Category: benzofurans

Solvent-Controlled Electron Transfer in Crystal Violet Lactone was written by Li, Xiang;Maroncelli, Mark. And the article was included in Journal of Physical Chemistry A in 2011.COA of Formula: C26H29N3O2 This article mentions the following:

Steady-state and picosecond time-resolved emission experiments are used to examine the excited-state charge transfer reaction of crystal violet lactone (CVL) in aprotic solvents. Solvatochromic anal. using a dielec. continuum model suggests dipole moments of 9-12 D for the initially excited (LE) state and ∼24 D for the charge-transfer (CT) state. Intensities of steady-state emission as well as kinetic data provide free energies for the LE → CT reaction that range from +12 kJ/mol in nonpolar solvents to -10 kJ/mol in highly polar solvents at 25 °C. Reaction rate constants, which lie in the range of 10-100 ns^-1 in most solvents, depend on both solvent polarity and solvent friction. In highly polar solvents, rates are correlated to solvation times in a manner that indicates that the reaction is a solvent-controlled electron transfer on an adiabatic potential surface having a modest barrier. In the experiment, the researchers used many compounds, for example, Crystal violet lactone (cas: 1552-42-7COA of Formula: C26H29N3O2).

Crystal violet lactone (cas: 1552-42-7) belongs to benzofurans derivatives. Many natural or synthetic compounds containing benzofuran skeletons have been found to possess remarkable activity as agrochemicals and pharmaceuticals. Benzofurans have also made significant and distinctive contributions to biology. They exhibit several biological activities that range from antiviral, antimicrobial, antitumor, anti-inflammatory.COA of Formula: C26H29N3O2

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Influence of mycophenolate mofetil dosage and plasma levels on the occurrence of chronic lung allograft dysfunction in lung transplants: a retrospective cohort analysis. was written by Steinack, Carolin;Saurer, Philipp;Gautschi, Fiorenza;Hage, René;Ortmanns, Gernot;Schuurmans, Macé M;Gaisl, Thomas. And the article was included in Swiss medical weekly in 2022.Application of 24280-93-1 This article mentions the following:

INTRODUCTION: Development of chronic lung allograft dysfunction is a limiting factor for post-lung transplant survival. We evaluated whether the dose of the immunosuppressant mycophenolate mofetil or plasma concentrations of the active metabolite mycophenolic acid affect the development of chronic lung allograft dysfunction. METHODS: In this retrospective cohort study we recruited 71 patients with a lung transplant between 2010 and 2014 which survived the first year after transplantation up to 1 July 2021. An event-time-analytical Cox proportional-hazards regression model with time-varying-covariates (18,431 measurements for MPA, mycophenolate mofetil dosage, lymphocytes) was used to predict chronic lung allograft dysfunction, with adjustment for sociodemographic factors and lung function at baseline. RESULTS: 37 patients did not develop chronic lung allograft dysfunction (age 41.3 ± 15.6 years, baseline FEV1 95.5 ± 19.1% predicted) and 34 patients developed chronic lung allograft dysfunction (age 50.9 ± 13.3 years, baseline FEV1 102.2 ± 25.4% predicted). Mean mycophenolic acid did not differ significantly between the groups (2.8 ± 1.7 and 3.0 ± 2.3 mg/l; p = 0.724). In the first 4 post-transplant years the death rate was 25%. A total of 50% of the patients died by the ninth post-transplant year. There was a dose-effect relationship between mycophenolate mofetil dosage, mycophenolic acid (r2 = 0.02, p <0.001), as well as lymphocyte levels (r2 = -0.007, p <0.001), but only the traditional risk factor age predicted chronic lung allograft dysfunction. Continuously measured mycophenolic acid did not predict chronic lung allograft dysfunction (hazard ratio 0.98, 95% confidence interval 0.90-1.06, p = 0.64 over a period of 382.97 patient-years). CONCLUSION: Mycophenolate mofetil dosage and mycophenolic acid were not associated with chronic lung allograft dysfunction development. Thus, the mycophenolate mofetil dose or mycophenolic acid plasma concentration are not a primary factor related to organ rejection, but chronic lung allograft dysfunction may be influenced by other components of immunosuppression or other factors. In the experiment, the researchers used many compounds, for example, (E)-6-(4-Hydroxy-6-methoxy-7-methyl-3-oxo-1,3-dihydroisobenzofuran-5-yl)-4-methylhex-4-enoic acid (cas: 24280-93-1Application of 24280-93-1).

(E)-6-(4-Hydroxy-6-methoxy-7-methyl-3-oxo-1,3-dihydroisobenzofuran-5-yl)-4-methylhex-4-enoic acid (cas: 24280-93-1) belongs to benzofurans derivatives. Many natural or synthetic compounds containing benzofuran skeletons have been found to possess remarkable activity as agrochemicals and pharmaceuticals. Benzofurans have also made significant and distinctive contributions to biology. They exhibit several biological activities that range from antiviral, antimicrobial, antitumor, anti-inflammatory.Application of 24280-93-1

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Comparison on the effect of seven drugs to prevent relapses of neuromyelitis optica spectrum disorders: A modeling analysis of literature aggregate data was written by Luo, Jieren;Yu, Jiesen;Sui, Zichao;Zhong, Ying;Zheng, Qingshan;Li, Lujin. And the article was included in International Immunopharmacology in 2022.Application In Synthesis of (E)-6-(4-Hydroxy-6-methoxy-7-methyl-3-oxo-1,3-dihydroisobenzofuran-5-yl)-4-methylhex-4-enoic acid This article mentions the following:

Neuromyelitis optica spectrum disorders (NMOSD) is an immune-mediated demyelinating disease of the central nervous system. This study aimed to perform a comprehensive comparison of the effect of seven drugs to prevent relapses of NMOSD. A literature search was conducted using public databases. Clin. studies on the seven drugs (eculizumab, inebilizumab, satralizumab, rituximab, tocilizumab, azathioprine, and mycophenolate mofetil) to prevent relapses of NMOSD were identified. A time-course model was established using the time to first relapse as the primary endpoint, in order to evaluate the long-term effect of each drug in preventing relapse. Twenty-four trials, including 2207 patients, were included in the model anal. The results showed that monoclonal antibody therapy could significantly prolong the time to first relapse. Among all seven drugs, eculizumab can most significantly prevent patient from relapse. The estimated proportion of relapse-free patients treated with eculizumab was 98.9% at 24 mo. Based on the construction of a time-course pharmacodynamic model, this study made a comprehensive quant. comparison of seven drugs for the treatment of NMOSD for the first time. These results can not only serve as a quant. supplement for the rational use of drugs in clin. practice but also provide a pharmacodynamic reference for clin. trial design and decision making in the future. In the experiment, the researchers used many compounds, for example, (E)-6-(4-Hydroxy-6-methoxy-7-methyl-3-oxo-1,3-dihydroisobenzofuran-5-yl)-4-methylhex-4-enoic acid (cas: 24280-93-1Application In Synthesis of (E)-6-(4-Hydroxy-6-methoxy-7-methyl-3-oxo-1,3-dihydroisobenzofuran-5-yl)-4-methylhex-4-enoic acid).

(E)-6-(4-Hydroxy-6-methoxy-7-methyl-3-oxo-1,3-dihydroisobenzofuran-5-yl)-4-methylhex-4-enoic acid (cas: 24280-93-1) belongs to benzofurans derivatives. Benzofuran derivatives have shown many biological activities, including antifungal and antimicrobial properties, and acting as antagonists of H3 receptors and angiotensin II. They are also prone to polymerisation in the presence of concentrated mineral acids and Lewis acids.Application In Synthesis of (E)-6-(4-Hydroxy-6-methoxy-7-methyl-3-oxo-1,3-dihydroisobenzofuran-5-yl)-4-methylhex-4-enoic acid

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Visualization of plant cell wall lignification using fluorescence-tagged monolignols was written by Tobimatsu, Yuki;Wagner, Armin;Donaldson, Lloyd;Mitra, Prajakta;Niculaes, Claudiu;Dima, Oana;Kim, Jeong Im;Anderson, Nickolas;Loque, Dominique;Boerjan, Wout;Chapple, Clint;Ralph, John. And the article was included in Plant Journal in 2013.Safety of 2-Nitrobenzofuran This article mentions the following:

Lignin is an abundant phenylpropanoid polymer produced by the oxidative polymerization of p-hydroxycinnamyl alcs. (monolignols). Lignification, i.e., deposition of lignin, is a defining feature of secondary cell wall formation in vascular plants, and provides an important mechanism for their disease resistance; however, many aspects of the cell wall lignification process remain unclear partly because of a lack of suitable imaging methods to monitor the process in vivo. In this study, a set of monolignol analogs γ-linked to fluorogenic aminocoumarin and nitrobenzofuran dyes were synthesized and tested as imaging probes to visualize the cell wall lignification process in Arabidopsis thaliana and Pinus radiata under various feeding regimens. In particular, we demonstrate that the fluorescence-tagged monolignol analogs can penetrate into live plant tissues and cells, and appear to be metabolically incorporated into lignifying cell walls in a highly specific manner. The localization of the fluorogenic lignins synthesized during the feeding period can be readily visualized by fluorescence microscopy and is distinguishable from the other wall components such as polysaccharides as well as the pre-existing lignin that was deposited earlier in development. In the experiment, the researchers used many compounds, for example, 2-Nitrobenzofuran (cas: 33094-66-5Safety of 2-Nitrobenzofuran).

2-Nitrobenzofuran (cas: 33094-66-5) belongs to benzofurans derivatives. Many natural or synthetic compounds containing benzofuran skeletons have been found to possess remarkable activity as agrochemicals and pharmaceuticals. Benzofurans are stable towards alkali and readily polymerize on treatment with sulfuric acid, due to which they are useful for the preparation of low cost chemically relatively inert resins.Safety of 2-Nitrobenzofuran

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Target and Suspect Screening of Urinary Biomarkers for Current-use Pesticides: Application of a Simple Extraction Method was written by Huang, Zhoubing;Li, Huizhen;Xiong, Jingjing;You, Jing. And the article was included in Environmental Toxicology and Chemistry in 2022.Reference of 1563-38-8 This article mentions the following:

Pesticide residues pose a great threat to human health. Biomonitoring with urine samples has often been used to assess pesticide exposure to humans, and identifying appropriate biomarkers is a premise of success. Current-use pesticides (CUPs) including neonicotinoids tend to be transformed in an organism, and thus the biomonitoring studies focusing on parent compounds alone may underestimate their risk. It is imperative to develop effective methods to analyze CUPs and their metabolites simultaneously and to identify viable metabolites as urinary biomarkers. For analyzing xenobiotics in urine, we optimized CH₃COCH₃-MgSO₄ extraction coupled with a high-performance liquid chromatog.-tandem mass spectrometry detection method. The method had sensitive method detection limits (0.11-1.39 ng/mL), low matrix effects, and satisfactory recovery and precision (49.4% ± 7.2%-99.8% ± 17.8%) for neonicotinoids and their metabolites. Application of the method for real samples showed that children living in rural areas in South China were ubiquitously exposed to CUPs, including neonicotinoids, fipronil, and chlorpyrifos, and urinary residues were mainly in the form of metabolites. Suitable biomarkers were identified for individual neonicotinoids, including imidacloprid-olefin and imidacloprid-guanidine for imidacloprid, acetamiprid-N-desmethyl for acetamiprid, thiacloprid-amide for thiacloprid, and N-desmethyl-thiamethoxam and thiamethoxam for thiamethoxam. Three metabolites were mainly reported in urine samples, including imidacloprid-urea, thiacloprid-amide, and N-desmethyl-thiamethoxam. In addition, the method was also applied for suspect screening, and an addnl. metabolite (clothianidin-desmethyl-nitrosoguanidine) was identified, showing its potential application in suspect anal. In the experiment, the researchers used many compounds, for example, 2,2-Dimethyl-2,3-dihydrobenzofuran-7-ol (cas: 1563-38-8Reference of 1563-38-8).

2,2-Dimethyl-2,3-dihydrobenzofuran-7-ol (cas: 1563-38-8) belongs to benzofurans derivatives.Benzofuran is one of the most significant oxygen-containing heterocycles consisting of fused benzene and furan ring, which are widely presented in various naturally occurring and synthetically active compounds. As benzofurans are prone to undergo ring opening of the heterocycle, examples of reduction of this type of aromatics by using dissolving metals are rather scarce.Reference of 1563-38-8

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Polymer screening method for chemically amplified electron-beam and x-ray resists was written by Yamamoto, Hiroki;Nakano, Atsuro;Okamoto, Kazumasa;Kozawa, Takahiro;Tagawa, Seiichi. And the article was included in Japanese Journal of Applied Physics, Part 1 in 2004.Product Details of 1552-42-7 This article mentions the following:

In the acid generation processes of chem. amplified electron-beam and x-ray resists, protons come from not acid generators but base polymers. This means that the selection of base polymers has a great effect on the acid generation efficiency. The authors describe a convenient method of screening polymers for acid generation. The authors also showed the difference in acid generation efficiencies among substituted polystyrenes. In the experiment, the researchers used many compounds, for example, Crystal violet lactone (cas: 1552-42-7Product Details of 1552-42-7).

Crystal violet lactone (cas: 1552-42-7) belongs to benzofurans derivatives. Benzofuran is the “”parent”” of many related compounds with more complex structures. For example, psoralen is a benzofuran derivative that occurs in several plants. As benzofurans are prone to undergo ring opening of the heterocycle, examples of reduction of this type of aromatics by using dissolving metals are rather scarce.Product Details of 1552-42-7

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Effects of fraxinellone on the peritrophic membrane of Mythimna separata(Lepidoptera:Noctuidae) was written by Lu, Min;Chen, Su-ying;Han, Li-bo;Hu, Jun-yun;Xu, Hui;Wu, Wen-jun. And the article was included in Kunchong Xuebao in 2014.Formula: C14H16O3 This article mentions the following:

Isolated from the root-bark of Diatamnus dasycarpus Turcz., fraxinellone exhibits stomach toxicity against pests. This study aims to clarify the insecticidal mechanism of fraxinellone by investigating the effects of fraxinellone on the peritrophic membrane of the 6th instar larvae of Mythimna separata. Through biochem. methods and SEM observation, the content of carbohydrates, the contents and components of proteins and the surface structure of the peritrophic membrane of the 6th instar larvae of M. separata after in vivo and in vitro treatments with fraxinellone were studied. In vivo treatment of fraxinellone (20 mg/mL) resulted in a drop of the protein content in the 6th instar larvae of M. separata. However, after M. separata larvae were subjected to in vivo (20 mg/mL fraxinellone) and in vitro (8 mg/mL fraxinellone) treatments with fraxinellone, the contents of carbohydrates of both treatments increased, which were 1.75 and 2.17 folds as high as those of the control, resp. SDS-PAGE result showed that partial proteins were hydrolyzed in the 6th instar larvae of M. separata subjected to in vivo and in vitro treatment with fraxinellone. SEM observation showed that the surface structure of peritrophic membrane changed after the 6th instar larvae of M. separata were treated with fraxinellone in vivo and in vitro. These results showed that fraxinellone affected the contents of carbohydrates and the contents and components of proteins, and altered the surface structure of the peritrophic membrane of M. separata larvae. This study provides a basis for further research on the insecticidal mechanisms of fraxinellone against pests. In the experiment, the researchers used many compounds, for example, (3R,3aR)-3-(Furan-3-yl)-3a,7-dimethyl-3a,4,5,6-tetrahydroisobenzofuran-1(3H)-one (cas: 28808-62-0Formula: C14H16O3).

(3R,3aR)-3-(Furan-3-yl)-3a,7-dimethyl-3a,4,5,6-tetrahydroisobenzofuran-1(3H)-one (cas: 28808-62-0) belongs to benzofurans derivatives. Benzofuran is a core structural unit found in many naturally occurring compounds with multidirectional biological activities. As benzofurans are prone to undergo ring opening of the heterocycle, examples of reduction of this type of aromatics by using dissolving metals are rather scarce.Formula: C14H16O3

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

General survey of Fructus Psoraleae from different origins and chemical identification of roasted from raw Fructus Psoraleae was written by Yang, Junjun;Yang, Jing;Du, Jie;Feng, Yuxin;Chai, Xin;Xiao, Mingming;Wang, Yuefei;Gao, Xiumei. And the article was included in Journal of Food and Drug Analysis in 2018.Related Products of 905954-17-8 This article mentions the following:

Fructus Psoraleae, a traditional Chinese medicine, is widely used for preventing and treating various diseases such as vitiligo, osteoporosis and psoriasis. Coumarin, such as psoralenoside, isopsoralenoside, psoralen and isopsoralen, are important compounds in Fructus Psoraleae. In our study, ultra performance liquid chromatog. coupled with diode array detector was employed for an excellent method validation for simultaneous quantification of psoralenoside, isopsoralenoside, psoralen and isopsoralen, which was further applied in performing general survey of Fructus Psoraleae from the different origins and chem. identification of the roasted from raw Fructus Psoraleae in the light of illuminating the transformed rule of psoralenoside and isopsoralenoside. There is a reciprocal relationship between (iso)psoralenoside and (iso)psoralen, and the total content remains balance in Fructus Psoraleae from the different origins. In addition, we found that (iso)psoralenoside in the powder of the raw Fructus Psoraleae could be easily transformed into (iso)psoralen in methanol aqueous solution, especially above 50% water, rather than the roasted one. Thus, we proposed a hypothesis that transformation between (iso)psoralenoside and (iso)psoralen was hindered by inactivation of β-glucosidase in the process of roasting Fructus Psoraleae, which was further verified by observing transformation of (iso)psoralenoside under the different conditions, such as temperature, pH and β-glucosidase. Therefore, we developed a feasible method to distinguish the roasted from raw Fructus Psoraleae by observing conversion from (iso)psoralenoside to (iso)psoralen in 50% methanol aqueous solution In summary, these results pave the way for elevating quality standard for Fructus Psoraleae and distinguishing the salt-processed from raw Fructus Psoraleae. In the experiment, the researchers used many compounds, for example, (Z)-3-(6-(((2S,3R,4S,5S,6R)-3,4,5-Trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)oxy)benzofuran-5-yl)acrylic acid (cas: 905954-17-8Related Products of 905954-17-8).

(Z)-3-(6-(((2S,3R,4S,5S,6R)-3,4,5-Trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)oxy)benzofuran-5-yl)acrylic acid (cas: 905954-17-8) belongs to benzofurans derivatives. Benzofuran is the “”parent”” of many related compounds with more complex structures. For example, psoralen is a benzofuran derivative that occurs in several plants. They are also prone to polymerisation in the presence of concentrated mineral acids and Lewis acids.Related Products of 905954-17-8

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

In vivo pharmacokinetic analyses of placental transfer of three drugs of different physicochemical properties in pregnant rats was written by Mehta, Darshan;Li, Miao;Nakamura, Noriko;Chidambaram, Mani;He, Xiaobo;Bryant, Matthew S.;Patton, Ralph;Davis, Kelly;Fisher, Jeffrey. And the article was included in Reproductive Toxicology in 2022.COA of Formula: C43H51N3O11 This article mentions the following:

Although the use of medication during pregnancy is common, information on exposure to the developing fetus and potential teratogenic effects is often lacking. This study used a rat model to examine the placental transfer of three small-mol. drugs with mol. weights ranging from approx. 300 to 800 Da with different physicochem. properties. Time-mated Sprague Dawley (Hsd:SD) rats aged 11-13 wk were administered either glyburide, rifaximin, or fentanyl at gestational day 15. Maternal blood, placentae, and fetuses were collected at 5 min, 30 min, 1 h, 4 h, 8 h, 24 h, 48 h, and 96 h post-dose. To characterize the rate and extent of placental drug transfer, we calculated several pharmacokinetic parameters such as maximum concentration (Cmax), time to maximum concentration (Tmax), area under the concentration-time curve (AUC), half-life (t1/2), clearance (CL), and volume of distribution (Vd) for plasma, placenta, and fetus tissues. The results indicated showed that fetal exposure was lowest for glyburide, accounting for only 2.2% of maternal plasma exposure as measured by their corresponding AUC ratio, followed by rifaximin (37.9%) and fentanyl (172.4%). The fetus/placenta AUC ratios were found to be 10.7% for glyburide, 11.8% for rifaximin, and 39.1% for fentanyl. These findings suggest that although the placenta acts as a protective shield for the fetus, the extent of protection varies for different drugs and depends on factors such as mol. weight, lipid solubility, transporter-mediated efflux, and binding to maternal and fetal plasma proteins. In the experiment, the researchers used many compounds, for example, (2S,16Z,18E,20S,21S,22R,23R,24R,25S,26R,27S,28E)-25-(Acetyloxy)-5,6,21,23-tetrahydroxy-27-methoxy-2,4,11,16,20,22,24,26-octamethyl-2,7-(epoxypentadeca[1,11,13]trienimino)benzofuro[4,5-e]pyrido[1,2-a]benzimidazole-1,15(2H)-dione (cas: 80621-81-4COA of Formula: C43H51N3O11).

(2S,16Z,18E,20S,21S,22R,23R,24R,25S,26R,27S,28E)-25-(Acetyloxy)-5,6,21,23-tetrahydroxy-27-methoxy-2,4,11,16,20,22,24,26-octamethyl-2,7-(epoxypentadeca[1,11,13]trienimino)benzofuro[4,5-e]pyrido[1,2-a]benzimidazole-1,15(2H)-dione (cas: 80621-81-4) belongs to benzofurans derivatives. Benzofurans are only weakly aromatic in nature and they are cleaved by many oxidative and reductive conditions. Introduction of benzofurans in organic synthesis, particularly drug synthesis, involves generally the use of their metalated species as nucleophiles in addition reactions or in metal-catalysed cross-coupling reactions.COA of Formula: C43H51N3O11

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Acid-base dissociation and tautomerism of two aminofluorescein dyes in solution was written by Mchedlov-Petrossyan, Nikolay O.;Cheipesh, Tatyana A.;Vodolazkaya, Natalya A.. And the article was included in Journal of Molecular Liquids in 2017.Product Details of 3326-34-9 This article mentions the following:

The four-step dissociation of two fluorescein dyes bearing the amino group in 4′- and 5′-positions of the phthalic moiety was studied in water. The constants describing the equilibrium H₄R²⁺⇌H₃R⁺ ⇌ H₂R ⇌ HR- ⇌ R^2- were determined using the spectrophotometric method, at 25 °. In water, four steps of aminofluoresceins dissociation occur within pH range of 0-9. On going to 50 mass % aqueous ethanol, the increase in the pK_a1, pK_a2 and decrease in the pK_a0, pK_a(-1) values take place. The visible absorption spectra, referring to all the ionic (mol.) forms, were singled out. On the whole, the behavior of 4′-aminofluorescein is closer to that of the mother compound The shift of the equilibrium on introducing 50 mass % ethanol into the aqueous solution allowed better understanding the detailed scheme of prototropic equilibrium The tautomeric equilibrium of the mols. shifts toward the colorless lactone. This effect is expressed stronger for the 5′-aminofluorescein. For this dye, even signs of such tautomers of the single-charged anion as anion-lactone and phenolate anion are observed in aqueous ethanol, which are atypical for fluorescein in water-based solvents. In the experiment, the researchers used many compounds, for example, 5-Amino-3′,6′-dihydroxy-3H-spiro[isobenzofuran-1,9′-xanthen]-3-one (cas: 3326-34-9Product Details of 3326-34-9).

5-Amino-3′,6′-dihydroxy-3H-spiro[isobenzofuran-1,9′-xanthen]-3-one (cas: 3326-34-9) belongs to benzofurans derivatives. Benzofuran derivatives are one of the most important oxygen-containing heterocycles. Introduction of benzofurans in organic synthesis, particularly drug synthesis, involves generally the use of their metalated species as nucleophiles in addition reactions or in metal-catalysed cross-coupling reactions.Product Details of 3326-34-9

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem