Day: November 22, 2022

Development and validation of an ultra-performance liquid chromatography method for the determination of wedelolactone in rat plasma and its application in a pharmacokinetic study was written by Chen, Qing;Wu, Xiaoxue;Gao, Xuemin;Song, Hua;Zhu, Xuan. And the article was included in Molecules in 2019.Related Products of 524-12-9 The following contents are mentioned in the article:

Wedelolactone is a coumarin ether with significant hepatoprotective effects. However, there are few pharmacokinetic studies of wedelolactone, which will affect the studies of its efficacy and potential toxicity. In this study, a selective ultra-performance liquid chromatog. (UPLC) method was developed to confirm the pharmacokinetic parameters of wedelolactone in rat plasma. The chromatog. separation was carried out on a Kromasil C18 UPLC column (250 × 4.6 mm; 5.0 mum) by gradient mobile phase of methanol-water containing 0.5% acetic acid (volume/volume). Perfect linearity was obtained and the samples were stable under different conditions. The intra-day and inter-day precisions (relative standard deviation, %) were within 3.81% and accuracies (relative error, %) ranged from -4.01% to 7.12%. The extraction recoveries in rat plasma ranged from 95.98% to 108.93%. This rapid method was successfully applied in the pharmacokinetic study of wedelolactone in rat plasma. Following the oral administration of 5.00 mg/kg wedelolactone, the wedelolactone was rapidly absorbed. Pharmacokinetic parameters were used to quant. describe the dynamic changes of wedelolactone in vivo, providing a theor. basis for pharmacol. research on drugs and preclin. medication. The study of wedelolactone can provide a theor. basis and quick anal. for the study of other traditional Chinese medicine. This study involved multiple reactions and reactants, such as 1,8,9-Trihydroxy-3-methoxy-6H-benzofuro[3,2-c]chromen-6-one (cas: 524-12-9Related Products of 524-12-9).

1,8,9-Trihydroxy-3-methoxy-6H-benzofuro[3,2-c]chromen-6-one (cas: 524-12-9) belongs to benzofurans derivatives. Benzofuran is the “”parent”” of many related compounds with more complex structures. For example, psoralen is a benzofuran derivative that occurs in several plants. Benzofurans have also made significant and distinctive contributions to biology. They exhibit several biological activities that range from antioxidant, antitubercular, antiplasmodial, insecticidal.Related Products of 524-12-9

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Caspase-1 Specific Light-Up Probe with Aggregation-Induced Emission Characteristics for Inhibitor Screening of Coumarin-Originated Natural Products was written by Lin, Hao;Yang, Haitao;Huang, Shuai;Wang, Fujia;Wang, Dong-Mei;Liu, Bin;Tang, Yi-Da;Zhang, Chong-Jing. And the article was included in ACS Applied Materials & Interfaces in 2018.Formula: C16H10O7 The following contents are mentioned in the article:

Caspase-1 is a key player in pyroptosis and inflammation. Caspase-1 inhibition is found to be beneficial to various diseases. Coumarin-originated natural products have an anti-inflammation function, but their direct inhibition effect to caspase-1 remains unexplored. To evaluate their interactions, the widely used com. coumarin-based probe (Ac-YVAD-AMC) is not suitable, as the background signal from coumarin-originated natural products could interfere with the screening results. Therefore, fluorescent probes using a large Stokes shift could help solve this problem. In this work, we chose the fluorophore of tetraphenylethylene-thiophene (TPETH) with aggregation-induced emission characteristics and a large Stokes shift of about 200 nm to develop a mol. probe. Bioconjugation between TPETH and hydrophilic peptides (DDYVADC) through a thiol-ene reaction generated a light-up probe, C1-P3. The probe has little background signal in aqueous media and exerts a fluorescent turn-on effect in the presence of caspase-1. Moreover, when evaluating the inhibition potency of coumarin-originated natural products, the new probe could generate a true and objective result but not for the com. probe (Ac-YVAD-AMC), which is evidenced by HPLC anal. The quick light-up response and accurate screening results make C1-P3 very useful in fundamental study and inhibitor screening toward caspase-1. This study involved multiple reactions and reactants, such as 1,8,9-Trihydroxy-3-methoxy-6H-benzofuro[3,2-c]chromen-6-one (cas: 524-12-9Formula: C16H10O7).

1,8,9-Trihydroxy-3-methoxy-6H-benzofuro[3,2-c]chromen-6-one (cas: 524-12-9) belongs to benzofurans derivatives.Benzofuran is one of the most significant oxygen-containing heterocycles consisting of fused benzene and furan ring, which are widely presented in various naturally occurring and synthetically active compounds. Benzofurans are stable towards alkali and readily polymerize on treatment with sulfuric acid, due to which they are useful for the preparation of low cost chemically relatively inert resins.Formula: C16H10O7

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Phytochemical and antioxidant assay of Eclipta alba (L.) leaf extract was written by Tripathi, K. Sharad;Jha, Saket;Dikshit, Anupam;Kumar, Rajesh. And the article was included in International Journal of Pharmaceutical Sciences and Research in 2021.Category: benzofurans The following contents are mentioned in the article:

Currently, pharmacol. activities of Eclipta alba (L.) plant extracts and individual phytoconstituents have revealed anticancer, hepatoprotective, snake venom neutralizing, anti-inflammatory and antimicrobial properties. The role of antioxidants is increasing day by day due to their multiple roles to reduce the harmful effects of oxidative stress. Phytoconstituents like wedelolactone and ursolic and oleanolic acids as well as luteolin and apigenin can form the basis of new drugs against cancer, arthritis, gastrointestinal disorders, skin diseases, and liver disorders. Plants have all these activities due to biol. active compounds, and for this, we have analyzed phytochem. screenings and antioxidant activity through the DPPH, ABTS·+, and reducing power assay and we got maximally phenols then flavonoids and flavonols and a good natural antioxidant agent. The best-known compound in E. alba i.e., Wedelolactone. It was analyzed by TLC, and it was present as 0.52 Rf value and present in pet ether extract and acetone extract and min. in ethanol extract The antioxidant activity was assessed through DPPH, ABTS·+ free radical scavenging activity and reducing power assay, this was explained in terms of effective concentration EC50 / IC₅₀ and Anti-oxidant Radical Power (ARP) values. The maximum free radical scavenging activity was showed in pet ether compared to other extracts This study involved multiple reactions and reactants, such as 1,8,9-Trihydroxy-3-methoxy-6H-benzofuro[3,2-c]chromen-6-one (cas: 524-12-9Category: benzofurans).

1,8,9-Trihydroxy-3-methoxy-6H-benzofuro[3,2-c]chromen-6-one (cas: 524-12-9) belongs to benzofurans derivatives. Benzofuran is a core structural unit found in many naturally occurring compounds with multidirectional biological activities. Substituted benzofurans find applications such as fluorescent sensors, oxidants, in drug discovery, and in another field of chemistry and agriculture.Category: benzofurans

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Wedelolactone improves the renal injury induced by lipopolysaccharide in HK-2 cells by upregulation of protein tyrosine phosphatase non-receptor type 2 was written by Zhi, Deyuan;Zhang, Meng;Lin, Jin;Liu, Pei;Wang, Yajun;Duan, Meili. And the article was included in Journal of International Medical Research in 2021.Synthetic Route of C16H10O7 The following contents are mentioned in the article:

To explore the effects of wedelolactone (WEL) on sepsis-induced renal injury in the human renal proximal tubular epithelial cell line HK-2. HK-2 cells were stimulated by 1μg/mL lipopolysaccharide (LPS) to trigger renal injury in vitro. HK-2 cells were pretreated with or without WEL (0.1, 1 and 10μM) before LPS stimulation. Protein and mRNA analyses were performed using enzyme-linked immunosorbent assays, Western blot anal. and quant. reverse transcription-polymerase chain reaction. The MTT assay and flow cytometry were used to measure cell viability and the rate of cell apoptosis. Protein tyrosine phosphatase non-receptor type 2 (PTPN2) knockdown was induced by the transection of HK-2 cells with short hairpin RNA. Cell viability was significantly increased in a dose-dependent manner by WEL in LPS-induced HK-2 cells. WEL also decreased the levels of four inflammatory cytokines and cell apoptosis in LPS-induced HK-2 cells. The level of PTPN2 was increased after WEL treatment. PTPN2 knockdown partly abolished the inhibitory effects of WEL on cell apoptosis, the levels of inflammatory cytokines and on p38 mitogen-activated protein kinase/nuclear factor-kappaB signalling in LPS-induced HK-2 cells. WEL improved renal injury by suppressing inflammation and cell apoptosis through upregulating PTPN2 in HK-2 cells. PTPN2 might be used as a potential therapeutic target for LPS-induced sepsis. This study involved multiple reactions and reactants, such as 1,8,9-Trihydroxy-3-methoxy-6H-benzofuro[3,2-c]chromen-6-one (cas: 524-12-9Synthetic Route of C16H10O7).

1,8,9-Trihydroxy-3-methoxy-6H-benzofuro[3,2-c]chromen-6-one (cas: 524-12-9) belongs to benzofurans derivatives. Benzofurans are only weakly aromatic in nature and they are cleaved by many oxidative and reductive conditions. Substituted benzofurans find applications such as fluorescent sensors, oxidants, in drug discovery, and in another field of chemistry and agriculture.Synthetic Route of C16H10O7

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Autophagy flux contributes to regulation of components of Eclipta prostrata L. on cigarette smoking-induced injury of bronchial epithelial cells was written by Ding, Shumin;Hou, Xuefeng;Wang, Gang;Qiu, Huihui;Liu, Ying;Zhou, Yuanli;Du, Mei;Tan, Xiaobin;Song, Jie;Wei, Yingjie;Shu, Luan;Li, Zhiyong;Feng, Liang;Jia, Xiaobin. And the article was included in Frontiers in Pharmacology in 2018.Electric Literature of C16H10O7 The following contents are mentioned in the article:

Excessive autophagy plays a crucial role in cigarette smoking extract (CSE)-induced inflammation response and oxidative damage of respiratory epithelial cells. The components from Eclipta prostrata L. (CCE) have been shown to be beneficial for CSE-induced epithelial cells injury. However, whether its protection on CSE-stress injury is related to its regulation on autophagy remains still unclear. In this study, CCE, containing mainly wedelolactone of 45.88% and demethylwedelolactone of 23.74%, could improve significantly 10% CSE-induced cell viability of normal human bronchial epithelial (NHBE) cells using CCK-8 kit. We revealed that CCE could remarkably increase autophagic factors Beclin-1, Atg5, ATF4 proteins expression levels and the transformation of LC3-I to LC3-II. Addnl., CCE up-regulated significantly p-p16 and p-p21 phosphorylation levels whereas down-regulated p-p53 in NHBE cells. The changes of typical autolysosom and representative autophagosome in the presence of CCE or/and autophagy inhibitor chloroquine (CQ) were also observed by transmission electron microscopy. These data demonstrated that CCE reduced CSE-induced autophagy flux activation in NHBE cells. The blockade of CCE on autophagy flux contributes to its protection against CSE-induced NHBE cells damage, and CCE is promising to be combination therapeutic mols. to excessive autophagic damage in respiratory diseases. This study involved multiple reactions and reactants, such as 1,8,9-Trihydroxy-3-methoxy-6H-benzofuro[3,2-c]chromen-6-one (cas: 524-12-9Electric Literature of C16H10O7).

1,8,9-Trihydroxy-3-methoxy-6H-benzofuro[3,2-c]chromen-6-one (cas: 524-12-9) belongs to benzofurans derivatives. Benzofuran derivatives have shown many biological activities, including antifungal and antimicrobial properties, and acting as antagonists of H3 receptors and angiotensin II. In nature, benzofurans have occupied an important role among the plant phenols & several pharmacologically active compounds.Electric Literature of C16H10O7

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

A standardized Wedelia chinensis extract overcomes the feedback activation of HER2/3 signaling upon androgen-ablation in prostate cancer was written by Tsai, Chin-Hsien;Tzeng, Sheue-Fen;Hsieh, Shih-Chuan;Tsai, Chia-Jui;Yang, Yu-Chih;Tsai, Mong-Hsun;Hsiao, Pei-Wen. And the article was included in Frontiers in Pharmacology in 2017.Recommanded Product: 524-12-9 The following contents are mentioned in the article:

Crosstalk between the androgen receptor (AR) and other signaling pathways in prostate cancer (PCa) severely affects the therapeutic outcome of hormonal therapy. Although anti-androgen therapy prolongs overall survival in PCa patients, resistance rapidly develops and is often associated with increased AR expression and upregulation of the HER2/3-AKT signaling pathway. However, single agent therapy targeting AR, HER2/3 or AKT usually fails due to the reciprocal feedback loop. Previously, we reported that wedelolactone, apigenin, and luteolin are the active compounds in Wedelia chinensis herbal extract, and act synergistically to inhibit the AR activity in PCa. Here, we further demonstrated that an herbal extract of W. chinensis (WCE) effectively disrupted the AR, HER2/3, and AKT signaling networks and therefore enhanced the therapeutic efficacy of androgen ablation in PCa. Furthermore, WCE remained effective in suppressing AR and HER2/3 signaling in an in vivo adapted castration-resistant PCa (CRPC) LNCaP cell model that was insensitive to androgen withdrawal and second-line antiandrogen, enzalutamide. This study provides preclin. evidence that the use of a defined, single plant-derived extract can augment the therapeutic efficacy of castration with significantly prolonged progression-free survival. These data also establish a solid basis for using WCE as a candidate agent in clin. studies. This study involved multiple reactions and reactants, such as 1,8,9-Trihydroxy-3-methoxy-6H-benzofuro[3,2-c]chromen-6-one (cas: 524-12-9Recommanded Product: 524-12-9).

1,8,9-Trihydroxy-3-methoxy-6H-benzofuro[3,2-c]chromen-6-one (cas: 524-12-9) belongs to benzofurans derivatives. Many natural or synthetic compounds containing benzofuran skeletons have been found to possess remarkable activity as agrochemicals and pharmaceuticals. Substituted benzofurans find applications such as fluorescent sensors, oxidants, in drug discovery, and in another field of chemistry and agriculture.Recommanded Product: 524-12-9

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Screening of medicinal plants: Rheum emodi induces interferon stimulated gene 56 (IFIT1), a antiviral protein was written by Naresh, Damuka;Saikia, Paramananda;Meetei, Potshangbam Angamba;Kanta, Abhishek;Vindal, Vaibhav. And the article was included in International Journal of Pharma Research and Health Sciences in 2018.Electric Literature of C16H10O7 The following contents are mentioned in the article:

Medicinal plants are important sources of medicines for healthcare. Several plants could offer a rich resource for agonistic mols. to cure various infectious diseases. Viruses are one of the major factors of human infectious diseases. Due to the increasing resistance to antiviral drug there is an urgent need to search for alternative agonistic compounds from plants. Plants are vital sources to induce innate immune system against viral disease. Interferon plays important role in innate immunity and mediates antiviral activity by inducing many interferon stimulating genes (ISGs) also called IFITs. ISGs block different stages of the virus replication, viral protein synthesis, and assembly of new virus particles. Among ISGs, ISG56, a component of innate immunity plays a critical role in mounting immune response against viruses. In this study, we screened plant extracts for their anti-viral properties by exploring their potential to induce ISG56 in cell culture rather than inhibition of viral protein function. Five medicinal plants were selected from NeMedPlant database. Out of the 5 ethnically known medicinal plants, Rheum emodi (RE) root extract was identified to induce ISG56 expression specifically. Therefore, the current study could provide an important insight into the development of a novel natural plant based anti-viral therapeutic from the RE extract without compromising on viral resistance. This study involved multiple reactions and reactants, such as 1,8,9-Trihydroxy-3-methoxy-6H-benzofuro[3,2-c]chromen-6-one (cas: 524-12-9Electric Literature of C16H10O7).

1,8,9-Trihydroxy-3-methoxy-6H-benzofuro[3,2-c]chromen-6-one (cas: 524-12-9) belongs to benzofurans derivatives. Benzofuran derivatives are one of the most important oxygen-containing heterocycles. Substituted benzofurans find applications such as fluorescent sensors, oxidants, in drug discovery, and in another field of chemistry and agriculture.Electric Literature of C16H10O7

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Caspase-11 promotes renal fibrosis by stimulating IL-1β maturation via activating caspase-1 was written by Miao, Nai-jun;Xie, Hong-yan;Xu, Dan;Yin, Jian-yong;Wang, Yan-zhe;Wang, Bao;Yin, Fan;Zhou, Zhuan-li;Cheng, Qian;Chen, Pan-pan;Zhou, Li;Xue, Hong;Zhang, Wei;Wang, Xiao-xia;Liu, Jun;Lu, Li-min. And the article was included in Acta Pharmacologica Sinica in 2019.Synthetic Route of C16H10O7 The following contents are mentioned in the article:

In this study, we investigated the roles of caspase-11 in the maturation of interleukin-1β (IL-1β) and development of renal interstitial fibrosis in vivo and in vitro. Mice were subjected to unilateral ureteral obstruction (UUO). The mice were treated with either caspase-11 inhibitor wedelolactone (Wed, 30 mg/kg/day, ig) for 7 days or caspase-11 siRNA (10 nmol/20 g body weight per day, iv) for 14 days. The mice were euthanized on day 14, their renal tissue and blood sample were collected. We found that the obstructed kidney had significantly higher caspase-11 levels and obvious tubular injury and interstitial fibrosis. Furthermore, caspase-11 inhibition significantly blunted caspase-1 activation, IL-1β maturation, transforming growth factor-β (TGF-β), fibronectin, and collagen I expressions in the obstructed kidney. Renal tubular epithelial NRK-52E cells were treated in vitro with angiotensin (Ang, 1μmol/L), which stimulated caspase-11 activation and IL-1β maturation. Treatment with IL-1β (20 ng/mL) significantly increased the expression of TGF-β, fibronectin, and collagen I in the cells. Ang II-induced expression of TGF-β, fibronectin, and collagen I were suppressed by caspase-11 siRNA or Wed. These results suggest that caspase-11 is involved in UUO-induced renal fibrosis. Elevation of caspase-11 in the obstructed kidney promotes renal fibrosis by stimulating caspase-1 activation and IL-1β maturation. This study involved multiple reactions and reactants, such as 1,8,9-Trihydroxy-3-methoxy-6H-benzofuro[3,2-c]chromen-6-one (cas: 524-12-9Synthetic Route of C16H10O7).

1,8,9-Trihydroxy-3-methoxy-6H-benzofuro[3,2-c]chromen-6-one (cas: 524-12-9) belongs to benzofurans derivatives. Benzofurans are only weakly aromatic in nature and they are cleaved by many oxidative and reductive conditions. Benzofurans have also made significant and distinctive contributions to biology. They exhibit several biological activities that range from antiviral, antimicrobial, antitumor, anti-inflammatory.Synthetic Route of C16H10O7

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

In-silico Design and ADMET Studies of Natural Compounds as Inhibitors of Xanthine Oxidase (XO) Enzyme was written by Malik, Neelam;Dhiman, Priyanka;Khatkar, Anurag. And the article was included in Current Drug Metabolism in 2017.Safety of 1,8,9-Trihydroxy-3-methoxy-6H-benzofuro[3,2-c]chromen-6-one The following contents are mentioned in the article:

Xanthine oxidase a ubiquitous enzyme has been found to be involved in various pathol. disorders including gout, hyperuricemia, inflammation, oxidative stress and cardiovascular diseases. Inhibitors of xanthine oxidase thus find a crucial role in the therapeutic treatment of these deadly diseases. Considering the side effects of today’s treatment regimen here we choose nature based compounds to act as xanthine oxidase inhibitors. In the present work, we performed in-silico docking of natural compounds to reveal the underlying mechanism of inhibition of xanthine oxidase. Further filtration of screened compounds with ADMET studies has been performed. An inhouse library of natural compounds screened through ADMET profile for the drug likeliness property was approached for docking studies using Schrodinger suite. Calculation of docking score was done by glide module and free binding energy calculations were performed through MM/GBSA software. Natural leads having better pharmacokinetic profile and mechanism of inhibition were obtained. Docking score, binding energy and different forces involved in interaction were calculated for the top-ranked mols. and good comparison with the standard drugs was achieved. Compounds having potential therapeutic activity with low systematic toxicity has been identified against xanthine oxidase which could serve as pharmacophore for the design and synthesis of new drug-like mols. This study involved multiple reactions and reactants, such as 1,8,9-Trihydroxy-3-methoxy-6H-benzofuro[3,2-c]chromen-6-one (cas: 524-12-9Safety of 1,8,9-Trihydroxy-3-methoxy-6H-benzofuro[3,2-c]chromen-6-one).

1,8,9-Trihydroxy-3-methoxy-6H-benzofuro[3,2-c]chromen-6-one (cas: 524-12-9) belongs to benzofurans derivatives.Benzofuran is one of the most significant oxygen-containing heterocycles consisting of fused benzene and furan ring, which are widely presented in various naturally occurring and synthetically active compounds. Benzofurans have also made significant and distinctive contributions to biology. They exhibit several biological activities that range from antioxidant, antitubercular, antiplasmodial, insecticidal.Safety of 1,8,9-Trihydroxy-3-methoxy-6H-benzofuro[3,2-c]chromen-6-one

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Identification of bioactive constituents in Coldenia procumbens L. and its antidiabetic activity against streptozotocin induced Wistar albino rats was written by Rethinam, Ganesan;Venkatanarasimhan, Mathuram. And the article was included in Journal of Complementary and Integrative Medicine in 2020.Related Products of 524-12-9 The following contents are mentioned in the article:

Type II diabetes, a multifactorial progressive disorder is the prime concern of the twenty-first century. Modern medicine is proven effective in delaying the effects of diabetes. However, the side effects are amplified over time. In order to find relief from side effects, people are rigorously searching for alternative treatment. In this study, we aim to identify the bioactive components in the Coldenia procumbens L. and assess its anti-diabetic effect. Initially, the plant was extracted using chloroform and methanol. Both the extracts were analyzed using IR Spectrum and NMR. The methanol extract of Coldenia procumbens L. was assessed for its anti-hyperglycemic activity against streptozotocin induced animals. The IR spectrum of the extracts was compared with standard compounds and four compounds, α-amyrin, β-sitosterol, β-stigmasterol and wedelolactone was identified. Methanol extract of Coldenia procumbens L. decreased glucose levels in serum and enzymes levels. Histopathol. of pancreas showed excellent recovery from the damage induced by streptozotocin. The compounds identified in Coldenia procumbens L. have significant anti-diabetic, insulin mimetic and insulin secretory activities with their complete mechanisms already studied in detail. Also, Coldenia procumbens L. methanol extract showed significant anti-hyperglycemic activity. The plant should be further studied to be developed as an alternative medicine. This study involved multiple reactions and reactants, such as 1,8,9-Trihydroxy-3-methoxy-6H-benzofuro[3,2-c]chromen-6-one (cas: 524-12-9Related Products of 524-12-9).

1,8,9-Trihydroxy-3-methoxy-6H-benzofuro[3,2-c]chromen-6-one (cas: 524-12-9) belongs to benzofurans derivatives. Benzofuran derivatives have shown many biological activities, including antifungal and antimicrobial properties, and acting as antagonists of H3 receptors and angiotensin II. They are also prone to polymerisation in the presence of concentrated mineral acids and Lewis acids.Related Products of 524-12-9

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem