Day: November 22, 2022

Isoflavones Protective Mechanisms Against Cardiovascular Diseases was written by Ramachandran, Vadivelan;Bairi, Raju;Rajagopal, Kalirajan;Elumalai, Manogaran. And the article was included in International Journal of Research in Pharmaceutical Sciences in 2020.Reference of 524-12-9 The following contents are mentioned in the article:

Isoflavones are polyphenolic compounds and a class of phytoestrogens naturally present in plants belongs to legume family and also quantified in fruits, vegetables and beverages.Soybean is rich source of isoflavones. Their chem. structure is similar to endogenously available female reproductive hormonal substance estradiol, and cellular targets are estrogen receptors. After bind to the estrogen receptors isoflavones exert estrogenic and antiestrogenic action based upon circulatory levels of estradiol. Cardiovascular diseases are leading cause of death in most of the developing countries and they may occur due to the structural and functional changes in either cardiac muscle or smooth muscle of the vasculature and both. Common cardiac diseases are heart attack, coronary heart disease, hyperlipidemia, angina pectoris, hypertension. Many epidemiol. studies data revealing that consumption of soy protein and soy enriched diet correlate with preventive chances of cardiovascular disease. The United States Food and Drug Administration (USFDA) and other countries declared that everyday consumption of food enriched soy along with low fat may decrease the risk of cardiovascular disease. In this review we attempt the mechanism based cardioprotection of isoflavones in different cardiovascular diseases. This study involved multiple reactions and reactants, such as 1,8,9-Trihydroxy-3-methoxy-6H-benzofuro[3,2-c]chromen-6-one (cas: 524-12-9Reference of 524-12-9).

1,8,9-Trihydroxy-3-methoxy-6H-benzofuro[3,2-c]chromen-6-one (cas: 524-12-9) belongs to benzofurans derivatives. Benzofurans are only weakly aromatic in nature and they are cleaved by many oxidative and reductive conditions. Benzofurans have also made significant and distinctive contributions to biology. They exhibit several biological activities that range from antiviral, antimicrobial, antitumor, anti-inflammatory.Reference of 524-12-9

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Wedelolactone inhibits human cytomegalovirus replication by targeting distinct steps of the viral replication cycle was written by Svrlanska, Adriana;Ruhland, Anna;Marschall, Manfred;Reuter, Nina;Stamminger, Thomas. And the article was included in Antiviral Research in 2020.Recommanded Product: 1,8,9-Trihydroxy-3-methoxy-6H-benzofuro[3,2-c]chromen-6-one The following contents are mentioned in the article:

Wedelolactone (WDL) is a coumestan present in the plants Eclipta prostrata and Wedelia calendulacea which are used for treatment of a multitude of health problems in traditional medicine. It has previously been shown that WDL exerts antiviral activity against human immunodeficiency virus and hepatitis C virus. In this study, we investigated the effect of WDL on lytic human cytomegalovirus (HCMV) infection. We demonstrate a strong interference with HCMV replication as analyzed in multi-round replication settings. A more detailed anal. of the underlying mechanisms revealed that WDL acts at two distinct steps of the viral replication cycle. During immediate early (IE) times, we observe an inhibition of IE1/IE2 expression. Although WDL was reported to interfere with NF-κB signaling our results suggest the existence of addnl. mechanisms that impede viral IE expression. During later time points of infection, WDL induced a disruption of the interaction between EZH2 and EED, components of the virus-supportive polycomb repressive complex 2 (PRC2). Thereby, the stability of the PRC2 complex as well as the related complex PRC1 was disturbed leading to diminished viral DNA synthesis. Taken together, we identify WDL as a potent agent against HCMV which interferes at two distinct steps of viral replication. This study involved multiple reactions and reactants, such as 1,8,9-Trihydroxy-3-methoxy-6H-benzofuro[3,2-c]chromen-6-one (cas: 524-12-9Recommanded Product: 1,8,9-Trihydroxy-3-methoxy-6H-benzofuro[3,2-c]chromen-6-one).

1,8,9-Trihydroxy-3-methoxy-6H-benzofuro[3,2-c]chromen-6-one (cas: 524-12-9) belongs to benzofurans derivatives. Benzofuran derivatives have shown many biological activities, including antifungal and antimicrobial properties, and acting as antagonists of H3 receptors and angiotensin II. Benzofurans are stable towards alkali and readily polymerize on treatment with sulfuric acid, due to which they are useful for the preparation of low cost chemically relatively inert resins.Recommanded Product: 1,8,9-Trihydroxy-3-methoxy-6H-benzofuro[3,2-c]chromen-6-one

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

MAP3K7-IKK inflammatory signaling modulates AR protein degradation and prostate cancer progression was written by Huang, Zhenlin;Tang, Bo;Yang, Yinhui;Yang, Zhaogang;Shi, Lei;Bai, Yang;Yan, Binyuan;Karnes, R. Jeffrey;Zhang, Jun;Jimenez, Rafael;Wang, Liguo;Wei, Qiang;Yang, Jinjian;Xu, Wanhai;Jia, Zhankui;Huang, Haojie. And the article was included in Cancer Research in 2021.Application of 524-12-9 The following contents are mentioned in the article:

Androgen receptor (AR) is a major survival factor for prostate cancer. Inflammation is implicated in many cancer types, including prostate cancer. Activation of MAP3K7 (also termed TAK1) and downstream IκB kinase β (IKKβ) by proinflammatory cytokines such as TNFα stimulates NF-κB survival pathways. Paradoxically, MAP3K7 is often deleted in human prostate cancer. Here, we demonstrate that AR protein expression is lower in inflammatory tumor areas compared with non-inflammatory tissues in patients with prostate cancer. Map3k7 knockout increased AR protein levels and activity in the mouse prostate, and MAP3K7 and AR protein levels were inversely correlated in prostate cancer patient specimens. TNFα treatment increased AR protein ubiquitination and proteasomal degradation Mechanistically, activation of IKKβ by TNFα induced phosphorylation and TRCP1/2 E3 ligase-mediated polyubiquitination and degradation of AR protein. TNFα suppressed prostate cancer proliferation, which could be rescued by blockade of AR degradation These findings reveal a previously unrecognized tumor suppressive function of the inflammation-activated MAP3K7-IKKβ axis in degrading AR protein. Moreover, they suggest that aberrant elevation of AR protein could be a prognostic biomarker and therapeutic target for MAP3K7-deficient prostate cancer. This study involved multiple reactions and reactants, such as 1,8,9-Trihydroxy-3-methoxy-6H-benzofuro[3,2-c]chromen-6-one (cas: 524-12-9Application of 524-12-9).

1,8,9-Trihydroxy-3-methoxy-6H-benzofuro[3,2-c]chromen-6-one (cas: 524-12-9) belongs to benzofurans derivatives. Benzofuran is a core structural unit found in many naturally occurring compounds with multidirectional biological activities. Introduction of benzofurans in organic synthesis, particularly drug synthesis, involves generally the use of their metalated species as nucleophiles in addition reactions or in metal-catalysed cross-coupling reactions.Application of 524-12-9

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Wedelolactone suppresses cell proliferation and migration through AKT and AMPK signaling in melanoma was written by Peng, Ya-Guang;Zhang, Li. And the article was included in Journal of Dermatological Treatment in 2019.Computed Properties of C16H10O7 The following contents are mentioned in the article:

Melanoma is a malignant tumor with high degree of malignancy, metastasis and high mortality. As melanoma is not sensitive to treatments, searching for new therapeutic agent is the priority. Wedelolactone (WDL) is a natural compound which has antiproliferation activities. In the current study, the effects of WDL on melanoma are evaluated and the underlying mechanisms are explored. We treated melanoma cell line MV3 cells with WDL and monitored the cell proliferation, invasion and migration, the mRNA and protein levels of Bax and Bcl-2, expression of cell-cycle regulators including cyclin D, proliferating cell nuclear antigen (PCNA) and p21. We detected the effect of WDL on AKT and AMPK signaling pathways activations. Finally, we evaluated the inhibitory effect of WDL in xenograft nude mice model in vivo. WDL inhibited MV3 cell proliferation, migration and invasion. WDL induced pro-apoptotic protein Bax expression but inhibited antiapoptotic protein Bcl-2 expression. WDL inhibited cyclin D expression while increased p21 expression. WDL inhibited AKT activation but induced AMPK activation. The induction of p21expression by WDL depended on AMPK signaling pathway. WDL inhibited melanoma in xenograft nude mice. WDL suppressed cell proliferation and regulated MV3 cell-cycle proteins through AKT and AMPK signaling in melanoma. This study involved multiple reactions and reactants, such as 1,8,9-Trihydroxy-3-methoxy-6H-benzofuro[3,2-c]chromen-6-one (cas: 524-12-9Computed Properties of C16H10O7).

1,8,9-Trihydroxy-3-methoxy-6H-benzofuro[3,2-c]chromen-6-one (cas: 524-12-9) belongs to benzofurans derivatives. Benzofuran is a core structural unit found in many naturally occurring compounds with multidirectional biological activities. Introduction of benzofurans in organic synthesis, particularly drug synthesis, involves generally the use of their metalated species as nucleophiles in addition reactions or in metal-catalysed cross-coupling reactions.Computed Properties of C16H10O7

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

A natural coumestan wedelolactone targets inflammatory cytokines to initiate apoptosis in human cervical cancer cells was written by Christobel, R. Gloria Jemmi;Jaganathan, Shyam Sundar;Abirami, M. P.;Rasappan, P.;Shila, S.. And the article was included in International Journal of Pharmaceutical Sciences and Research in 2019.Application of 524-12-9 The following contents are mentioned in the article:

Wedelolactone is a naturally (WDL) occurring coumestan of phytoestrogen category that possess anticancer and anti-inflammatory property. In this study, the anti-inflammatory effect of WDL on human cervical cancer cells (HeLa) and initiation of apoptosis mechanism were investigated. MTT assay and Trypan blue assay were demonstrated to detect the inhibitory effects of WDL on cell proliferation. The mRNA expression of IL-1β, TNFα, IL-6, TGFβ, and NF_κB were detected by RT PCR. Western blotting was performed to detect the expression of apoptosis-associated proteins; cleaved caspase-3, cleaved PARP, Bcl-2, and Bax. WDL significantly inhibited the growth and proliferation of HeLa cells in a concentration dependent manner with the IC50 of 10μM. mRNA expression of inflammatory cytokines and NFκB was significantly reduced in WDL treated groups. Moreover, WDL promoted the apoptosis of HeLa cells dose-dependently by down-regulating Bcl-2 and up-regulating cleaved caspase-3, cleaved PARP, and Bax. Collectively, WDL exerted anti-inflammatory effect through the suppression of NF-_kB activation, IL-1β, TNFα, IL-6 and promoted apoptosis in HeLa cells. Thus, use of WDL, especially through its anti-inflammatory effect, may have future applications in treating human cancers by sensitizing cancer cells to conventional cancer therapies. This study involved multiple reactions and reactants, such as 1,8,9-Trihydroxy-3-methoxy-6H-benzofuro[3,2-c]chromen-6-one (cas: 524-12-9Application of 524-12-9).

1,8,9-Trihydroxy-3-methoxy-6H-benzofuro[3,2-c]chromen-6-one (cas: 524-12-9) belongs to benzofurans derivatives. Benzofuran is the “”parent”” of many related compounds with more complex structures. For example, psoralen is a benzofuran derivative that occurs in several plants. Introduction of benzofurans in organic synthesis, particularly drug synthesis, involves generally the use of their metalated species as nucleophiles in addition reactions or in metal-catalysed cross-coupling reactions.Application of 524-12-9

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Facile green preparation of PLGA nanoparticles using wedelolactone: Its cytotoxicity and antimicrobial activities was written by Vinayagam, Ramachandran;Eun Lee, Kyung;David, Ernest;Nurul Matin, Muhammad;Gu Kang, Sang. And the article was included in Inorganic Chemistry Communications in 2021.Application In Synthesis of 1,8,9-Trihydroxy-3-methoxy-6H-benzofuro[3,2-c]chromen-6-one The following contents are mentioned in the article:

We synthesized a novel wedelolactone (I)-loaded poly-lactic-co-glycolic acid nanoparticle (WDL-PLGA NPs) and evaluated its antibacterial and induced cytotoxicity against breast cancer MDA-MB-231 cell line growth. The physicochem. properties of the WDL-PLGA NPs were defined by Fourier transform IR spectroscopy (FTIR), and dynamic scattering scanning (DLS) analyzer, and transmission microscopy (TEM) were anal. FTIR results showed that functional groups of WDL were involved in stabilizing as capping agents. The WDL-PLGA-NPs were spherical shaped with a crystallinity of 53.1 nm in average sizes and a surface charge of -33.0 mV predicted from TEM and zeta potential, resp. WDL-PLGA NPs exhibit significant antibacterial activity against Staphylococcus aureus, Escherichia coli, Klebsiella pneumonia, and Pseudomonas aeruginosa. The half-inhibitory concentration (IC₅₀) of the formulated WDL-PLGA NPs was 23μg/mL but 57μg/mL in WDL in the breast cancer MDA-MB-231 cell line. The apoptotic effect, nuclear condensation, ROS generation, the loss of mitochondrial membrane potential (Δψm) of WDL-PLGA NPs were analyzed. Thus, WDL-PLGA NPs reduced the levels of Bcl-2 but increased the levels of Bax, which results in driving the cells to undergo apoptosis. Thus, the WDL-PLGA NPs were biocompatible with antibacterial and anticancer properties. This study involved multiple reactions and reactants, such as 1,8,9-Trihydroxy-3-methoxy-6H-benzofuro[3,2-c]chromen-6-one (cas: 524-12-9Application In Synthesis of 1,8,9-Trihydroxy-3-methoxy-6H-benzofuro[3,2-c]chromen-6-one).

1,8,9-Trihydroxy-3-methoxy-6H-benzofuro[3,2-c]chromen-6-one (cas: 524-12-9) belongs to benzofurans derivatives. Benzofuran is the “”parent”” of many related compounds with more complex structures. For example, psoralen is a benzofuran derivative that occurs in several plants. They are also prone to polymerisation in the presence of concentrated mineral acids and Lewis acids.Application In Synthesis of 1,8,9-Trihydroxy-3-methoxy-6H-benzofuro[3,2-c]chromen-6-one

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Screening of novel phytochemicals as secreted frizzled-related protein 4 inhibitors: an early stage biomarker of type 2 diabetes was written by Yasmin, Aysha;Bukhari, Shazia Anwer;Zahoor, Muhammad Kashif;Mustafa, Ghulam;Rasul, Azhar. And the article was included in Pakistan Journal of Pharmaceutical Sciences in 2020.Reference of 524-12-9 The following contents are mentioned in the article:

Diabetes is increasing at an alarming rate worldwide with high mortality and posing severe health and economic burden. Secreted frizzled related protein 4 (SFRP4) is released from adipose tissues to suppress insulin exocytosis from β-cells of pancreas and acts as a biomarker for early detection of T2D. In present study, the 3D structure of human SFRP4 was predicted using comparative modeling approach and evaluated through online bioinformatics tools. The best predicted model of SFRP4 was used as a receptor in mol. docking studies. Phytochems. from already reported antidiabetic plants were docked and screened using mol. operating environment (MOE) software to target SFRP4. The ligands were optimized and a database was constructed in MOE. Out of 850 compounds from 150 antidiabetic plants taken from PubChem database, singrin was found to be the most potent one with root mean square deviation (RMSD) value of 1.39, S-score of -10.06 and by interactions to five amino acids of SFRP4 active pocket. Furthermore, boeravinone E, boeravinone D, wedelolactone, squamosamide and taxifolin also interacted strongly to SFRP4 by exhibiting RMSD values of 1.00, 0.94, 1.89, 1.37, 1.28 and S-scores of -12.45, -11.26, -9.25, -7.26, -10.66, resp. These phytochems. are proposed to act as potential medicine for delaying the onset and treating T2D by specifically targeting SFRP4. This study involved multiple reactions and reactants, such as 1,8,9-Trihydroxy-3-methoxy-6H-benzofuro[3,2-c]chromen-6-one (cas: 524-12-9Reference of 524-12-9).

1,8,9-Trihydroxy-3-methoxy-6H-benzofuro[3,2-c]chromen-6-one (cas: 524-12-9) belongs to benzofurans derivatives. Many natural or synthetic compounds containing benzofuran skeletons have been found to possess remarkable activity as agrochemicals and pharmaceuticals. Substituted benzofurans find applications such as fluorescent sensors, oxidants, in drug discovery, and in another field of chemistry and agriculture.Reference of 524-12-9

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Wedelolactone enhances osteoblastogenesis through ERK- and JNK-mediated BMP2 expression and Smad/1/5/8 phosphorylation was written by Zhu, Di;Deng, Xue;Han, Xiao-Fei;Sun, Xiao-Xin;Pan, Tao-Wen;Zheng, Lu-Ping;Liu, Yan-Qiu. And the article was included in Molecules in 2018.Application In Synthesis of 1,8,9-Trihydroxy-3-methoxy-6H-benzofuro[3,2-c]chromen-6-one The following contents are mentioned in the article:

Our previous study showed that wedelolactone, a compound isolated from Ecliptae herba, has the potential to enhance osteoblastogenesis. However, the mol. mechanisms by which wedelolactone promoted osteoblastogenesis from bone marrow mesenchymal stem cells (BMSCs) remain largely unknown. In this study, treatment with wedelolactone (2 μg/mL) for 3, 6, and 9 days resulted in an increase in phosphorylation of extracellular signal-regulated kinases (ERKs), c-Jun N-terminal protein kinase (JNK), and p38. Phosphorylation of mitogen-activated protein kinases (MAPKs), ERK and JNK started to increase on day 3 of treatment, and p38 phosphorylation was increased by day 6 of treatment. Expression of bone morphogenetic protein (BMP2) mRNA and phosphorylation of Smad1/5/8 was enhanced after treatment of cells with wedelolactone for 6 and 9 days. The addition of the JNK inhibitor SP600125, ERK inhibitor PD98059, and p38 inhibitor SB203580 suppressed wedelolactone-induced alk.-phosphatase activity, bone mineralization, and osteoblastogenesis-related marker genes including Runx2, Bglap, and Sp7. Increased expression of BMP2 mRNA and Smad1/5/8 phosphorylation was blocked by SP600125 and PD98059, but not by SB203580. These results suggested that wedelolactone enhanced osteoblastogenesis through induction of JNK- and ERK-mediated BMP2 expression and Smad1/5/8 phosphorylation. This study involved multiple reactions and reactants, such as 1,8,9-Trihydroxy-3-methoxy-6H-benzofuro[3,2-c]chromen-6-one (cas: 524-12-9Application In Synthesis of 1,8,9-Trihydroxy-3-methoxy-6H-benzofuro[3,2-c]chromen-6-one).

1,8,9-Trihydroxy-3-methoxy-6H-benzofuro[3,2-c]chromen-6-one (cas: 524-12-9) belongs to benzofurans derivatives. Benzofuran derivatives are one of the most important oxygen-containing heterocycles. Benzofurans have also made significant and distinctive contributions to biology. They exhibit several biological activities that range from antioxidant, antitubercular, antiplasmodial, insecticidal.Application In Synthesis of 1,8,9-Trihydroxy-3-methoxy-6H-benzofuro[3,2-c]chromen-6-one

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

A standardized herbal extract mitigates tumor inflammation and augments chemotherapy effect of docetaxel in prostate cancer was written by Tsai, Chin-Hsien;Tzeng, Sheue-Fen;Hsieh, Shih-Chuan;Yang, Yu-Chih;Hsiao, Yi-Wen;Tsai, Mong-Hsun;Hsiao, Pei-Wen. And the article was included in Scientific Reports in 2017.Recommanded Product: 524-12-9 The following contents are mentioned in the article:

Wedelia chinensis is rich in luteolin, apigenin, and wedelolactone that act synergistically to suppress androgen receptor activity in prostate cancer. Interestingly, our evaluation of a standardized Wedelia chinensis herbal extract (WCE) concluded its efficacy on hormone-refractory prostate cancer through systemic mechanisms. Oral administration of WCE significantly attenuated tumor growth and metastasis in orthotopic PC-3 and DU145 xenografts. Genome-wide transcriptome anal. of these tumors revealed that WCE suppressed the expression of IKKa/6fb phosphorylation and downstream cytokines/chemokines, e.g., IL6, CXCL1, and CXCL8. Through restraining the cytokines expression, WCE reduced tumor-elicited infiltration of MDSCs, TAMs and endothelial cells into the tumors, therefore inhibiting angiogenesis, tumor growth, and metastasis. In MDSCs, WCE also reduced STAT3 activation, downregulated S100A8 expression and prevented their expansion. Use of WCE in combination with docetaxel significantly suppressed docetaxel-induced NFkB activation, boosted the therapeutic effect and reduced the systemic toxicity caused by docetaxel monotherapy. These data suggest that a standardized preparation of Wedelia chinensis extract improved prostate cancer therapy through immunomodulation and has potential application as an adjuvant agent for castration-resistant prostate cancer. This study involved multiple reactions and reactants, such as 1,8,9-Trihydroxy-3-methoxy-6H-benzofuro[3,2-c]chromen-6-one (cas: 524-12-9Recommanded Product: 524-12-9).

1,8,9-Trihydroxy-3-methoxy-6H-benzofuro[3,2-c]chromen-6-one (cas: 524-12-9) belongs to benzofurans derivatives. Many natural or synthetic compounds containing benzofuran skeletons have been found to possess remarkable activity as agrochemicals and pharmaceuticals. As benzofurans are prone to undergo ring opening of the heterocycle, examples of reduction of this type of aromatics by using dissolving metals are rather scarce.Recommanded Product: 524-12-9

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

PTP1B inhibitory and anti-inflammatory properties of constituents from Eclipta prostrata was written by Le, Duc Dat;Nguyen, Duc Hung;Ma, Eun Sook;Lee, Jeong Hyung;Min, Byung Sun;Choi, Jae Sue;Woo, Mi Hee. And the article was included in Biological & Pharmaceutical Bulletin in 2021.Related Products of 524-12-9 The following contents are mentioned in the article:

The white-flowered leaves of Eclipta prostrata L. together with leaves of Scoparia dulcis and Cynodon dactylon are mixedly boiled in water and given to diabetic patients resulting in the significant improvement in the management of diabetes. However, the active constituents from this plant for antidiabetic and anti-obesity properties are remaining unclear. Thus, this study was to discover anti-diabetes and anti-obesity activities through protein tyrosine phosphatases (PTP)1B inhibitory effects. We found that the fatty acids (23, 24) showed potent PTP1B inhibition with IC₅₀ values of 2.14 and 3.21 μM, resp. Triterpenoid-glycosides (12-15) also exhibited strong to moderate PTP1B inhibitory effects, with IC₅₀ values ranging from 10.88 to 53.35 μM. Addnl., active compounds were investigated for their PTP1B inhibitory mechanism and docking anal. On the other hand, the anti-inflammatory activity from our study revealed that compounds (1-4, 7, 8, 10) displayed the significant inhibition nitric oxide (NO) production in lipopolysaccharide (LPS)-stimulated RAW264.7 cells. Especially, compound 9 showed the potent inhibitory effects in LPS-induced NO production on RAW264.7 cell. Therefore, further Western blot anal. was performed to identify the inhibitory expression including heme oxygenase-1 (HO-1) and inhibitor of kappa B (IκB) phosphorylation. This study involved multiple reactions and reactants, such as 1,8,9-Trihydroxy-3-methoxy-6H-benzofuro[3,2-c]chromen-6-one (cas: 524-12-9Related Products of 524-12-9).

1,8,9-Trihydroxy-3-methoxy-6H-benzofuro[3,2-c]chromen-6-one (cas: 524-12-9) belongs to benzofurans derivatives.Benzofuran is one of the most significant oxygen-containing heterocycles consisting of fused benzene and furan ring, which are widely presented in various naturally occurring and synthetically active compounds. Benzofurans are stable towards alkali and readily polymerize on treatment with sulfuric acid, due to which they are useful for the preparation of low cost chemically relatively inert resins.Related Products of 524-12-9

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem