Tag: 200-300

《Ground- and Excited-State Properties of Iron(II) Complexes Linked to Organic Chromophores》 was written by Dierks, Philipp; Paepcke, Ayla; Bokareva, Olga S.; Altenburger, Bjoern; Reuter, Thomas; Heinze, Katja; Kuehn, Oliver; Lochbrunner, Stefan; Bauer, Matthias. HPLC of Formula: 5471-63-6 And the article was included in Inorganic Chemistry in 2020. The article conveys some information:

Two new bichromophoric complexes, [Fe(bim-ant)2]2+ and [Fe(bim-pyr)2]2+ ([H2-bim]2+ = 1,1′-(pyridine-2,6-diyl)bis(3-methyl-1H-imidazol-3-ium); ant = 9-anthracenyl; pyr = 1-pyrenyl), are investigated to explore the possibility of tuning the excited-state behavior in photoactive iron(II) complexes to design substitutes for noble-metal compounds The ground-state properties of both complexes are characterized thoroughly by electrochem. methods and optical absorption spectroscopy, complemented by time-dependent d. functional theory calculations The excited states are investigated by static and time-resolved luminescence and femtosecond transient absorption spectroscopy. Both complexes exhibit room temperature luminescence, which originates from singlet states dominated by the chromophore (1Chrom). In the cationic pro-ligands and in the iron(II) complexes, the emission is shifted to red by up to 110 nm (5780 cm-1). This offers the possibility of tuning the organic chromophore emission by metal-ion coordination. The fluorescence lifetimes of the complexes are in the nanosecond range, while triplet metal-to-ligand charge-transfer (3MLCT) lifetimes are around 14 ps. An antenna effect as in ruthenium(II) polypyridine complexes connected to an organic chromophore is found in the form of an internal conversion within 3.4 ns from the 1Chrom to the 1MLCT states. Because no singlet oxygen forms from triplet oxygen in the presence of the iron(II) complexes and light, efficient intersystem crossing to the triplet state of the organic chromophore (3Chrom) is not promoted in the iron(II) complexes. Two new multichromophoric iron(II) pyridyl N-heterocyclic carbene complexes functionalized with anthracene and pyrene in its backbones are presented. Ground- and excited-state characterization in combination with time-dependent d. functional theory shows that the triplet metal-to-ligand charge-transfer lifetime is prolonged efficiently, and an antenna effect is observed from the excited chromophore to the singlet metal-to-ligand charge-transfer state. In the experiment, the researchers used 1,3-Diphenylisobenzofuran(cas: 5471-63-6HPLC of Formula: 5471-63-6)

1,3-Diphenylisobenzofuran(cas: 5471-63-6) can be used as a fluorescent probe for detection of superoxide anion radical (O2−) inside the membrane lipid layer by DPBF fluorescence quenching method. 1,3-Diphenylisobenzofuran(DPBF) can be used as quencher during the photoinactivation of TA-3 mouse mammary carcinoma cells containing hematoporphyrin.HPLC of Formula: 5471-63-6

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

《Synergistic antibacterial activity of physical-chemical multi-mechanism by TiO2 nanorod arrays for safe biofilm eradication on implant》 was written by Zhang, Xiangyu; Zhang, Guannan; Chai, Maozhou; Yao, Xiaohong; Chen, Weiyi; Chu, Paul K.. Related Products of 5471-63-6This research focused ontitanium dioxide nanorod array antibacterial activity biofilm eradication implant; Anti-biofilm; Light-triggered therapy; Physical insertion; TiO2 nanorod; Titanium implants. The article conveys some information:

Treatment of implant-associated infection is becoming more challenging, especially when bacterial biofilms form on the surface of the implants. Developing multi-mechanism antibacterial methods to combat bacterial biofilm infections by the synergistic effects are superior to those based on single modality due to avoiding the adverse effects arising from the latter. In this work, TiO2 nanorod arrays in combination with irradiation with 808 near-IR (NIR) light are proven to eradicate single specie biofilms by combining photothermal therapy, photodynamic therapy, and phys. killing of bacteria. The TiO2 nanorod arrays possess efficient photothermal conversion ability and produce a small amount of reactive oxygen species (ROS). Physiol., the combined actions of hyperthermia, ROS, and puncturing by nanorods give rise to excellent antibacterial properties on titanium requiring irradiation for only 15 min as demonstrated by our experiments conducted in vitro and in vivo. More importantly, bone biofilm infection is successfully treated efficiently by the synergistic antibacterial effects and at the same time, the TiO2 nanorod arrays improve the new bone formation around implants. In this protocol, besides the biocompatible TiO2 nanorod arrays, an extra photosensitizer is not needed and no other ions would be released. Our findings reveal a rapid bacteria-killing method based on the multiple synergetic antibacterial modalities with high biosafety that can be implemented in vivo and obviate the need for a second operation. The concept and antibacterial system described here have large clin. potential in orthopedic and dental applications. In the experimental materials used by the author, we found 1,3-Diphenylisobenzofuran(cas: 5471-63-6Related Products of 5471-63-6)

1,3-Diphenylisobenzofuran(cas: 5471-63-6) is a fluorescent dye. 1,3-Diphenylisobenzofuran is the model compound in studies of singlet fission.Related Products of 5471-63-6

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

HPLC of Formula: 5471-63-6In 2022 ,《Photophysical behaviors of a shape-persistent zinc porphyrin organic cage》 appeared in New Journal of Chemistry. The author of the article were Yang, Wei; Wang, Chen; Liu, Kunhui; Liu, Chao; Jiang, Jianzhuang. The article conveys some information:

A pair of chiral metallic porphyrin cages, (R)/(S)-PTC-1(Zn), were afforded by pure chiral cyclohexanediamine reacting with the zinc 5,15-di[3′,5′-diformyl-(1,1′-biphenyl)]porphyrin. Both their chiral tubular structures were demonstrated via single crystal diffraction and CD studies. In addition, the photophys. behavior of the metallic organic cage, in combination with the monomeric reference zinc 5,15-di[3′,5′-cyclohexyliminomethyl-1,1′-biphenyl]porphyrin (ZnCBPP), was systematically explored by using UV-visible, fluorescence and transient absorption (TA) spectroscopy in solution TA data disclose that PTC-1(Zn) possesses a much longer triplet lifetime than monomer ZnCBPP. In addition, the homogeneous system of the cage enables the production of more singlet oxygen than the monomeric compound according to 1,3-diphenylisobenzofuran photodegradation, ESR spectroscopy and aerobic oxidation of benzylamine under visible light irradiation The experimental part of the paper was very detailed, including the reaction process of 1,3-Diphenylisobenzofuran(cas: 5471-63-6HPLC of Formula: 5471-63-6)

1,3-Diphenylisobenzofuran(cas: 5471-63-6) is a fluorescent dye. 1,3-Diphenylisobenzofuran is the model compound in studies of singlet fission.HPLC of Formula: 5471-63-6

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Su, Qianqian; Wei, Han-Lin; Liu, Yachong; Chen, Chaohao; Guan, Ming; Wang, Shuai; Su, Yan; Wang, Haifang; Chen, Zhigang; Jin, Dayong published an article in 2021. The article was titled 《Six-photon upconverted excitation energy lock-in for ultraviolet-C enhancement》, and you may find the article in Nature Communications.Recommanded Product: 1,3-Diphenylisobenzofuran The information in the text is summarized as follows:

Photon upconversion of near-IR (NIR) irradiation into UV-C (UVC) emission offers many exciting opportunities for drug release in deep tissues, photodynamic therapy, solid-state lasing, energy storage, and photocatalysis. However, NIR-to-UVC upconversion remains a daunting challenge due to low quantum efficiency. Here, we report an unusual six-photon upconversion process in Gd3+/Tm3+-codoped nanoparticles following a heterogeneous core-multishell architecture. This design efficiently suppresses energy consumption induced by interior energy traps, maximizes cascade sensitizations of the NIR excitation, and promotes upconverted UVC emission from high-lying excited states. We realized the intense six-photon-upconverted UV emissions at 253 nm under 808 nm excitation. This work provides insight into mechanistic understanding of the upconversion process within the heterogeneous architecture, while offering exciting opportunities for developing nanoscale UVC emitters that can be remotely controlled through deep tissues upon NIR illumination. The experimental part of the paper was very detailed, including the reaction process of 1,3-Diphenylisobenzofuran(cas: 5471-63-6Recommanded Product: 1,3-Diphenylisobenzofuran)

1,3-Diphenylisobenzofuran(cas: 5471-63-6) can be used as a fluorescent probe for detection of superoxide anion radical (O2−) inside the membrane lipid layer by DPBF fluorescence quenching method. 1,3-Diphenylisobenzofuran(DPBF) can be used as quencher during the photoinactivation of TA-3 mouse mammary carcinoma cells containing hematoporphyrin.Recommanded Product: 1,3-Diphenylisobenzofuran

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

《Tuning Optical Properties of BODIPY Dyes by Pyrrole Conjugation for Photoacoustic Imaging》 was written by Merkes, Jean Michel; Lammers, Twan; Kancherla, Rajesh; Rueping, Magnus; Kiessling, Fabian; Banala, Srinivas. Formula: C20H14O And the article was included in Advanced Optical Materials in 2020. The article conveys some information:

Photoacoustic imaging (PAI) is increasingly employed in (pre-) clin. research, thus, development of suitable contrast agents, in particular fluorescence-quenched chromophores, for PAI is of high importance. Small mol. dyes are appropriate due to favorable circulation, excretion properties, and ease of conjugation to targeting moieties. The BODIPY chromophores have been widely used in bioimaging, yet they are not ideal for PAI due to high fluorescence. Hence, here nonfluorescent BODIPY are designed by 1H-pyrrole conjugation (PyBODIPY) to apply as probes for PAI. The PyBODIPYs exhibit absorption maxima up to 800 nm, and PA signal could be detected in concentrations of 1 nmol mL-1 and 35 pmol mm-3, by tube and tissue phantom, resp. In addition to nonfluorescent, PyBODIPYs are non-phototoxic, photostable, and show high molar extinction coefficients, as well as inertness toward nucleophilic addition PyBODIPYs are modified with PEG-400, to improve aqueous solubility and to enable in vivo imaging. Thus, PyBODIPY is an attractive small mol. to use as PA contrast agent, which could be coupled to targeting ligands for in vivo use. In addition, 1H-pyrrole conjugation might be applied to the design of novel near-IR ranged quenchers suitable for PAI, and promote the development of probes for clin. translation. The experimental part of the paper was very detailed, including the reaction process of 1,3-Diphenylisobenzofuran(cas: 5471-63-6Formula: C20H14O)

1,3-Diphenylisobenzofuran(cas: 5471-63-6) can be used as a fluorescent probe for detection of superoxide anion radical (O2−) inside the membrane lipid layer by DPBF fluorescence quenching method. 1,3-Diphenylisobenzofuran(DPBF) can be used as quencher during the photoinactivation of TA-3 mouse mammary carcinoma cells containing hematoporphyrin.Formula: C20H14O

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

The author of 《Efficient synthesis of chiral benzofuryl β-nitro alcohols via a catalytic asymmetric Henry reaction》 were Chen, Wei; Zhou, Zhao-Hui; Chen, Hong-Bin. And the article was published in Organic & Biomolecular Chemistry in 2017. Related Products of 50551-57-0 The author mentioned the following in the article:

Chiral β-amino alc. ligands were found to be effective for the copper(II)-catalyzed asym. Henry reaction of benzofuran-2-carboxaldehydes with nitromethane, which led to the formation of (S)-enriched benzofuryl β-nitro alcs. with satisfactory enantioselectivities (up to 98% ee). The experimental process involved the reaction of Ethyl 6-methoxybenzofuran-2-carboxylate(cas: 50551-57-0Related Products of 50551-57-0)

Ethyl 6-methoxybenzofuran-2-carboxylate(cas: 50551-57-0) belongs to benzofurans.Related Products of 50551-57-0Benzofurans containing one furan ring that have been implicated as psychoactive recreational drugs include 6-(2-aminopropyl)benzofuran (6-APB), 5-(2-aminopropyl)benzofuran (5-APB), 5-(2-ethylaminopropyl)benzofuran (5-EAPB), and 5-methylaminopropylbenzofuran (5-MAPB).

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Kim, Jinwoo; Jung, Yu Kyoung; Kim, Chonsaeng; Shin, Jin Soo; Scheers, Els; Lee, Joo-Youn; Han, Soo Bong; Lee, Chong-Kyo; Neyts, Johan; Ha, Jae-Du; Jung, Young-Sik published an article in Journal of Medicinal Chemistry. The title of the article was 《A Novel Series of Highly Potent Small Molecule Inhibitors of Rhinovirus Replication》.HPLC of Formula: 50551-57-0 The author mentioned the following in the article:

Human rhinoviruses (hRVs) are the main causative pathogen for common colds and are associated with the exacerbation of asthma. The wide variety in hRV serotypes has complicated the development of rhinovirus replication inhibitors. In the current investigation, the authors developed a novel series of benzothiophene derivatives and their analogs that potently inhibit the replication of both hRV-A and hRV-B strains. Compound 6g (I) inhibited the replication of hRV-B14, A21, and A71, with resp. EC50 values of 0.083, 0.078, and 0.015 μM. The results of a time-of-addition study against hRV-B14 and hRV-A16 and resistant mutation anal. on hRV-B14 implied that 6g acts at the early stage of the viral replication process, interacting with viral capsid protein. A mol. docking study suggested that 6g has a capsid-binding mode similar to that of pleconaril. Finally, derivatives of 6 also displayed significant inhibition against poliovirus 3 (PV3) replication, implying their potential inhibitory activities against other enterovirus species. After reading the article, we found that the author used Ethyl 6-methoxybenzofuran-2-carboxylate(cas: 50551-57-0HPLC of Formula: 50551-57-0)

Ethyl 6-methoxybenzofuran-2-carboxylate(cas: 50551-57-0) belongs to benzofurans.HPLC of Formula: 50551-57-0Benzofurans containing one furan ring that have been implicated as psychoactive recreational drugs include 6-(2-aminopropyl)benzofuran (6-APB), 5-(2-aminopropyl)benzofuran (5-APB), 5-(2-ethylaminopropyl)benzofuran (5-EAPB), and 5-methylaminopropylbenzofuran (5-MAPB).

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Luo, Huanhuan; Kong, Li; Zhang, Feng; Huang, Chenglong; Chen, Jiayi; Zhang, Hongbo; Yu, Han; Zheng, Song; Xu, Hongwei; Zhang, Yiran; Deng, Lianfu; Chen, Gang; Santos, Helder A.; Cui, Wenguo published an article in 2021. The article was titled 《Light-Controlled Nanosystem with Size-Flexibility Improves Targeted Retention for Tumor Suppression》, and you may find the article in Advanced Functional Materials.Safety of 1,3-Diphenylisobenzofuran The information in the text is summarized as follows:

Although great promise has been achieved with nanomedicines in cancer therapy, limitations are still encountered, such as short retention time in the tumor. Herein, a nanosystem that can modulate the particle size in situ by near-IR (NIR) light is self-assembled by crosslinking the surface-modified poly(lactic-co-glycolic acid) from the up-conversion nanoparticle with indocyanine green and doxorubicin-nitrobenezene-polyethylene glycol (DOX-NB-PEG). The nanosystem with its small size (100 nm) achieves better tumor targeting, while the PEG on the surface of the nanosystem can effectively shield the adsorption of proteins during blood circulation, maintaining a stable nanostructure and achieving good tumor targeting. Moreover, the nanosystem at the tumor realizes the rapid shedding of PEG on its surface by NIR irradiation, and the enhanced cellular uptake. At the same time, aggregation occurs inside the nanosystem to form bigger particles (600 nm) in situ, prolonging the retention time at the tumor and producing enhanced targeted therapeutic effects. In vitro data show higher cellular uptake and a higher rate of apoptosis after irradiation, and the in vivo data prove that the nanosystem have a longer residence time at the tumor site after NIR irradiation This nanosystem demonstrates an effective therapeutic strategy in targeted synergistic tumors. In the experiment, the researchers used 1,3-Diphenylisobenzofuran(cas: 5471-63-6Safety of 1,3-Diphenylisobenzofuran)

1,3-Diphenylisobenzofuran(cas: 5471-63-6) can be used as a fluorescent probe for detection of superoxide anion radical (O2−) inside the membrane lipid layer by DPBF fluorescence quenching method. 1,3-Diphenylisobenzofuran(DPBF) can be used as quencher during the photoinactivation of TA-3 mouse mammary carcinoma cells containing hematoporphyrin.Safety of 1,3-Diphenylisobenzofuran

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

《Fluorinated Phenanthrenes as Aryne Precursors: PAH Synthesis Based on Domino Ring Assembly Using 1,1-Difluoroallenes》 was written by Fuchibe, Kohei; Abe, Masashi; Idate, Hiroto; Ichikawa, Junji. Synthetic Route of C20H14O And the article was included in Chemistry – An Asian Journal in 2020. The article conveys some information:

On treatment with the catalyst InBr3, 1,1-difluoroallenes e.g., [1-(3,3-difluoropropa-1,2-dien-1-yl)cyclopent-3-en-1-yl]benzene that bear a cyclopentene moiety and an aryl group underwent domino ring assembly in the presence or absence of N-bromosuccinimide or N-iodosuccinimide to afford aryne precursors such as three-ringed ortho-fluoro(halo)phenanthrenes, four-ringed ortho-fluoro(halo)tetraphenes, ortho-fluoro(halo)chrysenes and 6-fluoro-benzo[c]phenanthrene. Metalation of the aryne precursors followed by elimination of the fluoride resulted in the unprecedented systematic generation of arynes bearing π-extended systems e.g., 9,14-dihydro-9,14-diphenyl-9,14-epoxybenzo[b]triphenylene. Diels-Alder reactions of these arynes with isobenzofurans afforded the corresponding cycloadducts e.g., I, whose reductive aromatization in an SnCl2/HBr system furnished fully aromatized benzotriphenylenes e.g., 9,14-diphenylbenzo[b]triphenylene. In addition, oxidative aryl-aryl coupling (Scholl reaction) of these benzotriphenylenes facilitated the synthesis of ‘half HBCs’ (hexabenzocoronenes) II (R1 = H, n-Hex, t-Bu). In addition to this study using 1,3-Diphenylisobenzofuran, there are many other studies that have used 1,3-Diphenylisobenzofuran(cas: 5471-63-6Synthetic Route of C20H14O) was used in this study.

1,3-Diphenylisobenzofuran(cas: 5471-63-6) can be used as a fluorescent probe for detection of superoxide anion radical (O2−) inside the membrane lipid layer by DPBF fluorescence quenching method. 1,3-Diphenylisobenzofuran(DPBF) can be used as quencher during the photoinactivation of TA-3 mouse mammary carcinoma cells containing hematoporphyrin.Synthetic Route of C20H14O

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

《Spectroscopic and theoretical methods to probe protein-ligand binding》 was published in Materials Today: Proceedings in 2020. These research results belong to Sreedhanya, S.; Jeena, V. R.; Ammu, S.; Aravindakumar, C. T.; Aravind, Usha K.. Synthetic Route of C20H14O The article mentions the following:

Protein-ligand binding studies have gained considerable attention owing to its application in biomedical research. The present study discusses the application of spectroscopic and theor. methods to probe the interaction between a model ligand, 1, 3-diphenylisobenzofuran (DPBF) and bovine serum albumin (BSA). The quenching of the intrinsic fluorescence of BSA arising from tryptophan residue in the presence of DPBF is monitored to follow the nature and mechanism associated with the binding process. The binding affinity and number of binding sites have been investigated. Synchronous fluorescence and UV-Vis spectroscopic studies have been carried out to follow the changes in the fluorophore micro-environment and binding mechanism. Theor. methods such as fluorescence resonance energy transfer (FRET) and mol. docking are also employed to predict the binding mechanism, binding modes, binding sites and the distance between the tryptophan residue in BSA and DPBF. The experimental part of the paper was very detailed, including the reaction process of 1,3-Diphenylisobenzofuran(cas: 5471-63-6Synthetic Route of C20H14O)

1,3-Diphenylisobenzofuran(cas: 5471-63-6) can be used as a fluorescent probe for detection of superoxide anion radical (O2−) inside the membrane lipid layer by DPBF fluorescence quenching method. 1,3-Diphenylisobenzofuran(DPBF) can be used to study the single crystal molecular structure and solution photophysical properties of DPBF.Synthetic Route of C20H14O

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem