Fang, Huaquan’s team published research in Organic Letters in 2016-11-04 | CAS: 50551-63-8

Organic Letters published new progress about Aryl iodides Role: RCT (Reactant), RACT (Reactant or Reagent). 50551-63-8 belongs to class benzofurans, name is 6-Methoxybenzofuran, and the molecular formula is C9H8O2, Quality Control of 50551-63-8.

Fang, Huaquan published the artcileA Pincer Ruthenium Complex for Regioselective C-H Silylation of Heteroarenes, Quality Control of 50551-63-8, the main research area is pincer ruthenium complex catalyst regioselective silylation heteroarene; heteroaryl silane preparation regioselective Hiyama Denmark coupling iodobenzene.

A pincer Ru(II) catalyst for the highly efficient undirected silylation of O- and S-heteroarenes with (TMSO)2MeSiH and Et3SiH is described, producing heteroarylsilanes with exclusive C2-regioselectivity, good functional-group tolerance, and high turnover numbers (up to 1960). The synthetic utility of the silylated products is demonstrated by Pd-catalyzed Hiyama-Denmark cross-coupling under mild conditions. One-pot, two-step silylation and coupling procedures have been also developed.

Organic Letters published new progress about Aryl iodides Role: RCT (Reactant), RACT (Reactant or Reagent). 50551-63-8 belongs to class benzofurans, name is 6-Methoxybenzofuran, and the molecular formula is C9H8O2, Quality Control of 50551-63-8.

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Graham, Samuel L.’s team published research in Journal of Medicinal Chemistry in 1990-02-28 | CAS: 50551-63-8

Journal of Medicinal Chemistry published new progress about Allergens Role: RCT (Reactant), RACT (Reactant or Reagent). 50551-63-8 belongs to class benzofurans, name is 6-Methoxybenzofuran, and the molecular formula is C9H8O2, HPLC of Formula: 50551-63-8.

Graham, Samuel L. published the artcileTopically active carbonic anhydrase inhibitors. 3. Benzofuran- and indole-2-sulfonamides, HPLC of Formula: 50551-63-8, the main research area is benzofuransulfonamide preparation carbonic anhydrase inhibition; indolesulfonamide preparation carbonic anhydrase inhibition; carbonic anhydrase inhibition benzofuransulfonamide indolesulfonamide; ocular hypotensive benzofuransulfonamide indolesulfonamide; glaucoma treatment indolesulfonamide benzofuransulfonamide.

Derivatives of 2-benzofuran- and 2-indolesulfonamide (e.g., I, II) were prepared for evaluation as topically active ocular hypotensive agents. These compounds were excellent inhibitors of carbonic anhydrase and lowered intraocular pressure in a rabbit model of ocular hypertension. However, their development for clin. use was precluded because they cause dermal sensitization in guinea pigs. A correlation between electrophilicity, as assessed by in vitro reactivity with reduced glutathione, and dermal sensitization potential was further documented.

Journal of Medicinal Chemistry published new progress about Allergens Role: RCT (Reactant), RACT (Reactant or Reagent). 50551-63-8 belongs to class benzofurans, name is 6-Methoxybenzofuran, and the molecular formula is C9H8O2, HPLC of Formula: 50551-63-8.

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Downstream Synthetic Route Of Isobenzofuran-1(3H)-one

COA of Formula: C8H6O2. Bye, fridends, I hope you can learn more about C8H6O2, If you have any questions, you can browse other blog as well. See you lster.

COA of Formula: C8H6O2. Kang, HJ; Jung, Y; Kwon, JH in [Kang, Hyun-Joong; Jung, Yerin; Kwon, Jung-Hwan] Korea Univ, Div Environm Sci & Ecol Engn, 145 Anam Ro, Seoul 02841, South Korea published Changes in ecotoxicity of naphthalene and alkylated naphthalenes during photodegradation in water in 2019, Cited 65. The Name is Isobenzofuran-1(3H)-one. Through research, I have a further understanding and discovery of 87-41-2.

Crude oil released into the environment contains many polycyclic aromatic hydrocarbons (PAHs). Alkylated PAHs are more abundant than unsubstituted PAHs and their toxicity is also of serious concern. Among the various physical, chemical, and biological weathering processes of crude oils, photodegradation is one of the most important for determining the environmental fate of oil residues. In this study, the photodegradation rate constants of naphthalene and alkylated naphthalenes were determined under simulated laboratory conditions at different temperature. Changes in the luminescence inhibition of Aliivibrio fischeri, as an indicator of the baseline toxicity, were observed in photodegradation mixtures. The major transformation products were also identified by gas chromatography-mass spectrometry. The photodegradation of naphthalene and the eight alkylated naphthalenes was described well by pseudofirst-order kinetics regardless of experimental temperature. The measured toxicity of the reaction mixtures obtained by photodegradative weathering slightly increased initially and then decreased with further weathering. In all cases, the observed toxicity was greater than accounted for by the parent compounds, indicating that the photodegradation products also contributed significantly to the overall toxicity of the mixtures. The identified photodegradation products were mostly oxygenated compounds such as alcohols, aldehydes, ketones, and quinones, which warrant further investigation. (C) 2019 Elsevier Ltd. All rights reserved.

COA of Formula: C8H6O2. Bye, fridends, I hope you can learn more about C8H6O2, If you have any questions, you can browse other blog as well. See you lster.

Reference:
Benzofuran – Wikipedia,
,Benzofuran | C8H6O – PubChem

Machine Learning in Chemistry about 87-41-2

Formula: C8H6O2. Welcome to talk about 87-41-2, If you have any questions, you can contact Gao, K; Huang, C; Yang, YS; Li, H; Wu, J; Hou, HW or send Email.

An article Cu(I)-Based Metal-Organic Frameworks as Efficient and Recyclable Heterogeneous Catalysts for Aqueous-Medium C-H Oxidation WOS:000458348000054 published article about AEROBIC OXIDATION; COORDINATION POLYMERS; BONDS ACTIVATION; HIGHLY EFFICIENT; FACILE SYNTHESIS; KETONES; WATER; ARYLALKANES; CONVERSION; SORPTION in [Gao, Kuan; Yang, Yisen; Li, Hong; Wu, Jie; Hou, Hongwei] Zhengzhou Univ, Coll Chem & Mol Engn, Zhengzhou 450001, Henan, Peoples R China; [Huang, Chao] Zhongyuan Univ Technol, Ctr Adv Mat Res, Zhengzhou 450001, Henan, Peoples R China in 2019, Cited 48. Formula: C8H6O2. The Name is Isobenzofuran-1(3H)-one. Through research, I have a further understanding and discovery of 87-41-2

The enantioselective transformation of ubiquitous C-H bonds into valuable C=O bonds offers an efficient synthetic approach to construct carbonyl functionalized molecules. However, the grand obstacles in the reaction are the selectivity issues and side reactions under the harsh reaction conditions. In order to overcome the limits, two Cu(I)-based MOFs {(NEt4)(0.5)[Cu-3 (TTPB)(0.75) (CN)(0.5)(H2O)]center dot H2O}(n) (1) and {[Cu-2 (TTPB)(0.5)]center dot DMF center dot 2H(2)O}(n) (2) were synthesized (H-4 TTPB = 5,5′ – (4′,5′ -bis (4- (1H-tetrazol-5-yl)phenyl)- [1,1′ :2′,1 ”-terphenyl]-4,4 ”-diyl) bis(1H-tetrazole)) under hydrothermal conditions with (triethylamine (TEA) and ethyldiisopropylamine (DIPEA) as structure-directing agents, respectively. Of these, 1 shows an anionic three-dimensional (3D) framework composed of two kinds of cagelike micropores with 7 X 17 angstrom and 10 x 17 angstrom, respectively. In comparison, 2 exhibits a 3D framework with open channels (14 x 8 angstrom). The stability studies showed that the crystallinity of 1 and 2 could remain in a series of organic solvents (ethanol, N,N-dimethylformamide, chloroform, dioxane, toluene) and acid and alkali aqueous solutions (pH = 1-13) at room temperature for 48 h. 1 and 2 with coordinatively unsaturated Cu(I) sites were applied as heterogeneous catalysts for the oxidation of arylacycloalkanes in aqueous medium and exhibited excellent catalytic activities, selectivities, and recyclabilities. Moreover, free-radical reaction mechanism and reversible valence-tautomeric conversions of central copper were confirmed during the process by control experiment.

Formula: C8H6O2. Welcome to talk about 87-41-2, If you have any questions, you can contact Gao, K; Huang, C; Yang, YS; Li, H; Wu, J; Hou, HW or send Email.

Reference:
Benzofuran – Wikipedia,
,Benzofuran | C8H6O – PubChem

Chemistry Milestones Of C8H6O2

Welcome to talk about 87-41-2, If you have any questions, you can contact Tseplin, EE; Tseplina, SN or send Email.. HPLC of Formula: C8H6O2

An article Application of polar solvent effects in absorption spectra for determination of lowest electron-excited states of phthalide WOS:000456799900022 published article about AQUEOUS-SOLUTION; FLUORESCENCE; MOLECULES; DYNAMICS; URACIL in [Tseplin, Evgeniy E.; Tseplina, Svetlana N.] Russian Acad Sci, Ufa Fed Res Ctr, Inst Mol & Crystal Phys, Prospekt Oktyabrya 151, Ufa 450075, Russia in 2019, Cited 37. HPLC of Formula: C8H6O2. The Name is Isobenzofuran-1(3H)-one. Through research, I have a further understanding and discovery of 87-41-2

The optical absorption spectra of phthalide in polar (methanol) and nonpolar (n-hexane) solvents are recorded. The electronic phthalide spectrum was calculated by TDDFT B3LYP/6-311 + G(d, p) using the polarisable continuum model. Based on an analysis of calculation data and the displacement of absorption bands in a polar solvent, it was established that the absorption bands of phthalide at energies of 3.51 and 3.96 eV correspond to singlet-triplet transitions to the T-1 and T-2 states, respectively.

Welcome to talk about 87-41-2, If you have any questions, you can contact Tseplin, EE; Tseplina, SN or send Email.. HPLC of Formula: C8H6O2

Reference:
Benzofuran – Wikipedia,
,Benzofuran | C8H6O – PubChem

Chemistry Milestones Of C8H6O2

Safety of Isobenzofuran-1(3H)-one. Bye, fridends, I hope you can learn more about C8H6O2, If you have any questions, you can browse other blog as well. See you lster.

Safety of Isobenzofuran-1(3H)-one. Authors Rumyantsev, AV; Pichugov, AV; Bushkov, NS; Aleshin, DY; Strelkova, TV; Lependina, OL; Zhizhko, PA; Zarubin, DN in ROYAL SOC CHEMISTRY published article about in [Rumyantsev, Andrey, V; Pichugov, Andrey, V; Bushkov, Nikolai S.; Aleshin, Dmitry Yu; Strelkova, Tatyana, V; Lependina, Olga L.; Zhizhko, Pavel A.; Zarubin, Dmitry N.] Russian Acad Sci, AN Nesmeyanov Inst Organoelement Cpds, Vavilov Str 28, Moscow 119991, Russia; [Rumyantsev, Andrey, V; Bushkov, Nikolai S.] Moscow MV Lomonosov State Univ, Dept Chem, Vorobevy Gory 1, Moscow 119991, Russia; [Pichugov, Andrey, V; Aleshin, Dmitry Yu] D Mendeleev Univ Chem Technol Russia, Higher Chem Coll, Miusskaya Sq 9, Moscow 125047, Russia in 2021, Cited 33. The Name is Isobenzofuran-1(3H)-one. Through research, I have a further understanding and discovery of 87-41-2

We report the first examples of direct imidation of lactones giving the corresponding cyclic imidates via oxo/imido heterometathesis with N-sulfinylamines catalysed by a well-defined silica-supported Ti imido complex.

Safety of Isobenzofuran-1(3H)-one. Bye, fridends, I hope you can learn more about C8H6O2, If you have any questions, you can browse other blog as well. See you lster.

Reference:
Benzofuran – Wikipedia,
,Benzofuran | C8H6O – PubChem

Downstream Synthetic Route Of 87-41-2

Formula: C8H6O2. Welcome to talk about 87-41-2, If you have any questions, you can contact Chen, LZ; Wu, J; Li, K; Wu, QQ; Chen, R; Liu, XH; Ruan, BF or send Email.

Recently I am researching about NF-KAPPA-B; TNF-ALPHA PRODUCTION; HEME OXYGENASE-1; INNATE IMMUNITY; INFLAMMATION; PATHWAY; NRF2; MACROPHAGES; ACTIVATION; INDUCTION, Saw an article supported by the National Natural Science Funding of ChinaNational Natural Science Foundation of China (NSFC) [21977001]. Formula: C8H6O2. Published in ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER in ISSY-LES-MOULINEAUX ,Authors: Chen, LZ; Wu, J; Li, K; Wu, QQ; Chen, R; Liu, XH; Ruan, BF. The CAS is 87-41-2. Through research, I have a further understanding and discovery of Isobenzofuran-1(3H)-one

Phthalide is a promising chemical scaffold and has been proved to show potent anti-inflammatory efficacy. In this study, three series, total of 31 novel phthalide derivatives were designed and synthesized, their anti-inflammatory activities were screened in vitro and in vivo. The anti-inflammatory activity of all the compounds were screened on LPS induced NO production to evaluating their inhibitory effects. Structure-activity relationship has been concluded, and finally 3-((4-((4-ufluorobenzyl)oxy)phenyl)(-hydroxy)methyl)-5,7-dimethoxyisobenzofuran-1 (3H)-one (compound 9o) was found to be the active one with low toxicity, which showed 95.23% inhibitory rate at 10 mu M with IC50 value of 0.76 mu M against LPS-induced NO over expression. Preliminary mechanism studies indicated that compound 9o activated Nrf2/HO-1 signaling pathway via accumulation ROS and blocks the NF-kappa B/MAPK signaling pathway. The in vivo anti-inflammatory activity shown that compound 90 had obvious therapeutic effect against the adjuvant-induced rat arthritis model. (C) 2020 Elsevier Masson SAS. All rights reserved.

Formula: C8H6O2. Welcome to talk about 87-41-2, If you have any questions, you can contact Chen, LZ; Wu, J; Li, K; Wu, QQ; Chen, R; Liu, XH; Ruan, BF or send Email.

Reference:
Benzofuran – Wikipedia,
,Benzofuran | C8H6O – PubChem

Get Up to Speed Quickly on Emerging Topics:87-41-2

Welcome to talk about 87-41-2, If you have any questions, you can contact Mourad, AAE; Mourad, MAE or send Email.. Category: benzofurans

Recently I am researching about 2-AMINOTHIAZOLE DERIVATIVES; ANTIVIRAL ACTIVITY; ALPHA; POTENT; DISCOVERY; ADIPOGENESIS; METABOLISM; BENZAMIDES; INDOLES; ACID, Saw an article supported by the . Category: benzofurans. Published in PERGAMON-ELSEVIER SCIENCE LTD in OXFORD ,Authors: Mourad, AAE; Mourad, MAE. The CAS is 87-41-2. Through research, I have a further understanding and discovery of Isobenzofuran-1(3H)-one

Aims: Partial PPAR gamma agonists attracted substantially heightened interest as safer thiazolidinediones alternatives. On the other hand, Wnt/beta-catenin antagonists have been highlighted as promising strategy for type 2 diabetes management via up-regulating PPAR gamma gene expression. We aimed at synthesizing novel partial PPAR gamma agonists with beta-catenin inhibitory activity which could enhance insulin sensitivity and avoid the side effects of full PPAR gamma agonists. Main methods: We synthesized novel series of alpha-phthlimido-o-toluoyl-2-aminothiazoles hybrids for evaluating their antidiabetic activity and discovering its mechanistic pathway. We assessed effect of the new hybrids on PPAR gamma activation using a luciferase reporter assay system. Moreover, intracellular triglyceride levels, gene levels of c/EBP alpha, PPAR gamma and PPAR gamma targets including GLUT4, adiponectin, aP2 were measured in 3T3-L1 cells. Uptake of 2-DOG together with PPAR gamma and beta-catenin protein levels were evaluated in 3T3-L1cells. In addition, molecular docking studies with PPAR gamma LBD, physicochemical properties and structure activity relationship of the novel hybrids were also studied. Key findings: Three of the synthesized hybrids showed partial PPAR gamma agonistic activity and distinct PPAR gamma binding pattern. These compounds modulated PPAR gamma gene expression and PPAR gamma target genes; and increased glucose uptake in 3T3-L1 and slightly induced adipogenesis compared to rosiglitazone. Moreover, these compounds reduced beta-catenin protein level which reflected in increased both PPAR gamma gene and protein levels that leads to improved insulin sensitivity and increased GLUT4 and adiponectin gene expression. Significance: Our synthesized compounds act as novel partial PPAR gamma agonists and beta-catenin inhibitors that have potent insulin sensitizing activity and mitigate the lipogenic side effects of TZDs.

Welcome to talk about 87-41-2, If you have any questions, you can contact Mourad, AAE; Mourad, MAE or send Email.. Category: benzofurans

Reference:
Benzofuran – Wikipedia,
,Benzofuran | C8H6O – PubChem

Never Underestimate The Influence Of Isobenzofuran-1(3H)-one

Application In Synthesis of Isobenzofuran-1(3H)-one. Bye, fridends, I hope you can learn more about C8H6O2, If you have any questions, you can browse other blog as well. See you lster.

Application In Synthesis of Isobenzofuran-1(3H)-one. In 2020 POLYCYCL AROMAT COMP published article about NATIONAL-CANCER-INSTITUTE; DRUG DISCOVERY; CELL-LINES in [Hassan, A. Y.; Abdel-Aziem, A.; Hussain, A. O.] Al Azhar Univ, Chem Dept, Fac Sci, Girls Branch, POB 11754,Yousef Abbas Str, Cairo, Egypt; [Mohamed, M. A.] Al Azhar Univ, Girls Branch, Fac Sci, Biochem Div,Chem Dept, Cairo, Egypt in 2020, Cited 25. The Name is Isobenzofuran-1(3H)-one. Through research, I have a further understanding and discovery of 87-41-2.

5-Amino-1-phenyl-1H-pyrazole-4-carbohydraizde(1) was used as a key to synthesize new imidazopyrazol-5(1H)-one 5, pyrazolopyrimidines 7 and 9. Furthermore, imidazopyrazoles 13, 15, pyrazolopyridine 16 and pyrazolopyrazolopyridopyrimidine 17 were prepared from pyrazoles 10 and 11. The structure of the new compounds was confirmed by spectral data as well as elemental analysis. Some compounds were selected by the national cancer institute NCI (USA) for anticancer activity against different human cancer cell lines. The results indicated that compound 12 exhibited strong anticancer activity toward Renal Cancer UO-31(GI, 42.81%), while compound 3 was strong active against Breast Cancer MCF7 (GI, 49.88%) and moderate against T-47D (GI, 38.15%) cell lines. However, compound 17 showed strong activity against Leukemia CCRF-CEM (GI, 41.37%) and SR (GI, 44.95%), whereas, compound 9 showed weak activity toward all tested cancer cell lines.

Application In Synthesis of Isobenzofuran-1(3H)-one. Bye, fridends, I hope you can learn more about C8H6O2, If you have any questions, you can browse other blog as well. See you lster.

Reference:
Benzofuran – Wikipedia,
,Benzofuran | C8H6O – PubChem

New explortion of 87-41-2

Bye, fridends, I hope you can learn more about C8H6O2, If you have any questions, you can browse other blog as well. See you lster.. SDS of cas: 87-41-2

Authors Fang, X; Ma, Q; Zhang, KX; Yao, SY; Feng, Y; Jin, YS; Liang, S in TAYLOR & FRANCIS LTD published article about ENDOTHELIAL-CELLS; OXIDATIVE STRESS; SENKYUNOLIDE I; Z-LIGUSTILIDE; CHUANXIONG; INJURY; STROKE in [Fang, Xin; Ma, Qiang; Feng, Yi; Liang, Shuang] Shanghai Univ Tradit Chinese Med, Innovat Res Inst Tradit Chinese Med, Shanghai 201203, Peoples R China; [Zhang, Kai-Xia; Yao, Song-Yun; Jin, Yong-Sheng] Second Mil Med Univ, Sch Pharm, Shanghai 200433, Peoples R China in 2020, Cited 25. SDS of cas: 87-41-2. The Name is Isobenzofuran-1(3H)-one. Through research, I have a further understanding and discovery of 87-41-2

As part of our continuing efforts to discover structurally interesting bioactive phthalide derivatives, 23 of them with a structure incorporating thiophen or halogens were designed and synthesized, 17 of which are previously unreported. In vitro antiplatelet aggregation activity screening showed that 14b could significantly inhibit platelet aggregation induced by arachidonic acid, compared with edaravone (p < 0.01). Meanwhile, oxidative damage models using SH-SY5Y and PC12 cells induced by H2O2 were built to evaluate the antioxidant activity of the phthalide derivatives. In SH-SY5Y cells, compared with aspirin, 1a significantly increased the relative cell survival rate (p < 0.05). Compared with edaravone, 1a (p < 0.01) and 15b (p < 0.05) significantly increased the relative cell survival rate. In PC12 cells, 1a (p < 0.01), 15b (p < 0.01), and 12a (p < 0.05) remarkably increased the cell survival rate compared with edaravone. The present study identified lead structures to develop potential anti-ischemic stroke agents. Bye, fridends, I hope you can learn more about C8H6O2, If you have any questions, you can browse other blog as well. See you lster.. SDS of cas: 87-41-2

Reference:
Benzofuran – Wikipedia,
,Benzofuran | C8H6O – PubChem