Ono, Masahiro et al. published their research in Journal of Medicinal Chemistry in 2011 | CAS: 551001-79-7

(5-Methoxybenzofuran-2-yl)boronic acid (cas: 551001-79-7) belongs to benzofurans derivatives. Benzofuran is the “”parent”” of many related compounds with more complex structures. For example, psoralen is a benzofuran derivative that occurs in several plants. In nature, benzofurans have occupied an important role among the plant phenols & several pharmacologically active compounds.COA of Formula: C9H9BO4

Novel 18F-Labeled Benzofuran Derivatives with Improved Properties for Positron Emission Tomography (PET) Imaging of β-Amyloid Plaques in Alzheimer’s Brains was written by Ono, Masahiro;Cheng, Yan;Kimura, Hiroyuki;Cui, Mengchao;Kagawa, Shinya;Nishii, Ryuichi;Saji, Hideo. And the article was included in Journal of Medicinal Chemistry in 2011.COA of Formula: C9H9BO4 This article mentions the following:

In vivo imaging of β-amyloid plaques in the brain may lead to the early diagnosis of Alzheimer’s disease (AD) and monitoring of the progression and effectiveness of treatment. In the present study, we report on the development of two potential PET probes, [18F]FPYBF-2 ([18F]10) and [18F]FPHBF-2 ([18F]21), for imaging of β-amyloid plaques in AD brain. In experiments in vitro, 10 and 21 displayed high affinity for Aβ(1-42) aggregates (Ki = 2.41 and 3.85 nM, resp.). In biodistribution experiments using normal mice, they displayed high uptake in the brain (7.38 and 8.18% ID/g at 2 min postinjection, resp.), and the radioactivity washed out from the brain rapidly (3.15 and 3.87% ID/g at 60 min postinjection, resp.), which is highly desirable for β-amyloid imaging agents. In vivo, they clearly labeled β-amyloid plaques in Tg2576 mice. Furthermore, the specific labeling of β-amyloid plaques by 10 and 21 was observed in autoradiographs of sections of autopsied AD brain. These new fluorinated benzofuran derivatives are promising PET probes for imaging cerebral β-amyloid plaques. In the experiment, the researchers used many compounds, for example, (5-Methoxybenzofuran-2-yl)boronic acid (cas: 551001-79-7COA of Formula: C9H9BO4).

(5-Methoxybenzofuran-2-yl)boronic acid (cas: 551001-79-7) belongs to benzofurans derivatives. Benzofuran is the “”parent”” of many related compounds with more complex structures. For example, psoralen is a benzofuran derivative that occurs in several plants. In nature, benzofurans have occupied an important role among the plant phenols & several pharmacologically active compounds.COA of Formula: C9H9BO4

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem