Brief introduction of 5-Bromo-2,3-dihydrobenzofuran

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Iridium-catalyzed C-H amination with anilines at room temperature: Compatibility of iridacycles with external oxidants

Described herein is the development of an iridium-catalyzed direct C-H amination of benzamides with anilines at room temperature, representing a unique example of an Ir catalyst system that is compatible with external oxidants. Mechanistic details, such as the isolation and characterization of key iridacycle intermediates, are also discussed.

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Reference£º
Benzofuran – Wikipedia,
Benzofuran | C8H3367O – PubChem

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WATER-SOLUBLE FLUORO-SUBSTITUTED CYANINE DYES AS REACTIVE FLUORESCENCE LABELLING REAGENTS

Disclosed are cyanine dyes that are useful for labelling and detecting biological and other materials. The dyes are of formula (I): in which at least one of groups R1, R2, R3, R4, R5, R6, R7, R8, R9, R10 R11, R12, R13 and R14 is -L-M or -L-P, where L is a linking group, M is a target bonding group and P is a conjugated component, and at least one of groups R3, R4, R5, R6, R7, R8, R9 and R10 comprises fluorine. The use of cyanine dyes substituted by fluorine and having additional substitution with three or more sulphonic acid groups for labelling biological target molecules results in a labelled product in which there is reduced dye-dye aggregation and improved photostability, compared with cyanine dyes having no such substitutions. The dyes of the present invention are particularly useful in assays involving fluorescence detection where continual or repeated excitation is a requirement, for example in kinetic studies, or in microarray analyses where microarray slides may need to be reanalysed over a period of days.

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Reference£º
Benzofuran – Wikipedia,
Benzofuran | C8H3329O – PubChem

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A pest control composition and its use (by machine translation)

[Problem] leucine aminopeptidase, such as fleas excellent control effect against harmful organisms with a pest control composition. (1) Condensed heterocyclic compound represented by the formula [a], A group; antiparasitic agent, B group; insecticide ¡¤ acaricide and group C; other pharmaceutically active ingredient is selected from the group consisting of one or more pest control active ingredients for animal 1, containing a pest control composition. (R1 Is H, halogen, alkyl or C1 a-3; R5 The CF3 , C2 F5 As a; R6 Alkyl such as C1 a-6 is; X is CH or N; Y is NH, NCH3 , O or S; n is an integer of 0 – 2)[Drawing] no (by machine translation)

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Benzofuran – Wikipedia,
Benzofuran | C8H3342O – PubChem

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A concise and convenient synthesis of 4-(trifluoromethylthio)aniline

4-(Trifluoromethylthio)aniline, a key agricultural intermediate, can be synthesized from 4-nitrobromobenzene. First 4-nitrothioanisole was obtained by the methylthiotriazine of 4-nitrobromobenzene with sodium salt of methyl mercaptan in the presence of phase-transfer catalyst in a 91.4 % yield; then 4-(trifuroromethylthio)nitrobenzene was produced through chlorination in a 83.7 % yield and fluorination in a 86.3 % yield; finally the hydrogenation in the presence of Pd/C can afford 4-(trifluoromethylthio)aniline with a 98 % yield.

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Reference£º
Benzofuran – Wikipedia,
Benzofuran | C8H3361O – PubChem

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AMIDE COMPOUND AND USE THEREOF FOR PEST CONTROL

A fused heterocyclic compound represented by formula (1) has an excellent pest control effect. (In the formula, R1 represents a C1-C6 chain hydrocarbon group which may have one or more atoms or groups selected from group X, or the like; R2, R3, R4 and R5 may be the same or different, and each represents a C1-C6 chain hydrocarbon group which may have one or more atoms or groups selected from group X, or the like; R6 represents a C1-C6 chain hydrocarbon group which may have one or more atoms or groups selected from group W, or the like; R7 and R11 may be the same or different, and each represents a C1-C6 chain hydrocarbon group which may have one or more atoms or groups selected from group X, or the like; R8, R9 and R10 may be the same or different, and each represents a C1-C6 chain hydrocarbon group which may have one or more atoms or groups selected from group X, or the like; Q represents an oxygen atom or a sulfur atom; and each of m and n represents 0, 1 or 2.)

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Benzofuran – Wikipedia,
Benzofuran | C8H3344O – PubChem

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Selective oxidation and chlorination of trifluoromethylsulfide using trichloroisocyanuric acid in ionic liquid

A route to chemoselective oxidation and chlorination of aryltrifluoromethylsulfide using trichloroisocyanuric acid (TCCA) in ionic liquid, an efficiently O-methylation reaction and a reduction of nitro- to amido- in excellent yields have been developed.

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Benzofuran – Wikipedia,
Benzofuran | C8H3385O – PubChem

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Synthesis of alpha-enaminones from cyclic ketones and anilines using oxoammonium salt as an oxygen transfer reagent

A convenient and straightforward transformation of cyclic ketones with anilines at room temperature has been developed using oxoammonium salt TEMPO+PF6- as an oxidant. This method enabled the synthesis of a broad range of alpha-enaminones. The 18O-labeling experiment demonstrated that oxoammonium salt served as the oxygen transfer reagent.

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Benzofuran – Wikipedia,
Benzofuran | C8H3388O – PubChem

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Acylation of Amines with Dichloromaleoyl Chloride

The reaction of dichloromaleoyl chloride (2) with ammonia in ether yields the ammonium salt of (Z)-2,3-dichloro-3-cyanoacrylic acid (6) and with aqueous ammonia the ammonium salt of (Z)-2-amino-3-chloro-3-cyanoacrylic acid (1).With primary aliphatic and aromatic amines dichloromaleamides 8 are obtained, the two chlorine atoms of which can be replaced with other amines to form after cis/trans isomerization diaminofumaramides 11.

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Benzofuran – Wikipedia,
Benzofuran | C8H3356O – PubChem

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With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.66826-78-6,5-Bromo-2,3-dihydrobenzofuran,as a common compound, the synthetic route is as follows.

(i) Production of Ethyl 2,3-Dihydronaphtho[2,3-b]furan-6-carboxylate 5-Bromo-2,3-dihydrobenzofuran (38.86 g), which was prepared according to the literature (Alabaster, Ramon J. et al., Synthesis, 1988, vol. 12, pp950.), was dissolved in THF (300 mL) and cooled to -78 C. n-Butyl-lithium in hexane (1.6M; 160 mL) was added to the solution and stirred for 30 min. DMF (40 mL) was added to the mixture and was allowed to warm to room temperature. Water was added to the mixture and the solvent was evaporated. The residue was diluted with ethyl acetate, washed with water and brine, dried and concentrated to give crude product of 5-formyl-2,3-dihydrobenzofuran (28.47 g) as an oil.

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Reference£º
Patent; Takeda Chemical Industries, Ltd.; US6649643; (2003); B1;,
Benzofuran – Wikipedia
Benzofuran | C8H6O – PubChem

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66826-78-6 5-Bromo-2,3-dihydrobenzofuran 2776159, abenzofuran compound, is more and more widely used in various.

66826-78-6, 5-Bromo-2,3-dihydrobenzofuran is a benzofuran compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

PREPARATION 108 2,3-Dihydrobenzofuran-5-ylboronic Acid Obtained as a colourless solid (38%), m.p. >240 C.(decomp.), from 5-bromo-2,3-dihydrobenzofuran (Synthesis, 1988, 952) and trimethyl borate, using the procedure of Preparation 101. delta(DMSOd6): 3.33 (t,2H), 4.48 (t,2H), 6.68 (d,1H), 7.56 (d,1H), 7.63 (s,1H), 7.70 (brs,2H).

66826-78-6 5-Bromo-2,3-dihydrobenzofuran 2776159, abenzofuran compound, is more and more widely used in various.

Reference£º
Patent; Pfizer INC; US6387931; (2002); B1;,
Benzofuran – Wikipedia
Benzofuran | C8H6O – PubChem