Chemistry can be defined as the study of matter and the changes it undergoes. 54008-77-4. You¡¯ll sometimes hear it called the central science because it is the connection between physics and all the other sciences, starting with biology.54008-77-4, Name is 2-Bromobenzofuran, molecular formula is C8H5BrO, introducing its new discovery.
Design and synthesis of 4-heteroaryl 1,2,3,4-tetrahydroisoquinolines as triple reuptake inhibitors
(Chemical Equation Presented) A series of 4-bicyclic heteroaryl 1,2,3,4-tetrahydroisoquinoline inhibitors of the serotonin transporter (SERT), norepinephrine transporter (NET), and dopamine transporter (DAT) was discovered. The synthesis and structure-activity relationship (SAR) of these triple reuptake inhibitors (TRIs) will be discussed. Compound 10i (AMR-2), a very potent inhibitor of SERT, NET, and DAT, showed efficacy in the rat forced-swim and mouse tail suspension models with minimum e ffective doses of 0.3 and 1 mg/kg (po), respectively. At efficacious doses in these assays, 10i exhibited substantial occupancy levels at the three transporters in both rat and mouse brain. The study of the metabolism of 10i revealed the formation of a significant active metabolite, compound 13.
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Reference£º
Benzofuran – Wikipedia,
Benzofuran | C8H3245O – PubChem