Category: 5471-63-6

《Synthesis, characterization and photochemical properties of novel octakis(p-fluorophenoxy)substituted phthalocyanine and its gallium and indium complexes》 was written by Burtsev, I. D.; Platonova, Ya. B.; Volov, A. N.; Tomilova, L. G.. Product Details of 5471-63-6 And the article was included in Polyhedron in 2020. The article conveys some information:

Octakis(p-fluorophenoxy)-substituted phthalocyanine and its complexes of gallium and indium were obtained in high yields (89% and 86%, resp.). Unmetalated phthalocyanine and gallium complex were synthesized for the first time and the new method for the synthesis of indium complex is proposed. The obtained compounds were characterized by a combination of MALDI-TOF mass spectrometry, UV-visible, and NMR spectroscopies. Photochem. properties of gallium and indium phthalocyanines were investigated. These complexes maintained high production of singlet oxygen and potentially can be used in photodynamic therapy. In the experimental materials used by the author, we found 1,3-Diphenylisobenzofuran(cas: 5471-63-6Product Details of 5471-63-6)

1,3-Diphenylisobenzofuran(cas: 5471-63-6) can be used as a fluorescent probe for detection of superoxide anion radical (O2−) inside the membrane lipid layer by DPBF fluorescence quenching method. 1,3-Diphenylisobenzofuran(DPBF) can be used to study the single crystal molecular structure and solution photophysical properties of DPBF.Product Details of 5471-63-6

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

《Perfluoropolyether nanoemulsion encapsulating chlorin e6 for sonodynamic and photodynamic therapy of hypoxic tumor》 was written by Hong, Liang; Pliss, Artem M.; Zhan, Ye; Zheng, Wenhan; Xia, Jun; Liu, Liwei; Qu, Junle; Prasad, Paras N.. Application of 5471-63-6 And the article was included in Nanomaterials in 2020. The article conveys some information:

Sonodynamic therapy (SDT) has emerged as an important modality for cancer treatment. SDT utilizes ultrasound excitation, which overcomes the limitations of light penetration in deep tumors, as encountered by photodynamic therapy (PDT) which uses optical excitations. A comparative study of these modalities using the same sensitizer drug can provide an assessment of their effects. However, the efficiency of SDT and PDT is low in a hypoxic tumor environment, which limits their applications. In this study, we report a hierarchical nanoformulation which contains a Food and Drug Administration (FDA) approved sensitizer chlorin, e6, and a uniquely stable high loading capacity oxygen carrier, perfluoropolyether. This oxygen carrier possesses no measurable cytotoxicity. It delivers oxygen to overcome hypoxia, and at the same time, boosts the efficiency of both SDT and PDT. Moreover, we comparatively analyzed the efficiency of SDT and PDT for tumor treatment throughout the depth of the tissue. Our study demonstrates that the strengths of PDT and SDT could be combined into a single multifunctional nanoplatform, which works well in the hypoxia environment and overcomes the limitations of each modality. The combination of deep tissue penetration by ultrasound and high spatial activation by light for selective treatment of single cells will significantly enhance the scope for therapeutic applications. The experimental part of the paper was very detailed, including the reaction process of 1,3-Diphenylisobenzofuran(cas: 5471-63-6Application of 5471-63-6)

1,3-Diphenylisobenzofuran(cas: 5471-63-6) can be used as a fluorescent probe for detection of superoxide anion radical (O2−) inside the membrane lipid layer by DPBF fluorescence quenching method. 1,3-Diphenylisobenzofuran(DPBF) can be used as quencher during the photoinactivation of TA-3 mouse mammary carcinoma cells containing hematoporphyrin.Application of 5471-63-6

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Related Products of 5471-63-6In 2021 ,《Supramolecular Tadalafil Nanovaccine for Cancer Immunotherapy by Alleviating Myeloid-Derived Suppressor Cells and Heightening Immunogenicity》 was published in Small Methods. The article was written by Zhang, Tian; Xiong, Honggang; Ma, Xianbin; Gao, Yuan; Xue, Peng; Kang, Yuejun; Sun, Zhi-Jun; Xu, Zhigang. The article contains the following contents:

Tumor-induced immune suppression mediated by myeloid-derived suppressor cells (MDSCs) and insufficient immunogenicity are two major factors for the poor overall response rate to the immune checkpoint blockade (ICB). Here, a tumor microenvironment responsive nanoprodrug (FIT nanoparticles) is presented for co-delivering tadalafil (TAD) and indocyanine green (ICG) photosensitizer to simultaneously targeting intratumor MDSCs and amplifying tumor immunogenicity. The resulting nanoprodrug shows high drug loading (nearly 100%), tumor-specific release, and robust therapeutic efficacy by virtue of promoting immunogenic cell death (ICD) induction and alleviation of MDSCs for augmenting the photothermal immunotherapy. In an in vivo colon tumor model, the released TAD in the tumor can effectively ameliorate MDSCs immunosuppressive activity, while the photosensitizer ICG is capable of inducing ICD to promote sufficient dendritic cells maturation and T cell infiltration. The results reported here may provide a superior candidate of adjuvants for strengthening immune response and ICB efficacy.1,3-Diphenylisobenzofuran(cas: 5471-63-6Related Products of 5471-63-6) was used in this study.

1,3-Diphenylisobenzofuran(cas: 5471-63-6) is a fluorescent dye. 1,3-Diphenylisobenzofuran is the model compound in studies of singlet fission.Related Products of 5471-63-6

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

《Construction of FRET-Based Off-On Fluorescent Nanoprobes for Sensitive Detection of Intracellular Singlet Oxygen》 was written by Ping, Jian-tao; Qin, Jing-lei; Zhou, Chao; Guo, Lan-ying; Liu, Bei; Chen, Zhi-hua; Geng, Zhao-xin; Peng, Hong-shang. Computed Properties of C20H14O And the article was included in ChemNanoMat in 2020. The article conveys some information:

Singlet oxygen (1O2) detection remains an active area of research in the field of biol. and biomedical science. In this work, we reported a novel Off-On type FRET-based fluorescent 1O2 nanoprobe comprising the energy-donating conjugated polymer, poly(9,9-dioctylfluorenyl-2,7-diyl) (PFO), and the energy-accepting 1O2 indicator, 3-diphenylisobenzofuran (DPBF). Prior to the reaction with 1O2, the nanoprobe was in Off-state because fluorescence of PFO was completely quenched by loaded DPBF; in the presence of 1O2, it switched to On-state due to the depletion of DPBF. The as-prepared 1O2 nanoprobe had a particle size of ~59 nm, good biocompatibility, high specificity and sensitivity with a limit of detection of 353 nM. Importantly, the fluorescent nanoprobes were highly sensitive to 1O2 under two-photon excitation. Using a multiphoton confocal microscope, generation of intracellular 1O2 during photodynamic therapy was sensitively detected by recording fluorescence intensity of the nanoprobes. In the experiment, the researchers used many compounds, for example, 1,3-Diphenylisobenzofuran(cas: 5471-63-6Computed Properties of C20H14O)

1,3-Diphenylisobenzofuran(cas: 5471-63-6) can be used as a fluorescent probe for detection of superoxide anion radical (O2−) inside the membrane lipid layer by DPBF fluorescence quenching method. 1,3-Diphenylisobenzofuran(DPBF) can be used as quencher during the photoinactivation of TA-3 mouse mammary carcinoma cells containing hematoporphyrin.Computed Properties of C20H14O

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Wei, Fangmian; Kuang, Shi; Rees, Thomas W.; Liao, Xinxing; Liu, Jiangping; Luo, Diqing; Wang, Jinquan; Zhang, Xiting; Ji, Liangnian; Chao, Hui published an article in 2021. The article was titled 《Ruthenium(II) complexes coordinated to graphitic carbon nitride: Oxygen self-sufficient photosensitizers which produce multiple ROS for photodynamic therapy in hypoxia》, and you may find the article in Biomaterials.Synthetic Route of C20H14O The information in the text is summarized as follows:

The photodynamic therapy (PDT) of cancer is limited by tumor hypoxia as PDT efficiency depends on O2 concentration A novel oxygen self-sufficient photosensitizer (Ru-g-C3N4) was therefore designed and synthesized via a facile one-pot method in order to overcome tumor hypoxia-induced PDT resistance. The photosensitizer is based on [Ru(bpy)2]2+ coordinated to g-C3N4 nanosheets by Ru-N bonding. Compared to pure g-C3N4, the resulting nanosheets exhibit increased water solubility, stronger visible light absorption, and enhanced biocompatibility. Once Ru-g-C3N4 is taken up by hypoxic tumor cells and exposed to visible light, the nanosheets not only catalyze the decomposition of H2O2 and H2O to generate O2, but also catalyze H2O2 and O2 concurrently to produce multiple ROS (·OH, ·O-2, and 1O2). In addition, Ru-g-C3N4 affords luminescence imaging, while continuously generating O2 to alleviate hypoxia greatly improving PDT efficacy. To the best of our knowledge, this oxygen self-sufficient photosensitizer produced via grafting a metal complex onto g-C3N4 is the first of its type to be reported. In the experimental materials used by the author, we found 1,3-Diphenylisobenzofuran(cas: 5471-63-6Synthetic Route of C20H14O)

1,3-Diphenylisobenzofuran(cas: 5471-63-6) can be used as a fluorescent probe for detection of superoxide anion radical (O2−) inside the membrane lipid layer by DPBF fluorescence quenching method. 1,3-Diphenylisobenzofuran(DPBF) can be used to study the single crystal molecular structure and solution photophysical properties of DPBF.Synthetic Route of C20H14O

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Liu, Ting; Zhang, Honglin; Zhang, Xiyu; Zhao, Hua; Zhang, Zhiguo; Tian, Ye published an article in 2021. The article was titled 《The effect of imidazole on the singlet oxygen quantum yield of sinoporphyrin sodium》, and you may find the article in Chemical Physics.Related Products of 5471-63-6 The information in the text is summarized as follows:

In this paper, the effect of imidazole on the singlet oxygen quantum yield (ΦΔ) of sinoporphyrin sodium (DVDMS) was studied. A relative method was used to measure ΦΔ with Rose Bengal (RB) as the reference and 1,3-diphenylisobenzofuran (DPBF) as the singlet oxygen trapping reagent. It can be found that ΦΔ of DVDMS decreased with the increment of imidazole concentration, and kept 0.33 after the imidazole concentration was above 0.26 M. The process of 1O2 generation and optical properties of DVDMS in different imidazole concentrations were studied to analyze the reason for the above behavior. The invariability of UV-vis absorption and photoluminescence spectra suggested that the reduction of ΦΔ was attributed to the decrease of interaction between DVDMS and O2, which was caused by the surrounding of imidazole on DVDMS. For efficient implementation of PDT, it is necessary to identify the factors that may reduce the effect of PDT. In the experiment, the researchers used many compounds, for example, 1,3-Diphenylisobenzofuran(cas: 5471-63-6Related Products of 5471-63-6)

1,3-Diphenylisobenzofuran(cas: 5471-63-6) can be used as a fluorescent probe for detection of superoxide anion radical (O2−) inside the membrane lipid layer by DPBF fluorescence quenching method. 1,3-Diphenylisobenzofuran(DPBF) can be used as quencher during the photoinactivation of TA-3 mouse mammary carcinoma cells containing hematoporphyrin.Related Products of 5471-63-6

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Zhang, Jiayin; Wang, Qiyu; Hong, Liang; Song, Guoli; Zhang, Zhiguo published an article in 2021. The article was titled 《Optimal fluorescence and photosensitivity properties of dual-functional NaYb1-xF4:Tmx3+ nanoparticles for applications in imaging guided photodynamic therapy》, and you may find the article in RSC Advances.Formula: C20H14O The information in the text is summarized as follows:

The fluorescence and photosensitivity properties of NaYb1-xF4:Tmx3+ nanoparticles were optimized to develop noninvasive near-IR fluorescence imaging-guided photodynamic therapy. The emission at 800 nm from Tm3+ presented an exponential increase with an increase in the Tm3+ doping concentration from 0 to 2%. The photosensitivity properties of NaYb1-xF4:Tmx3+ nanoparticles were also studied via the chemoprobe method, which used a reactive oxygen quencher, 1,3-diphenylisobenzofuran (DPBF). With the increase in the doping concentration of Tm3+, the generation rate of reactive oxygen species in NaYb1-xF4:Tmx3+ nanoparticles decreased linearly at a rate of 0.3. The doping concentration of Tm3+ had two opposite effects on the 800 nm emission and generation rates of reactive oxygen species. The competitive relationship was discussed and an optimal value for the Tm3+ doping concentration of approx. 1% was determined At this concentration, the energy of the Yb3+ excited state can be fully utilized, and the fluorescence and photosensitivity properties are an effective combination. In addition to this study using 1,3-Diphenylisobenzofuran, there are many other studies that have used 1,3-Diphenylisobenzofuran(cas: 5471-63-6Formula: C20H14O) was used in this study.

1,3-Diphenylisobenzofuran(cas: 5471-63-6) can be used as a fluorescent probe for detection of superoxide anion radical (O2−) inside the membrane lipid layer by DPBF fluorescence quenching method. 1,3-Diphenylisobenzofuran(DPBF) can be used as quencher during the photoinactivation of TA-3 mouse mammary carcinoma cells containing hematoporphyrin.Formula: C20H14O

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Sun, Jifu; Dai, Ying; Hou, Yuqi; Wu, Qianwen; Ma, Linzheng; Zhao, Jianzhang; Wang, Bo published their research in Journal of Physical Chemistry A in 2021. The article was titled 《Weakened Triplet-Triplet Annihilation of Diiodo-BODIPY Moieties without Influence on Their Intrinsic Triplet Lifetimes in Diiodo-BODIPY-Functionalized Pillar[5]arenes》.HPLC of Formula: 5471-63-6 The article contains the following contents:

The triplet-triplet annihilation (TTA) effect of sensitizers themselves can lead to the addnl. quenching of lifetimes of triplet states; therefore, how to weaken the TTA effect of sensitizers is an urgent issue to be resolved for their further applications. Besides, it remains a tremendous challenge for constructing supramol. systems of photosensitizers based on photosensitizer-functionalized pillararenes because there have been very few investigations on them. Thus, 2,6-diiodo-1,3,5,7-tetramethyl-8-phenyl-4,4-difluoroboradiazaindacene (DIBDP) and ethoxy pillar[5]arene (EtP5) were utilized to synthesize a DIBDP-functionalized pillar[5]arene (EtP5-DIBDP), a cyano-containing DIBDP (G) used as a guest mol. was also prepared, and they were used to investigate the electron-transfer mechanism between EtP5 and DIBDP moieties and weaken the TTA effect of DIBDP moieties. The theor. computational results of frontier MOs and isosurfaces of spin d. preliminarily predicted that the cavities of the EtP5 moiety had influence on the fluorescence emission of DIBDP units but not on their triplet states in EtP5-DIBDP. The fluorescence emission intensities in a variety of solvents with different polarities and electrochem. studies revealed that there was electron transfer from EtP5 to the DIBDP units, and the electron-transfer process had influence on the fluorescence emission but not on the triplet states of DIBDP moieties in EtP5-DIBDP, which verified the results of d. functional theory calculations The triplet state lifetimes of EtP5-DIBDP were longer than those of DIBDP and G and the photooxidation abilities of EtP5-DIBDP were better than those of DIBDP and G at a high concentration (1.0 x 10-5 M) in various solvents; in contrast, the intrinsic triplet state lifetimes and singlet oxygen quantum yields (ΦΔ) of DIBDP, G, and EtP5-DIBDP were very similar. This was because the steric hindrance of EtP5 moieties could weaken the TTA effect of DIBDP moieties without influencing their intrinsic triplet state lifetimes in EtP5-DIBDP. In the experiment, the researchers used many compounds, for example, 1,3-Diphenylisobenzofuran(cas: 5471-63-6HPLC of Formula: 5471-63-6)

1,3-Diphenylisobenzofuran(cas: 5471-63-6) can be used as a fluorescent probe for detection of superoxide anion radical (O2−) inside the membrane lipid layer by DPBF fluorescence quenching method. 1,3-Diphenylisobenzofuran(DPBF) can be used to study the single crystal molecular structure and solution photophysical properties of DPBF.HPLC of Formula: 5471-63-6

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

《External-photocatalyst-free visible-light-mediated aerobic oxidation and 1,4-bisfunctionalization of N-alkyl isoquinolinium salts》 was written by Zhou, Youkang; Liu, Wei; Xing, Zhiming; Guan, Jiali; Song, Zhibin; Peng, Yiyuan. Application In Synthesis of 1,3-Diphenylisobenzofuran And the article was included in Organic Chemistry Frontiers in 2020. The article conveys some information:

Visible-light-mediated aerobic alternate transformations of N-alkyl isoquinolinium salts I [X = I, Br, BF4; R = H, OMe, Ph, Cl, Br; R1 = H, Br, Ph, I; R2 = H, Et, naphthalen-1-yl, 2-bromophenyl, etc.] and 2,2′-(butane-1,4-diyl)bis(isoquinolin-2-ium) iodide/quinolinium salts II [R3 = H, Br, Ph, naphthalen-1-yl; R4 = H, naphthalen-1-yl, 3-methylphenyl, 2-phenylethyl; R5 = H, Ph, Br, OMe, Cl] in the absence of any extra added photocatalyst are reported. Here, a highly concise, sustainable and low-cost protocol to produce unsaturated lactams III/IV and 2,2′-(butane-1,4-diyl)bis(isoquinolin-1(2H)-one) from oxidation of their corresponding isoquinolinium salts I or quinolinium salts II using air as an oxidant was developed. Important building blocks for further modification of biol. active isoquinolones, 4-iodoisoquinolinones III and 2,2′-(butane-1,4-diyl)bis(4-iodoisoquinolin-1(2H)-one) were also produced through 1,4-bisfunctionalization of isoquinolinium salts I without the use of any transition metal. Gram-scale synthesis was achieved under sunlight with exposure to the open air. Mechanism studies suggested that singlet oxygen generation triggered by isoquinolinium salts I/quinolinium salts II under visible light irradiation and trace water may lead to multiple pathways for the aerobic transformations of N-alkyl iminium salts. The experimental process involved the reaction of 1,3-Diphenylisobenzofuran(cas: 5471-63-6Application In Synthesis of 1,3-Diphenylisobenzofuran)

1,3-Diphenylisobenzofuran(cas: 5471-63-6) can be used as a fluorescent probe for detection of superoxide anion radical (O2−) inside the membrane lipid layer by DPBF fluorescence quenching method. 1,3-Diphenylisobenzofuran(DPBF) can be used as quencher during the photoinactivation of TA-3 mouse mammary carcinoma cells containing hematoporphyrin.Application In Synthesis of 1,3-Diphenylisobenzofuran

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Reference of 1,3-DiphenylisobenzofuranIn 2020 ,《Electrochemically deposited poly(selenophene)-fullerene photoactive layer: Tuning of the spectroscopic properties towards visible light-driven generation of singlet oxygen》 appeared in Applied Surface Science. The author of the article were Nyga, Aleksandra; Motyka, Radoslaw; Bussetti, Gianlorenzo; Calloni, Alberto; Sangarashettyhalli Jagadeesh, Madan; Fijak, Sylwia; Pluczyk-Malek, Sandra; Data, Przemyslaw; Blacha-Grzechnik, Agata. The article conveys some information:

A selenophene-containing fullerene dyad (C60Se) was electrochem. co-deposited with bis-selenophene (BisSe) to form a visible light absorbing poly(selenophene) layer with incorporated fullerene photosensitizers on platinum (Pt) or indium-tin oxide (ITO) substrates. The resulting photoactive films (P(C60Se_BisSe)) were characterized by cyclic voltammetry, UV-Vis, IR, Raman and X-ray photoelectron spectroscopies. The efficiency of P(C60Se_BisSe) towards singlet oxygen photogeneration was investigated by applying reactions with chem. traps, i.e. α-terpinene and 1,3-diphenylisobenzofuran (DPBF), monitored by UV-Vis spectroscopy. The composition of the electropolymerized layer was controlled by varying the monomers ratio in the feed solution and it had a strong influence on the spectroscopic and photosensitizing properties of the deposited film. It has been shown that the efficiency of the visible light-driven singlet oxygen generation can be increased by optimizing the ratio between C60 photosensitizers and organic units in the layer. In the experiment, the researchers used 1,3-Diphenylisobenzofuran(cas: 5471-63-6Reference of 1,3-Diphenylisobenzofuran)

1,3-Diphenylisobenzofuran(cas: 5471-63-6) can be used as a fluorescent probe for detection of superoxide anion radical (O2−) inside the membrane lipid layer by DPBF fluorescence quenching method. 1,3-Diphenylisobenzofuran(DPBF) can be used as quencher during the photoinactivation of TA-3 mouse mammary carcinoma cells containing hematoporphyrin.Reference of 1,3-Diphenylisobenzofuran

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem