Design, Synthesis, and Pharmacological Evaluation of First-in-Class Multitarget N-Acylhydrazone Derivatives as Selective HDAC6/8 and PI3Kα Inhibitors was written by Rodrigues, Daniel A.;Guerra, Fabiana S.;Sagrillo, Fernanda S.;Pinheiro, Pedro de Sena M.;Alves, Marina A.;Thota, Sreekanth;Chaves, Lorrane S.;Sant’Anna, Carlos M. R.;Fernandes, Patricia D.;Fraga, Carlos A. M.. And the article was included in ChemMedChem in 2020.Application In Synthesis of Methyl benzofuran-2-carboxylate This article mentions the following:
Targeting histone deacetylases (HDACs) and phosphatidylinositol 3-kinases (PI3Ks) is a very promising approach for cancer treatment. This manuscript describes the design, synthesis, in vitro pharmacol. profile, and mol. modeling of a novel class of N-acylhydrazone (NAH) derivatives that act as HDAC6/8 and PI3Kα dual inhibitors. The surprising selectivity for PI3Kα may be related to differences in the conformation in the active site. Cellular studies showed that these compounds act in HDAC6 inhibition and the PI3/K/AKT/mTOR pathway. The compounds that are selective for inhibition of HDAC6/8 and inhibit PI3Kα show potential for the treatment of cancer. In the experiment, the researchers used many compounds, for example, Methyl benzofuran-2-carboxylate (cas: 1646-27-1Application In Synthesis of Methyl benzofuran-2-carboxylate).
Methyl benzofuran-2-carboxylate (cas: 1646-27-1) belongs to benzofurans derivatives. Benzofuran derivatives are one of the most important oxygen-containing heterocycles. Benzofurans have also made significant and distinctive contributions to biology. They exhibit several biological activities that range from antiviral, antimicrobial, antitumor, anti-inflammatory.Application In Synthesis of Methyl benzofuran-2-carboxylate
Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem