Category: 76-54-0

Chemical Composition of Bee Pollen and Leishmanicidal Activity of Rhusflavone was written by Gomes, Ayala Nara Pereira;Camara, Celso Amorim;dos Santos Sousa, Alexsandro;de Assis Ribeiro dos Santos, Francisco;de Santana Filho, Paulo Cesar;Dorneles, Gilson Pires;Romao, Pedro Roosevelt Torres;Silva, Tania Maria Sarmento. And the article was included in Revista Brasileira de Farmacognosia in 2021.Application In Synthesis of 2′,7′-Dichloro-3′,6′-dihydroxy-3H-spiro[isobenzofuran-1,9′-xanthen]-3-one This article mentions the following:

Bee pollen monofloral from Attalea funifera Mart., Arecaceae, known as piacava, was analyzed with ultra-performance liquid chromatog. coupled with diode array detector and quadrupole time-of-flight mass spectrometry for the profiling and structural characterization of the replicated compounds The principal compound was isolated and tested against Leishmania amazonensis. Fifty-eight compounds were identified, including one sugar, ten flavonoids, two putrescine derivatives, sixteen hydroxycinnamic acid amide derivatives, two coumarate derivatives, and twenty-seven lipids. The isolated compound identified as the biflavonoid rhusflavone showed high leishmanicidal activity against both promastigote (IC₅₀ = 5 μM) and amastigote (76.7% mortality at 2 μM) forms of L. amazonensis, acting via a mechanism involving reactive oxygen species production, mitochondrial dysfunction, and membrane disruption in parasites. The compound showed low toxicity to mammalian cells and human erythrocytes, with selectivity index for erythrocytes >100 and for macrophages (CC50 macrophages/IC₅₀ amastigotes) > 10. These results indicate that rhusflavone is a promising candidate for the development of drugs against L. amazonensis. In the experiment, the researchers used many compounds, for example, 2′,7′-Dichloro-3′,6′-dihydroxy-3H-spiro[isobenzofuran-1,9′-xanthen]-3-one (cas: 76-54-0Application In Synthesis of 2′,7′-Dichloro-3′,6′-dihydroxy-3H-spiro[isobenzofuran-1,9′-xanthen]-3-one).

2′,7′-Dichloro-3′,6′-dihydroxy-3H-spiro[isobenzofuran-1,9′-xanthen]-3-one (cas: 76-54-0) belongs to benzofurans derivatives. Benzofuran is a core structural unit found in many naturally occurring compounds with multidirectional biological activities. Substituted benzofurans find applications such as fluorescent sensors, oxidants, in drug discovery, and in another field of chemistry and agriculture.Application In Synthesis of 2′,7′-Dichloro-3′,6′-dihydroxy-3H-spiro[isobenzofuran-1,9′-xanthen]-3-one

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Pulmonary oxidative stress in wild bats exposed to coal dust: A model to evaluate the impact of coal mining on health was written by Pedroso-Fidelis, Giulia dos Santos;Farias, Hemelin Resende;Mastella, Gustavo Antunes;Boufleur-Niekraszewicz, Liana Appel;Dias, Johnny Ferraz;Alves, Marcio Correa;Silveira, Paulo Cesar Lock;Nesi, Renata Tiscoski;Carvalho, Fernando;Zocche, Jairo Jose;Pinho, Ricardo Aurino. And the article was included in Ecotoxicology and Environmental Safety in 2020.Electric Literature of C20H10Cl2O5 This article mentions the following:

This study aimed to verify possible alterations involving histol. and oxidative stress parameters in the lungs of wild bats in the Carboniferous Basin of Santa Catarina (CBSC) state, Southern Brazil, as a means to evaluate the impact of coal dust on the health of wildlife. Specimens of frugivorous bat species Artibeus lituratus and Sturnira lilium were collected from an area free of coal dust contamination and from coal mining areas. Chem. composition, histol. parameters, synthesis of oxidants and antioxidant enzymes, and oxidative damage in the lungs of bats were analyzed. Levels of Na, Cl, Cu, and Br were higher in both species collected in the CBSC than in the controls. Levels of K and Rb were higher in A. lituratus, and levels of Si, Ca, and Fe were higher in S. lilium collected in the carboniferous basin. Both bat species inhabiting the CBSC areas exhibited an increase in the degree of pulmonary emphysema compared to their counterparts collected from control areas. Sturnira lilium showed increased reactive oxygen species (ROS) and 2′,7′-dichlorofluorescein (DCF) levels, while A. lituratus showed a significant decrease in nitrite levels in the CBSC samples. Superoxide dismutase (SOD) activity did not change significantly; however, the activity of catalase (CAT) and levels of glutathione (GSH) decreased in the A. lituratus group from CBSC compared to those in the controls. There were no differences in NAD(P)H quinone dehydrogenase 1 protein (NQO1) abundance or nitrotyrosine expression among the different groups of bats. Total thiol levels showed a significant reduction in A. lituratus from CBSC, while the amount of malondialdehyde (MDA) was higher in both A. lituratus and S. lilium groups from coal mining areas. Our results suggested that bats, especially A. lituratus, living in the CBSC could be used as sentinel species for harmful effects of coal dust on the lungs. In the experiment, the researchers used many compounds, for example, 2′,7′-Dichloro-3′,6′-dihydroxy-3H-spiro[isobenzofuran-1,9′-xanthen]-3-one (cas: 76-54-0Electric Literature of C20H10Cl2O5).

2′,7′-Dichloro-3′,6′-dihydroxy-3H-spiro[isobenzofuran-1,9′-xanthen]-3-one (cas: 76-54-0) belongs to benzofurans derivatives. Many natural or synthetic compounds containing benzofuran skeletons have been found to possess remarkable activity as agrochemicals and pharmaceuticals. Introduction of benzofurans in organic synthesis, particularly drug synthesis, involves generally the use of their metalated species as nucleophiles in addition reactions or in metal-catalysed cross-coupling reactions.Electric Literature of C20H10Cl2O5

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Reduction of oxidative stress improves insulin signaling in cardiac tissue of obese mice. was written by Rodrigues, Matheus Scarpatto;Pieri, Bruno Luiz da Silva;Silveira, Gustavo de Bem;Zaccaron, Rubya Pereira;Venturini, Ligia Milanez;Comin, Vitor Hugo;Luiz, Karine Damian;Silveira, Paulo Cesar Lock. And the article was included in Einstein (Sao Paulo, Brazil) in 2020.Related Products of 76-54-0 This article mentions the following:

OBJECTIVE: To evaluate the effects of oxidative stress on insulin signaling in cardiac tissue of obese mice. METHODS: Thirty Swiss mice were equally divided (n=10) into three groups: Control Group, Obese Group, and Obese Group Treated with N-acetylcysteine. After obesity and insulin resistance were established, the obese mice were treated with N-acetylcysteine at a dose of 50mg/kg daily for 15 days via oral gavage. RESULTS: Higher blood glucose levels and nitrite and carbonyl contents, and lower protein levels of glutathione peroxidase and phosphorylated protein kinase B were observed in the obese group when compared with their respective control. On the other hand, treatment with N-acetylcysteine was effective in reducing blood glucose levels and nitrite and carbonyl contents, and significantly increased protein levels of glutathione peroxidase and phosphorylated protein kinase B compared to the Obese Group. CONCLUSION: Obesity and/or a high-lipid diet may result in oxidative stress and insulin resistance in the heart tissue of obese mice, and the use of N-acetylcysteine as a methodological and therapeutic strategy suggested there is a relation between them. In the experiment, the researchers used many compounds, for example, 2′,7′-Dichloro-3′,6′-dihydroxy-3H-spiro[isobenzofuran-1,9′-xanthen]-3-one (cas: 76-54-0Related Products of 76-54-0).

2′,7′-Dichloro-3′,6′-dihydroxy-3H-spiro[isobenzofuran-1,9′-xanthen]-3-one (cas: 76-54-0) belongs to benzofurans derivatives. Benzofuran is the “”parent”” of many related compounds with more complex structures. For example, psoralen is a benzofuran derivative that occurs in several plants. In nature, benzofurans have occupied an important role among the plant phenols & several pharmacologically active compounds.Related Products of 76-54-0

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

The antioxidant activity of the extracts from disposition of the waste sawdust substrate from shiitake mushroom (Lentinula edodes) cultivation by the two-step hot/hot-compressed water percolation was written by Sato, Tomonori;Uehara, Kenji;Kudo, Shinji;Sakaki, Ikuko;Hayashi, Jun-ichiro;Shindo, Sho. And the article was included in Mokuzai Gakkaishi in 2022.Electric Literature of C20H10Cl2O5 This article mentions the following:

Disposition of the waste sawdust substrate from sawdust-based cultivation of shiitake mushrooms (Lentinula edodes) is an important issue. In this study, we evaluated the physiol. activity in the water extracts of waste sawdust substrate which had been extracted, by the two-step hot/hot-compressed water percolation. The 180°C water extract of waste sawdust substrate contained some isoprenoid and high amounts of polyphenol. Addnl., high antioxidant activity was found in the 180°C water extract of the waste sawdust substrate in in vitro experiment (DPPH scavenging activity) and the human keratinocyte, HaCaT. This study suggested that the two-step hot/hot-compressed water percolation elutes the antioxidant components in the 180°C fraction from the waste sawdust substrate. In the experiment, the researchers used many compounds, for example, 2′,7′-Dichloro-3′,6′-dihydroxy-3H-spiro[isobenzofuran-1,9′-xanthen]-3-one (cas: 76-54-0Electric Literature of C20H10Cl2O5).

2′,7′-Dichloro-3′,6′-dihydroxy-3H-spiro[isobenzofuran-1,9′-xanthen]-3-one (cas: 76-54-0) belongs to benzofurans derivatives. Benzofuran is the “”parent”” of many related compounds with more complex structures. For example, psoralen is a benzofuran derivative that occurs in several plants. Substituted benzofurans find applications such as fluorescent sensors, oxidants, in drug discovery, and in another field of chemistry and agriculture.Electric Literature of C20H10Cl2O5

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Investigation of the interactions between flavonoids and human organic anion transporting polypeptide 1B1 using fluorescent substrate and 3D-QSAR analysis was written by Xiang, Yiqun;Liu, Shuai;Yang, Jingjie;Wang, Zhongmin;Zhang, Hongjian;Gui, Chunshan. And the article was included in Biochimica et Biophysica Acta, Biomembranes in 2020.Name: 2′,7′-Dichloro-3′,6′-dihydroxy-3H-spiro[isobenzofuran-1,9′-xanthen]-3-one This article mentions the following:

Organic anion transporting polypeptide 1B1 (OATP1B1) is a key hepatic uptake transporter whose inhibition could lead to adverse drug-drug and drug-food interactions. Flavonoids are widely distributed in food and beverages and thus our bodies are frequently exposed to them. Therefore, investigation of the interactions between OATP1B1 and flavonoids could be of great significance. In the present study, 25 common flavonoids were investigated for their interactions with OATP1B1 using the fluorescent substrate 2′,7′-dichlorofluorescein (DCF) and three-dimensional quant. structure-activity relationship (3D-QSAR) anal. Kinetic study showed that OATP1B1-mediated DCF uptake exhibited a monophasic saturation kinetics with a K_m value of 9.7 ± 2.4 μM. Inhibition assay for flavonoids on OATP1B1-mediated DCF uptake was performed and their IC₅₀ values were determined upon which reliable and predictive CoMFA (q² = 0.604, r² = 0.841) and CoMSIA (q² = 0.534, r² = 0.807) models were developed. Our exptl. and computational results showed that flavonoid aglycons interacted with OATP1B1 much stronger than their glycosides such as 3-O- and 7-O-glycosides as bulky hydrophilic and hydrogen-bond forming substituents at C-3 and C-7 positions on rings A and C were unfavorable for their binding. On the other hand, the presence of hydrogen-bond forming groups on ring B was beneficial as long as the number of hydroxyl groups was not >2. Our results also indicated that flavones usually interacted with OATP1B1 much stronger than their 3-hydroxyflavone counterparts (flavonols). The obtained information and 3D-QSAR models could be useful for elucidating and predicting the interactions between flavonoids and human OATP1B1. In the experiment, the researchers used many compounds, for example, 2′,7′-Dichloro-3′,6′-dihydroxy-3H-spiro[isobenzofuran-1,9′-xanthen]-3-one (cas: 76-54-0Name: 2′,7′-Dichloro-3′,6′-dihydroxy-3H-spiro[isobenzofuran-1,9′-xanthen]-3-one).

2′,7′-Dichloro-3′,6′-dihydroxy-3H-spiro[isobenzofuran-1,9′-xanthen]-3-one (cas: 76-54-0) belongs to benzofurans derivatives. Benzofurans are compounds with a planar structure having 10 pi electrons that include the lone pair on oxygen atom, which makes it more susceptible to electrophilic attack. Substituted benzofurans find applications such as fluorescent sensors, oxidants, in drug discovery, and in another field of chemistry and agriculture.Name: 2′,7′-Dichloro-3′,6′-dihydroxy-3H-spiro[isobenzofuran-1,9′-xanthen]-3-one

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Structure, antioxidant property and protection on PC12 of a polysaccharide isolated and screened from Abelmoschus esculentus L.Moench (okra) was written by Pan, Li-Chao;Sun, Yang-Yang;Zhang, Xiao-Ling;Zhu, Zhen-Yuan;Liu, Chun-Yu;Sun, Hui-Qing;Geng, Xue-Qing;Jiang, Wei;Wang, Jia-He. And the article was included in Natural Product Research in 2022.HPLC of Formula: 76-54-0 This article mentions the following:

AeP-P-2, a pectic polysaccharide, was extracted from the fruit pod of okra. It composed of rhamnose (Rha), arabinose (Ara), glucose (Glc), galactose (Gal) and galacturonic acid (GalA) with the ratio of 4.75:2.01:1.00:4.91:7.24. The main structural feature of AeP-P-2 are 1,4-linked galacturonan units (homogalacturonan backbone) and (1 → 2) and (1 → 2,4) linked Rha (rhamnogalacturonan I region). And the other side chains contained →1-linked Ara, (1 → 5)-linked Ara, (1 → 4)-linked Glc, (1 → 6)-linked Gal, (1 → 4)-linked Rha, (1 → 2,4)-linked Rha, →1-linked Ara and →1-linked Gal. When the concentration of AeP-P-2 was 3.2 mg/mL, the scavenging rates on DPPH·, ABTS, O2-· and ·OH reached to 61.88%, 87.10%, 52.17% and 60.32%, resp. AeP-P-2 also could protect PC12 cells from the damage of H2O2 and reduce apoptosis caused by oxidative damage by decreasing the level of ROS. The findings indicated that okra was a functional vegetable and AeP-P-2 was worth studying and developing into antioxidant component. In the experiment, the researchers used many compounds, for example, 2′,7′-Dichloro-3′,6′-dihydroxy-3H-spiro[isobenzofuran-1,9′-xanthen]-3-one (cas: 76-54-0HPLC of Formula: 76-54-0).

2′,7′-Dichloro-3′,6′-dihydroxy-3H-spiro[isobenzofuran-1,9′-xanthen]-3-one (cas: 76-54-0) belongs to benzofurans derivatives. Benzofuran derivatives are one of the most important oxygen-containing heterocycles. Benzofurans have also made significant and distinctive contributions to biology. They exhibit several biological activities that range from antioxidant, antitubercular, antiplasmodial, insecticidal.HPLC of Formula: 76-54-0

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Dietary supplementation with curcumin-loaded nanocapsules in lambs: Nanotechnology as a new tool for nutrition was written by Marcon, Hiam;Griss, Luiz G.;Molosse, Vitor L.;Cecere, Bruno G. O.;Alba, Davi F.;Leal, Karoline W.;Galli, Gabriela M.;Souza, Carine F.;Baldissera, Matheus D.;Gundel, Samanta;de A. Bassotto, Vitoria;Ourique, Aline F.;Vedovatto, Marcelo;Da Silva, Aleksandro S.. And the article was included in Animal Nutrition in 2021.Category: benzofurans This article mentions the following:

Curcumin-containing nanocapsule powder formulations have not been used in ruminant feed to date, despite the fact that curcumin is known to be a functional food additive. The objective of this study was to determine whether Et polymethacrylate (Eudragit L-100) nanocapsules loaded with curcumin (N-CU) would improve health and growth of lambs. Thirty-two male Lacaune lambs (body weight [BW] = 16 ± 0.99 kg; 45 d of age) were randomly assigned to 1 of 4 treatments: T0, T1, T2 and T4, representing supplementation of curcumin at 0, 1, 2, and 4 mg/kg concentrate, resp. The animals in each treatment were allocated in 4 pens of 2 lambs each (8 lambs per treatment). The experiment lasted 17 d, with samples and measurements collected on d 0, 7, 12, and 17. The T2 lambs had greater average daily gain than T0 lambs. Regression anal. showed that the ideal dose of N-CU to enhance weight gain was 1.89 mg/kg concentrate There were significant interactions (P < 0.05) between treatments x time for hematol. variables, particularly for increases in erythrocytes (T2) and reductions in counts of leukocytes, neutrophils, and lymphocytes in T1 and T2. There were significant interactions between treatment x time for total protein, globulin, urea, and triglyceride levels. Stimulation of the antioxidant system was also observed There were increased levels of non-protein thiols (NPSH), as well as increased activities of superoxide dismutase (SOD) and glutathione S-transferase (GST) in the supplemented animals. Levels of reactive oxygen species (ROS) were lower in the serum of supplemented lambs. In general, the 4 mg/kg dose had no pos. effects on growth or health. This was an unexpected result, given the known properties of curcumin. Taken together, these findings suggest that addition of low concentrations of nanoencapsulated curcumin (T1 and T2) in lamb feed improves health, minimizing oxidative stress and generates anti-inflammatory effects that may have contributed indirectly to greater weight gain. Nanocapsules potentiate the effects of curcumin and may emerge as a new tool in animal nutrition. In the experiment, the researchers used many compounds, for example, 2′,7′-Dichloro-3′,6′-dihydroxy-3H-spiro[isobenzofuran-1,9′-xanthen]-3-one (cas: 76-54-0Category: benzofurans).

2′,7′-Dichloro-3′,6′-dihydroxy-3H-spiro[isobenzofuran-1,9′-xanthen]-3-one (cas: 76-54-0) belongs to benzofurans derivatives. Benzofuran derivatives are one of the most important oxygen-containing heterocycles. Benzofurans have also made significant and distinctive contributions to biology. They exhibit several biological activities that range from antiviral, antimicrobial, antitumor, anti-inflammatory.Category: benzofurans

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Dual-Channel Theranostic System for Quantitative Self-Indication and Low-Temperature Synergistic Therapy of Cancer was written by Wang, Cheng;Chen, Shaoqing;Yu, Fangying;Lv, Jianghong;Zhao, Rui;Hu, Fuqiang;Yuan, Hong. And the article was included in Small in 2021.Synthetic Route of C20H10Cl2O5 This article mentions the following:

A conventional theranostic system usually employs a single fluorescence channel to show the pharmacokinetic events, which usually fails to quant. reveal the true cumulative drug release and with low accuracy. Herein, indocyanine green (ICG) and chlorins e6 (Ce6) are selected not only as conventional photothermal/photodynamic agents, but also to offer two independent fluorescence channels to cross validate the authenticity of pharmacokinetic events and to quant. reveal cumulative drug release in tumor tissues in a “turn on” manner. Employing the Ca2+ of amorphous calcium carbonate as a reversible linker, the photosensitivity and fluorescence of Ce6 are phys. quenched by ICG during circulation to reduce the side effect of photodynamic therapy (PDT) while being readily restored in tumor tissue to reveal the quant. drug release. Most importantly, the combination of photothermal therapy (PTT) and PDT allows low-temperature synergistic therapy of cancer through the controlled expression of heat shock protein in cells and mild hyperthermia enhanced reactive oxygen species diffusion/penetration among cells. This work not only develops a facile approach to fabricate a dual-channel theranostic system to precisely indicate the accumulation and quant. drug release in tumor tissue, but also presents a unique low-temperature synergistic strategy to destroy tumor in an effective and minimally invasive manner. In the experiment, the researchers used many compounds, for example, 2′,7′-Dichloro-3′,6′-dihydroxy-3H-spiro[isobenzofuran-1,9′-xanthen]-3-one (cas: 76-54-0Synthetic Route of C20H10Cl2O5).

2′,7′-Dichloro-3′,6′-dihydroxy-3H-spiro[isobenzofuran-1,9′-xanthen]-3-one (cas: 76-54-0) belongs to benzofurans derivatives. Benzofuran is the “”parent”” of many related compounds with more complex structures. For example, psoralen is a benzofuran derivative that occurs in several plants. Benzofurans are stable towards alkali and readily polymerize on treatment with sulfuric acid, due to which they are useful for the preparation of low cost chemically relatively inert resins.Synthetic Route of C20H10Cl2O5

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Fluorescence lifetime predicts performance of voltage sensitive fluorophores in cardiomyocytes and neurons was written by Boggess, Steven C.;Lazzari-Dean, Julia R.;Raliski, Benjamin K.;Mun, Dong Min;Li, Amy Y.;Turnbull, Joshua L.;Miller, Evan W.. And the article was included in RSC Chemical Biology in 2021.Computed Properties of C20H10Cl2O5 This article mentions the following:

Voltage imaging with fluorescent indicators offers a powerful complement to traditional electrode or Ca²⁺-imaging approaches for monitoring elec. activity. Small mol. fluorescent indicators present the unique opportunity for exquisite control over mol. structure, enabling detailed investigations of structure/function relationships. In this paper, we tune the conjugation between aniline donors and aromatic π systems within the context of photoinduced electron transfer (PeT) based voltage indicators. We describe the design and synthesis of four new voltage-sensitive fluorophores (VoltageFluors, or VFs). Three of these dyes have higher relative voltage sensitivities (ΔF/F) than the previously-reported indicator, VF2.1.Cl. We pair these new indicators with existing VFs to construct a library of voltage indicators with varying degrees of conjugation between the aniline nitrogen lone pair and the aromatic π system. Using a combination of steady-state and time-resolved fluorescence spectroscopy, cellular electrophysiol., fluorescence lifetime imaging microscopy (FLIM), and functional imaging in mammalian neurons and human cardiomyocytes, we establish a detailed link between the photophys. properties of VF dyes and their ability to report on membrane potential dynamics with high signal-to-noise. Anilines with intermediate degrees of conjugation to the aromaticπ system experience intermediate rates of PeT and possess the highest absolute voltage sensitivities. Measured using FLIM in patch-clamped HEK cells, we find that the absolute voltage sensitivity of fluorescence lifetime (Δτ_fl per mV), coupled with traditional fluorescence intensity-based metrics like ΔF/F and signal-to-noise ratio (SNR), provides a powerful method to both predict and understand indicator performance in cellular systems. In the experiment, the researchers used many compounds, for example, 2′,7′-Dichloro-3′,6′-dihydroxy-3H-spiro[isobenzofuran-1,9′-xanthen]-3-one (cas: 76-54-0Computed Properties of C20H10Cl2O5).

2′,7′-Dichloro-3′,6′-dihydroxy-3H-spiro[isobenzofuran-1,9′-xanthen]-3-one (cas: 76-54-0) belongs to benzofurans derivatives.Benzofuran is one of the most significant oxygen-containing heterocycles consisting of fused benzene and furan ring, which are widely presented in various naturally occurring and synthetically active compounds. In nature, benzofurans have occupied an important role among the plant phenols & several pharmacologically active compounds.Computed Properties of C20H10Cl2O5

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Atmospheric conditions and composition that influence PM_2.5 oxidative potential in Beijing, China was written by Campbell, Steven J.;Wolfer, Kate;Utinger, Battist;Westwood, Joe;Zhang, Zhi-Hui;Bukowiecki, Nicolas;Steimer, Sarah S.;Vu, Tuan V.;Xu, Jingsha;Straw, Nicholas;Thomson, Steven;Elzein, Atallah;Sun, Yele;Liu, Di;Li, Linjie;Fu, Pingqing;Lewis, Alastair C.;Harrison, Roy M.;Bloss, William J.;Loh, Miranda;Miller, Mark R.;Shi, Zongbo;Kalberer, Markus. And the article was included in Atmospheric Chemistry and Physics in 2021.Related Products of 76-54-0 This article mentions the following:

Epidemiol. studies have consistently linked exposure to PM_2.5 with adverse health effects. The oxidative potential (OP) of aerosol particles has been widely suggested as a measure of their potential toxicity. Several acellular chem. assays are now readily employed to measure OP; however, uncertainty remains regarding the atm. conditions and specific chem. components of PM_2.5 that drive OP. A limited number of studies have simultaneously utilized multiple OP assays with a wide range of concurrent measurements and investigated the seasonality of PM_2.5 OP. In this work, filter samples were collected in winter 2016 and summer 2017 during the atm. pollution and human health in a Chinese megacity campaign (APHHBeijing), and PM_2.5 OP was analyzed using four acellular methods: ascorbic acid (AA), dithiothreitol (DTT), 2,7- dichlorofluorescin/hydrogen peroxidase (DCFH) and ESR spectroscopy (EPR). Each assay reflects different oxidising properties of PM_2.5, including particle-bound reactive oxygen species (DCFH), superoxide radical production (EPR) and catalytic redox chem. (DTT/AA), and a combination of these four assays provided a detailed overall picture of the oxidising properties of PM_2.5 at a central site in Beijing. Pos. correlations of OP (normalized per volume of air) of all four assays with overall PM_2.5 mass were observed, with stronger correlations in winter compared to summer. In contrast, when OP assay values were normalized for particle mass, days with higher PM_2.5 mass concentrations (μgm-3) were found to have lower mass-normalized OP values as measured by AA and DTT. This finding supports that total PM_2.5 mass concentrations alone may not always be the best indicator for particle toxicity. Univariate anal. of OP values and an extensive range of addnl. measurements, 107 in total, including PM_2.5 composition, gas-phase composition and meteorol. data, provided detailed insight into the chem. components and atm. processes that determine PM_2.5 OP variability. Multivariate statistical analyses highlighted associations of OP assay responses with varying chem. components in PM_2.5 for both mass- and volume-normalized data. AA and DTT assays were well predicted by a small set of measurements in multiple linear regression (MLR) models and indicated fossil fuel combustion, vehicle emissions and biogenic secondary organic aerosol (SOA) as influential particle sources in the assay response. Mass MLR models of OP associated with compositional source profiles predicted OP almost as well as volume MLR models, illustrating the influence of mass composition on both particle-level OP and total volume OP. Univariate and multivariate anal. showed that different assays cover different chem. spaces, and through comparison of mass- and volume-normalized data we demonstrate that mass-normalized OP provides a more nuanced picture of compositional drivers and sources of OP compared to volume-normalized anal. This study constitutes one of the most extensive and comprehensive composition datasets currently available and provides a unique opportunity to explore chem. variations in PM_2.5 and how they affect both PM_2.5 OP and the concentrations of particlebound reactive oxygen species. In the experiment, the researchers used many compounds, for example, 2′,7′-Dichloro-3′,6′-dihydroxy-3H-spiro[isobenzofuran-1,9′-xanthen]-3-one (cas: 76-54-0Related Products of 76-54-0).

2′,7′-Dichloro-3′,6′-dihydroxy-3H-spiro[isobenzofuran-1,9′-xanthen]-3-one (cas: 76-54-0) belongs to benzofurans derivatives. Benzofurans are compounds with a planar structure having 10 pi electrons that include the lone pair on oxygen atom, which makes it more susceptible to electrophilic attack. Introduction of benzofurans in organic synthesis, particularly drug synthesis, involves generally the use of their metalated species as nucleophiles in addition reactions or in metal-catalysed cross-coupling reactions.Related Products of 76-54-0

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem