Brief introduction of 3199-61-9

As the paragraph descriping shows that 3199-61-9 is playing an increasingly important role.

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.3199-61-9,Ethyl benzofuran-2-carboxylate,as a common compound, the synthetic route is as follows.

A mixture of ethyl benzofuran-2-carboxylate 1 (3.80g, 20mmol), and hydrazine monohydrate (3mL, 61.5mmol) in EtOH (5mL) was refluxed for 3h. After cooling the formed precipitate was filtered off, washed with water (5¡Á10mL) dried and used without further purification. Yield 85%. Mp 190-192C (lit. 190-194C [47]). 1H NMR (DMSO-d6): delta 4.56 (s, 2H, NH2), 7.31 (m, 1H, Ar), 7.42 (m, 1H, Ar), 7.50 (s, 1H, Ar), 7.63 (d, J=8.5Hz, 1H, Ar), 7.74 (d, J=8.0Hz, 1H, Ar), 10.00 (s, 1H, NH). IR (Nujol) 3322, 3184, 1661, 1601cm-1m/z 177 (M+H)+. Anal. Calcd for C9H8N2O2: C, 61.36; H, 4.58; N, 15.90. Found: C, 61.29; H, 4.59; N, 15.93.

As the paragraph descriping shows that 3199-61-9 is playing an increasingly important role.

Reference£º
Article; Baldisserotto, Anna; Demurtas, Monica; Lampronti, Ilaria; Moi, Davide; Balboni, Gianfranco; Vertuani, Silvia; Manfredini, Stefano; Onnis, Valentina; European Journal of Medicinal Chemistry; vol. 156; (2018); p. 118 – 125;,
Benzofuran – Wikipedia
Benzofuran | C8H6O – PubChem