Tag: 100-200

PPh₃-assisted esterification of acyl fluorides with ethers via C(sp₃)-O bond cleavage accelerated by TBAT was written by Wang, Zhenhua;Wang, Xiu;Nishihara, Yasushi. And the article was included in Catalysts in 2019.Related Products of 1646-27-1 This article mentions the following:

The triphenylphosphine (PPh₃)-assisted methoxylation of acyl fluorides with cyclopentyl Me ether (CPME) accelerated by tetrabutylammonium difluorotriphenysilicate (TBAT) via regiospecific C-OMe bond cleavage was described. CPME was utilized not only as the solvent, but also as methoxylating agent. The reported method was featured by C-O and C-F bond cleavage under metal-free conditions, good functional-group tolerance and wide substrate scope. Mechanistic studies revealed that the radical process was not involved. In the experiment, the researchers used many compounds, for example, Methyl benzofuran-2-carboxylate (cas: 1646-27-1Related Products of 1646-27-1).

Methyl benzofuran-2-carboxylate (cas: 1646-27-1) belongs to benzofurans derivatives. Benzofurans are compounds with a planar structure having 10 pi electrons that include the lone pair on oxygen atom, which makes it more susceptible to electrophilic attack. Substituted benzofurans find applications such as fluorescent sensors, oxidants, in drug discovery, and in another field of chemistry and agriculture.Related Products of 1646-27-1

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Development of ^99mTc-Labeled Pyridyl Benzofuran Derivatives To Detect Pancreatic Amylin in Islet Amyloid Model Mice was written by Yoshimura, Masashi;Ono, Masahiro;Watanabe, Hiroyuki;Kimura, Hiroyuki;Saji, Hideo. And the article was included in Bioconjugate Chemistry in 2016.Recommanded Product: (5-Methoxybenzofuran-2-yl)boronic acid This article mentions the following:

While islet amyloid deposition comprising amylin is one of pathol. hallmarks of type 2 diabetes mellitus (T2DM), no useful amylin-imaging probe has been reported. In this study, we evaluated two ^99mTc-labeled pyridyl benzofuran derivatives as novel amylin-imaging probes using the newly established islet amyloid model mouse. Binding experiments in vitro demonstrated that [^99mTc]1 displayed a higher affinity for amylin aggregates than [^99mTc]2. Autoradiog. studies using human pancreas sections with T2DM revealed that [^99mTc]1 clearly labeled islet amyloid in T2DM pancreatic sections, while [^99mTc]2 did not. Although the initial uptake of [^99mTc]1 by the normal mouse pancreas was low (0.74%ID/g at 2 min post-injection), [^99mTc]1 showed higher retention in the model mouse pancreas than that of the normal mouse, and exhibited strong binding to amylin aggregates in the living pancreas of the model mice. These results suggest that [^99mTc]1 is a potential imaging probe targeting islet amyloids in the T2DM pancreas. In the experiment, the researchers used many compounds, for example, (5-Methoxybenzofuran-2-yl)boronic acid (cas: 551001-79-7Recommanded Product: (5-Methoxybenzofuran-2-yl)boronic acid).

(5-Methoxybenzofuran-2-yl)boronic acid (cas: 551001-79-7) belongs to benzofurans derivatives. Benzofuran is the “”parent”” of many related compounds with more complex structures. For example, psoralen is a benzofuran derivative that occurs in several plants. Substituted benzofurans find applications such as fluorescent sensors, oxidants, in drug discovery, and in another field of chemistry and agriculture.Recommanded Product: (5-Methoxybenzofuran-2-yl)boronic acid

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Hydrophobicity parameters determined by reversed-phase liquid chromatography. V. Relationship between the capacity factor and the octanol-water partition coefficient for simple heteroaromatic compounds and their ester derivatives was written by Yamagami, Chisako;Takao, Narao. And the article was included in Chemical & Pharmaceutical Bulletin in 1992.COA of Formula: C10H8O3 This article mentions the following:

The log k‘ (k‘: capacity factor) values of various heteroaromatic compounds were measured by reversed-phase high-performance liquid chromatog. (RPLC) using a Capcell pack C₁₈ column and methanol-water eluents, and the relation with log P values (P: 1-octanol-water partition coefficient) was examined as a function of the mobile phase composition Furans having nonhydrogen-bonding or weakly hydrogen-accepting substituents exhibited a good linear relation at 50% MeOH concentration Amphiprotic substituents, CONHR, showed an acceleration effect (less retained than nonhydrogen-bonders and hydrogen-acceptors under the condition of equivalent log P), as is often observed in heterocyclic systems. The relation was more complicated at other methanol contents, due to different retention behavior demonstrated by the ester-type substituents, CO₂R and CONR₂ (ester effect). To gain more insight into this ester effect, the retention behavior of ester derivatives of various heteroaromatics such as furan, benzofuran, N-methylpyrrole and indole was also studied. The factors affecting the log P-log k‘ relation were discussed, and the optimum RPLC condition for predicting the log P value was described. In the experiment, the researchers used many compounds, for example, Methyl benzofuran-2-carboxylate (cas: 1646-27-1COA of Formula: C10H8O3).

Methyl benzofuran-2-carboxylate (cas: 1646-27-1) belongs to benzofurans derivatives. Benzofuran derivatives have shown many biological activities, including antifungal and antimicrobial properties, and acting as antagonists of H3 receptors and angiotensin II. Introduction of benzofurans in organic synthesis, particularly drug synthesis, involves generally the use of their metalated species as nucleophiles in addition reactions or in metal-catalysed cross-coupling reactions.COA of Formula: C10H8O3

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Facile preparation of aromatic esters from aromatic bromides with ethyl formate or DMF and molecular iodine via aryllithium was written by Ushijima, Sousuke;Moriyama, Katsuhiko;Togo, Hideo. And the article was included in Tetrahedron in 2012.HPLC of Formula: 1646-27-1 This article mentions the following:

Various aromatic bromides were treated with n-BuLi and subsequently with Et formate, followed by the reaction with ethanol and mol. iodine in the presence of K₂CO₃ to provide the corresponding aromatic Et esters in good yields. Moreover, aromatic bromides could be transformed into the corresponding aromatic Me esters in good yields by the treatment with n-BuLi and subsequently with DMF, followed by the reaction with methanol, mol. iodine, and K₂CO₃. Some aromatics could be also converted into the corresponding aromatic esters in good yields by the treatment with n-BuLi, and subsequently with Et formate or DMF, followed by the reaction with mol. iodine and K₂CO₃. The present reactions offer a novel route for the transition-metal-free, carbon-monoxide-free, and therefore environmentally benign one-pot conversion of aromatic bromides and aromatics into aromatic esters. In the experiment, the researchers used many compounds, for example, Methyl benzofuran-2-carboxylate (cas: 1646-27-1HPLC of Formula: 1646-27-1).

Methyl benzofuran-2-carboxylate (cas: 1646-27-1) belongs to benzofurans derivatives. Benzofurans are compounds with a planar structure having 10 pi electrons that include the lone pair on oxygen atom, which makes it more susceptible to electrophilic attack. Benzofurans have also made significant and distinctive contributions to biology. They exhibit several biological activities that range from antiviral, antimicrobial, antitumor, anti-inflammatory.HPLC of Formula: 1646-27-1

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

β-Deprotonation by lithium diisopropylamide. Vinyl carbanions from oxygen heterocycles in the synthesis of carboxylic acids in the benzofuran, flavone, and coumarin series and in the regiospecific acylation of 2,6-dimethylchromone was written by Costa, Ana M. B. S. R. C. S.;Dean, Francis M.;Jones, Michael A.;Smith, Dennis A.;Varma, Rajender S.. And the article was included in Journal of the Chemical Society, Chemical Communications in 1980.Category: benzofurans This article mentions the following:

LiN(CHMe₂)₂, at -70° deprotonated benzofuran, at the α-position in the absence of activating groups, whereas, in the presence of activating groups, the β-proton was removed. In flavone and 4-methoxycoumarin (I), β-deprotonation occurred readily and the carbanions formed were easily carboxylated giving previously unaccessible acids. E.g., I (R = H) underwent deprotonation and carboxylation to give the acid I (R = CO₂H). In 2,6-dimethylchromone, β-deprotonation was kinetically favored allowing 3-acylation to be achieved. In the experiment, the researchers used many compounds, for example, Methyl benzofuran-2-carboxylate (cas: 1646-27-1Category: benzofurans).

Methyl benzofuran-2-carboxylate (cas: 1646-27-1) belongs to benzofurans derivatives. Benzofuran derivatives are one of the most important oxygen-containing heterocycles. Substituted benzofurans find applications such as fluorescent sensors, oxidants, in drug discovery, and in another field of chemistry and agriculture.Category: benzofurans

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Syntheses of 3-acetoacetylaminobenzo[b]furan derivatives having cysteinyl leukotriene 2 receptor antagonistic activity was written by Ando, Kumiko;Tsuji, Eriko;Ando, Yuko;Kuwata, Noriko;Kunitomo, Jun-ichi;Yamashita, Masayuki;Ohta, Shunsaku;Kohno, Shigekatsu;Ohishi, Yoshitaka. And the article was included in Organic & Biomolecular Chemistry in 2004.Category: benzofurans This article mentions the following:

Triene-containing acetoacetylaminobenzo[b]furan derivatives such as I [R = Br, (E)-Et₂NC(:O)CH:CMe; R¹ = MeCO, EtO₂C, 4-NCC₆H₄] are prepared from 3-aminobenzo[b]furans as cysteinyl leukotriene 1 and 2 receptor antagonists. Hydroxyoxobutenylaminobenzo[b]furans (the enol isomers of 3-acetoacetylaminobenzo[b]furans) are obtained as stable isomers because of intramol. hydrogen bonding. (cyanohydroxyoxobutenylamino)benzo[b]furans I [R = Br, (E)-Et₂NC(:O)CH:CMe; R¹ = MeCO, EtO₂C, 4-NCC₆H₄] are moderately active inhibitors of agonist-induced calcium release; I show little selectivity between cysteinyl leukotriene 1 and cysteinyl leukotriene 2 receptors. The structures of I [R = Br, (E)-Et₂NC(:O)CH:CMe; R¹ = MeCO, 4-NCC₆H₄] are determined by X-ray crystallog. In the experiment, the researchers used many compounds, for example, 3-Aminobenzofuran-2-carboxamide (cas: 54802-10-7Category: benzofurans).

3-Aminobenzofuran-2-carboxamide (cas: 54802-10-7) belongs to benzofurans derivatives. Benzofuran derivatives have shown many biological activities, including antifungal and antimicrobial properties, and acting as antagonists of H3 receptors and angiotensin II. Benzofurans have also made significant and distinctive contributions to biology. They exhibit several biological activities that range from antioxidant, antitubercular, antiplasmodial, insecticidal.Category: benzofurans

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Carboxylic esters as radical leaving groups: a new and efficient gas-phase synthesis of benzofurans was written by Black, Michael;Cadogan, J. I. G.;Cartwright, Gary A.;McNab, Hamish;MacPherson, Andrew D.. And the article was included in Journal of the Chemical Society, Chemical Communications in 1993.Related Products of 1646-27-1 This article mentions the following:

Flash vacuum pyrolysis (FVP) of 2-allyloxycinnamate esters gives benzofurans in high yield, via cyclization of a phenoxyl radical and subsequent cleavage of the carboxylic ester function; coumarins are obtained by FVP of the corresponding phenols. Flash vacuum pyrolysis of Me 3-[2-(allyloxy)phenyl]-2-propenoate (I) gave benzofuranone (II) in 68% yield. In cases where lower yields were obtained, coumarins were the major products. In the experiment, the researchers used many compounds, for example, Methyl benzofuran-2-carboxylate (cas: 1646-27-1Related Products of 1646-27-1).

Methyl benzofuran-2-carboxylate (cas: 1646-27-1) belongs to benzofurans derivatives. Benzofurans are compounds with a planar structure having 10 pi electrons that include the lone pair on oxygen atom, which makes it more susceptible to electrophilic attack. Benzofurans have also made significant and distinctive contributions to biology. They exhibit several biological activities that range from antioxidant, antitubercular, antiplasmodial, insecticidal.Related Products of 1646-27-1

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Ru-catalyzed branched versus linear selective C3-alkylation of 2-aroylbenzofurans with acrylates via C-H activation was written by Kommagalla, Yadagiri;Srinivas, Kolluru;Ramana, Chepuri V.. And the article was included in Chemistry – A European Journal in 2014.COA of Formula: C10H8O3 This article mentions the following:

The carbonyl-directed C3-H activation and alkylation of 2-aroylbenzo[b]furans with acrylates occurs selectively either in a linear or branched fashion, depending on the catalyst employed; [Ru(p-cymene)Cl₂]₂ or Ru(PPh₃)₃Cl₂, resp. Two alternate pathways-funded upon the differences in steric and electronic preferences of these two complexes is proposed for the selectivity of linear vs. branched products. © 2014 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim. In the experiment, the researchers used many compounds, for example, Methyl benzofuran-2-carboxylate (cas: 1646-27-1COA of Formula: C10H8O3).

Methyl benzofuran-2-carboxylate (cas: 1646-27-1) belongs to benzofurans derivatives. Benzofurans are only weakly aromatic in nature and they are cleaved by many oxidative and reductive conditions. Benzofurans have also made significant and distinctive contributions to biology. They exhibit several biological activities that range from antiviral, antimicrobial, antitumor, anti-inflammatory.COA of Formula: C10H8O3

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Tandem Synthesis of 2-Carboxybenzofurans via Sequential Cu-Catalyzed C-O Coupling and Mo(CO)₆-Mediated Carbonylation Reactions was written by Mo, Qinliang;Sun, Nan;Jin, Liqun;Hu, Baoxiang;Shen, Zhenlu;Hu, Xinquan. And the article was included in Journal of Organic Chemistry in 2020.Reference of 1646-27-1 This article mentions the following:

A modular tandem synthesis of 2-carboxybenzofurans from 2-gem-dibromovinylphenols has been established based on a sequence of Cu-catalyzed intramol. C-O coupling and Mo(CO)₆-mediated intermol. carbonylation reactions. This protocol allowed one-step access to a broad variety of functionalized benzofuran-2-carboxylic acids, esters, and amides in good to excellent yields under Pd- and CO gas-free conditions. In the experiment, the researchers used many compounds, for example, Methyl benzofuran-2-carboxylate (cas: 1646-27-1Reference of 1646-27-1).

Methyl benzofuran-2-carboxylate (cas: 1646-27-1) belongs to benzofurans derivatives. Benzofuran derivatives have shown many biological activities, including antifungal and antimicrobial properties, and acting as antagonists of H3 receptors and angiotensin II. Benzofurans have also made significant and distinctive contributions to biology. They exhibit several biological activities that range from antioxidant, antitubercular, antiplasmodial, insecticidal.Reference of 1646-27-1

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Discovery of novel benzofuran scaffold as 4-hydroxyphenylpyruvate dioxygenase inhibitors was written by Huang, Hao;Zhang, Jian-qiu;Liu, Jian-min;Wang, Man-man;Shu, Lei;Yan, Yi-le;Zhan, Xiao-hang;Wang, Ping;Huan, Xue-ting;Zhang, Da-yong. And the article was included in Pest Management Science in 2021.Reference of 1646-27-1 This article mentions the following:

4-Hydroxyphenylpyruvate dioxygenase (HPPD) plays an important role in addressing the issue of plant protection research. This study sheds new light on the differences in mol. scaffold from commercialized HPPD inhibitors. The compounds A1-A18 and B1-B27 were synthesized for in vitro and greenhouse experiments The greenhouse experiment data indicated that compounds B14 and B18 displayed excellent herbicidal activity, which was higher compared to that of mesotrione. In vitro testing indicated that the compounds were HPPD inhibitors. Moreover, mol. simulation results show that the compounds B14, B18, and mesotrione shared similar interplay with surrounding residues, which led to a perfect interaction with the active site of Arabidopsis thaliana HPPD. Based on crop selectivity results, compounds B14 and B18 were selected for maize studies (injury≤10%), indicating its potential for weed control in maize fields. These results showed that the pyrazole-benzofuran structure could be used as possible lead compounds for the development of HPPD inhibitors. In the experiment, the researchers used many compounds, for example, Methyl benzofuran-2-carboxylate (cas: 1646-27-1Reference of 1646-27-1).

Methyl benzofuran-2-carboxylate (cas: 1646-27-1) belongs to benzofurans derivatives.Benzofuran is one of the most significant oxygen-containing heterocycles consisting of fused benzene and furan ring, which are widely presented in various naturally occurring and synthetically active compounds. Benzofurans have also made significant and distinctive contributions to biology. They exhibit several biological activities that range from antioxidant, antitubercular, antiplasmodial, insecticidal.Reference of 1646-27-1

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem