Yamaguchi, Yuki published the artcileSynthetic Models Related to Methoxalen and Menthofuran-Cytochrome P450 (CYP) 2A6 Interactions. Benzofuran and Coumarin Derivatives as Potent and Selective Inhibitors of CYP2A6, HPLC of Formula: 50551-63-8, the main research area is benzofuran derivative preparation human microsomal cytochrome inhibitor; coumarin derivative preparation human microsomal cytochrome inhibitor; human microsomal cytochrome inhibitor reduce smoking tobacco cancer.
Human microsomal cytochrome P 450 (CYP) 2A6 contributes extensively to nicotine detoxication but also activates tobacco-specific procarcinogens to mutagenic products. A series of benzofuran and coumarin derivatives having inhibitory effects on the activity of human CYP2A6 have been described. Synthesized benzofuran I [IC50 = 2.20 μM] and coumarin II [R= 5-methoxy: IC50 = 0.13μM , R=6-methoxy: IC50 = 0.64 μM] derivatives were found to be more selective than methoxalen and menthofuran. These compounds can be used as a lead compounds in the design of CYP2A6 inhibitor drugs to reduce smoking and tobacco-related cancers.
Chemical & Pharmaceutical Bulletin published new progress about Coumarins Role: BSU (Biological Study, Unclassified), PAC (Pharmacological Activity), SPN (Synthetic Preparation), THU (Therapeutic Use), BIOL (Biological Study), PREP (Preparation), USES (Uses). 50551-63-8 belongs to class benzofurans, name is 6-Methoxybenzofuran, and the molecular formula is C9H8O2, HPLC of Formula: 50551-63-8.
Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem