Category: benzofurans

Application of 4265-16-1, The reaction rate of a catalyzed reaction is faster than the reaction rate of the uncatalyzed reaction at the same temperature.4265-16-1, Name is Benzo[b]furan-2-carboxaldehyde, molecular formula is C9H6O2. In a Patent，once mentioned of 4265-16-1

This invention relates to color-changing styryl-like compounds and the preparing of the same. A compound according to the present invention has, as its principal ring, an indoline ring of 2nd position, and has, at stimulation reversible or irreversible change(s) between a closed ring structure of a non-plane molecular structure indicated by the following chemical formula(1) showing white or pale color, and an open ring structure of a plane molecular structure indicated by the following chemical formula(2) showing vivid visible color: STR1 wherein Q, R1, R2, R3, Y, Z, A and X are defined in the detailed specification.

A reaction mechanism is the microscopic path by which reactants are transformed into products. Each step is an elementary reaction. In my other articles, you can also check out more blogs about 4265-16-1

Reference：
Benzofuran – Wikipedia,
Benzofuran | C8H670O – PubChem

One of the major reasons for studying chemical kinetics is to use measurements of the macroscopic properties of a system, Recommanded Product: 1207453-90-4, such as the rate of change in the concentration of reactants or products with time.In a article, mentioned the application of 1207453-90-4, Name is 6-Fluoro-4-nitroisobenzofuran-1(3H)-one, molecular formula is C8H4FNO4

The present invention provides novel dihydropyridophthalazinone compounds of Formula (I) as PARP inhibitors, and their pharmaceutically acceptable salts, solvates, hydrates, prodrugs and metabolites thereof, the preparation thereof, and the use of such compounds to treat DNA repair dysregulation diseases and conditions such as cancer. The present provides therapeutic applications for the treatment of stroke, myocardial infarction, neurodegenerative diseases, ovarian cancer, breast cancer, prostate cancer, lung cancer, colorectal cancer, and melanoma.

Sometimes chemists are able to propose two or more mechanisms that are consistent with the available data. Recommanded Product: 1207453-90-4, If a proposed mechanism predicts the wrong experimental rate law, however, the mechanism must be incorrect.Welcome to check out more blogs about 1207453-90-4, in my other articles.

Reference：
Benzofuran – Wikipedia,
Benzofuran | C8H3319O – PubChem

In homogeneous catalysis, the catalyst is in the same phase as the reactant. The number of collisions between reactants and catalyst is at a maximum.In a patent, 41717-32-2, name is 1-Benzofuran-2-carbonitrile, introducing its new discovery. HPLC of Formula: C9H5NO

The optimization campaign for a nitrofuran antitubercular hit (N-benzyl-5-nitrofuran-2-carboxamide; JSF-3449) led to the design, synthesis, and biological profiling of a family of analogs. These compounds exhibited potent in vitro antitubercular activity (MIC = 0.019?0.20 muM) against the Mycobacterium tuberculosis H37Rv strain and low in vitro cytotoxicity (CC50 = 40?>120 muM) towards Vero cells. Significant improvements in mouse liver microsomal stability and mouse pharmacokinetic profile were realized by introduction of an alpha alpha-dimethylbenzyl moiety. Among these compounds, JSF-4088 is highlighted due to its in vitro antitubercular potency (MIC = 0.019 muM) and Vero cell cytotoxicity (CC50 > 120 muM). The findings suggest a rationale for the continued evolution of this promising series of antitubercular small molecules.

We’ll also look at important developments in the pharmaceutical industry because understanding organic chemistry is important in understanding health, medicine, the role of 41717-32-2, and how the biochemistry of the body works.HPLC of Formula: C9H5NO

Reference：
Benzofuran – Wikipedia,
Benzofuran | C8H609O – PubChem

Application of 10242-10-1, Because a catalyst decreases the height of the energy barrier, its presence increases the reaction rates of both the forward and the reverse reactions by the same amount.10242-10-1, Name is 5-Chlorobenzofuran-2-carboxylic acid, molecular formula is C9H5ClO3. In a article，once mentioned of 10242-10-1

The present invention provides a novel compound having a superior activity as an ERR-alpha modulator and useful as an agent for the prophylaxis or treatment of ERR-alpha associated diseases. The present invention relates to a compound represented by the formula (1) wherein each symbol is as defined in the specification, or a salt thereof

A reaction mechanism is the microscopic path by which reactants are transformed into products. Each step is an elementary reaction. In my other articles, you can also check out more blogs about 10242-10-1

Reference：
Benzofuran – Wikipedia,
Benzofuran | C8H3174O – PubChem

Chemistry is traditionally divided into organic and inorganic chemistry. Quality Control of 5-Methoxybenzofuran-2-carboxylic acid, The former is the study of compounds containing at least one carbon-hydrogen bonds.In a patent，Which mentioned a new discovery about 10242-08-7

A simple one-pot conversion of carboxylic acids to carbamates is achieved by propylphosphonic anhydride (T3P) in combination with azidotrimethylsilane and an alcohol via the Curtius rearrangement. Besides diverse primary to tertiary alcohols, the reaction tolerated a wide scope of aromatic, heterocyclic, and aliphatic carboxylic acids which underwent rearrangement in excellent yields. Georg Thieme Verlag Stuttgart – New York.

If you are interested in 10242-08-7, you can contact me at any time and look forward to more communication. Quality Control of 5-Methoxybenzofuran-2-carboxylic acid

Reference：
Benzofuran – Wikipedia,
Benzofuran | C8H3099O – PubChem

Electric Literature of 496-41-3, A catalyst don’t appear in the overall stoichiometry of the reaction it catalyzes, but it must appear in at least one of the elementary reactions in the mechanism for the catalyzed reaction. 496-41-3, Name is Benzofuran-2-carboxylic acid, molecular formula is C9H6O3. In a Article，once mentioned of 496-41-3

Several analogs of the alpha-tropanyl esters of 2-(4-chlorophenoxy)butyric acid (SM21) and 2-phenylthiobutyric acid (SM32), endowed with potent antinociceptive and cognition enhancing activity, were synthesized, aimed at obtaining more potent and safe drug candidates. Variation of the acyl moiety, as well as the conformational restriction of atropine to give the alpha-tropanyl ester of 2,3-dihydrobenzofurane-3-carboxylic acid (18), practically abolished activity. In the case of 18, the antimuscarinic activity was also severely affected by the conformation restrain. On the contrary, conformational restriction of phenoxybutyric and phenylthiobutyric acid derivatives to give the alpha-tropanyl ester of 2,3-dihydro-benzofurane-2-carboxylic acid and 2,3-dihydro-benzothiophene-2-carboxylic acid, afforded potent analgesic drugs that unfortunately were too toxic to be reliable drug candidates. A series of related esters of benzofurane-3-carboxylic acid and benzothiophene-3-carboxylic acid were also studied and found to be potent but toxic analgesics.

Balanced chemical reaction does not necessarily reveal either the individual elementary reactions by which a reaction occurs or its rate law.Electric Literature of 496-41-3. In my other articles, you can also check out more blogs about 496-41-3

Reference：
Benzofuran – Wikipedia,
Benzofuran | C8H1954O – PubChem

One of the major reasons for studying chemical kinetics is to use measurements of the macroscopic properties of a system, Safety of 4-Bromo-5-fluorobenzofuran, such as the rate of change in the concentration of reactants or products with time.In a article, mentioned the application of 286836-29-1, Name is 4-Bromo-5-fluorobenzofuran, molecular formula is C8H4BrFO

The present invention provides serotonergic benzofurans of Formula (I) where A, R, R1, R2, R3, and R4 are as described in the specification.

One of the oldest and most widely used commercial enzyme inhibitors is aspirin, Safety of 4-Bromo-5-fluorobenzofuran, which selectively inhibits one of the enzymes involved in the synthesis of molecules that trigger inflammation. you can also check out more blogs about 286836-29-1

Reference：
Benzofuran – Wikipedia,
Benzofuran | C8H3626O – PubChem

496-41-3, Name is Benzofuran-2-carboxylic acid, belongs to benzofurans compound, is a common compound. HPLC of Formula: C9H6O3In an article, once mentioned the new application about 496-41-3.

The invention provides 1-(1-imido)-2-aryl methyl-1,2,3,4-tetrahydroisoquinoline derivatives and a preparation method and application thereof. Stirring is conducted for 10-24 h at a certain temperature in organic solvent methylbenzene with 1,2,3,4-tetrahydroisoquinoline, aldehyde, carboxylic acid and isonitrile as raw materials and molecular sieves as additives. High-purity 1-(1-imido)-2-aryl methyl-1,2,3,4-tetrahydroisoquinoline derivatives are obtained after vacuum concentration, column chromatography and other operation are conducted on reaction mixed liquid. Raw materials are easy to obtain, reaction conditions are mild, and operation is easy; 1-(1-imido)-2-aryl methyl-1,2,3,4-tetrahydroisoquinoline derivatives with various substituent groups are easy to obtain, the requirement of high-flux sieving for tetrahydroisoquinoline derivatives can be well met, and great application and market value is achieved.

Do you like my blog? If you like, you can also browse other articles about this kind. Thanks for taking the time to read the blog about 496-41-3

Reference：
Benzofuran – Wikipedia,
Benzofuran | C8H1686O – PubChem

One of the major reasons for studying chemical kinetics is to use measurements of the macroscopic properties of a system, Computed Properties of C10H8O3, such as the rate of change in the concentration of reactants or products with time.In a article, mentioned the application of 24673-56-1, Name is 3-Methylbenzofuran-2-carboxylic acid, molecular formula is C10H8O3

The invention provides a method of synthesizing aromatic dichloro methyl ester. The method from the solution proceeding aryl carboxylic acid, alkali as additive, with the dichloromethane in the air condition efficiently synthesizing aromatic abnormal growth ester compound. With the conventional ester compound compared with the synthesis method, the method of this invention has raw materials of reaction (aryl carboxylic acid and dichloromethane) is cheap, simple reaction conditions, to a plurality of functional groups on the aromatic ring has good tolerant, high productivity of the obvious advantage. The method of the invention can be widely applied to the pharmaceutical industry and academia, material, such as natural product in the synthesis of the field. (by machine translation)

One of the oldest and most widely used commercial enzyme inhibitors is aspirin, Computed Properties of C10H8O3, which selectively inhibits one of the enzymes involved in the synthesis of molecules that trigger inflammation. you can also check out more blogs about 24673-56-1

Reference：
Benzofuran – Wikipedia,
Benzofuran | C8H2687O – PubChem

In homogeneous catalysis, the catalyst is in the same phase as the reactant. The number of collisions between reactants and catalyst is at a maximum.In a patent, 652-12-0, name is Tetrafluorophthalic anhydride, introducing its new discovery. name: Tetrafluorophthalic anhydride

Liver X receptor (LXR) agonists are candidates for the treatment of atherosclerosis via induction of ABCA1 (ATP-binding cassette A1) gene expression, which contributes to reverse cholesterol transport (RCT) and to cholesterol efflux from the liver and intestine. However, LXR agonists also induce genes involved in lipogenesis, such as SREBP-1c (sterol regulatory binding element protein 1c) and FAS (fatty acid synthase), thereby causing an undesirable increase in plasma and hepatic triglyceride (TG) levels. Recent studies indicate that LXRalpha contributes to lipogenesis in liver, and selective LXRbeta activation improves RCT in mice. Therefore, LXRbeta-selective agonists are promising candidates to improve atherosclerosis without increasing plasma or hepatic TG levels. However, the ligand-binding domains in the two LXR isoforms alpha/beta share high sequence identity, and few LXR ligands show subtype selectivity. In this study we identified a tetrachlorophthalimide analogue as an LXRbeta-selective agonist. Structural development led to (E)-4,5,6,7-tetrachloro-2-(2-styrylphenyl)isoindoline-1,3-dione (24 a), which shows potent and selective LXRbeta agonistic activity in reporter gene assays. In binding assays, compound 24 a bound to LXRbeta preferentially over LXRalpha. It also induced the expression of ABCA1 mRNA but not SREBP-1c mRNA in cells. Compound 24 a appears to be a promising lead compound for therapeutic agents to treat atherosclerosis without the side effects induced by LXRalpha/beta dual agonists.

We’ll also look at important developments in the pharmaceutical industry because understanding organic chemistry is important in understanding health, medicine, the role of 652-12-0, and how the biochemistry of the body works.name: Tetrafluorophthalic anhydride

Reference：
Benzofuran – Wikipedia,
Benzofuran | C8H3748O – PubChem