Category: 76-54-0

Immunostimulatory nanomedicines synergize with checkpoint blockade immunotherapy to eradicate colorectal tumors was written by Duan, Xiaopin;Chan, Christina;Han, Wenbo;Guo, Nining;Weichselbaum, Ralph R.;Lin, Wenbin. And the article was included in Nature Communications in 2019.Application In Synthesis of 2′,7′-Dichloro-3′,6′-dihydroxy-3H-spiro[isobenzofuran-1,9′-xanthen]-3-one This article mentions the following:

Nanoparticles can potentially stimulate tumor microenvironments to elicit antitumor immunity. Herein, we demonstrate effective immunotherapy of colorectal cancer via systemic delivery of an immunostimulatory chemotherapeutic combination in nanoscale coordination polymer (NCP) core-shell particles. Oxaliplatin and dihydroartemesinin have contrasting physicochem. properties but strong synergy in reactive oxygen species (ROS) generation and anticancer activity. The combined ROS generation is harnessed for immune activation to synergize with an anti-PD-L1 antibody for the treatment of murine colorectal cancer tumors. The favorable biodistribution and tumor uptake of NCPs and the absence of peripheral neuropathy allow for repeated dosing to afford 100% tumor eradication. The involvement of innate and adaptive immune systems elicit strong and long lasting antitumor immunity which prevents tumor formation when cured mice are challenged with cancer cells. The intrinsically biodegradable, well tolerated, and systemically available immunostimulatory NCP promises to enter clin. testing as an immunotherapy against colorectal cancer. In the experiment, the researchers used many compounds, for example, 2′,7′-Dichloro-3′,6′-dihydroxy-3H-spiro[isobenzofuran-1,9′-xanthen]-3-one (cas: 76-54-0Application In Synthesis of 2′,7′-Dichloro-3′,6′-dihydroxy-3H-spiro[isobenzofuran-1,9′-xanthen]-3-one).

2′,7′-Dichloro-3′,6′-dihydroxy-3H-spiro[isobenzofuran-1,9′-xanthen]-3-one (cas: 76-54-0) belongs to benzofurans derivatives. Benzofurans are only weakly aromatic in nature and they are cleaved by many oxidative and reductive conditions. Substituted benzofurans find applications such as fluorescent sensors, oxidants, in drug discovery, and in another field of chemistry and agriculture.Application In Synthesis of 2′,7′-Dichloro-3′,6′-dihydroxy-3H-spiro[isobenzofuran-1,9′-xanthen]-3-one

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

An Arabidopsis mutant over-expressing subtilase SBT4.13 uncovers the role of oxidative stress in the inhibition of growth by intracellular acidification was written by Bissoli, Gaetano;Munoz-Bertomeu, Jesus;Bueso, Eduardo;Sayas, Enric;Vilcara, Edgardo A.;Felipo, Amelia;Ninoles, Regina;Rubio, Lourdes;Fernandez, Jose A.;Serrano, Ramon. And the article was included in International Journal of Molecular Sciences in 2020.Reference of 76-54-0 This article mentions the following:

Intracellular acid stress inhibits plant growth by unknown mechanisms and it occurs in acidic soils and as consequence of other stresses. In order to identify mechanisms of acid toxicity, we screened activation-tagging lines of Arabidopsis thaliana for tolerance to intracellular acidification induced by organic acids. A ominant mutant, Sbt4.13-1D, was isolated twice and shown to over-express subtilase SBT4.13, a protease secreted into endoplasmic reticulum. Activity measurements and immuno-detection indicate that the mutant contains less plasma membrane H+-ATPase (PMA) than wild type, explaining the small size, elec. depolarization and decreased cytosolic pH of the mutant but not organic acid tolerance. Addition of acetic acid to wild-type plantlets induces production of ROS (Reactive Oxygen Species) measured by dichlorodihydrofluorescein diacetate. Acid-induced ROS production is greatly decreased in sbt4.13-1D and atrboh-D,F mutants. The latter is deficient in two major NADPH oxidases (NOXs) and is tolerant to organic acids. These results suggest that intracellular acidification activates NOXs and the resulting oxidative stress is important for inhibition of growth. The inhibition of acid-activated NOXs in the sbt4.13-1D mutant compensates inhibition of PMA to increase acid tolerance. In the experiment, the researchers used many compounds, for example, 2′,7′-Dichloro-3′,6′-dihydroxy-3H-spiro[isobenzofuran-1,9′-xanthen]-3-one (cas: 76-54-0Reference of 76-54-0).

2′,7′-Dichloro-3′,6′-dihydroxy-3H-spiro[isobenzofuran-1,9′-xanthen]-3-one (cas: 76-54-0) belongs to benzofurans derivatives. Benzofurans are only weakly aromatic in nature and they are cleaved by many oxidative and reductive conditions. In nature, benzofurans have occupied an important role among the plant phenols & several pharmacologically active compounds.Reference of 76-54-0

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Acetaldehyde dehydrogenase 2 deficiency increases mitochondrial reactive oxygen species emission and induces mitochondrial protease Omi/HtrA2 in skeletal muscle was written by Wakabayashi, Yuka;Tamura, Yuki;Kouzaki, Karina;Kikuchi, Naoki;Hiranuma, Kenji;Menuki, Kunitaka;Tajima, Takafumi;Yamanaka, Yoshiaki;Sakai, Akinori;Nakayama, Keiichi I.;Kawamoto, Toshihiro;Kitagawa, Kyoko;Nakazato, Koichi. And the article was included in American Journal of Physiology in 2020.Name: 2′,7′-Dichloro-3′,6′-dihydroxy-3H-spiro[isobenzofuran-1,9′-xanthen]-3-one This article mentions the following:

ALDH2 is an enzyme involved in redox homeostasis as well as the detoxification process in alc. metabolism Nearly 8% of the world′s population have an inactivating mutation in the ALDH2 gene. Herein, we report that ALDH2 is expressed in skeletal muscle and is localized to the mitochondrial fraction. Oxidative muscles had a higher amount of ALDH2 protein than glycolytic muscles. We next comprehensively investigated whether ALDH2 knockout in mice induces mitochondrial adaptations in gastrocnemius muscle (for example, content, enzymic activity, respiratory function, supercomplex formation, and functional networking). We found that ALDH2 deficiency resulted in partial mitochondrial dysfunction in gastrocnemius muscle because it increased mitochondrial reactive oxygen species (ROS) emission (2′,7′-dichlorofluorescein and MitoSOX oxidation rate during respiration) and the frequency of regional mitochondrial depolarization. Moreover, we determined whether ALDH2 deficiency and the related mitochondrial dysfunction trigger mitochondrial stress and quality control responses in gastrocnemius muscle (for example, mitophagy markers, dynamics, and the unfolded protein response). We found that ALDH2 deficiency upregulated the mitochondrial serine protease Omi/HtrA2 (a marker of the activation of a branch of the mitochondrial unfolded protein response). In summary, ALDH2 deficiency leads to greater mitochondrial ROS production, but homeostasis can be maintained via an appropriate stress response. In the experiment, the researchers used many compounds, for example, 2′,7′-Dichloro-3′,6′-dihydroxy-3H-spiro[isobenzofuran-1,9′-xanthen]-3-one (cas: 76-54-0Name: 2′,7′-Dichloro-3′,6′-dihydroxy-3H-spiro[isobenzofuran-1,9′-xanthen]-3-one).

2′,7′-Dichloro-3′,6′-dihydroxy-3H-spiro[isobenzofuran-1,9′-xanthen]-3-one (cas: 76-54-0) belongs to benzofurans derivatives. Benzofurans are compounds with a planar structure having 10 pi electrons that include the lone pair on oxygen atom, which makes it more susceptible to electrophilic attack. In nature, benzofurans have occupied an important role among the plant phenols & several pharmacologically active compounds.Name: 2′,7′-Dichloro-3′,6′-dihydroxy-3H-spiro[isobenzofuran-1,9′-xanthen]-3-one

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Aggregation-induced emission nanoparticles with NIR and photosensitizing characteristics for resistant bacteria elimination and real-time tracking was written by Yuan, Huanxiang;Li, Zelin;Bai, Haotian;Chen, Zhuo;Yao, Chuang;Jia, Shaochuan;Li, Li;Qi, Ruilian;Zhao, Cui-Hua. And the article was included in Materials Chemistry Frontiers in 2021.Reference of 76-54-0 This article mentions the following:

Because of the steady increase in multi-drug-resistant bacterial infections, we developed a viable treatment strategy using new antibacterial nanomaterials with photosensitizing effects. In this work, three triphenylamine derivates (TPA-2PE, TPA-PCN, and TPA-2PCN) and amphiphilic polystyrene maleic anhydride (PSMA) were used to successfully prepare three corresponding nanoparticles. Compared to TPA-2PE, the introduced cyano unit resulted in a red shift for TPA-PCN and TPA-2PCN with near-IR (NIR) emission. The specific aggregation-induced emission (AIE) characteristic contributed to the retentive photophys. property and the increased fluorescence quantum yield (QY) of these luminous mols. in nanoparticles. Our in vitro study indicated that the nanoparticles were able to tightly bind to the surface of bacteria by hydrogen bond interaction, and their bacterial toxicity was successfully directed against antibiotic-resistant Escherichia coli. The bactericidal performance was further amplified under white light irradiation by the supplied photosensitizing effect. Addnl., the killed bacteria were stained with the nanoparticles and subsequently emitted NIR emission, regardless of the interference of bacterial autofluorescence. The sterilization effects of the nanoparticles were tracked in situ and qual. characterized by the NIR self-reporting function. In the protocol reported herein, we describe all the essential factors for addressing antibiotic resistance, and therefore, this work includes all the necessary criteria for designing addnl. antibacterial nanomaterials in the future. In the experiment, the researchers used many compounds, for example, 2′,7′-Dichloro-3′,6′-dihydroxy-3H-spiro[isobenzofuran-1,9′-xanthen]-3-one (cas: 76-54-0Reference of 76-54-0).

2′,7′-Dichloro-3′,6′-dihydroxy-3H-spiro[isobenzofuran-1,9′-xanthen]-3-one (cas: 76-54-0) belongs to benzofurans derivatives. Benzofurans are compounds with a planar structure having 10 pi electrons that include the lone pair on oxygen atom, which makes it more susceptible to electrophilic attack. Introduction of benzofurans in organic synthesis, particularly drug synthesis, involves generally the use of their metalated species as nucleophiles in addition reactions or in metal-catalysed cross-coupling reactions.Reference of 76-54-0

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Hemistepsin a induces apoptosis of hepatocellular carcinoma cells by downregulating STAT3 was written by Cho, Il Je;Kim, Jae Kwang;Kim, Eun Ok;Park, Sang Mi;Kim, Sang Chan;Ki, Sung Hwan;Ku, Sae Kwang. And the article was included in International Journal of Molecular Sciences in 2021.Name: 2′,7′-Dichloro-3′,6′-dihydroxy-3H-spiro[isobenzofuran-1,9′-xanthen]-3-one This article mentions the following:

Hemistepta lyrata (Bunge) Bunge is a biennial medicinal plant possessing beneficial effects including anti-inflammation, and hemistepsin A (HsA) isolated from H. lyrata has been known as a hepatoprotective sesquiterpene lactone. In this report, we explored the cytotoxic effects of H. lyrata on hepatocellular carcinoma (HCC) cells and investigated the associated bioactive compounds and their relevant mechanisms. From the viability results of HCC cells treated with various H. lyrata extracts, HsA was identified as the major compound contributing to the H. lyrata-mediated cytotoxicity. HsA increased expression of cleaved PARP and cells with Sub-G1 phase, Annexin V binding, and TUNEL staining, which imply HsA induces apoptosis. In addition, HsA provoked oxidative stress by decreasing the reduced glutathione/oxidized glutathione ratio and accumulating reactive oxygen species and glutathione-protein adducts. Moreover, HsA inhibited the transactivation of signal transducer and activator of transcription 3 (STAT3) by its dephosphorylation at Y705 and glutathione conjugation. Stable expression of a constitutive active mutant of STAT3 prevented the reduction of cell viability by HsA. Finally, HsA enhanced the sensitivity of sorafenib-mediated cytotoxicity by exaggerating oxidative stress and Y705 dephosphorylation of STAT3. Therefore, HsA will be a promising candidate to induce apoptosis of HCC cells via downregulating STAT3 and sensitizing conventional chemotherapeutic agents. In the experiment, the researchers used many compounds, for example, 2′,7′-Dichloro-3′,6′-dihydroxy-3H-spiro[isobenzofuran-1,9′-xanthen]-3-one (cas: 76-54-0Name: 2′,7′-Dichloro-3′,6′-dihydroxy-3H-spiro[isobenzofuran-1,9′-xanthen]-3-one).

2′,7′-Dichloro-3′,6′-dihydroxy-3H-spiro[isobenzofuran-1,9′-xanthen]-3-one (cas: 76-54-0) belongs to benzofurans derivatives. Benzofurans are only weakly aromatic in nature and they are cleaved by many oxidative and reductive conditions. Benzofurans have also made significant and distinctive contributions to biology. They exhibit several biological activities that range from antiviral, antimicrobial, antitumor, anti-inflammatory.Name: 2′,7′-Dichloro-3′,6′-dihydroxy-3H-spiro[isobenzofuran-1,9′-xanthen]-3-one

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Characterization of extracellular vesicles from preconditioned human adipose-derived stromal/stem cells was written by Gebner, Alec;Koch, Benjamin;Klann, Kevin;Fuhrmann, Dominik C.;Farmand, Samira;Schubert, Ralf;Muench, Christian;Geiger, Helmut;Baer, Patrick C.. And the article was included in International Journal of Molecular Sciences in 2021.Application of 76-54-0 This article mentions the following:

Cell-free therapy using extracellular vesicles (EVs) from adipose-derived mesenchymal stromal/stem cells (ASCs) seems to be a safe and effective therapeutic option to support tissue and organ regeneration. The application of EVs requires particles with a maximum regenerative capability and hypoxic culture conditions as an in vitro preconditioning regimen has been shown to alter the mol. composition of released EVs. Nevertheless, the EV cargo after hypoxic preconditioning has not yet been comprehensively examined The aim of the present study was the characterization of EVs from hypoxic preconditioned ASCs. We investigated the EV proteome and their effects on renal tubular epithelial cells in vitro. While no effect of hypoxia was observed on the number of released EVs and their protein content, the cargo of the proteins was altered. Proteomic anal. showed 41 increased or decreased proteins, 11 in a statistically significant manner. Furthermore, the uptake of EVs in epithelial cells and a pos. effect on oxidative stress in vitro were observed In conclusion, culture of ASCs under hypoxic conditions was demonstrated to be a promising in vitro preconditioning regimen, which alters the protein cargo and increases the anti-oxidative potential of EVs. These properties may provide new potential therapeutic options for regenerative medicine. In the experiment, the researchers used many compounds, for example, 2′,7′-Dichloro-3′,6′-dihydroxy-3H-spiro[isobenzofuran-1,9′-xanthen]-3-one (cas: 76-54-0Application of 76-54-0).

2′,7′-Dichloro-3′,6′-dihydroxy-3H-spiro[isobenzofuran-1,9′-xanthen]-3-one (cas: 76-54-0) belongs to benzofurans derivatives. Benzofurans are compounds with a planar structure having 10 pi electrons that include the lone pair on oxygen atom, which makes it more susceptible to electrophilic attack. Introduction of benzofurans in organic synthesis, particularly drug synthesis, involves generally the use of their metalated species as nucleophiles in addition reactions or in metal-catalysed cross-coupling reactions.Application of 76-54-0

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Luminescent metal organic frameworks-based chemiluminescence resonance energy transfer platform for turn-on detection of fluoride ion was written by Sun, Yuan;Xu, Xiaotong;Zhao, Yaxin;Tan, Haonan;Li, Yinhuan;Du, Jianxiu. And the article was included in Talanta in 2020.Safety of 2′,7′-Dichloro-3′,6′-dihydroxy-3H-spiro[isobenzofuran-1,9′-xanthen]-3-one This article mentions the following:

A luminescent metal organic frameworks (MOFs)-based chemiluminescence resonance energy transfer (CRET) platform was constructed for turn-on detection of fluoride ion. A hybrid MOFs was prepared by encapsulating strong fluorescence 2′,7′-dichlorofluorescein (DCF) into the frames of NH₂-MIL-101(Al) MOFs, which led to a significant suppression of fluorescence signal of DCF. In the presence of fluoride ion, it destroyed the structure of the hybrid MOFs and released DCF mols. from the frames due to the formation of more stable aluminum hexafluoride complex ions [AlF^3-₆] between fluoride ion and aluminum ion. The released DCF mols. accepted the energy originating from the chem. reaction of bis(2,4,6-trichlorophenyl)oxalate (TCPO) with hydrogen peroxide (H₂O₂), producing a strong chemiluminescence (CL) emission. The CL signal was strong dependent on the concentration of fluoride ion presented and showed a linear response in the range of 0.5-80.0μmol L^-1 (9.5μg L^-1-1.52 mg L^-1). The detection limit was 0.05μmol L^-1 (about 0.95μg L^-1) fluoride ion and the relative standard deviations was 2.3% for 40.0μmol L^-1 fluoride ion solution (n = 11). This MOFs-based CRET method was successfully applied to the determination of fluoride ion in drinking water samples, demonstrating its potential application in anal. of real samples. In the experiment, the researchers used many compounds, for example, 2′,7′-Dichloro-3′,6′-dihydroxy-3H-spiro[isobenzofuran-1,9′-xanthen]-3-one (cas: 76-54-0Safety of 2′,7′-Dichloro-3′,6′-dihydroxy-3H-spiro[isobenzofuran-1,9′-xanthen]-3-one).

2′,7′-Dichloro-3′,6′-dihydroxy-3H-spiro[isobenzofuran-1,9′-xanthen]-3-one (cas: 76-54-0) belongs to benzofurans derivatives. Benzofuran is a core structural unit found in many naturally occurring compounds with multidirectional biological activities. Benzofurans are stable towards alkali and readily polymerize on treatment with sulfuric acid, due to which they are useful for the preparation of low cost chemically relatively inert resins.Safety of 2′,7′-Dichloro-3′,6′-dihydroxy-3H-spiro[isobenzofuran-1,9′-xanthen]-3-one

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

A fluorescence turn-on assay for simple and sensitive determination of hemin and blood stains was written by Zhao, Liang;Chen, Fuqian;Huang, Wenyi;Bao, Huayu;Hu, Yingjie;Huang, Xin-an;Deng, Tao;Liu, Fang. And the article was included in Sensors and Actuators, B: Chemical in 2020.SDS of cas: 76-54-0 This article mentions the following:

Hemin, a sort of important Fe(III)-coordinated protoporphyrin IX complexes, plays critical roles in many biol. processes. Besides, hemin and its derivatives have been considered as biochem. markers to distinguish blood against other colored samples. The development of simple and sensitive methods for hemin determination is thus becoming important. In this research, a novel dihydrofluorescein derivative has been synthesized and applied as the fluorescence reporter. Inorganic H₂O₂ and organic tert-Bu hydroperoxide (TBHP), artemisinin (ART) have been used as peroxide sources to generate reactive radical species under hemin catalysis, which subsequently oxidize non fluorescent dihydrofluorescein to its fluorescent form. The limit of detection (LOD) was found down to picomolar levels (64 pM, 350 pM, 420 pM for H₂O₂, TBHP, ART systems resp.). Moreover, a simple detection strip has been prepared by incorporating both ART and fluorescence reporter into the filter papers, which offers a simple strategy to conveniently distinguish blood stains against other colored stains. In the experiment, the researchers used many compounds, for example, 2′,7′-Dichloro-3′,6′-dihydroxy-3H-spiro[isobenzofuran-1,9′-xanthen]-3-one (cas: 76-54-0SDS of cas: 76-54-0).

2′,7′-Dichloro-3′,6′-dihydroxy-3H-spiro[isobenzofuran-1,9′-xanthen]-3-one (cas: 76-54-0) belongs to benzofurans derivatives. Benzofuran is the “”parent”” of many related compounds with more complex structures. For example, psoralen is a benzofuran derivative that occurs in several plants. Benzofurans have also made significant and distinctive contributions to biology. They exhibit several biological activities that range from antiviral, antimicrobial, antitumor, anti-inflammatory.SDS of cas: 76-54-0

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

The Effect of a Weak Static Magnetic Field in the Range of Magnitudes from a “Zero” Field (0.01μT) to 100μT on the Production of Reactive Oxygen Species in Nonactivated Neutrophils was written by Novikov, V. V.;Yablokova, E. V.;Shaev, I. A.;Fesenko, E. E.. And the article was included in Biophysics (Moscow, Russian Federation) in 2020.Computed Properties of C20H10Cl2O5 This article mentions the following:

Abstract: It was shown that 40-min exposure of peritoneal neutrophils to hypomagnetic conditions (with a residual field of 0.01μT) caused a significant (25%) decrease in the intensity of intracellular dichlorofluorescein fluorescence. This effect of the weak magnetic field persisted if the constant magnetic field was increased to 1μT. Upon further increase of the field to 2.5μT, the effect of the field disappeared and reappeared at 5μT in a reduced form, reaching a maximum at 7μT. There was an equally pronounced and stable inhibitory effect under a sequential increase in the induction of a constant magnetic field (9, 15, and 19.5μT), the degree of manifestation of which was significantly reduced only at 30μT. Fluorescence intensity of the 2,7-dichlorodydrofluorescein oxidation products did not differ from the control values at a constant magnetic field of 45μT. There was no observed effect on these processes under further increase of the field to 74 and 100μT. In the experiment, the researchers used many compounds, for example, 2′,7′-Dichloro-3′,6′-dihydroxy-3H-spiro[isobenzofuran-1,9′-xanthen]-3-one (cas: 76-54-0Computed Properties of C20H10Cl2O5).

2′,7′-Dichloro-3′,6′-dihydroxy-3H-spiro[isobenzofuran-1,9′-xanthen]-3-one (cas: 76-54-0) belongs to benzofurans derivatives. Many natural or synthetic compounds containing benzofuran skeletons have been found to possess remarkable activity as agrochemicals and pharmaceuticals. Benzofurans have also made significant and distinctive contributions to biology. They exhibit several biological activities that range from antiviral, antimicrobial, antitumor, anti-inflammatory.Computed Properties of C20H10Cl2O5

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Utilizing biodegradable alloys as guided bone regeneration (GBR) membrane: Feasibility and challenges was written by Chen, Kai;Zhao, Li;Sun, Jie;Gu, Xuenan;Huang, Chenyang;Su, Haoran;Fan, Yubo. And the article was included in Science China Materials in 2022.Reference of 76-54-0 This article mentions the following:

Guided bone regeneration (GBR) is a therapeutic procedure used to enhance alveolar bone volume before dental implants. Com. non-absorbable membranes (i.e., titanium membranes) typically require a second surgery to remove, whereas absorbable membranes (i.e., collagen membranes) will fail when put over extensive bone lesions due to their low mech. strength. The GBR membrane that has been sought is still being developed. Biodegradable metals (BMs), particularly Mg and Zn, have recently been postulated as promising barrier membrane candidates. Herein, the goal of this research is to evaluate the mech. and biol. feasibility of using BMs as GBR membranes. It shows that BMs have a wide range of potential applications as GBR membranes, owing to their benign biocompatibility, sufficient mech. support, tunable degradation rate, good osteogenic capabilities, broad-spectrum antibacterial behavior, and improved wound healing ability. The rapid degradation rate, hydrogen evolution impact, and stress corrosion cracking behavior all pose obstacles to the use of Mg-based membranes, which can be improved by surface modifications, heat treatment, alloying, etc. Due to its acceptable degradation rate and lack of gas production, Zn appears to be a better candidate for usage as a GBR membrane. In general, advances in the development of BMs have paved the door for BMs to be used as GBR membranes in oral clin. trials. In the experiment, the researchers used many compounds, for example, 2′,7′-Dichloro-3′,6′-dihydroxy-3H-spiro[isobenzofuran-1,9′-xanthen]-3-one (cas: 76-54-0Reference of 76-54-0).

2′,7′-Dichloro-3′,6′-dihydroxy-3H-spiro[isobenzofuran-1,9′-xanthen]-3-one (cas: 76-54-0) belongs to benzofurans derivatives. Benzofurans are compounds with a planar structure having 10 pi electrons that include the lone pair on oxygen atom, which makes it more susceptible to electrophilic attack. Benzofurans have also made significant and distinctive contributions to biology. They exhibit several biological activities that range from antioxidant, antitubercular, antiplasmodial, insecticidal.Reference of 76-54-0

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem