Properties and Exciting Facts About 2,2-Dimethyl-2,3-dihydrobenzofuran-7-ol

If you are interested in 1563-38-8, you can contact me at any time and look forward to more communication. Product Details of 1563-38-8

Chemistry is traditionally divided into organic and inorganic chemistry. Product Details of 1563-38-8, The former is the study of compounds containing at least one carbon-hydrogen bonds.In a patent,Which mentioned a new discovery about 1563-38-8

A set of new aryloxy-quinones were synthesized and evaluated in vitro against the epimastigote form of Trypanosoma cruzi and their unspecific cytotoxicity was tested on murine macrophages J-774 cells. Most of these novel compounds were found to be much more potent and selective than the standard drug nifurtimox. Interestingly, 2-phenoxy-naphthoquinone 3b displayed a remarkable nanomolar inhibitory activity, IC50 = 20 nM, and a high selectivity index, SI = 625. The Epc1 was determined for the most interesting compounds and no correlation with the trypanosomicidal effect was found. Therefore, an in silico study was carried out to obtain a pharmacophoric model and quantitative structure-trypanosomicidal activity relationship. The designed pharmacophore recognized the more potent and selective molecules, exhibiting five pharmacophoric features. A correlation coefficient R2 of 0.99 of pIC50 plotted against the predicted values indicated that the 3D-QSAR equation could be applied to further predictions of newly designed trypanosomicidal compounds.

If you are interested in 1563-38-8, you can contact me at any time and look forward to more communication. Product Details of 1563-38-8

Reference:
Benzofuran – Wikipedia,
Benzofuran | C8H2426O – PubChem