Category: 700-85-6

Brief introduction of 700-85-6

700-85-6 5-Fluoroisobenzofuran-1(3H)-one 13770566, abenzofuran compound, is more and more widely used in various fields.

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.700-85-6,5-Fluoroisobenzofuran-1(3H)-one,as a common compound, the synthetic route is as follows.,700-85-6

To a solution of 5-fluoro-3H-isobenzofuran-1-one (1.00 g, 6.57 mmol) in DMF (5 ml) was25 added CH3I (0.82 ml, 13.1 mmol) at -20C followed by addition of NaH (0.34 g, 7.89mmol) portion wise. The reaction mixture was stirred at room temperature for 3h. Progressof the reaction was monitored by TLC and LCMS. After completion, the reaction mixturewas diluted with ice-cold saturated aqueous NH4CI solution (50 ml) and extracted withEtOAc (2 x 30 ml). The organic layer was separated, dried over anhydrous Na2S04 and30 concentrated under vacuum. The crude obtained was purified by combi-flash columnX-~chromatography (4% EtOAc in hexanes) to afford 5-fluoro-3-methyi-3H-isobenzofuran-1-one X-27a (0.44 g) an as an off-white solid.Yield: 35%Basic LCMS Method 2 (ES+): 167 (M+H)+, 87 % purity.5 1H NMR (400 MHz, DMSO-d5) o 1.56 (d, J=6.36 Hz, 3H) 5.68 (q, J=6.36 Hz, 1 H) 7.41-7.48 (m, 1 H) 7.62 (dd, J=8.80, 1.96 Hz, 1 H) 7.87-7.93 (m, 1 H).

700-85-6 5-Fluoroisobenzofuran-1(3H)-one 13770566, abenzofuran compound, is more and more widely used in various fields.

Reference£º
Patent; UCB PHARMA GMBH; MUELLER, Christa E.; PEGURIER, Cecile; DELIGNY, Michael Louis Robert; EL-TAYEB, Ali; HOCKEMEYER, Joerg; LEDECQ, Marie; MERCIER, Joel; PROVINS, Laurent; BOSHTA, Nader M.; BHATTARAI, Sanjay; NAMASIVAYAM, Vigneshwaran; FUNKE, Mario; SCHWACH, Lukas; GOLLOS, Sabrina; VON LAUFENBERG, Daniel; BARRE, Anais; (493 pag.)WO2018/122232; (2018); A1;,
Benzofuran – Wikipedia
Benzofuran | C8H6O – PubChem

Simple exploration of 700-85-6

As the paragraph descriping shows that 700-85-6 is playing an increasingly important role.

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.700-85-6,5-Fluoroisobenzofuran-1(3H)-one,as a common compound, the synthetic route is as follows.,700-85-6

250ml single-mouth bottle to join5-F-benzofuran-1 (3H) ketone 2g, absolute ethanol 120ml, dropping thionyl chloride 4.8ml, drop complete, reflux 14h, vacuum evaporated.

As the paragraph descriping shows that 700-85-6 is playing an increasingly important role.

Reference£º
Patent; Chongqing Institute of Pharmaceutical Industry Co., Ltd.; Dan, Chunyan; Cai, Pengfei; Zuo, Xiaoyong; Luo, Bin; Xie, Shouquan; Liu, Caiping; Yang, Qiaobin; (8 pag.)CN105524044; (2016); A;,
Benzofuran – Wikipedia
Benzofuran | C8H6O – PubChem

Brief introduction of 700-85-6

700-85-6 5-Fluoroisobenzofuran-1(3H)-one 13770566, abenzofuran compound, is more and more widely used in various.

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.700-85-6,5-Fluoroisobenzofuran-1(3H)-one,as a common compound, the synthetic route is as follows.

A mixture of5-fluoro-3H-isobenzofuran-1-one (1 g, 6.6 mmol, 1 eq), N-bromosuccinimide (1.2 g,6.8 mmol, 1.03 eq) and dibenzoyl peroxide (111 mg, 0.5 mmol, 0.07 eq) in CCw is stirred at 80C for 1.5h. The precipitated is filtered and the filtrate is concentrated. The residue is partitioned between DCM andwater. The two layers are separated and the aqueous layer is extracted with DCM. The combined organiclayers are dried (filtered through phase separator) and concentrated to afford the desired product.

700-85-6 5-Fluoroisobenzofuran-1(3H)-one 13770566, abenzofuran compound, is more and more widely used in various.

Reference£º
Patent; GALAPAGOS NV; MAMMOLITI, Oscar; JANSEN, Koen, Karel; MENET, Christel, Jeanne, Marie; PALISSE, Adeline, Marie, Elise; TRICARICO, Giovanni, Alessandro; EL BKASSINY, Sandy; JAUNET, Alexis, Patrick, Claude; ALLART, Brigitte; DUTHION, Beranger; BREBION, Franck Laurent; (324 pag.)WO2019/7696; (2019); A1;,
Benzofuran – Wikipedia
Benzofuran | C8H6O – PubChem