The invention concerns a novel method for synthesis of 4-benzofuran-carboxylic acid or alkyl ester thereof. This method is characterized in that a reaction for aromatization of a compound of formula (II) is performed for the synthesis of the compound of formula (I), according to the scheme A2 below: wherein R independently represents hydrogen or a linear or branched C1-15 alkyl group. With the invention, it is possible to industrially synthesize 4-benzofuran-carboxylic acid or alkyl ester thereof with good yield and very good purity.

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Reference：
Benzofuran – Wikipedia,
Benzofuran | C8H2797O – PubChem