Tag: M.W=100-150

Xia, Anjie published the artcileMetal-Free Aerobic Oxidative Selective C-C Bond Cleavage in Heteroaryl-Containing Primary and Secondary Alcohols, Recommanded Product: 6-Methoxybenzofuran, the main research area is metal free oxidative carbon bond cleavage heteroaryl alc.

A transition-metal-free aerobic oxidative selective C-C bond-cleavage reaction in primary and secondary heteroaryl alcs. is reported. This reaction was highly efficient and tolerated various heteroaryl alcs., generating a carboxylic acid derivative and a neutral heteroaromatic compound Exptl. studies combined with d. functional theory calculations revealed the mechanism underlying the selective C-C bond cleavage. This strategy also provides an alternative simple approach to carboxylation reaction.

Organic Letters published new progress about C-C bond cleavage. 50551-63-8 belongs to class benzofurans, name is 6-Methoxybenzofuran, and the molecular formula is C9H8O2, Recommanded Product: 6-Methoxybenzofuran.

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Mann, Inderjit S. published the artcileTransition metal-directed synthesis of moracin M, a phytoalexin of Morus alba Linn, Formula: C9H8O2, the main research area is moracin M; resorcinylbenzofuran; benzofuran resorcinyl; coupling stannylbenzofuran bromozincbenzofuran iodoresorcinol; iodoresorcinoltricarbonylchromium coupling halobenzofuran.

2-(5-Resorcinyl)benzofurans have been synthesized by the Pd-catalyzed cross-coupling of 2-trimethylstannyl- or 2-bromozincbenzofurans with functionalized 5-iodoresorcinols. These were synthesized by the triisopropylsilyloxy-directed remote (C-5) lithiation/iodination of the O,O-bis(triisopropylsilyl)resorcinoltricarbonylchrhomium(0) complex. The method was applied to the synthesis of moracin M (I).

Tetrahedron published new progress about Coupling reaction. 50551-63-8 belongs to class benzofurans, name is 6-Methoxybenzofuran, and the molecular formula is C9H8O2, Formula: C9H8O2.

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Mann, Inderjit S. published the artcileTransition metal-mediated synthesis of some prenylated phytoalexins of Morus alba Linn, Category: benzofurans, the main research area is moracin prenylated; resorcinylbenzofuran; benzofuran resorcinyl; coupling stannylbenzofuran iodoresorcinol chromium carbonyl.

Directed functionalization of resorcinol and benzofuran rings was achieved by activation with a coordinated tricarbonylchromium(0) unit and vicinal or remote lithiation directed by methoxy or tert-butyldiphenylsilyloxy groups resp. The process was applied either before [to the geranylbenzofuran for mulberrofuran B (I, R = Me, R1 = geranyl, R2-R4 = H)] or after [for moracin C (I, R-R2 = H, R3 = prenyl, R4 = Me)] Pd-catalyzed coupling of the 2-stannylated benzofuran and the 5-iodinated resorcinol moieties. In addition moracin I (I, R, R1, R3 = H, R2 = prenyl, R4 = Me) was synthesized by a Stille coupling of the stannylated benzofuran with the phloroglucinol triflate. Application to the synthesis of albafuran A (I, R, R1, R3, R4 = H, R2 = geranyl) gave, unexpectedly, the 3-geranylbenzofuran II.

Tetrahedron published new progress about Coupling reaction. 50551-63-8 belongs to class benzofurans, name is 6-Methoxybenzofuran, and the molecular formula is C9H8O2, Category: benzofurans.

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Clough, John M. published the artcileTransition metal-mediated organic synthesis: synthesis of moracin M, Category: benzofurans, the main research area is halobenzofuran metalloresorcinol chromium carbonyl coupling; metallobenzofuran haloresorcinol chromium carbonyl coupling; coupling benzofuran resorcinol palladium catalyst; moracin M.

The Pd-catalyzed cross-coupling of 2-halo- or 2-metallobenzofurans with both 5-metallo- or 5-haloresorcinol tricarbonyl chromium(0) complexes or with the uncomplexed resorcinols, has been evaluated and in consequence, moracin M (I) has been synthesized in good yield by the cross-coupling of 6-(tert-butyldiphenylsiloxy)-2-trimethylstannylbenzofuran with 5-iodoresorcinol bis(triisopropylsilyl) ether and fluoride ion deprotection of the product.

Tetrahedron Letters published new progress about Coupling reaction. 50551-63-8 belongs to class benzofurans, name is 6-Methoxybenzofuran, and the molecular formula is C9H8O2, Category: benzofurans.

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Yamaguchi, Yuki published the artcileSynthetic Models Related to Methoxalen and Menthofuran-Cytochrome P450 (CYP) 2A6 Interactions. Benzofuran and Coumarin Derivatives as Potent and Selective Inhibitors of CYP2A6, HPLC of Formula: 50551-63-8, the main research area is benzofuran derivative preparation human microsomal cytochrome inhibitor; coumarin derivative preparation human microsomal cytochrome inhibitor; human microsomal cytochrome inhibitor reduce smoking tobacco cancer.

Human microsomal cytochrome P 450 (CYP) 2A6 contributes extensively to nicotine detoxication but also activates tobacco-specific procarcinogens to mutagenic products. A series of benzofuran and coumarin derivatives having inhibitory effects on the activity of human CYP2A6 have been described. Synthesized benzofuran I [IC50 = 2.20 μM] and coumarin II [R= 5-methoxy: IC50 = 0.13μM , R=6-methoxy: IC50 = 0.64 μM] derivatives were found to be more selective than methoxalen and menthofuran. These compounds can be used as a lead compounds in the design of CYP2A6 inhibitor drugs to reduce smoking and tobacco-related cancers.

Chemical & Pharmaceutical Bulletin published new progress about Coumarins Role: BSU (Biological Study, Unclassified), PAC (Pharmacological Activity), SPN (Synthetic Preparation), THU (Therapeutic Use), BIOL (Biological Study), PREP (Preparation), USES (Uses). 50551-63-8 belongs to class benzofurans, name is 6-Methoxybenzofuran, and the molecular formula is C9H8O2, HPLC of Formula: 50551-63-8.

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Vargas, David A. published the artcileBiocatalytic strategy for highly diastereo- and enantioselective synthesis of 2,3-dihydrobenzofuran-based tricyclic scaffolds, Quality Control of 50551-63-8, the main research area is diastereoselective enantioselective synthesis dihydrobenzofuran scaffold myoglobin engineering; benzofuran cyclopropanation; biocatalysis; carbene transfer; dihydrobenzofurans; myoglobin.

2,3-Dihydrobenzofurans are key pharmacophores in many natural and synthetic bioactive mols. A biocatalytic strategy is reported here for the highly diastereo- and enantioselective construction of stereochem. rich 2,3-dihydrobenzofurans in high enantiopurity (>99.9% de and ee), high yields, and on a preparative scale via benzofuran cyclopropanation with engineered myoglobins. Computational and structure-reactivity studies provide insights into the mechanism of this reaction, enabling the elaboration of a stereochem. model that can rationalize the high stereoselectivity of the biocatalyst. This information was leveraged to implement a highly stereoselective route to a drug mol. and a tricyclic scaffold featuring five stereogenic centers via a single-enzyme transformation. This work expands the biocatalytic toolbox for asym. C-C bond transformations and should prove useful for further development of metalloprotein catalysts for abiotic carbene transfer reactions.

Angewandte Chemie, International Edition published new progress about Crystal structure. 50551-63-8 belongs to class benzofurans, name is 6-Methoxybenzofuran, and the molecular formula is C9H8O2, Quality Control of 50551-63-8.

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Ross, Rachel J. published the artcileRhodium-Catalyzed Intermolecular Cyclopropanation of Benzofurans, Indoles, and Alkenes via Cyclopropene Ring Opening, Related Products of benzofurans, the main research area is rhodium catalyzed diastereoselective intermol cyclopropanation; benzofuran indole alkene cyclopropene ring opening.

The generation of metal carbenoids via ring opening of cyclopropenes by transition metals offers a simple entry into highly reactive intermediates. Herein, we describe a diastereoselective intermol. rhodium-catalyzed cyclopropanation of heterocycles and alkenes using cyclopropenes as carbene precursors with a low loading of a com. available rhodium catalyst. The reported method is scalable and could be performed with catalyst loadings as low as 0.2 mol %, with no impact to the reaction yield or selectivity.

Organic Letters published new progress about Crystal structure. 50551-63-8 belongs to class benzofurans, name is 6-Methoxybenzofuran, and the molecular formula is C9H8O2, Related Products of benzofurans.

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Sun, Nan published the artcileZeolite-catalyzed synthesis of 2,3-unsubstituted benzo[b]furans via the intramolecular cyclization of 2-aryloxyacetaldehyde acetals, Synthetic Route of 50551-63-8, the main research area is benzofuran preparation tin exchanged zeolite catalyst cyclization aryloxyacetaldehyde acetal.

An efficient and environmentally benign heterogeneous catalytic process for the synthesis of 2,3-unsubstituted benzo[b]furans was established via the intramol. cyclization of 2-aryloxyacetaldehyde acetals. By using tin-exchanged H-β zeolite (Sn-β) as catalyst, a wide range of functionalized 2,3-unsubstituted benzo[b]furans could be prepared in good to excellent yields. The Sn-β zeolite catalyst also exhibited excellent shape selectivity on the cyclization of meta-substituted 2-aryloxyacetaldehyde acetals, and 6-substituted isomers were preferably formed up to 97% regio-selectivity. Moreover, Sn-β zeolite could be easily recovered and reused without any noticeable activity loss.

Tetrahedron published new progress about Beta zeolites Role: CAT (Catalyst Use), USES (Uses) (tin-exchanged). 50551-63-8 belongs to class benzofurans, name is 6-Methoxybenzofuran, and the molecular formula is C9H8O2, Synthetic Route of 50551-63-8.

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Nath, Sarbasri published the artcileFast Synthesis of Benzofurans from Coumarins, Application In Synthesis of 50551-63-8, the main research area is coumarin zinc oxide catalyst microwave irradiation ring contraction; benzofuran preparation green chem.

A new solid support, Zinc oxide was used as a green catalyst for the ring contraction of coumarins to benzofurans. Employing microwave induced synthesis whenever possible, minimizing the use of toxic solvents. Benzofurans was achieved from coumarins by ring contraction reaction in single step. Microwave irradiation was used to shorten the reaction time and to improve the yield.

Journal of Ultra Chemistry published new progress about Benzofurans Role: SPN (Synthetic Preparation), PREP (Preparation). 50551-63-8 belongs to class benzofurans, name is 6-Methoxybenzofuran, and the molecular formula is C9H8O2, Application In Synthesis of 50551-63-8.

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Zhang, Bang-Le published the artcileA new efficient method for the total synthesis of linear furocoumarins, Product Details of C9H8O2, the main research area is furocoumarin total synthesis; psoralen total synthesis; benzofuran preparation; nitroalkyl phenol Nef oxidation intramol cyclocondensation.

A new efficient method for the synthesis of linear furocoumarins by a Nef reaction and intramol. cyclocondensation in one pot results in the construction of a benzofuran ring. This method provides a new strategy to furnish the benzofuran framework easily, and also allows the convenient synthesis of furocoumarin derivatives with different substituents on the coumarin ring by a subsequent Pechmann reaction. This strategy has also been applied to the preparation of four addnl. benzofuran derivatives

Synlett published new progress about Coumarins Role: SPN (Synthetic Preparation), PREP (Preparation). 50551-63-8 belongs to class benzofurans, name is 6-Methoxybenzofuran, and the molecular formula is C9H8O2, Product Details of C9H8O2.

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem