Tag: 641-70-3

641-70-3, 3-Nitrophthalic anhydride is a benzofuran compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated,641-70-3

3-Nitrophthalic anhydride (22.3 g, 115 mmol) was added slowly to a well-stirred flask containing conc. NH3 (28%, 33.5 mL). After complete addition the flask was cooled to 0 C with ensuing precipitation. The precipitate was collected by filtration and suspended in water and acidified to pH 2. 217 C). 1H NMR (300 MHz, DMSO-d6) delta 8.16 (dd, J = 8.1, 1.2 Hz, 1H), 8.10 (dd, J = 7.8, 1.2 Hz, 1H), 8.01 (br s, 1H), 7.69 (dd, J = 7.8, 8.1 Hz, 1H), 7.60 (br s, 1H). 13C NMR (75 MHz, DMSO-d6) delta 166.1, 165.7, 147.2, 134.2, 133.0, 132.0, 129.6, 126.9

As the paragraph descriping shows that 641-70-3 is playing an increasingly important role.

Reference£º
Article; Hansen, Martin; Jacobsen, Stine Engesgaard; Plunkett, Shane; Liebscher, Gudrun Eckhard; McCorvy, John D.; Braeuner-Osborne, Hans; Kristensen, Jesper Langgaard; Bioorganic and Medicinal Chemistry; vol. 23; 14; (2015); p. 3933 – 3937;,
Benzofuran – Wikipedia
Benzofuran | C8H6O – PubChem

641-70-3, 3-Nitrophthalic anhydride is a benzofuran compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

General procedure: A mixture of a cyclic anhydride 1 (1 mmol), guanidiniumchloride (2) (1 mmol), Et3N (2 mmol) and FeCl3 (10 mol%)in PEG-400 (0.5 mL) at 60C for aromatic derivatives andat 100C for aliphatic derivatives was stirred for an appropriatetime. The reaction progress was monitored by thinlayerchromatography. After the completion of the reaction,the reaction mixture was cooled to room temperature andthen was extracted with H2O and EtOAc. The organic layerwas dried over MgSO4 and then evaporated under reducedpressure. The residue was purified by column chromatographyon silica gel using n-hexane-EtOAc (7:3). The desired1H-isoindole-1,3(2H)-diones were obtained in 70-95%yields. Spectroscopy data for compounds 3 are in goodagreement with those previously reported.

641-70-3 3-Nitrophthalic anhydride 21631, abenzofuran compound, is more and more widely used in various.

Reference£º
Article; Ekhtiari, Zeinab; Havasi, Forugh; Nikpour, Farzad; Zeitschrift fur Naturforschung, B: Chemical Sciences; vol. 71; 9; (2016); p. 941 – 944;,
Benzofuran – Wikipedia
Benzofuran | C8H6O – PubChem

641-70-3, 3-Nitrophthalic anhydride is a benzofuran compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

A round bottom flask was charged with a solution of glacial acetic acid (75 ml) and alpha-amino glutarimide hydrochloride (8.5 g). Sodium acetate anhydrous (4.5 g) was added lot-wise to the solution at 25 C. to 30 C. followed by addition of 3-nitro phthalic anhydride (log) at the same temperature. The reaction mixture was stirred at 118 C. for 18 hr. After the completion of reaction, the reaction mass was cooled to 60 C. and the solvent was distilled off under vacuum to get the residue. To the residue obtained, water (100 ml) was added; the mixture was stirred for 1 hr at 25 C. to 30 C. and the mass filtered. The wet cake obtained was slurried with water (100 ml*2), filtered and dried in an air tray dryer until the water content was less than 0.5% to afford 2-(2,6-dioxopiperidin-3-yl)-4-nitroisoindoline-1,3-dione (14 g). Yield: 89.7%, Purity: 98%.

As the paragraph descriping shows that 641-70-3 is playing an increasingly important role.

Reference£º
Patent; Apicore US LLC; Kovi, Ravishanker; Bobbili, Veerabhadra Rao; Kannapan, Jayaraman; (13 pag.)US2017/260157; (2017); A1;,
Benzofuran – Wikipedia
Benzofuran | C8H6O – PubChem

641-70-3, 3-Nitrophthalic anhydride is a benzofuran compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Et3N (23.27 g, 0.23 mol) was added dropwise into the solution of 3-nitro-phthalic anhydride (7, 44.0 g, 0.23 mol) and 3-aminopiperidine-2,6-dione hydrochloride (8, 37.9 g, 0.23 mol) in THF (600 ml). After reacting for 30 min below 20 C, the precipitation was filtered, washed with THF (30 mL¡Á3), and then dried in vacuo to give intermediate 11 (67.20 g, 91.0%) as a white solid (HPLC, 95.24%).

The synthetic route of 641-70-3 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Huang, Daowei; Shen, Chengwu; Wang, Wenya; Huang, Lei; Ni, Feng; Li, Jianqi; Synthetic Communications; vol. 46; 16; (2016); p. 1343 – 1348;,
Benzofuran – Wikipedia
Benzofuran | C8H6O – PubChem