With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.1914-60-9,2,3-Dihydrobenzofuran-2-carboxylic acid,as a common compound, the synthetic route is as follows.
A mixture of 5-bromopyridin-3-amine (300 mg, 1.73 mmol), 2,3- dihydrobenzofuran-2-carboxylic acid (426 mg, 2.60 mmol) and EDCI.HC1 (497 mg, 2.60 mmol) in pyridine (4 mL) was stirred at 50 C for 2 h. The reaction mixture turned into brown solution from yellow. The reaction mixture was concentrated and the residue was diluted with water (25 mL), and then extracted with EtOAc (25 mL x3). The combined organic layer was washed with brine (25 mL), dried over anhydrous Na2S04 and concentrated. The residue was purified by Combi Flash (20% to 50% EtOAc in pentane) to give N-(5-bromopyridin-3-yl)- 2,3-dihydrobenzofuran-2-carboxamide (500 mg, yield: 91%) as yellow gum. (1699) NMR (400 MHz, CDCb) d 3.49-3.57 (1H, m), 3.64-3.74 (1H, m), 5.28 (1H, dd, J= 10.8, (1700) 6.5 Hz), 6.94-7.01 (2H, m), 7.18-7.26 (2H, m), 8.39-8.49 (3H, m), 8.54 (1H, d, J= 2.3 Hz)., 1914-60-9
As the paragraph descriping shows that 1914-60-9 is playing an increasingly important role.
Reference£º
Patent; PETRA PHARMA CORPORATION; KESICKI, Edward A.; LINDSTROeM, Johan; PERSSON, Lars Boukharta; VIKLUND, Jenny; FORSBLOM, Rickard; GINMAN, Tobias; HICKEY, Eugene R.; DAHLGREN, Markus K.; GERASYUTO, Aleksey I.; (391 pag.)WO2019/126730; (2019); A1;,
Benzofuran – Wikipedia
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