Donor-directed immunologic safety of COVID-19 vaccination in renal transplant recipients was written by Kueht, Michael;Kirk, Katie;Scott Lea, A.;Stevenson, Heather L.;Fair, Jeff;Kathleen Gamilla-Crudo, A.;Hussain, Syed;Mujtaba, Muhammad. And the article was included in Human Immunology in 2022.Application of 24280-93-1 This article mentions the following:
Infection risk and COVID-19 outcomes make SARS-CoV-2 vaccination essential for solid-organ transplant recipients. Reports of immune activation after vaccination causing graft failure raise concerns, but data are limited. Here, we document graft function, donor-derived-cell-free-DNA(dd-cfDNA), and donor-specific antibodies (DSA) in solid-organ renal transplant recipients after vaccination. Retrospective demographics, graft function, and immunol. parameters were collected in 96 renal transplant patients one month after their second vaccine dose. For-cause biopsies were performed based on clinician judgment. Similar proportions of subjects experienced increases (39.6%) and decreases (44.8%) in serum creatinine in the post-vaccination period, p = 0.56. Similar proportions of subjects experienced increases (23%) and decreases (25%) in serum ddcfDNA in the post-vaccination period, p = 0.87. Post-vaccination changes in serum creatinine and ddcfDNA (r(95) = -0.04, p = 0.71), serum creatinine and cumulative DSA MFI (r(95) = 0.07, p = 0.56), and ddcfDNA and cumulative DSA MFI (r(95) = 0.13, p = 0.21) were not significantly correlated. Five subjects had increased cumulative DSA MFI, but there were no de novo cases. Biopsies on three subjects confirmed pre-existing diagnoses. Our study found minimal evidence of donor-directed immunol. activity post-vaccination, and all immunol. changes did not correlate to graft dysfunction. We believe these findings do not amount to evidence of post-vaccination deleterious donor-directed activation. SARS-CoV-2 vaccination is immunol. safe and should continue for renal transplant recipients. In the experiment, the researchers used many compounds, for example, (E)-6-(4-Hydroxy-6-methoxy-7-methyl-3-oxo-1,3-dihydroisobenzofuran-5-yl)-4-methylhex-4-enoic acid (cas: 24280-93-1Application of 24280-93-1).
(E)-6-(4-Hydroxy-6-methoxy-7-methyl-3-oxo-1,3-dihydroisobenzofuran-5-yl)-4-methylhex-4-enoic acid (cas: 24280-93-1) belongs to benzofurans derivatives. Benzofuran is a core structural unit found in many naturally occurring compounds with multidirectional biological activities. Benzofurans have also made significant and distinctive contributions to biology. They exhibit several biological activities that range from antiviral, antimicrobial, antitumor, anti-inflammatory.Application of 24280-93-1
Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem