With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.66826-78-6,5-Bromo-2,3-dihydrobenzofuran,as a common compound, the synthetic route is as follows.
(i) Production of Ethyl 2,3-Dihydronaphtho[2,3-b]furan-6-carboxylate 5-Bromo-2,3-dihydrobenzofuran (38.86 g), which was prepared according to the literature (Alabaster, Ramon J. et al., Synthesis, 1988, vol. 12, pp950.), was dissolved in THF (300 mL) and cooled to -78 C. n-Butyl-lithium in hexane (1.6M; 160 mL) was added to the solution and stirred for 30 min. DMF (40 mL) was added to the mixture and was allowed to warm to room temperature. Water was added to the mixture and the solvent was evaporated. The residue was diluted with ethyl acetate, washed with water and brine, dried and concentrated to give crude product of 5-formyl-2,3-dihydrobenzofuran (28.47 g) as an oil.
As the paragraph descriping shows that 66826-78-6 is playing an increasingly important role.
Patent; Takeda Chemical Industries, Ltd.; US6649643; (2003); B1;,
Benzofuran – Wikipedia
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