Day: November 22, 2022

Rapid characterization of chemical constituents and metabolites of Qi-Jing-Sheng-Bai granule by using UHPLC-Q-TOF-MS was written by Wu, Ran;Lin, Shan;Wang, Jinxin;Tian, Saisai;Ke, Xisong;Qu, Yi;Tian, Xinhui;Qi, Xiaopo;Ye, Ji;Zhang, Weidong. And the article was included in Journal of Separation Science in 2018.Category: benzofurans The following contents are mentioned in the article:

Qi-Jing-Sheng-Bai granule is an effective traditional Chinese medicine formula that has been widely used for the treatment of leukopenia post radiotherapy or chemotherapy. However, its chem. constituents were still unclear, which hindered interpreting bioactive constituents and studying integrative mechanisms. In this study, we developed a three-step strategy to characterize the chem. constituents and metabolites of Qi-Jing-Sheng-Bai by using ultra-high performance liquid chromatog. coupled with quadrupole time-of-flight mass spectrometry. As a result, a total of 143 compounds, including 56 flavonoids, 51 saponins, and 36 other compounds, of which contained six pairs of isomers, were tentatively identified and characterized via reference standards and by comparing mass spectrometry data with literature. After oral administration of 15 g/kg Qi-Jing-Sheng-Bai, a number of 42 compounds including 24 prototype compounds and 18 metabolites have been detected in the serum of rats. This work serves as the first reference for Qi-Jing-Sheng-Bai chem. components and metabolites. Moreover, it provided a rapid and valid anal. strategy for characterization of the chem. compounds and metabolites of traditional Chinese medicine formula. This study involved multiple reactions and reactants, such as 1,8,9-Trihydroxy-3-methoxy-6H-benzofuro[3,2-c]chromen-6-one (cas: 524-12-9Category: benzofurans).

1,8,9-Trihydroxy-3-methoxy-6H-benzofuro[3,2-c]chromen-6-one (cas: 524-12-9) belongs to benzofurans derivatives. Benzofuran is a core structural unit found in many naturally occurring compounds with multidirectional biological activities. In nature, benzofurans have occupied an important role among the plant phenols & several pharmacologically active compounds.Category: benzofurans

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Disease modifying potential of wedelolactone rich fraction of Eclipta alba in adjuvant induced arthritis in rats by inhibition of pro-inflammatory cytokines was written by Atre, B. N.;Arulmozhi, S.;Sathiyanarayanan, L.;Dhapte, V. V.;Mahadik, K. R.. And the article was included in International Journal of Pharmaceutical Sciences and Research in 2020.Application of 524-12-9 The following contents are mentioned in the article:

Eclipta alba (Family-Asteraceae) is a herb commonly used in traditional Ayurvedic medicine for the treatment of inflammation, pain, and wounds. The present study is aimed to validate the ethnobotanical use of Eclipta alba in an animal model. The animals were induced with arthritis by injection of FCA on day 0 and treated with wedelolactone rich fractions of Eclipta alba (100, 200 and 400 mg/kg) from day 12 to day 28. WEA caused a significant effect in arthritis by inhibiting the joint inflammation and decreasing hyperalgesia and allodynia. WEA significantly decreased the biochem. markers and serum Tumor Necrosis factor-alpha, Interleukin 1beta and Interleukin-6 levels and significantly increased the antioxidant profile. WEA (400 mg/kg) exhibited anti-rheumatic activity as evidenced by altered hematol. milieu (ESR, CRP, WBC, RBC and Hb), histopathol. of ankle joints, reduced cytokine levels, paw volume and related parameters associated with arthritis. Taken together, these results demonstrated the antiarthritic activity of WEA against exptl. arthritis, and the underlying mechanism behind this efficacy might be mediated by inhibition of proinflammatory cytokines by wedelolactone in combination with other phytoconstituents. This study involved multiple reactions and reactants, such as 1,8,9-Trihydroxy-3-methoxy-6H-benzofuro[3,2-c]chromen-6-one (cas: 524-12-9Application of 524-12-9).

1,8,9-Trihydroxy-3-methoxy-6H-benzofuro[3,2-c]chromen-6-one (cas: 524-12-9) belongs to benzofurans derivatives. Benzofurans are only weakly aromatic in nature and they are cleaved by many oxidative and reductive conditions. In nature, benzofurans have occupied an important role among the plant phenols & several pharmacologically active compounds.Application of 524-12-9

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Protective effects of wedelolactone on dextran sodium sulfate induced murine colitis partly through inhibiting the NLRP3 inflammasome activation via AMPK signaling was written by Wei, Wencheng;Ding, Meiling;Zhou, Kai;Xie, Haifeng;Zhang, Mian;Zhang, Chaofeng. And the article was included in Biomedicine & Pharmacotherapy in 2017.COA of Formula: C16H10O7 The following contents are mentioned in the article:

It has been reported that the ethanol extract of Wedelia chinensis attenuates murine colitis. Wedelolactone (WEL), a coumestane-type compound with many pharmacol. activities, was isolated from W. chinensis. The present study aims to investigate the beneficial effects and underlying mechanisms of WEL on ulcerative colitis. In a dextran sodium sulfate (DSS)-induced mouse model, oral administration of WEL (50 mg/kg) significantly attenuated pathol. colonic damage and inhibited inflammatory infiltration, myeloperoxidase and alk. phosphatase activities through MAPKs and NF-κB signaling pathways, while activating AMPK in colons treated with DSS. Further study revealed that WEL treatment dramatically inhibited NLRP3 inflammasome activation and caspase-1 phosphorylation to decrease IL-1β release in colons treated with DSS. In addition, WEL effectively regulates the disorder of skeleton proteins in colonic epithelial cells NCM460 exposed to TNF-α and protects the intestinal barrier function by activating AMPK in vivo. In summary, the AMPK-NLRP3-IL-1β signaling axis plays an important role in colitis following WEL treatments. These findings provide new insights into the pharmacol. actions of WEL as a potential therapeutic agent for colitis. This study involved multiple reactions and reactants, such as 1,8,9-Trihydroxy-3-methoxy-6H-benzofuro[3,2-c]chromen-6-one (cas: 524-12-9COA of Formula: C16H10O7).

1,8,9-Trihydroxy-3-methoxy-6H-benzofuro[3,2-c]chromen-6-one (cas: 524-12-9) belongs to benzofurans derivatives. Benzofuran is a core structural unit found in many naturally occurring compounds with multidirectional biological activities. Benzofurans have also made significant and distinctive contributions to biology. They exhibit several biological activities that range from antiviral, antimicrobial, antitumor, anti-inflammatory.COA of Formula: C16H10O7

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Cytotoxicity of Geotrigona, melipona and Scaptotrigona ecuadorian pot-honeys in human ovarian cancer cell model was written by Huq, Fazlul;Yu, Jun Qing;Pedro, Silvia RM;Perez-Perez, Elizabeth;Maza, Favian;Vit, Patricia. And the article was included in World Journal of Pharmacy and Pharmaceutical Sciences in 2021.Related Products of 524-12-9 The following contents are mentioned in the article:

Honey is a traditional natural medicine constantly revisited as an anticancer agent administered alone and in combination. Chemotherapy with cytotoxic agents decrease the quality of life of patients. Hence, the need of studies on complementary and alternative medicine to improve therapeutic outcomes, as investigated here for honey. The human ovarian cancer model based on MTT tetrazolium salt colorimetric assay was used to determine cytotoxicity of three types of pot-honey produced by Ecuadorian stingless bees known with ethnic names “abeja de tierra”, “catiana” and “bunga negra” corresponding to Geotrigona leucogastra, Scaptotrigona sp and Melipona grandis. The honeys were characterized for their antioxidant activity measured with three methods, flavonoid, polyphenols and protein contents. The Melipona grandis pot-honey was the most active with IC₅₀ value of 0.15 mg mL^-1 for the A2780, and also in overcoming cisplatin resistance with a remarkably low IC₅₀ 0.05 mg mL^-1 for the A2780^cisR, and a resistance factor of 0.32. This pot-honey demonstrated a distinctive characteristic illustrated by a wide reduction of the IC₅₀ value in the cisplatin resistant A2780^cisR cell line. This study involved multiple reactions and reactants, such as 1,8,9-Trihydroxy-3-methoxy-6H-benzofuro[3,2-c]chromen-6-one (cas: 524-12-9Related Products of 524-12-9).

1,8,9-Trihydroxy-3-methoxy-6H-benzofuro[3,2-c]chromen-6-one (cas: 524-12-9) belongs to benzofurans derivatives. Many natural or synthetic compounds containing benzofuran skeletons have been found to possess remarkable activity as agrochemicals and pharmaceuticals. Benzofurans are stable towards alkali and readily polymerize on treatment with sulfuric acid, due to which they are useful for the preparation of low cost chemically relatively inert resins.Related Products of 524-12-9

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

High-Throughput Screening at the Membrane Interface Reveals Inhibitors of Amyloid-β was written by Cox, Sarah J.;Lam, Brian;Prasad, Ajay;Marietta, Hannah A.;Stander, Nicholas V.;Joel, Joseph G.;Sahoo, Bikash R.;Guo, Fucheng;Stoddard, Andrea K.;Ivanova, Magdalena I.;Ramamoorthy, Ayyalusamy. And the article was included in Biochemistry in 2020.Formula: C16H10O7 The following contents are mentioned in the article:

Aggregation and the formation of oligomeric intermediates of amyloid-β (Aβ) at the membrane interface of neuronal cells are implicated in the cellular toxicity and pathol. of Alzheimer’s disease. Small mol. compounds have been shown to suppress amyloid aggregation and cellular toxicity, but often the presence of a lipid membrane negates their activity. A high-throughput screen of 1800 small mols. was performed to search for membrane active inhibitors, and 21 primary hits were discovered. Through the use of fluorescence-based assays, transmission electron microscopy, and dot blot assays, the initial 21 primary hits were narrowed down to five lead compounds NMR and CD experiments were used for further confirmation of amyloid inhibition at the membrane interface and to obtain insights into the secondary structure of amyloid-β, while size exclusion chromatog. was used to characterize the size of Aβ species. Lastly, dye-leakage assays allowed us to understand how the addition of the five lead compounds affected amyloid-β’s ability to permeate the lipid bilayer. These results provide insights into small mols. that stabilize small amyloid species in the presence of membranes for the development of tool compounds for deeper investigations of these transient species. This study involved multiple reactions and reactants, such as 1,8,9-Trihydroxy-3-methoxy-6H-benzofuro[3,2-c]chromen-6-one (cas: 524-12-9Formula: C16H10O7).

1,8,9-Trihydroxy-3-methoxy-6H-benzofuro[3,2-c]chromen-6-one (cas: 524-12-9) belongs to benzofurans derivatives. Benzofuran is the “”parent”” of many related compounds with more complex structures. For example, psoralen is a benzofuran derivative that occurs in several plants. As benzofurans are prone to undergo ring opening of the heterocycle, examples of reduction of this type of aromatics by using dissolving metals are rather scarce.Formula: C16H10O7

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Wedelolactone acts as proteasome inhibitor in breast cancer cells was written by Nehybova, Tereza;Smarda, Jan;Daniel, Lukas;Stiborek, Marek;Kanicky, Viktor;Spasojevic, Ivan;Preisler, Jan;Damborsky, Jiri;Benes, Petr. And the article was included in International Journal of Molecular Sciences in 2017.Computed Properties of C16H10O7 The following contents are mentioned in the article:

Wedelolactone is a multi-target natural plant coumestan exhibiting cytotoxicity towards cancer cells. Although several mol. targets of wedelolactone have been recognized, the mol. mechanism of its cytotoxicity has not yet been elucidated. In this study, we show that wedelolactone acts as an inhibitor of chymotrypsin-like, trypsin-like, and caspase-like activities of proteasome in breast cancer cells. The proteasome inhibitory effect of wedelolactone was documented by (i) reduced cleavage of fluorogenic proteasome substrates; (ii) accumulation of polyubiquitinated proteins and proteins with rapid turnover in tumor cells; and (iii) mol. docking of wedelolactone into the active sites of proteasome catalytic subunits. Inhibition of proteasome by wedelolactone was independent on its ability to induce reactive oxygen species production by redox cycling with copper ions, suggesting that wedelolactone acts as copper-independent proteasome inhibitor. We conclude that the cytotoxicity of wedelolactone to breast cancer cells is partially mediated by targeting proteasomal protein degradation pathway. Understanding the structural basis for inhibitory mode of wedelolactone might help to open up new avenues for design of novel compounds efficiently inhibiting cancer cells. This study involved multiple reactions and reactants, such as 1,8,9-Trihydroxy-3-methoxy-6H-benzofuro[3,2-c]chromen-6-one (cas: 524-12-9Computed Properties of C16H10O7).

1,8,9-Trihydroxy-3-methoxy-6H-benzofuro[3,2-c]chromen-6-one (cas: 524-12-9) belongs to benzofurans derivatives. Benzofuran is a core structural unit found in many naturally occurring compounds with multidirectional biological activities. Benzofurans are stable towards alkali and readily polymerize on treatment with sulfuric acid, due to which they are useful for the preparation of low cost chemically relatively inert resins.Computed Properties of C16H10O7

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Enhancement of skin anti-inflammatory activities of Eclipta prostrata L. from the ultrasonic extraction process was written by Lee, Hyeon Yong. And the article was included in Applied Sciences in 2017.Electric Literature of C16H10O7 The following contents are mentioned in the article:

This work first showed that the skin anti-inflammatory activities of Eclipta prostrata L. (E. prostrata L.)n be increased through an ultrasonic extraction process at a frequency of 120 kHz with 70% ethanol at 40 °C for 6 h. The extract from the ultrasound extraction (UE) contained 378.6 mg/100 g of wedelolactone (a major bioactive substance in E. prostrata L.), compared with the 172.9 mg/100 g from a conventional extraction process with 70% ethanol at 80 °C for 12 h (EE). The UE showed less than 10% of low cytotoxicity against normal fibroblast cells, and also exhibited much higher antioxidant activities than that from the EE when treating with 0.3 mg/mL of the extracts It was proved that the high antioxidant activities of the UE were closely correlated with the enhancement of skin anti-inflammatory activities by effectively suppressing the production of tumor necrosis factor-alpha and interleukin-6 from macrophages. The production of prostaglandin E2 from human skin cells was also greatly reduced, compared with the EE for all ranges of the treatments. These results strongly indicate that the various biol. activities of E. prostrata L. can be improved by a simple ultrasound extraction process because of the high elution of bioactive substances even at a low temperature This study involved multiple reactions and reactants, such as 1,8,9-Trihydroxy-3-methoxy-6H-benzofuro[3,2-c]chromen-6-one (cas: 524-12-9Electric Literature of C16H10O7).

1,8,9-Trihydroxy-3-methoxy-6H-benzofuro[3,2-c]chromen-6-one (cas: 524-12-9) belongs to benzofurans derivatives. Benzofurans are compounds with a planar structure having 10 pi electrons that include the lone pair on oxygen atom, which makes it more susceptible to electrophilic attack. As benzofurans are prone to undergo ring opening of the heterocycle, examples of reduction of this type of aromatics by using dissolving metals are rather scarce.Electric Literature of C16H10O7

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Ethyl acetate fraction of Eclipta alba: a potential phytopharmaceutical targeting adipocyte differentiation was written by Gupta, Abhishek;Kumar, Ashok;Kumar, Durgesh;Nandan, Shiv;Shankar, Kripa;Varshney, Salil;Rajan, Sujith;Srivastava, Ankita;Gupta, Sanchita;Kanojiya, Sanjeev;Narender, T.;Gaikwad, Anil Nilkanth. And the article was included in Biomedicine & Pharmacotherapy in 2017.Reference of 524-12-9 The following contents are mentioned in the article:

Natural products have always fascinated mankind for their miraculous properties. Eclipta alba (E. alba), a medicinal herb has long been used in traditional medicine for curing several pathologies. It has been shown to have anti-diabetic effect as well as hepato-protective activity. Here, in order to address metabolic derangements, the study was designed to evaluate the efficacy of E. alba and its fractions in adipogenesis inhibition and dyslipidemia. Of the crude extract and fractions screened, Et acetate fraction of E. alba inhibited adipocyte differentiation in 3T3-L1 pre-adipocytes and hMSC derived adipocytes. It inhibited mitotic clonal expansion and caused cell cycle arrest in G1 and S phase as suggested by western blot anal. and flow cytometry. It was also shown to have lipolytic effects. Oral administration of Et acetate fraction of E. alba to hamsters unveiled its anti-adipogenic as well as anti-dyslipidemic activity in-vivo. Mass spectrometry anal. of Et acetate fraction confirmed the presence of several bioactive components, projecting it as an effective phytopharmaceutical agent. In conclusion, Et acetate fraction of E. alba possesses potent anti-adipogenic as well as anti-dyslipidemic activity and could be projected as an herbal formulation towards obesity. This study involved multiple reactions and reactants, such as 1,8,9-Trihydroxy-3-methoxy-6H-benzofuro[3,2-c]chromen-6-one (cas: 524-12-9Reference of 524-12-9).

1,8,9-Trihydroxy-3-methoxy-6H-benzofuro[3,2-c]chromen-6-one (cas: 524-12-9) belongs to benzofurans derivatives. Benzofuran derivatives are one of the most important oxygen-containing heterocycles. They are also prone to polymerisation in the presence of concentrated mineral acids and Lewis acids.Reference of 524-12-9

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

IKKα regulates human keratinocyte migration through surveillance of the redox environment was written by Lisse, Thomas S.;Rieger, Sandra. And the article was included in Journal of Cell Science in 2017.Application of 524-12-9 The following contents are mentioned in the article:

Although the functions of H2O2 in epidermal wound repair are conserved throughout evolution, the underlying signaling mechanisms are largely unknown. In this study we used human keratinocytes (HEK001) to investigate H2O2-dependent wound repair mechanisms. Scratch wounding led to H2O2 production in two or three cell layers at the wound margin within âˆ?0 min and subsequent cysteine modification of proteins via sulfenylation. Intriguingly, exogenous H2O2 treatment resulted in preferential sulfenylation of keratinocytes that adopted a migratory phenotype and detached from neighboring cells, suggesting that one of the primary functions of H2O2 is to stimulate signaling factors involved in cell migration. Based on previous findings that revealed epidermal growth factor receptor (EGFR) involvement in H2O2-dependent cell migration, we analyzed oxidation of a candidate upstream target, the inhibitor of κB kinase α (IKKα; encoded by CHUK), as a mechanism of action. We show that IKKα is sulfenylated at a conserved cysteine residue in the kinase domain, which correlates with de-repression of EGF promoter activity and increased EGF expression. Thus, this indicates that IKKα promotes migration through dynamic interactions with the EGF promoter depending on the redox state within cells. This study involved multiple reactions and reactants, such as 1,8,9-Trihydroxy-3-methoxy-6H-benzofuro[3,2-c]chromen-6-one (cas: 524-12-9Application of 524-12-9).

1,8,9-Trihydroxy-3-methoxy-6H-benzofuro[3,2-c]chromen-6-one (cas: 524-12-9) belongs to benzofurans derivatives.Benzofuran is one of the most significant oxygen-containing heterocycles consisting of fused benzene and furan ring, which are widely presented in various naturally occurring and synthetically active compounds. Benzofurans have also made significant and distinctive contributions to biology. They exhibit several biological activities that range from antioxidant, antitubercular, antiplasmodial, insecticidal.Application of 524-12-9

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

An assessment of dose-dependent UV-B sensitivity in Eclipta alba: Biochemical traits, antioxidative properties, and wedelolactone yield was written by Rai, Kshama;Agrawal, Shashi Bhushan. And the article was included in Environmental Science and Pollution Research in 2021.Name: 1,8,9-Trihydroxy-3-methoxy-6H-benzofuro[3,2-c]chromen-6-one The following contents are mentioned in the article:

The UV-B-induced signals play a crucial role in improving the analeptic values of medicinally important plants. Eclipta alba L. (Hassak), commonly known as False Daisy, holds supreme stature with its pharmaceutical association in treating various ailments, particularly in Ayurvedic medicine. The present study aimed to evaluate the response of E. alba plants exposed to ambient (AT) and two different supplemental UV-B doses (eUV-B, ambient ±7.2 kJ m-2 day-1), i.e., intermittent (IT) and continuous (CT) UV-B treatment for 130 and 240 h resp. Antioxidative activities and medicinally important compounds (wedelolactone) were measured in different plants parts at three growth stages. Under both the eUV-B treatments, the photosynthetic pigments were adversely affected (along with reductions in protein content) with a concomitant increase in secondary metabolites. Substantial variations in enzymic antioxidants and non-enzymic compounds showed the adaptive resilience strategies of plants against eUV-B. The wedelolactone content increased in leaves but compromised in stem and roots under IT. The results concluded that IT UV-B exposure led to the improvement of plant growth and the yield of wedelolactone compared to CT, suggesting its ameliorative role in improving the test plant’s medicinal value. This study involved multiple reactions and reactants, such as 1,8,9-Trihydroxy-3-methoxy-6H-benzofuro[3,2-c]chromen-6-one (cas: 524-12-9Name: 1,8,9-Trihydroxy-3-methoxy-6H-benzofuro[3,2-c]chromen-6-one).

1,8,9-Trihydroxy-3-methoxy-6H-benzofuro[3,2-c]chromen-6-one (cas: 524-12-9) belongs to benzofurans derivatives. Benzofurans are only weakly aromatic in nature and they are cleaved by many oxidative and reductive conditions. As benzofurans are prone to undergo ring opening of the heterocycle, examples of reduction of this type of aromatics by using dissolving metals are rather scarce.Name: 1,8,9-Trihydroxy-3-methoxy-6H-benzofuro[3,2-c]chromen-6-one

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem