Tag: 100-200

Condensation of salicylonitrile with some α-halo carbonyl compounds was written by Trofimov, F. A.;Lelyak, G. F.;Shevchenko, L. I.;Grinev, A. N.. And the article was included in Khimiya Geterotsiklicheskikh Soedinenii in 1974.Application of 54802-10-7 This article mentions the following:

Benzofurans (I; R = H, Br, R1 = OMe, NH2, Ph, Me, R2 = Ac, H) were obtained in 20-84% yields by condensation of a salicylonitrile with XCH2COR1 (X = Cl, Br). Hydrolysis of I (R = H, R1 = OMe, R2 = Ac) by NaOH gave 90% I (R = H, R1 = OH, R2 = Ac) which was decarboxylated by heating in DMF to give 31% II. In the experiment, the researchers used many compounds, for example, 3-Aminobenzofuran-2-carboxamide (cas: 54802-10-7Application of 54802-10-7).

3-Aminobenzofuran-2-carboxamide (cas: 54802-10-7) belongs to benzofurans derivatives. Many natural or synthetic compounds containing benzofuran skeletons have been found to possess remarkable activity as agrochemicals and pharmaceuticals. As benzofurans are prone to undergo ring opening of the heterocycle, examples of reduction of this type of aromatics by using dissolving metals are rather scarce.Application of 54802-10-7

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Design, Synthesis, and Pharmacological Evaluation of First-in-Class Multitarget N-Acylhydrazone Derivatives as Selective HDAC6/8 and PI3Kα Inhibitors was written by Rodrigues, Daniel A.;Guerra, Fabiana S.;Sagrillo, Fernanda S.;Pinheiro, Pedro de Sena M.;Alves, Marina A.;Thota, Sreekanth;Chaves, Lorrane S.;Sant’Anna, Carlos M. R.;Fernandes, Patricia D.;Fraga, Carlos A. M.. And the article was included in ChemMedChem in 2020.Application In Synthesis of Methyl benzofuran-2-carboxylate This article mentions the following:

Targeting histone deacetylases (HDACs) and phosphatidylinositol 3-kinases (PI3Ks) is a very promising approach for cancer treatment. This manuscript describes the design, synthesis, in vitro pharmacol. profile, and mol. modeling of a novel class of N-acylhydrazone (NAH) derivatives that act as HDAC6/8 and PI3Kα dual inhibitors. The surprising selectivity for PI3Kα may be related to differences in the conformation in the active site. Cellular studies showed that these compounds act in HDAC6 inhibition and the PI3/K/AKT/mTOR pathway. The compounds that are selective for inhibition of HDAC6/8 and inhibit PI3Kα show potential for the treatment of cancer. In the experiment, the researchers used many compounds, for example, Methyl benzofuran-2-carboxylate (cas: 1646-27-1Application In Synthesis of Methyl benzofuran-2-carboxylate).

Methyl benzofuran-2-carboxylate (cas: 1646-27-1) belongs to benzofurans derivatives. Benzofuran derivatives are one of the most important oxygen-containing heterocycles. Benzofurans have also made significant and distinctive contributions to biology. They exhibit several biological activities that range from antiviral, antimicrobial, antitumor, anti-inflammatory.Application In Synthesis of Methyl benzofuran-2-carboxylate

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

In-Water Synthesis of Quinazolinones from 1,1-Dichloro-2-nitroethene and Anthranilamides was written by Zhu, Fengjuan;Song, Runjiang;Li, Shen;Shao, Xusheng. And the article was included in Synlett in 2016.Category: benzofurans This article mentions the following:

An efficient synthetic methodol. was developed for direct formation of quinazolinones with 2-nitromethyl substituent via 1,1-dichloro-2-nitroethene and anthranilamides. This strategy provides an alternative for quinazolinones construction with merits of proceeding in water, easy purification, and no addition of catalysts. In the experiment, the researchers used many compounds, for example, 3-Aminobenzofuran-2-carboxamide (cas: 54802-10-7Category: benzofurans).

3-Aminobenzofuran-2-carboxamide (cas: 54802-10-7) belongs to benzofurans derivatives. Benzofuran is the “”parent”” of many related compounds with more complex structures. For example, psoralen is a benzofuran derivative that occurs in several plants. Benzofurans have also made significant and distinctive contributions to biology. They exhibit several biological activities that range from antioxidant, antitubercular, antiplasmodial, insecticidal.Category: benzofurans

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

NHC-Catalyzed Enantioselective Dearomatizing Hydroacylation of Benzofurans and Benzothiophenes for the Synthesis of Spirocycles was written by Janssen-Mueller, Daniel;Fleige, Mirco;Schluens, Danny;Wollenburg, Marco;Daniliuc, Constantin G.;Neugebauer, Johannes;Glorius, Frank. And the article was included in ACS Catalysis in 2016.Recommanded Product: 551001-79-7 This article mentions the following:

Benzofurans and benzothiophenes have been efficiently employed as substrates in an enantioselective intramol. hydroacylation. Breaking aromaticity in a 5-exo-trig cyclization of easily accessible heteroarenes by NHC-catalyzed hydroacylation gives access to a simple class of mainly unexplored spirocycles with up to 99% enantiomeric excess (ee). The formed product class bears interesting three-dimensional pseudoaxial chirality and shows typical ketone reactivity. D. functional theory (DFT) calculations reveal erosion of the ee via a stepwise mechanism bearing a hetero Wheland intermediate. Theor. data are in agreement with deuterium-labeling studies and a linear correlation between electronics (σ) and the ee. In the experiment, the researchers used many compounds, for example, (5-Methoxybenzofuran-2-yl)boronic acid (cas: 551001-79-7Recommanded Product: 551001-79-7).

(5-Methoxybenzofuran-2-yl)boronic acid (cas: 551001-79-7) belongs to benzofurans derivatives. Benzofuran derivatives have shown many biological activities, including antifungal and antimicrobial properties, and acting as antagonists of H3 receptors and angiotensin II. Benzofurans are stable towards alkali and readily polymerize on treatment with sulfuric acid, due to which they are useful for the preparation of low cost chemically relatively inert resins.Recommanded Product: 551001-79-7

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Novel ¹⁸F-Labeled Benzofuran Derivatives with Improved Properties for Positron Emission Tomography (PET) Imaging of β-Amyloid Plaques in Alzheimer’s Brains was written by Ono, Masahiro;Cheng, Yan;Kimura, Hiroyuki;Cui, Mengchao;Kagawa, Shinya;Nishii, Ryuichi;Saji, Hideo. And the article was included in Journal of Medicinal Chemistry in 2011.COA of Formula: C9H9BO4 This article mentions the following:

In vivo imaging of β-amyloid plaques in the brain may lead to the early diagnosis of Alzheimer’s disease (AD) and monitoring of the progression and effectiveness of treatment. In the present study, we report on the development of two potential PET probes, [¹⁸F]FPYBF-2 ([¹⁸F]10) and [¹⁸F]FPHBF-2 ([¹⁸F]21), for imaging of β-amyloid plaques in AD brain. In experiments in vitro, 10 and 21 displayed high affinity for Aβ(1-42) aggregates (K_i = 2.41 and 3.85 nM, resp.). In biodistribution experiments using normal mice, they displayed high uptake in the brain (7.38 and 8.18% ID/g at 2 min postinjection, resp.), and the radioactivity washed out from the brain rapidly (3.15 and 3.87% ID/g at 60 min postinjection, resp.), which is highly desirable for β-amyloid imaging agents. In vivo, they clearly labeled β-amyloid plaques in Tg2576 mice. Furthermore, the specific labeling of β-amyloid plaques by 10 and 21 was observed in autoradiographs of sections of autopsied AD brain. These new fluorinated benzofuran derivatives are promising PET probes for imaging cerebral β-amyloid plaques. In the experiment, the researchers used many compounds, for example, (5-Methoxybenzofuran-2-yl)boronic acid (cas: 551001-79-7COA of Formula: C9H9BO4).

(5-Methoxybenzofuran-2-yl)boronic acid (cas: 551001-79-7) belongs to benzofurans derivatives. Benzofuran is the “”parent”” of many related compounds with more complex structures. For example, psoralen is a benzofuran derivative that occurs in several plants. In nature, benzofurans have occupied an important role among the plant phenols & several pharmacologically active compounds.COA of Formula: C9H9BO4

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Reactions with mercaptans. V. Action of aromatic thiols on furocoumarins, furochromones, and 2-aralkylidene-3(2H)-thianaphenone 1,1-dioxides was written by Asker, Wafia;Shalaby, Ahmed F. A. M.;Zayed, Salah M. A. D.. And the article was included in Journal of Organic Chemistry in 1958.Synthetic Route of C10H8O3 This article mentions the following:

In conjunction with the study of the pharmacol. action of S-containing compounds, it was found that xanthotoxin (I, R = OMe, R’ = H) (II) treated with PhSH and 4-MeC₆H₄SH (III) in the presence of piperidine (IV) gave addition products, V (Ar = Ph) (VI) and V (Ar = C₆H₄Me-4) (VII), resp. Other ring compounds were treated similarly. Thiol adducts: General procedure. The compound under investigation (0.5 g.), 0.5 g. aromatic thiol, and a few drops freshly distilled IV warmed 10 hrs. on a steam bath in case of II, the mixture cooled, washed with petr. ether, and crystallized gave 80% VI, m. 132° (EtOH), and 72% VII, m. 136° (EtOH). O₂S.C-(:CHAr).CO.C:C.CR”:CR’.CR:CH (VIII) were prepared by the condensation of 3(2H)-thianaphthenone 1,1-dioxides with BzH (method of Mustafa and Z., loc. cit.). The following VIII were prepare (R, R’, R”, Ar, reaction temperature, m.p., % yield given): Me, H, H, Ph (IX), 150°, 209° (AcOH), 92; H, Me, H, Ph (X), 160°, 210° (AcOH), 78; H, H, Me, Ph (XI), 60°, 158° (EtOH), 75; H, H, Cl, Ph (XII), 170°, 216° (AcOH), 85; H, H, H, C₆H₄OMe-4, 150°, 165° (EtOH), 71. VIII were condensed with PhSH and III by heating 3 hrs. at the stated temperature in the absence of a catalyst to give the following thiol adducts, O₂S.CH(CHAr)(SAr’).CO.C:C.CR”:CR’.CR:CH (VIII used, Ar’, reaction temperature, m.p. % yield given): IX, Ph (XIII), 100°, 116° (C₆H₆-petr. ether), 85; IX, C₆H₄Me-4, 130°, 156° (C₆H₆), 82; X, Ph, 120°, 155° (C₆H₆), 79; X, C₆H₄Me-4, 130°, 182° (C₆H₆), 76; XI, Ph, 100°, 137° (C₆H₆), 92; XI, C₆H₄Me-4, 100°, 135° (C₆H₆-petr. ether), 91; XII, Ph, 120°, 150° (C₆H₆), 87. VI (1 g.) and 100 ml. 4% alc. KOH refluxed 4 hrs. and worked up gave 0.25 g. PhSH as the Pb salt and 0.5 g. II. XIII (0.2 g.) heated 20 min. in a bath kept at 140°, cooled, and the product crystallized (EtOH) gave IX. I (R’ = H, R = OCH₂CH:CMe₂), and PhSH (equimolar amounts), and a few drops IV heated 3 hrs. in an oil bath kept at 155-60°, the mixture cooled, washed with petr. ether, and the resulting solid crystallized (C₆H₆) gave 85% I (R’ = H, R = OH), m.p. and mixed m.p. 233°. I (R’ = OMe, R = H), coumarilic acid, or its Me ester failed to react with PhSH in the presence of IV. Khellin [XIV (R = R’ = OMe)] (XV) (1 g.), 2 g. PhSH, and a few drops IV heated 3 hrs. at 100° and worked up gave 0.8 g. XIV (R’ = OMe, R = OH) (XVI), m. 204°. XV treated with III as above also gave XVI. XIV (R’ = H, R = OMe) treated with PhSH as above gave XIV (R’ = H, R = OH), m. 155°. XVI (0.5 g.) in 30 ml. dry Et₂O and 2 ml. MeOH treated with Et₂O-CH₂N₂ (from 4 g. nitrosomethylurea), kept 24 hrs. in an ice chest, treated again with the same amount Et₂O-CH₂N₂, kept 48 hrs. at 0°, the solid collected (the Et₂O solution allowed to evaporate slowly yielded addnl. material), and crystallized (dilute MeOH) gave XV, m. 153°. In the experiment, the researchers used many compounds, for example, Methyl benzofuran-2-carboxylate (cas: 1646-27-1Synthetic Route of C10H8O3).

Methyl benzofuran-2-carboxylate (cas: 1646-27-1) belongs to benzofurans derivatives. Benzofurans are compounds with a planar structure having 10 pi electrons that include the lone pair on oxygen atom, which makes it more susceptible to electrophilic attack. As benzofurans are prone to undergo ring opening of the heterocycle, examples of reduction of this type of aromatics by using dissolving metals are rather scarce.Synthetic Route of C10H8O3

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Borrowing Carbonate-Enabled Allylic Amination Reactions under Additive- and Reductant-Free Nickel Catalysis Employing Allylic Alcohols was written by Vaidya, Gargi Nikhil;Nagpure, Mithilesh;Kumar, Dinesh. And the article was included in ACS Sustainable Chemistry & Engineering in 2021.Product Details of 54802-10-7 This article mentions the following:

“Borrowing carbonate”-enabled allylic cross-amination reactions employing allylic alcs., e.g., cinnamyl alc., (E)-3-(4-methoxyphenyl)prop-1-en-1-ol, and (E)-3-(furan-2-yl)prop-1-en-1-ol, were discovered via merging acyl/allyl C-O bonds activation under nickel catalysis. The key component of this protocol is the ability of nickel [Ni(II)-Ni(0)] to execute a relay process via the nucleophilic trapping of the generated acyl Ni complex, resulting from the acyl C-O bond cleavage of dialkyl carbonates, followed by selective allylic C-O bond activations (allylic C-O vs alkyl C-O vs acyl C-O) to yield π-allyl-Ni-complexes. The finding truly represents Ni-catalyzed green allylic amination reactions under additive(s)-free conditions with excellent chemo- (N vs O), regio- (linear vs branched), and stereoselectivity (E vs Z) with a wide range of fundamentally challenging N-heterocycles, e.g., 2(1H)-pyridone, isoquinolin-1(2H)-one, and benzo[d]thiazol-2(3H)-one, and allylic alcs. The reaction is scalable, does not require harmful reaction media and a globe box, and is successfully applied to the scale-up synthesis of pharmaceuticals (cinnarizine, flunarizine, and naftifine) with promising yields. In the experiment, the researchers used many compounds, for example, 3-Aminobenzofuran-2-carboxamide (cas: 54802-10-7Product Details of 54802-10-7).

3-Aminobenzofuran-2-carboxamide (cas: 54802-10-7) belongs to benzofurans derivatives. Benzofuran derivatives are one of the most important oxygen-containing heterocycles. Benzofurans have also made significant and distinctive contributions to biology. They exhibit several biological activities that range from antiviral, antimicrobial, antitumor, anti-inflammatory.Product Details of 54802-10-7

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Synthesis of some benzofuro[3,2-d]pyrimidine derivatives as antibacterial and antifungal agents was written by Sangapure, S. S.;Veeresh, D. H.;Yadav, Bodke. And the article was included in Indian Journal of Heterocyclic Chemistry in 2000.Application In Synthesis of 3-Aminobenzofuran-2-carboxamide This article mentions the following:

Condensation of 3-amino-2-benzofurancarboxamide with aromatic aldehydes in presence of catalytic amount of conc hydrochloric acid gave 2-aryl-3,4-dihydro-4-oxobenzofuro[3,2-d]pyrimidines in a single step. Some 2,4-disubstituted benzofuro[3,2-d]pyrimidines have been synthesized. Benzofuropyrimidine derivatives have been screened for antibacterial and antifungal activity against S. aureus, E. coli and C. albicans. In the experiment, the researchers used many compounds, for example, 3-Aminobenzofuran-2-carboxamide (cas: 54802-10-7Application In Synthesis of 3-Aminobenzofuran-2-carboxamide).

3-Aminobenzofuran-2-carboxamide (cas: 54802-10-7) belongs to benzofurans derivatives. Many natural or synthetic compounds containing benzofuran skeletons have been found to possess remarkable activity as agrochemicals and pharmaceuticals. In nature, benzofurans have occupied an important role among the plant phenols & several pharmacologically active compounds.Application In Synthesis of 3-Aminobenzofuran-2-carboxamide

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Gas chromatographic analysis of benzofuran derivatives was written by Nakanishi, Teruo;Ito, Kiyoshi. And the article was included in Nippon Nogei Kagaku Kaishi in 1969.COA of Formula: C10H8O3 This article mentions the following:

Retention times (tr in min) of 53 benzofuran derivatives are given for 3 stationary phases at 140-300°. The columns were: (1) 5% diethylene glycol adipate on Chromosorb W, 3 mm inner diameter × 1.11 m; (2) 20% Apiezon grease L on Neosorb NC, 3 mm inner diameter × 1.11 m; (3) 10% Silicone SE-30 on Chromosorb W, 3 mm inner diameter × 0.74 m. A H flame ionization detector was used in each case. In the experiment, the researchers used many compounds, for example, Methyl benzofuran-2-carboxylate (cas: 1646-27-1COA of Formula: C10H8O3).

Methyl benzofuran-2-carboxylate (cas: 1646-27-1) belongs to benzofurans derivatives. Benzofurans are only weakly aromatic in nature and they are cleaved by many oxidative and reductive conditions. They are also prone to polymerisation in the presence of concentrated mineral acids and Lewis acids.COA of Formula: C10H8O3

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Synthesis, characterisation and antibacterial activities of titanium(III) complexes with schiff bases derived from benzofuran was written by Kannojia, Poonam;Sahdev. And the article was included in Oriental Journal of Chemistry in 2011.COA of Formula: C9H8N2O2 This article mentions the following:

Titanium(III) chloride reacts with Schiff bases derived from benzaldehydes/acetophenone with 3-aminobenzofuran-2-carboxamide/ethyl 3-aminobenzofuran-2-carboxylate to yield complexes having general composition [Ti(L)₂(H₂O)₂]Cl₃ (L = Schiff base). The ligands and their corresponding Ti(III) complexes were characterized by elemental analyses, molar conductance,magnetic susceptibility, IR and electronic spectra and TGA. The ligands act in a bidentate manner. Based on these studies octahedral geometries are proposed for these complexes. The ligands and their Ti(III)complexes have screened for antibacterial activities. In the experiment, the researchers used many compounds, for example, 3-Aminobenzofuran-2-carboxamide (cas: 54802-10-7COA of Formula: C9H8N2O2).

3-Aminobenzofuran-2-carboxamide (cas: 54802-10-7) belongs to benzofurans derivatives. Benzofuran derivatives have shown many biological activities, including antifungal and antimicrobial properties, and acting as antagonists of H3 receptors and angiotensin II. Benzofurans have also made significant and distinctive contributions to biology. They exhibit several biological activities that range from antiviral, antimicrobial, antitumor, anti-inflammatory.COA of Formula: C9H8N2O2

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem