Syntheses of 3-acetoacetylaminobenzo[b]furan derivatives having cysteinyl leukotriene 2 receptor antagonistic activity was written by Ando, Kumiko;Tsuji, Eriko;Ando, Yuko;Kuwata, Noriko;Kunitomo, Jun-ichi;Yamashita, Masayuki;Ohta, Shunsaku;Kohno, Shigekatsu;Ohishi, Yoshitaka. And the article was included in Organic & Biomolecular Chemistry in 2004.Category: benzofurans This article mentions the following:
Triene-containing acetoacetylaminobenzo[b]furan derivatives such as I [R = Br, (E)-Et2NC(:O)CH:CMe; R1 = MeCO, EtO2C, 4-NCC6H4] are prepared from 3-aminobenzo[b]furans as cysteinyl leukotriene 1 and 2 receptor antagonists. Hydroxyoxobutenylaminobenzo[b]furans (the enol isomers of 3-acetoacetylaminobenzo[b]furans) are obtained as stable isomers because of intramol. hydrogen bonding. (cyanohydroxyoxobutenylamino)benzo[b]furans I [R = Br, (E)-Et2NC(:O)CH:CMe; R1 = MeCO, EtO2C, 4-NCC6H4] are moderately active inhibitors of agonist-induced calcium release; I show little selectivity between cysteinyl leukotriene 1 and cysteinyl leukotriene 2 receptors. The structures of I [R = Br, (E)-Et2NC(:O)CH:CMe; R1 = MeCO, 4-NCC6H4] are determined by X-ray crystallog. In the experiment, the researchers used many compounds, for example, 3-Aminobenzofuran-2-carboxamide (cas: 54802-10-7Category: benzofurans).
3-Aminobenzofuran-2-carboxamide (cas: 54802-10-7) belongs to benzofurans derivatives. Benzofuran derivatives have shown many biological activities, including antifungal and antimicrobial properties, and acting as antagonists of H3 receptors and angiotensin II. Benzofurans have also made significant and distinctive contributions to biology. They exhibit several biological activities that range from antioxidant, antitubercular, antiplasmodial, insecticidal.Category: benzofurans
Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem