In organic chemistry, atoms other than carbon and hydrogen are generally referred to as heteroatoms. The most common heteroatoms are nitrogen, oxygen and sulfur. Now I present to you an article called Mind the Metal: A Fragment Library-Derived Zinc Impurity Binds the E2 Ubiquitin-Conjugating Enzyme Ube2T and Induces Structural Rearrangements, published in 2017-10-12, which mentions a compound: 3939-12-6, mainly applied to small mol zinc impurity E2 enzyme Ube2T crystal structure, Synthetic Route of C6H3FN2.
Efforts to develop inhibitors, activators and effectors of biol. reactions using small mol. libraries are often hampered by interference compounds, artifacts and false positives that permeate the pool of initial hits. Here we report the discovery of a promising initial hit compound targeting the Fanconi anemia ubiquitin-conjugating enzyme Ube2T and describe its biophys. and biochem. characterization. Anal. of the co-crystal structure led to the identification of a contaminating zinc ion as solely responsible for the observed effects. Zinc binding to the active site cysteine induces a domain swap in Ube2T that leads to cyclic trimerization organized in an open ended linear assembly. Our study serves as a cautionary tale for screening small mol. libraries and provides insights into the structural plasticity of ubiquitin-conjugating enzymes.
I hope my short article helps more people learn about this compound(6-Fluoronicotinonitrile)Synthetic Route of C6H3FN2. Apart from the compound(3939-12-6), you can read my other articles to know other related compounds.
Reference:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem