Category: 127264-14-6

127264-14-6, Name is 5-(2-Bromoethyl)-2,3-dihydrobenzofuran, belongs to benzofuran compound, is a common compound. Recommanded Product: 5-(2-Bromoethyl)-2,3-dihydrobenzofuranIn an article, once mentioned the new application about 127264-14-6.

Structural modifications to tetrahydropyridine-3-carboxylate esters en route to the discovery of M5-preferring muscarinic receptor orthosteric antagonists

The M5 muscarinic acetylcholine receptor is suggested to be a potential pharmacotherapeutic target for the treatment of drug abuse. We describe herein the discovery of a series of M5-preferring orthosteric antagonists based on the scaffold of 1,2,5,6-tetrahydropyridine-3- carboxylic acid. Compound 56, the most selective compound in this series, possesses an 11-fold selectivity for the M5 over M1 receptor and shows little activity at M2-M4. This compound, although exhibiting modest affinity (Ki = 2.24 muM) for the [3H]N-methylscopolamine binding site on the M5 receptor, is potent (IC50 = 0.45 nM) in inhibiting oxotremorine-evoked [3H]DA release from rat striatal slices. Further, a homology model of human M5 receptor based on the crystal structure of the rat M3 receptor was constructed, and docking studies of compounds 28 and 56 were performed in an attempt to understand the possible binding mode of these novel analogues to the receptor.

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Benzofuran – Wikipedia,
Benzofuran | C8H3843O – PubChem

Application of 127264-14-6, The reaction rate of a catalyzed reaction is faster than the reaction rate of the uncatalyzed reaction at the same temperature.127264-14-6, Name is 5-(2-Bromoethyl)-2,3-dihydrobenzofuran, molecular formula is C10H11BrO. In a Patent£¬once mentioned of 127264-14-6

PYRROLIDINE DERIVATIVES

Compounds of the formula STR1 wherein R, Y and R 1 are as defined in the specification. These compounds are muscarinic receptor antagonists which are selective for smooth muscle muscarinic sites over cardiac muscarinic sites, and are useful in the treatment of diseases associated with altered motility on tone of smooth muscle, including irritable bowel syndrome, diverticular disease, urinary incontinence, oesophageal achalasia and chronic obstructive airways disease.

We¡¯ll also look at important developments in the pharmaceutical industry because understanding organic chemistry is important in understanding health, medicine, the role of 127264-14-6, and how the biochemistry of the body works.Application of 127264-14-6

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Benzofuran – Wikipedia,
Benzofuran | C8H3820O – PubChem

In heterogeneous catalysis, the catalyst is in a different phase from the reactants. Quality Control of 5-(2-Bromoethyl)-2,3-dihydrobenzofuran, At least one of the reactants interacts with the solid surface in a physical process called adsorption in such a way. 127264-14-6, name is 5-(2-Bromoethyl)-2,3-dihydrobenzofuran. In an article£¬Which mentioned a new discovery about 127264-14-6

OXAZOLE AND THIAZOLE DERIVATIVES AND THEIR USES

A quaternary ammonium compound of formula (I) having M3 receptor antagonist activity; a composition comprising such a compound; the use of such a compound in therapy (such as asthma or COPD); and a method of treating a patient with such a compound.

I hope this article can help some friends in scientific research. I am very proud of our efforts over the past few months and hope to 127264-14-6, help many people in the next few years.Quality Control of 5-(2-Bromoethyl)-2,3-dihydrobenzofuran

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Benzofuran – Wikipedia,
Benzofuran | C8H3831O – PubChem

Related Products of 127264-14-6, The reaction rate of a catalyzed reaction is faster than the reaction rate of the uncatalyzed reaction at the same temperature.127264-14-6, Name is 5-(2-Bromoethyl)-2,3-dihydrobenzofuran, molecular formula is C10H11BrO. In a Article£¬once mentioned of 127264-14-6

A new solvent system (Cyclopentyl methyl ether-water) in process development of darifenacin HBr

Darifenacin is a potent and competitive M3 selective receptor antagonist (M3SRA), and its hydrobromide salt (1) is the active ingredient of pharmaceutical formulations for oral treatment of urinary incontinence. The present work demonstrates an efficient, commercial manufacturing process for darifenacin hydrobromide (1).

A reaction mechanism is the microscopic path by which reactants are transformed into products. Each step is an elementary reaction. In my other articles, you can also check out more blogs about 127264-14-6

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Benzofuran – Wikipedia,
Benzofuran | C8H3840O – PubChem

127264-14-6, Name is 5-(2-Bromoethyl)-2,3-dihydrobenzofuran, belongs to benzofuran compound, is a common compound. Product Details of 127264-14-6In an article, once mentioned the new application about 127264-14-6.

A METHOD FOR THE PREPARATION OF DARIFENACIN HYDROGEN BROMIDE

A method of preparing (3S)-l-[2-(2,3-dihydro-5-benzofuranyl)ethyl}-alpha,alpha-diphenyl-3- pyrrolidine acetamide hydrogen bromide, wherein 3-(S)-(I -carbamoyl- 1,1- diphenylmethyl)pyrrolidine or its salt with an organic acid is alkylated in the presence of an inorganic base with 5-(2-bromoethyl)-2,3-dihydrobenzofurane in a heterogeneous system of the solvents water and an organic solvent selected from C6 to C9 aliphatic, alicyclic or aromatic hydrocarbons, after separation of the two phases the crude darifenacin base is isolated, which is converted to the hydrobromide by addition of a C3 to C9 ketone or C3 to C9 alcohol and concentrated hydrobromic acid.

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Benzofuran – Wikipedia,
Benzofuran | C8H3826O – PubChem

In heterogeneous catalysis, the catalyst is in a different phase from the reactants. SDS of cas: 127264-14-6, At least one of the reactants interacts with the solid surface in a physical process called adsorption in such a way. 127264-14-6, name is 5-(2-Bromoethyl)-2,3-dihydrobenzofuran. In an article£¬Which mentioned a new discovery about 127264-14-6

1-SUBSTITUTED-3-PYRROLIDINE DERIVATIVES AS MUSCARINIC RECEPTOR ANTAGONISTS

This invention generally relates to the derivatives of 1-substituted-3-pyrroli dines having the structure of Formula (I): The compounds of this invention can function as..muscarinic receptor antagonists, and can be used for the treatment of various diseases of the respiratory, urinary and gastrointestinal systems mediated through muscarinic receptors. The invention also relates to a process for the preparation of the compounds of the present invention. pharmaceutical compositions containing the compounds of the present invention and the methods for treating the diseases mediated through muscarinic receptors.

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Benzofuran – Wikipedia,
Benzofuran | C8H3812O – PubChem

127264-14-6, 5-(2-Bromoethyl)-2,3-dihydrobenzofuran is a benzofuran compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

EXAMPLE 3; This example illustrates a process for preparing (S)-2-{1-[2-(2,3-dihydrobenzofuran-5-yl)ethyl]-3-pyrrolidinyl}-2,2-diphenylacetamide or a salt thereof wherein a substantially enantiomerically pure 2,2-diphenyl-2-[(3S)-pyrrolidin-3-yl]acetamide or salt thereof, as determined by the inventive method, is used as an intermediate compound. In particular, this example illustrates that when using 2,2-diphenyl-2-[(3S)-pyrrolidin-3-yl]acetamide having less than 0.2percent of the (R)-enantiomer as determined by the HPLC method of Example 1, the obtained (S)-darifenacin hydrobromide has less than 0.06percent of the (R)-enantiomer of darifenacin hydrobromide as determined by the HPLC method of Example 2.To a flask was added: 2,2-diphenyl-2-[(3S)-pyrrolidin-3-yl]acetamide (54.15 g, 125.8 mmol, 99.63percent ee as determined by chiral HPLC method of Example 1), 5-(2-bromoethyl)-2,3-dihydrobenzofuran (34.86 g, 153.5 mmol), potassium hydroxide (20.78 g, 370.4 mmol), methyltriethylammonium chloride (2.810 g, 18.53 mmol), methylethylketone (170 mL) and water (34.0 mL). The reaction mixture was heated to reflux (approximately 75¡ã C.) and stirred for 6 hours, after which time the reaction mixture was cooled to 20-25¡ã C. After cooling, methylethylketone (96 mL) and water (106 mL) were added with stirring and the layers were separated. Ammonium chloride (106 mL, 10percent aqueous solution) was added to the organic layer with stirring and the layers were separated. The organic layer was evaporated to dryness and methylethylketone (106 mL) was added to the residue. The mixture was stirred until dissolution and hydrobromic acid (13 mL) was added, after which a precipitate formed. The resulting suspension was cooled to 0-5¡ã C. and stirred at this temperature for 2 hours. The suspension was filtered and the solid was washed with methylethylketone (2.x.20 mL). A solid was obtained (90.72 g, l.o.d.=41.51percent, 84.92percent yield, 95.68percent HPLC purity, 99.88percent ee as determined by chiral HPLC method of Example 2).

127264-14-6, The synthetic route of 127264-14-6 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Medichem, S.A.; US2008/312455; (2008); A1;,
Benzofuran – Wikipedia
Benzofuran | C8H6O – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.127264-14-6,5-(2-Bromoethyl)-2,3-dihydrobenzofuran,as a common compound, the synthetic route is as follows.

2,2-Diphenyl-2-pyrrolidin-3-yl-acetamide (2, 2.8 g, 0.01 mol) and 5-(2-bromoethyl)-2,3-dihydrobenzofuran (3, 4.54 g, 0.02 mol) were refluxed in acetone (70 mL) containing K2CO3 (2.76 g, 0.02 mol). After completion of the reaction mass was concentrated under vacuum and the obtained residue was poured into water. The separated solid was filtered and dried. The crude product was purified over silica gel column using MDC: MeOH (99:1 to 96:4) as eluent to obtain product in 4 g yield. IR (KBr): 3220, 3056, 2946, 2856, 1698, 1614, 1491, 1443, 1359, 1243, 1219, 1101, 1076, 814, 752,701 cm-1; 1H MNR (300 MHz, CDCl3): delta 0.68 (m, 1H), 1.40-1.44 (m, 1H), 2.41-2.61 (m, 2H), 2.41-2.61 (m, 2H), 2.75-3.16 (m, 1H), 2.78 (m, 1H), 3.08 (t, J=8.6 Hz, 2H), 3.20-3.25 (m, 1H), 3.23-3.60 (m, 1H), 3.38-3.43 (m, 1H), 4.44 (t, J=8.9 Hz, 2H), 6.62 (d, J=8.1 Hz, 1H), 6.84 (d, J=8.1 Hz, 1H), 6.90 (d, J=6.9 Hz, 4H), 6.98 (s, 1H), 7.20-7.33 (m, 2H), 7.40 (d, J=6.6 Hz, 4H), 8.15 (brs, 1H); 13C NMR (75 MHz, CDCl3): delta 27.55, 29.06, 32.22, 40.06, 43.41, 50.94, 70.58, 108.36, 125.16, 126.33, 126.51, 126.96, 127.46, 127.69, 127.77, 128.55, 132.13, 141.18, 141.73, 157.81, 176.85; DIP MS: m/z (percent) 573 [M+H]+ (100). Anal. Calcd for C38H40N2O3: C, 79.69; H, 7.04; N, 4.89. Found: C, 79.48; H, 7.10; N, 4.79percent., 127264-14-6

The synthetic route of 127264-14-6 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Vasantha; Lakshmanarao; Srinivasa Rao; Sivalakshmi Devi; Venkata Suryanarayana; Indian Journal of Chemistry – Section B Organic and Medicinal Chemistry; vol. 52; 6; (2013); p. 824 – 828;,
Benzofuran – Wikipedia
Benzofuran | C8H6O – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.127264-14-6,5-(2-Bromoethyl)-2,3-dihydrobenzofuran,as a common compound, the synthetic route is as follows.

Advanced intermediate VII (4.3 g; 0.01 mol) is stirred up in an aqueous solution of potassium carbonate (6.1 g; 0.044 mol in 20 ml of water) at the laboratory temperature. A toluene solution (20 ml) of intermediate VIII (2.41 g; 0.011 mol) is added to the mixture and the mixture is heated in an oil bath T=90 ¡ãC while being stirred for 3.5 h. After cooling the toluene layer is separated and the aqueous layer is extracted with toluene. The combined toluene extracts are shaken with water and the solvent is distilled off at a reduced pressure. The evaporation residue is dissolved in ethylmethylketone, and an equimolar amount of 48percent hydrobromic acid is added. The separated darifenacine hydrobromide is filtered off and dried.Yield: 86percent of theory.

127264-14-6, 127264-14-6 5-(2-Bromoethyl)-2,3-dihydrobenzofuran 21831160, abenzofuran compound, is more and more widely used in various fields.

Reference£º
Patent; ZENTIVA, K.S.; WO2009/94957; (2009); A1;,
Benzofuran – Wikipedia
Benzofuran | C8H6O – PubChem

127264-14-6, 5-(2-Bromoethyl)-2,3-dihydrobenzofuran is a benzofuran compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

EXAMPLE 13Preparation of (R)-3-((bis(3-fluorophenyl)methoxy)carbonylamin l-(2-(2,3-dihydrobenzofuran-5-yl)ethyl)-l-azoniabicyclo[2.2.2]octane bromide (compound 32)To a solution of (R)-bis(3-fluorophenyl)methyl quinuclidin-3- ylcarbamate (53 mg, 0.14 mmol, prepared as in example 1) in ethyl acetate (2 ml), 5-(2-bromoethyl)-2,3-dihydrobenzofuran (32.3 mg, 0.14 mmol) was added. The resulting mixture was stirred at room temperature for 8 days and then the solvent was evaporated and the crude was purified by flash chromatography (DCM/MeOH=95/5) to collect (R)-3-((bis(3-fluorophenyl)- methoxy)carbonylamino)- l-(2-(2,3-dihydrobenzofuran-5-yl)ethyl)-l- azoniabicyclo[2.2.2]octane bromide (22.2 mg).1H NMR (300 MHz, DMSO-d6) delta ppm 8.08 (d, 1 H), 7.36 – 7.51 (m, 2H), 7.26 (d, 4 H), 7.06 – 7.19 (m, 3 H), 7.00 (d, 1 H), 6.64 – 6.81 (m, 2 H), 4.50 (t, 2 H), 3.92 – 4.13 (m, 1 H), 3.83 (t, 1 H), 3.37 – 3.59 (m, 4 H), 3.33 (d, 2 H), 3.19 – 3.25 (m, 1 H), 3.15 (t, 2 H), 2.90 (m, 2 H), 2.04 – 2.25 (m, 2 H), 1.68 – 2.04 (m, 3 H);LC-MS (ESI POS): 519.30 (M+)., 127264-14-6

As the paragraph descriping shows that 127264-14-6 is playing an increasingly important role.

Reference£º
Patent; CHIESI FARMACEUTICI S.p.A.; AMARI, Gabriele; RICCABONI, Mauro; DE ZANI, Daniele; WO2012/146515; (2012); A1;,
Benzofuran – Wikipedia
Benzofuran | C8H6O – PubChem