With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.3199-61-9,Ethyl benzofuran-2-carboxylate,as a common compound, the synthetic route is as follows.,3199-61-9
General procedure: To ethyl-1-benzofuran-2-carboxylate (2) (1mmol) containing ethanol was added water (2:1, 30mL) and otassium hydroxide (2mmol). The mixture refluxed for 2h. The reaction was monitored by thin layer chromatography. After completion of the reaction, the reaction mixture was decanted into ice water and extracted the ethyl acetate ayer to give target compounds 3a and 3b. 126.96.36.199. Benzofuran-2-carboxylic acid (3a) White crystal; yield: 85%; mp 190C [mp lit. 191-192C] ; 1H NMR (500MHz, DMSO-d6): 7.35 (t, J=7.5Hz, 1H, H5-benzofuran), 7.50 (t, J=7.5Hz, 1H, H6-benzofuran), 7.66 (s, 1H, H3-benzofuran), 7.69 (d, J=8.5Hz, 1H, H7-benzofuran), 7.79 (d, J=7.5Hz, H4-benzofuran), 13.5 (bs, 1H, -OH).
The synthetic route of 3199-61-9 has been constantly updated, and we look forward to future research findings.
Article; Abedinifar, Fahimeh; Farnia, S. Morteza F.; Mahdavi, Mohammad; Nadri, Hamid; Moradi, Alireza; Ghasemi, Jahan B.; Kuecuekk?l?nc, Tuba Tueylue; Firoozpour, Loghman; Foroumadi, Alireza; Bioorganic Chemistry; vol. 80; (2018); p. 180 – 188;,
Benzofuran – Wikipedia
Benzofuran | C8H6O – PubChem