Category: 50551-63-8

Vargas, David A. published the artcileBiocatalytic strategy for highly diastereo- and enantioselective synthesis of 2,3-dihydrobenzofuran-based tricyclic scaffolds, Quality Control of 50551-63-8, the main research area is diastereoselective enantioselective synthesis dihydrobenzofuran scaffold myoglobin engineering; benzofuran cyclopropanation; biocatalysis; carbene transfer; dihydrobenzofurans; myoglobin.

2,3-Dihydrobenzofurans are key pharmacophores in many natural and synthetic bioactive mols. A biocatalytic strategy is reported here for the highly diastereo- and enantioselective construction of stereochem. rich 2,3-dihydrobenzofurans in high enantiopurity (>99.9% de and ee), high yields, and on a preparative scale via benzofuran cyclopropanation with engineered myoglobins. Computational and structure-reactivity studies provide insights into the mechanism of this reaction, enabling the elaboration of a stereochem. model that can rationalize the high stereoselectivity of the biocatalyst. This information was leveraged to implement a highly stereoselective route to a drug mol. and a tricyclic scaffold featuring five stereogenic centers via a single-enzyme transformation. This work expands the biocatalytic toolbox for asym. C-C bond transformations and should prove useful for further development of metalloprotein catalysts for abiotic carbene transfer reactions.

Angewandte Chemie, International Edition published new progress about Crystal structure. 50551-63-8 belongs to class benzofurans, name is 6-Methoxybenzofuran, and the molecular formula is C9H8O2, Quality Control of 50551-63-8.

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Yamaguchi, Yuki published the artcileSynthetic Models Related to Methoxalen and Menthofuran-Cytochrome P450 (CYP) 2A6 Interactions. Benzofuran and Coumarin Derivatives as Potent and Selective Inhibitors of CYP2A6, HPLC of Formula: 50551-63-8, the main research area is benzofuran derivative preparation human microsomal cytochrome inhibitor; coumarin derivative preparation human microsomal cytochrome inhibitor; human microsomal cytochrome inhibitor reduce smoking tobacco cancer.

Human microsomal cytochrome P 450 (CYP) 2A6 contributes extensively to nicotine detoxication but also activates tobacco-specific procarcinogens to mutagenic products. A series of benzofuran and coumarin derivatives having inhibitory effects on the activity of human CYP2A6 have been described. Synthesized benzofuran I [IC50 = 2.20 μM] and coumarin II [R= 5-methoxy: IC50 = 0.13μM , R=6-methoxy: IC50 = 0.64 μM] derivatives were found to be more selective than methoxalen and menthofuran. These compounds can be used as a lead compounds in the design of CYP2A6 inhibitor drugs to reduce smoking and tobacco-related cancers.

Chemical & Pharmaceutical Bulletin published new progress about Coumarins Role: BSU (Biological Study, Unclassified), PAC (Pharmacological Activity), SPN (Synthetic Preparation), THU (Therapeutic Use), BIOL (Biological Study), PREP (Preparation), USES (Uses). 50551-63-8 belongs to class benzofurans, name is 6-Methoxybenzofuran, and the molecular formula is C9H8O2, HPLC of Formula: 50551-63-8.

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Application of 50551-63-8, Because a catalyst decreases the height of the energy barrier, its presence increases the reaction rates of both the forward and the reverse reactions by the same amount.50551-63-8, Name is 6-Methoxybenzofuran, molecular formula is C9H8O2. In a article，once mentioned of 50551-63-8

A novel ligand-free palladium-catalyzed C-2 arylation of benzofurans has been developed using N?-acyl arylhydrazines as the coupling partners and TEMPO as an oxidant. This protocol features a wide functional-group tolerance and highly regioselective products with good to excellent yields.

A reaction mechanism is the microscopic path by which reactants are transformed into products. Each step is an elementary reaction. In my other articles, you can also check out more blogs about 50551-63-8

Reference：
Benzofuran – Wikipedia,
Benzofuran | C8H1320O – PubChem

Chemistry is an experimental science, and the best way to enjoy it and learn about it is performing experiments. Recommanded Product: 50551-63-8. Introducing a new discovery about 50551-63-8, Name is 6-Methoxybenzofuran

New molecules with a triphenylmethane-type structure have been synthesised based on the structure of coloured compounds obtained from natural substrates.Satisfactory yields were obtained from benzofuran derivatives as starting material, which have been condensed in methanol with aromatic aldehydes in the presence of catalytic amounts of mineral acids.Several of the new compounds behave as pH indicators.The condensation products, obtained from suitably functionalized starting products, can be easily oxidised giving rise to new triphenylmethane-type dyes, such as 10.

Note that a catalyst decreases the activation energy for both the forward and the reverse reactions and hence accelerates both the forward and the reverse reactions.Recommanded Product: 50551-63-8, you can also check out more blogs about50551-63-8

Reference：
Benzofuran – Wikipedia,
Benzofuran | C8H1319O – PubChem

Reference of 50551-63-8, Because a catalyst decreases the height of the energy barrier, its presence increases the reaction rates of both the forward and the reverse reactions by the same amount.50551-63-8, Name is 6-Methoxybenzofuran, molecular formula is C9H8O2. In a article，once mentioned of 50551-63-8

2,3-Dihydrobenzofurans are key pharmacophores in many natural and synthetic bioactive molecules. A biocatalytic strategy is reported here for the highly diastereo- and enantioselective construction of stereochemically rich 2,3-dihydrobenzofurans in high enantiopurity (>99.9% de and ee), high yields, and on a preparative scale via benzofuran cyclopropanation with engineered myoglobins. Computational and structure-reactivity studies provide insights into the mechanism of this reaction, enabling the elaboration of a stereochemical model that can rationalize the high stereoselectivity of the biocatalyst. This information was leveraged to implement a highly stereoselective route to a drug molecule and a tricyclic scaffold featuring five stereogenic centers via a single-enzyme transformation. This work expands the biocatalytic toolbox for asymmetric C?C bond transformations and should prove useful for further development of metalloprotein catalysts for abiotic carbene transfer reactions.

A reaction mechanism is the microscopic path by which reactants are transformed into products. Each step is an elementary reaction. In my other articles, you can also check out more blogs about 50551-63-8

Reference：
Benzofuran – Wikipedia,
Benzofuran | C8H1330O – PubChem

Chemistry is an experimental science, and the best way to enjoy it and learn about it is performing experiments. COA of Formula: C9H8O2. Introducing a new discovery about 50551-63-8, Name is 6-Methoxybenzofuran

This invention is to provide a compound of the formula: wherein R1 is an optionally substituted 5- to 6-membered ring; the ring A is an optionally substituted 6- to 7-membered ring; the ring B is an optionally substituted benzene ring; n is an integer of 1 or 2; Z is a chemical bond or a divalent group; R2 is (1) an optionally substituted amino group in which a nitrogen atom may form a quaternary ammonium, (2) an optionally substituted nitrogen-containing heterocyclic ring group which may contain a sulfur atom or an oxygen atom as ring constituting atoms and wherein a nitrogen atom may form a quaternary ammonium, (3) a group binding through a sulfur atom or (4) a group of the formula: ?wherein k is 0 or 1, and when k is 0, a phosphorus atom may form a phosphonium; and R5 and R6 are independently an optionally substituted hydrocarbon group, an optionally substituted hydroxy group or an optionally substituted amino group, and R5 and R6 may bind to each other to form a cyclic group together with the adjacent phosphorus atom, or a salt thereof , which is useful for antagonizing CCR5 and also for the prevention and treatment of infectious disease of HIV.

Note that a catalyst decreases the activation energy for both the forward and the reverse reactions and hence accelerates both the forward and the reverse reactions.COA of Formula: C9H8O2, you can also check out more blogs about50551-63-8

Reference：
Benzofuran – Wikipedia,
Benzofuran | C8H1318O – PubChem

Reference of 50551-63-8, Because a catalyst decreases the height of the energy barrier, its presence increases the reaction rates of both the forward and the reverse reactions by the same amount.50551-63-8, Name is 6-Methoxybenzofuran, molecular formula is C9H8O2. In a article，once mentioned of 50551-63-8

2-(5-Resorcinyl)benzofurans have been synthesised by the palladium catalysed cross coupling of 2-trimethylstannyl- or 2-bromozinc benzofurans with the appropriately functionalised 5-iodoresorcinols.These were synthesised by the tri-isopropylsilyloxy directed remote (C-5) lithiation/iodination of the O,O-di(triisopropylsilyl)resorcinoltricarbonylchromium(0) complex.The method was applied to the synthesis of moracin M, a phytoalexin of Morus alba Linn.

A reaction mechanism is the microscopic path by which reactants are transformed into products. Each step is an elementary reaction. In my other articles, you can also check out more blogs about 50551-63-8

Reference：
Benzofuran – Wikipedia,
Benzofuran | C8H1323O – PubChem

One of the major reasons for studying chemical kinetics is to use measurements of the macroscopic properties of a system, name: 6-Methoxybenzofuran, such as the rate of change in the concentration of reactants or products with time.In a article, mentioned the application of 50551-63-8, Name is 6-Methoxybenzofuran, molecular formula is C9H8O2

An efficient and environmentally benign heterogeneous catalytic process for the synthesis of 2,3-unsubstituted benzo[b]furans has been established via the intramolecular cyclization of 2-aryloxyacetaldehyde acetals. By utilizing tin-exchanged H-beta zeolite (Sn-beta) as catalyst, a wide range of functionalized 2,3-unsubstituted benzo[b]furans could be prepared in good to excellent yields. The Sn-beta zeolite catalyst also exhibited excellent shape selectivity on the cyclization of meta-substituted 2-aryloxyacetaldehyde acetals, and 6-substituted isomers were preferably formed up to 97% regio-selectivity. Moreover, Sn-beta zeolite could be easily recovered and reused without any noticeable activity loss.

Sometimes chemists are able to propose two or more mechanisms that are consistent with the available data. name: 6-Methoxybenzofuran, If a proposed mechanism predicts the wrong experimental rate law, however, the mechanism must be incorrect.Welcome to check out more blogs about 50551-63-8, in my other articles.

Reference：
Benzofuran – Wikipedia,
Benzofuran | C8H1327O – PubChem

Synthetic Route of 50551-63-8, Catalysts function by providing an alternate reaction mechanism that has a lower activation energy than would be found in the absence of the catalyst. In some cases, the catalyzed mechanism may include additional steps.In a article, 50551-63-8, molcular formula is C9H8O2, introducing its new discovery.

An optimized process for the preparation of 6-hydroxybenzofuran is described. This process consists of three steps: the reaction of 2-hydroxy-4-methoxybenzaldehyde with chloroacetic acid, the formation of the 6-methoxybenzofuran in acetic anhydride, and the demethylation with sodium 1-dodecanethiolate to afford the desired product. The entire process is safe, cost effective, environmentally benign, and scalable. A production scale of over 2.6 kg product was achieved in good overall yield.

The proportionality constant is the rate constant for the particular unimolecular reaction. the reaction rate is directly proportional to the concentration of the reactant. I hope my blog about 50551-63-8 is helpful to your research. Synthetic Route of 50551-63-8

Reference：
Benzofuran – Wikipedia,
Benzofuran | C8H1326O – PubChem

One of the major reasons for studying chemical kinetics is to use measurements of the macroscopic properties of a system, HPLC of Formula: C9H8O2, such as the rate of change in the concentration of reactants or products with time.In a article, mentioned the application of 50551-63-8, Name is 6-Methoxybenzofuran, molecular formula is C9H8O2

The reaction of 2,3-dichloro-5,6-dicyano-p-benzoquinone (DDQ) with 6-methoxy-3-methylbenzofuran gave carbon-oxygen adduct.The reaction in less polar solvents such as benzene and CH2Cl2 proceeds faster than that in more polar solvents such as THF and dioxane.In contrast, the reaction of DDQ with indoles gave carbon-carbon adducts.This reaction proceeds rapidly with increasing solvent polarity.

One of the oldest and most widely used commercial enzyme inhibitors is aspirin, HPLC of Formula: C9H8O2, which selectively inhibits one of the enzymes involved in the synthesis of molecules that trigger inflammation. you can also check out more blogs about 50551-63-8

Reference：
Benzofuran – Wikipedia,
Benzofuran | C8H1328O – PubChem