New learning discoveries about 23145-07-5

As the paragraph descriping shows that 23145-07-5 is playing an increasingly important role.

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.23145-07-5,5-Bromobenzofuran,as a common compound, the synthetic route is as follows.

23145-07-5, Under a nitrogen stream, 5-bromo-benzofuran (25g, 0.126mol), 4,4,4′,4′,5,5,5′,5′-octamethyl-2,2′-bi-(1,3,2-dioxaborolane) (38.67g, 0.152mol), Pd(dppf)Cl2 (3.11g, 3mol%), KOAc (37.36g, 0.381mol) and 1,4-dioxane (500ml) were mixed, and the mixture was stirred for 12 hours at 130 C. After completion of the reaction, and extracted with ethyl acetate, to remove water with MgSO4, KaramukuroMatogurafi By (hexane:: EA = 10 1 (v / v)), 2-(benzofuran-5-yl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane(23.23g, 75% yield).

As the paragraph descriping shows that 23145-07-5 is playing an increasingly important role.

Reference£º
Patent; DOOSAN CORPORATION; KIM, HOE MOON; KIM, SUNG MOO; KIM, YOUNG BAE; KIM, TAE HYUNG; PARK, HO CHEOL; LEE, CHANG JUN; BACK, YOUNG MI; SHIN, JIN YONG; (222 pag.)JP2016/40292; (2016); A;,
Benzofuran – Wikipedia
Benzofuran | C8H6O – PubChem

New learning discoveries about 23145-07-5

As the paragraph descriping shows that 23145-07-5 is playing an increasingly important role.

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.23145-07-5,5-Bromobenzofuran,as a common compound, the synthetic route is as follows.

2.25 g of magnesium for a Grignard reaction in 15 ml of anhydrous THF are placed in a round-bottomed flask equipped with a mechanical stirrer, and under a stream of nitrogen.A mixture of 13.6 g of 5-bromobenzofuran in 35 ml of anhydrous THF is then added.The mixture is stirred for one hour, followed by addition of a solution of 5 g of 4,6-dichloro-1H-indole-2,3-dione in 50 ml of anhydrous THF.The mixture is stirred at room temperature for 4 hours 30 minutes.Water is added and the resulting mixture is extracted with ethyl acetate.The organic phase is separated out, dried over Na2SO4, filtered and evaporated under vacuum.The residue is taken up in ethyl acetate and washed with 1N sodium hydroxide solution.The organic phase is dried over Na2SO4, filtered and evaporated under vacuum.The solid is taken up in ethyl ether and filtered off. 4.2 g of expected product are obtained.TLC: 6/4 hexane/EtOAc, Rf=0.35, 23145-07-5

As the paragraph descriping shows that 23145-07-5 is playing an increasingly important role.

Reference£º
Patent; SANOFI; US2012/40996; (2012); A1;,
Benzofuran – Wikipedia
Benzofuran | C8H6O – PubChem

Brief introduction of 23145-07-5

The synthetic route of 23145-07-5 has been constantly updated, and we look forward to future research findings.

23145-07-5, 5-Bromobenzofuran is a benzofuran compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Compound 4 (5-bromobenzofuran, 5.4 g, 27.5 mmol),Compound 13 (4,4,5,5-tetramethyl-2-(4-(tetrahydro-2H-pyran-2-yloxy)phenyl)-1,3,2-dioxaborolan , 7.6g, 25.0mmol) dissolved in MeOH(8.0 mL, 1 mL/g), toluene (80.0 mL, 10 mL/g),Further, Cs2CO3 (16.3 g, 50.0 mmol) was added, followed by nitrogen.Pd(PPh3)4 (1.4 g, 1.2 mmol) was added under nitrogen.It was then stirred under reflux for 3 hours. After the reaction,The reaction was filtered through celite and concentrated under reduced pressure.Silica gel column chromatography (hexane: EtOAc = 5:1)Purification was carried out to give a white solid compound 14 (5.3 g, yield 72percent).

The synthetic route of 23145-07-5 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Dongjin Shimeiken Co., Ltd.; Cui Zhenyu; Jiang Bingnan; Yin Xingyi; Song Zhenyin; Jin Xingxie; Li Dongxuan; Cui Zhien; Li Xuanzhi; Shen Guichun; (45 pag.)CN109206387; (2019); A;,
Benzofuran – Wikipedia
Benzofuran | C8H6O – PubChem

Some tips on 23145-07-5

23145-07-5 5-Bromobenzofuran 90015, abenzofuran compound, is more and more widely used in various.

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.23145-07-5,5-Bromobenzofuran,as a common compound, the synthetic route is as follows.

Under a nitrogen stream, 5-bromobenzofuran (25 g, 0.126 mol), 4,4,4 ‘, 4,5,5,5,5-octamethyl-2,2’-bi (1,3,2-dioxaborolane) (38.67 g, 0.152 Dioxane (500 ml), and the mixture was stirred at 130 C for 12 hours. The reaction was terminated. The mixture was extracted with ethyl acetate, the water was removed with MgSO 4 and purified by column chromatography to obtain 23.23 g of benzofuran-5-yl) -4,4,5,5-etramethyl-1,3,2-dioxaborolane , Yield: 75%).

23145-07-5 5-Bromobenzofuran 90015, abenzofuran compound, is more and more widely used in various.

Reference£º
Patent; Doosan Co., ltd; Kim, Tae Hyoung; Kim, Song Mu; Lee, Chang Jun; Sin, Jin Yong; Baek, Young Mi; Park, Ho Chul; (40 pag.)KR101599586; (2016); B1;,
Benzofuran – Wikipedia
Benzofuran | C8H6O – PubChem