With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.206347-30-0,7-Bromo-2,3-dihydrobenzofuran,as a common compound, the synthetic route is as follows.
Take a 100mL double-necked bottle, add 7-bromo-2,3-dihydrobenzofuran (5.0g, 25mmol),Sulfur powder (0.88g, 28mmol, 100mass%), under the protection of nitrogen, add THF (50mL), the reaction system was cooled to -78 , stirred for 5min,Then, n-BuLi (39 mL, 51 mmol, 1.3 mol/L) was added dropwise. After the dropwise addition was completed, the reaction solution was stirred at -78C for 1 hour.A saturated ammonium chloride solution (30 mL) was added dropwise to the reaction system at -78C to quench the reaction.Then the reaction solution was raised to room temperature, EtOAc (100 mL) and water (100 mL) were added to the reaction system, the liquid was separated, the aqueous phase was extracted with EtOAc (80 mL¡Á3), and the organic phases were combined,The organic phase was washed with saturated brine and separated, and the collected organic phase was washed with saturated brine (100 mL), dried over anhydrous sodium sulfate, filtered, and the filtrate was spin-dried under reduced pressure.The crude product of the title compound was obtained as a yellow liquid (3.8 g, 99%), which was directly used in the next reaction without further purification., 206347-30-0
206347-30-0 7-Bromo-2,3-dihydrobenzofuran 22571869, abenzofuran compound, is more and more widely used in various fields.
Reference£º
Patent; Guangdong Dongyangguang Pharmaceutical Co., Ltd.; Luo Huichao; Ren Qingyun; Yin Junjun; Wu Chunlin; Fan Yuxin; Mo Yufeng; Zhang Yingjun; (102 pag.)CN111057074; (2020); A;,
Benzofuran – Wikipedia
Benzofuran | C8H6O – PubChem