Tag: 3199-61-9

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.3199-61-9,Ethyl benzofuran-2-carboxylate,as a common compound, the synthetic route is as follows.,3199-61-9

General procedure: To ethyl-1-benzofuran-2-carboxylate (2) (1mmol) containing ethanol was added water (2:1, 30mL) and otassium hydroxide (2mmol). The mixture refluxed for 2h. The reaction was monitored by thin layer chromatography. After completion of the reaction, the reaction mixture was decanted into ice water and extracted the ethyl acetate ayer to give target compounds 3a and 3b. 4.1.2.1. Benzofuran-2-carboxylic acid (3a) White crystal; yield: 85%; mp 190C [mp lit. 191-192C] [50]; 1H NMR (500MHz, DMSO-d6): 7.35 (t, J=7.5Hz, 1H, H5-benzofuran), 7.50 (t, J=7.5Hz, 1H, H6-benzofuran), 7.66 (s, 1H, H3-benzofuran), 7.69 (d, J=8.5Hz, 1H, H7-benzofuran), 7.79 (d, J=7.5Hz, H4-benzofuran), 13.5 (bs, 1H, -OH).

The synthetic route of 3199-61-9 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Abedinifar, Fahimeh; Farnia, S. Morteza F.; Mahdavi, Mohammad; Nadri, Hamid; Moradi, Alireza; Ghasemi, Jahan B.; Kuecuekk?l?nc, Tuba Tueylue; Firoozpour, Loghman; Foroumadi, Alireza; Bioorganic Chemistry; vol. 80; (2018); p. 180 – 188;,
Benzofuran – Wikipedia
Benzofuran | C8H6O – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.3199-61-9,Ethyl benzofuran-2-carboxylate,as a common compound, the synthetic route is as follows.

A mixture of ethyl benzofuran-2-carboxylate 1 (3.80g, 20mmol), and hydrazine monohydrate (3mL, 61.5mmol) in EtOH (5mL) was refluxed for 3h. After cooling the formed precipitate was filtered off, washed with water (5¡Á10mL) dried and used without further purification. Yield 85%. Mp 190-192C (lit. 190-194C [47]). 1H NMR (DMSO-d6): delta 4.56 (s, 2H, NH2), 7.31 (m, 1H, Ar), 7.42 (m, 1H, Ar), 7.50 (s, 1H, Ar), 7.63 (d, J=8.5Hz, 1H, Ar), 7.74 (d, J=8.0Hz, 1H, Ar), 10.00 (s, 1H, NH). IR (Nujol) 3322, 3184, 1661, 1601cm-1m/z 177 (M+H)+. Anal. Calcd for C9H8N2O2: C, 61.36; H, 4.58; N, 15.90. Found: C, 61.29; H, 4.59; N, 15.93.

As the paragraph descriping shows that 3199-61-9 is playing an increasingly important role.

Reference£º
Article; Baldisserotto, Anna; Demurtas, Monica; Lampronti, Ilaria; Moi, Davide; Balboni, Gianfranco; Vertuani, Silvia; Manfredini, Stefano; Onnis, Valentina; European Journal of Medicinal Chemistry; vol. 156; (2018); p. 118 – 125;,
Benzofuran – Wikipedia
Benzofuran | C8H6O – PubChem