Authors Fang, X; Ma, Q; Zhang, KX; Yao, SY; Feng, Y; Jin, YS; Liang, S in TAYLOR & FRANCIS LTD published article about ENDOTHELIAL-CELLS; OXIDATIVE STRESS; SENKYUNOLIDE I; Z-LIGUSTILIDE; CHUANXIONG; INJURY; STROKE in [Fang, Xin; Ma, Qiang; Feng, Yi; Liang, Shuang] Shanghai Univ Tradit Chinese Med, Innovat Res Inst Tradit Chinese Med, Shanghai 201203, Peoples R China; [Zhang, Kai-Xia; Yao, Song-Yun; Jin, Yong-Sheng] Second Mil Med Univ, Sch Pharm, Shanghai 200433, Peoples R China in 2020, Cited 25. SDS of cas: 87-41-2. The Name is Isobenzofuran-1(3H)-one. Through research, I have a further understanding and discovery of 87-41-2
As part of our continuing efforts to discover structurally interesting bioactive phthalide derivatives, 23 of them with a structure incorporating thiophen or halogens were designed and synthesized, 17 of which are previously unreported. In vitro antiplatelet aggregation activity screening showed that 14b could significantly inhibit platelet aggregation induced by arachidonic acid, compared with edaravone (p < 0.01). Meanwhile, oxidative damage models using SH-SY5Y and PC12 cells induced by H2O2 were built to evaluate the antioxidant activity of the phthalide derivatives. In SH-SY5Y cells, compared with aspirin, 1a significantly increased the relative cell survival rate (p < 0.05). Compared with edaravone, 1a (p < 0.01) and 15b (p < 0.05) significantly increased the relative cell survival rate. In PC12 cells, 1a (p < 0.01), 15b (p < 0.01), and 12a (p < 0.05) remarkably increased the cell survival rate compared with edaravone. The present study identified lead structures to develop potential anti-ischemic stroke agents. Bye, fridends, I hope you can learn more about C8H6O2, If you have any questions, you can browse other blog as well. See you lster.. SDS of cas: 87-41-2
Reference:
Benzofuran – Wikipedia,
,Benzofuran | C8H6O – PubChem