Category: benzofurans

《Photosensitizer doped zeolitic imidazolate framework-8 nanocomposites for combined antibacterial therapy to overcome methicillin-resistant Staphylococcus aureus (MRSA)》 was written by Li, Juan; Gopal, Ashna; Karaosmanoglu, Sena; Lin, Jiafu; Munshi, Tasnim; Zhang, Wenjun; Chen, Xianfeng; Yan, Li. COA of Formula: C20H14OThis research focused onzeolitic imidazolate nanocomposite antibiotic methicillin resistant Staphylococcus; Antibacterial therapy; Photodynamic therapy; Photosensitizer; Zeolitic imidazolate framework 8. The article conveys some information:

Antibiotics have played an important role in the treatment of bacteria related infections. However, the rapid emergence of multidrug-resistant bacteria and limited number of antibiotics available is a great challenge to humankind. To address this problem, we are proposing a photosensitizer-modified biodegradable zeolitic imidazolate framework-8 nanocomposite that can kill not only Gram-pos. bacteria Staphylococcus aureus, but also methicillin-resistant Staphylococcus aureus (MRSA) with high efficacy. In vivo testing revealed that these nanocomposites are highly effective for in vivo wound disinfection with minimal side-effects. In conclusion, this photosensitizer-modified biodegradable nanocomposite could be very promising for a synergistic antibacterial therapy to overcome MRSA. The experimental part of the paper was very detailed, including the reaction process of 1,3-Diphenylisobenzofuran(cas: 5471-63-6COA of Formula: C20H14O)

1,3-Diphenylisobenzofuran(cas: 5471-63-6) is a fluorescent dye. 1,3-Diphenylisobenzofuran is the model compound in studies of singlet fission.COA of Formula: C20H14O

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

SDS of cas: 5471-63-6In 2021 ,《Penetration of Singlet Oxygen into Films with Oxygen Permeability Coefficient Close to that of Skin》 was published in Photochemistry and Photobiology. The article was written by Harada, Nobuyuki; Kataoka, Mika; Nakanosho, Masahiro; Uyama, Hiroshi. The article contains the following contents:

Although its antiviral and antibacterial functions help prevent infection, singlet oxygen (1O2)-which is generated by the action of light on an endogenous photosensitizer-is cytotoxic. In the present study, we investigated the ability of 1O2-generated by the action of visible light on a photosensitizer-to penetrate skin. We used two polymer films with oxygen permeability coefficients similar to that of skin-i.e. cellulose acetate (CA) and Et cellulose (EC). Both films contained 1,3-diphenylisobenzofuran (DPBF), which was used as an 1O2 probe. 1O2 Generated externally did not permeate the films by mere contact. Therefore, we conclude that the potential for 1O2 to penetrate the skin is very low, and films that generate 1O2 are safe and useful for preventing infections by contact. We also proved that 1O2 can move between the layers of integrated polymer films when they are joined together.1,3-Diphenylisobenzofuran(cas: 5471-63-6SDS of cas: 5471-63-6) was used in this study.

1,3-Diphenylisobenzofuran(cas: 5471-63-6) is a fluorescent dye. 1,3-Diphenylisobenzofuran is the model compound in studies of singlet fission.SDS of cas: 5471-63-6

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Synthetic Route of C20H14OIn 2021 ,《Photodynamic treatment of colorectal cancer using chlorin e6-loaded poly(lactide-co-glycolide)-based nanoparticles》 appeared in Journal of Biomedical Nanotechnology. The author of the article were Lin, Beibei; Xu, Xuegu; Zhang, Xiaobi; Yu, Yinfei; Wang, Xiaoling. The article conveys some information:

We prepared poly(lactide-co-glycolide) (PLGA) encapsulated with chlorin e6 (Ce6) in an effort to increase the stability and efficiency of photosensitizers for photodynamic therapy (PDT). We determined that Ce6-loaded PLGA nanoparticles (PLGA-Ce6 NPs) had drug-loading efficiency of 5%. The efficiency of encapsulation was 82%, the zeta potential was-25 mV, and the average diameter was 130 nm. The encapsulation of Ce6 in PLGA nanoparticles showed excellent stability. The nanoparticles exhibited sustained Ce6 release profiles with 50% released at the end of 3 days, whereas free Ce6 showed rapid release within 1 day. Ce6 release patterns were controlled by encapsulation into PLGA. The uptake of PLGA-Ce6 NPs was significantly enhanced by endocytosis in the first 8 h in the HCT-116 cell line. An intracellular reactive oxygen species assay revealed the enhanced uptake of the nanoparticles. An in vitro anti-tumor activity assay showed that the PLGA-Ce6 NPs exhibited enhanced phototoxicity toward HCT-116 cells and a slightly lower IC50 value in HCT-116 cells than Ce6 solution alone. Exposure of HCT-116 cell spheroids to PLGA-Ce6 NPs penetrated more profoundly and had better phototoxicity than pure drugs. These findings suggest that PLGA-Ce6 NPs might serve as PDT for colorectal cancer. In the experiment, the researchers used 1,3-Diphenylisobenzofuran(cas: 5471-63-6Synthetic Route of C20H14O)

1,3-Diphenylisobenzofuran(cas: 5471-63-6) can be used as a fluorescent probe for detection of superoxide anion radical (O2−) inside the membrane lipid layer by DPBF fluorescence quenching method. 1,3-Diphenylisobenzofuran(DPBF) can be used as quencher during the photoinactivation of TA-3 mouse mammary carcinoma cells containing hematoporphyrin.Synthetic Route of C20H14O

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Harada, Nobuyuki; Masuda, Kiyoshi; Nakamura, Jun-ich; Uyama, Hiroshi published their research in Polymer Journal (Tokyo, Japan) in 2021. The article was titled 《Fabrication and evaluation of durable, optically clear, and self-disinfecting films》.Name: 1,3-Diphenylisobenzofuran The article contains the following contents:

Phenoxy-substituted phthalocyanine zinc (PPcZn) was synthesized and used as a photosensitizer to prepare a variety of self-disinfecting films by incorporating it into a cellulose acetate (CA) film at various concentrations The generation of singlet oxygen (1O2) from the films containing PPcZn irradiated with visible light was detected by a film containing 1,3-diphenylisobenzofuran (DPBF). The rate of 1O2 generation followed a pseudofirst-order kinetic model. Antiviral activity was confirmed under visible light irradiation using Bacteriophage Qβ. The film exhibited superior water resistance, photostability, mech. strength, and sustained 1O2 production over 6 mo under continuous exposure to room light. These data show the promise of this film in real-life applications as self-disinfecting surfaces. In addition to this study using 1,3-Diphenylisobenzofuran, there are many other studies that have used 1,3-Diphenylisobenzofuran(cas: 5471-63-6Name: 1,3-Diphenylisobenzofuran) was used in this study.

1,3-Diphenylisobenzofuran(cas: 5471-63-6) can be used as a fluorescent probe for detection of superoxide anion radical (O2−) inside the membrane lipid layer by DPBF fluorescence quenching method. 1,3-Diphenylisobenzofuran(DPBF) can be used to study the single crystal molecular structure and solution photophysical properties of DPBF.Name: 1,3-Diphenylisobenzofuran

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Sapkal, Suryakant B.; Shelke, Kiran F.; Shingate, Bapurao B.; Shingare, Murlidhar S. published their research in Chinese Chemical Letters on December 31 ,2010. The article was titled 《An efficient synthesis of benzofuran derivatives under conventional/non-conventional method》.Formula: C12H12O4 The article contains the following contents:

1-Methyl-3-Et imidazolium bromide [meim]Br/basic alumina (Al2O3) has been found to promote the cyclocondensation of chloroacetone/chloroethyl acetate with salicylaldehydes under conventional as well as microwave irradiation to yield benzofuran derivatives, e.g. I (R = Me, OEt). In the part of experimental materials, we found many familiar compounds, such as Ethyl 6-methoxybenzofuran-2-carboxylate(cas: 50551-57-0Formula: C12H12O4)

Ethyl 6-methoxybenzofuran-2-carboxylate(cas: 50551-57-0) belongs to benzofurans.Formula: C12H12O4Benzofurans containing one furan ring that have been implicated as psychoactive recreational drugs include 6-(2-aminopropyl)benzofuran (6-APB), 5-(2-aminopropyl)benzofuran (5-APB), 5-(2-ethylaminopropyl)benzofuran (5-EAPB), and 5-methylaminopropylbenzofuran (5-MAPB).

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Wang, Xiao-Hui; Wei, Xiao-Fei; Liu, Jin-Hua; Yang, Wei; Liu, Yuan-An; Cheng, Kun; He, Xiao-Ying; Fu, Xiu-Li; Zhang, Yu; Zhang, Hong-Xin published an article in 2021. The article was titled 《Chlorin e6-1,3-diphenylisobenzofuran polymer hybrid nanoparticles for singlet oxygen-detection photodynamic abaltion》, and you may find the article in Methods and Applications in Fluorescence.Recommanded Product: 5471-63-6 The information in the text is summarized as follows:

Adual-functional nanosysterm is developed by means of Chlorin e6 (Ce6) as photosensitizer and 1,3- Diphenylisobenzofuran (DPBF) as fluorescent singlet oxygen (1O2) probe. Under 660 nmlaser irradation, Ce6 exhibites efficient 1O2 generation, and subsequently the production of 1O2 is assessed by the ratiometric fluorescence of PFO and DPBF under one-photon and two-photon excitation mode. The nanoparticles with excellent biocompatibility can be internalized into Hela cells and applied for tumor treatment. For intracellular PDT, the nanoparticles perform a high phototoxicity, while the PDT proccess can be evaluated in time by monitoring fluorescence signals of DPBF. This theranostic nanosysterm provides a facile strategy to fabricate 1O2-detection PDT, which can realize accurate and efficient photodynamic therapy based on singlet oxygen detection. In the part of experimental materials, we found many familiar compounds, such as 1,3-Diphenylisobenzofuran(cas: 5471-63-6Recommanded Product: 5471-63-6)

1,3-Diphenylisobenzofuran(cas: 5471-63-6) can be used as a fluorescent probe for detection of superoxide anion radical (O2−) inside the membrane lipid layer by DPBF fluorescence quenching method. 1,3-Diphenylisobenzofuran(DPBF) can be used as quencher during the photoinactivation of TA-3 mouse mammary carcinoma cells containing hematoporphyrin.Recommanded Product: 5471-63-6

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

HPLC of Formula: 50551-57-0On October 1, 2010 ,《Novel imidazoline compounds as partial or full agonists of D2-like dopamine receptors inspired by I2-imidazoline binding sites ligand 2-BFI》 was published in Bioorganic & Medicinal Chemistry. The article was written by Giorgioni, Gianfabio; Ambrosini, Dario; Vesprini, Cristian; Hudson, Alan; Nasuti, Cinzia; Di Stefano, Antonio; Sozio, Piera; Ciampi, Osele; Costa, Barbara; Martini, Claudia; Carrieri, Antonio; Carbonara, Giuseppe; Enzensperger, Christoph; Pigini, Maria. The article contains the following contents:

Based on the well known biol. versatility of the imidazoline nucleus, we prepared the novel derivatives 3a-k inspired by 2-BFI scaffold to assess imidazoline mols. as D2-like dopamine receptor ligands. Conservative chem. modifications of the lead structure, such as the introduction of an hydroxy group in the aromatic ring alone or associated with N-benzyl substitution, provided partial (3f)(I) or nearly full (3e and 3h) agonists, all endowed with D2-like potency comparable to that of dopamine. The experimental part of the paper was very detailed, including the reaction process of Ethyl 6-methoxybenzofuran-2-carboxylate(cas: 50551-57-0HPLC of Formula: 50551-57-0)

Ethyl 6-methoxybenzofuran-2-carboxylate(cas: 50551-57-0) belongs to benzofurans.HPLC of Formula: 50551-57-0Benzofurans containing one furan ring that have been implicated as psychoactive recreational drugs include 6-(2-aminopropyl)benzofuran (6-APB), 5-(2-aminopropyl)benzofuran (5-APB), 5-(2-ethylaminopropyl)benzofuran (5-EAPB), and 5-methylaminopropylbenzofuran (5-MAPB).

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

COA of Formula: C12H12O4On October 15, 2008 ,《Aminostyrylbenzofuran derivatives as potent inhibitors for Aβ fibril formation》 was published in Bioorganic & Medicinal Chemistry Letters. The article was written by Byun, Ji Hun; Kim, HyeYun; Kim, YoungSoo; Mook-Jung, Inhee; Kim, Dong Jin; Lee, Won Koo; Yoo, Kyung Ho. The article contains the following contents:

The synthesis of a novel series of aminostyrylbenzofurans I (R1, R2 = H, Br, Cl, F, I, OH, OMe; R3 = NH2, NHMe, NMe2; R4 = H, OMe) and their inhibitory activities for Aβ fibril formation were described. All the synthesized compounds were evaluated by thioflavin T (ThT) assay and displayed potent inhibitory activities for Aβ fibril formation. Among them, compounds I (R1 = R4 = H; R2 = OMe; R3 = NMe2) and I (R1 = OMe, R2 = R4 = H; R3 = NHMe) exhibited excellent inhibitory activities (IC50 = 0.07 and 0.08 μM, resp.) than those of Curcumin (IC50 = 0.80 μM) and IMSB (IC50 = 8.00 μM) as reference compounds Both compounds were selected as promising candidates for further biol. evaluation. In the part of experimental materials, we found many familiar compounds, such as Ethyl 6-methoxybenzofuran-2-carboxylate(cas: 50551-57-0COA of Formula: C12H12O4)

Ethyl 6-methoxybenzofuran-2-carboxylate(cas: 50551-57-0) belongs to benzofurans.COA of Formula: C12H12O4Benzofurans containing one furan ring that have been implicated as psychoactive recreational drugs include 6-(2-aminopropyl)benzofuran (6-APB), 5-(2-aminopropyl)benzofuran (5-APB), 5-(2-ethylaminopropyl)benzofuran (5-EAPB), and 5-methylaminopropylbenzofuran (5-MAPB).

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

《Gold nanoshells coated 5-aminolevulinic liposomes for photothermal-photodynamic antitumor therapy》 was written by Jiang, Yifei; Liu, Yang; Fang, Siyuan; Ji, Min. SDS of cas: 5471-63-6 And the article was included in Journal of Nanoscience and Nanotechnology in 2020. The article conveys some information:

In this study, a novel antitumor system was designed on the basis of photodynamic therapy and photothermal therapy using gold nanoshells coated 5-aminolevulinic acid (5-ALA) liposomes (GNALs). As a widely used photosensitizer prodrug, 5-aminolevulinic acid (5-ALA)-derived protoporphyrin IX (PpIX) can accumulate to a higher level in tumors than in normal tissues. Protoporphyrin IX (PpIX) initiates a series of cytotoxic reactions after irradiation of target tissue with a measured dose of light with appropriate wavelength, which may be dependent on the generation of reactive oxygen species. Gold nanoshells can strongly absorb NIR lasers at the same time, and can generate hyperthermia to provide photothermic effects. Gold nanoshells coated 5-ALA-Liposomes (GNALs) exhibit a uniform-sized spherical shape of 185.8±0.91 nm, with a zeta potential of 33±1.6 mV. Liposomes with specific sizes ranging from 100 to 200 nm can escape into the tumor interstitial tissue and accumulate preferentially in tumor tissue owing to the EPR effect. In addition, NIR light-excited nanosystems significantly promoted antitumor effects in this study compared to single photodynamic therapy. It was also found that the increased temperature promoted inhibition rate of SKOV3 cells. The novel drug delivery system shows great potential in photothermal-photodynamic antitumor therapy. In the experiment, the researchers used 1,3-Diphenylisobenzofuran(cas: 5471-63-6SDS of cas: 5471-63-6)

1,3-Diphenylisobenzofuran(cas: 5471-63-6) can be used as a fluorescent probe for detection of superoxide anion radical (O2−) inside the membrane lipid layer by DPBF fluorescence quenching method. 1,3-Diphenylisobenzofuran(DPBF) can be used as quencher during the photoinactivation of TA-3 mouse mammary carcinoma cells containing hematoporphyrin.SDS of cas: 5471-63-6

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

The author of 《Benzofurans. LIV. New access to hydroxybenzofurans》 were Rene, Loic; Royer, Rene. And the article was published in Bulletin de la Societe Chimique de France in 1973. Category: benzofurans The author mentioned the following in the article:

Hydroxybenzofurans were prepared in overall yields I 70, II 60, III 30, IV 55%, by cyclizing methoxysalicylaldehydes with ClCH2CO2Et to a mixture of Et methoxycoumarilate, methoxycoumarilic acid, and methoxybenzofuran. The coumarilic acid derivatives were decarboxylated with Cu in quinoline and the methoxybenzofurans were demethylated by pyridine-HCl. The experimental process involved the reaction of Ethyl 6-methoxybenzofuran-2-carboxylate(cas: 50551-57-0Category: benzofurans)

Ethyl 6-methoxybenzofuran-2-carboxylate(cas: 50551-57-0) belongs to benzofurans.Category: benzofuransBenzofurans containing one furan ring that have been implicated as psychoactive recreational drugs include 6-(2-aminopropyl)benzofuran (6-APB), 5-(2-aminopropyl)benzofuran (5-APB), 5-(2-ethylaminopropyl)benzofuran (5-EAPB), and 5-methylaminopropylbenzofuran (5-MAPB).

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem