Brief introduction of 700-85-6

700-85-6 5-Fluoroisobenzofuran-1(3H)-one 13770566, abenzofuran compound, is more and more widely used in various fields.

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.700-85-6,5-Fluoroisobenzofuran-1(3H)-one,as a common compound, the synthetic route is as follows.,700-85-6

To a solution of 5-fluoro-3H-isobenzofuran-1-one (1.00 g, 6.57 mmol) in DMF (5 ml) was25 added CH3I (0.82 ml, 13.1 mmol) at -20C followed by addition of NaH (0.34 g, 7.89mmol) portion wise. The reaction mixture was stirred at room temperature for 3h. Progressof the reaction was monitored by TLC and LCMS. After completion, the reaction mixturewas diluted with ice-cold saturated aqueous NH4CI solution (50 ml) and extracted withEtOAc (2 x 30 ml). The organic layer was separated, dried over anhydrous Na2S04 and30 concentrated under vacuum. The crude obtained was purified by combi-flash columnX-~chromatography (4% EtOAc in hexanes) to afford 5-fluoro-3-methyi-3H-isobenzofuran-1-one X-27a (0.44 g) an as an off-white solid.Yield: 35%Basic LCMS Method 2 (ES+): 167 (M+H)+, 87 % purity.5 1H NMR (400 MHz, DMSO-d5) o 1.56 (d, J=6.36 Hz, 3H) 5.68 (q, J=6.36 Hz, 1 H) 7.41-7.48 (m, 1 H) 7.62 (dd, J=8.80, 1.96 Hz, 1 H) 7.87-7.93 (m, 1 H).

700-85-6 5-Fluoroisobenzofuran-1(3H)-one 13770566, abenzofuran compound, is more and more widely used in various fields.

Reference£º
Patent; UCB PHARMA GMBH; MUELLER, Christa E.; PEGURIER, Cecile; DELIGNY, Michael Louis Robert; EL-TAYEB, Ali; HOCKEMEYER, Joerg; LEDECQ, Marie; MERCIER, Joel; PROVINS, Laurent; BOSHTA, Nader M.; BHATTARAI, Sanjay; NAMASIVAYAM, Vigneshwaran; FUNKE, Mario; SCHWACH, Lukas; GOLLOS, Sabrina; VON LAUFENBERG, Daniel; BARRE, Anais; (493 pag.)WO2018/122232; (2018); A1;,
Benzofuran – Wikipedia
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