Month: March 2022

23405-32-5, Methyl 1-oxo-1,3-dihydroisobenzofuran-5-carboxylate is a benzofuran compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Compound 2 was converted to 1,3-dihydro-1-oxoisobenzofuran-5-carbohydrazide (3) by reacting with hydrazine hydrate in methanol. To a mixture of methyl-1,3-dihydro-1-oxoisobenzofuran-5-carboxylate (2, 5.2 mmol) and methanol (5 mL) at 20-25 C, hydrazine hydrate (5 mL) was added. The reaction mass was refluxed for 4 h and the reaction completion was monitored by TLC. The reaction mass was filtered, washed with water followed by methanol and finally dried to get the pure product. White colour solid, yield: 98 %, m.p.: 220-230 C. IR (KBr, numax, cm-1): 3284 (-NH), 3178 (-NH2), 3053 (-CH), 1759 (lactone C=O), 1644 (amide C=O), 1045 (C-O); 1H NMR (400 MHz, DMSO-d6) delta ppm: 5.44 (2H, d, CH2), 7.41 (1H, m, ArH), 7.72 (1H, m, ArH), 8.01 (1H, dd, ArH), 9.81 (1H, s, CONH), 4.50 (2H, -NH2); 13C NMR (100 MHz, DMSO-d6) delta ppm: 170.2, 164.5, 144.8, 134.8, 128.7, 127.6, 126.4, 123.8, 60.6. LC-MS: m/z: 192 [M]+, 193 [M+1]+. Elemental analysis of C9H8N2O3 calcd. (found) %: C, 56.28 (56.23); H, 4.20 (4.20); N, 14.58 (14.58); O, 24.98 (24.99)., 23405-32-5

As the paragraph descriping shows that 23405-32-5 is playing an increasingly important role.

Reference：
Article; Rao, Nunna Madhava; Viveka, Tella Lakshmi; Raju, Koneti Mallikarjuna; Chary, Maringanti Thirumala; Asian Journal of Chemistry; vol. 32; 1; (2020); p. 95 – 100;,
Benzofuran – Wikipedia
Benzofuran | C8H6O – PubChem

57830-14-5, 5-Phenoxyisobenzofuran-1(3H)-one is a benzofuran compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

57830-14-5, 5-phenoxyisobenzofuran-1(3H)-one (1.0g, 4.42mmol), xylene 10mL, benzyl triethyl ammonium chloride (300 mg, 1.32 mmol) and boron trifluoride diethyl ether (200 mg, 1.41 mmol) were added to the reaction flask, and the mixture was heated to 100 C dropwise to add thionyl chloride (5.0 g, 42.03 mmol). The reaction was carried out at 135 C for 5 hours. After the reaction was completed by thin layer chromatography, the filtrate was concentrated under reduced pressure. The filtrate was concentrated to 3 mL of methanol. The mixture was stirred at 55 C for 1 hour, then concentrated to dryness under reduced pressure. The potassium carbonate solution and the sodium chloride solution were washed and concentrated to dryness to give the title compound 2c (1.0 g, 83.0%).Used directly in the next step.

As the paragraph descriping shows that 57830-14-5 is playing an increasingly important role.

Reference：
Patent; Sichuan Kelun Botai Bio-pharmaceutical Co., Ltd.; Cai Jiaqiang; Xie Yinong; You Zejin; Song Changwei; Zhang Jichao; Li Lu; Zhang Qiaoling; Wang Yongqiang; Chen Xing; Jiao Shihu; Li Youqiang; Wang Tao; Zeng Hong; Song Hongmei; Ye Qijun; Su Donghai; Zhou Xin; Zhang Shaohua; Wang Lichun; Wang Jingyi; (122 pag.)CN108341777; (2018); A;,
Benzofuran – Wikipedia
Benzofuran | C8H6O – PubChem

57830-14-5, 5-Phenoxyisobenzofuran-1(3H)-one is a benzofuran compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

57830-14-5, 5-phenoxyisobenzofuran-1(3H)-one (1.0g, 4.42mmol), xylene 10mL, benzyl triethyl ammonium chloride (300 mg, 1.32 mmol) and boron trifluoride diethyl ether (200 mg, 1.41 mmol) were added to the reaction flask, and the mixture was heated to 100 C dropwise to add thionyl chloride (5.0 g, 42.03 mmol). The reaction was carried out at 135 C for 5 hours. After the reaction was completed by thin layer chromatography, the filtrate was concentrated under reduced pressure. The filtrate was concentrated to 3 mL of methanol. The mixture was stirred at 55 C for 1 hour, then concentrated to dryness under reduced pressure. The potassium carbonate solution and the sodium chloride solution were washed and concentrated to dryness to give the title compound 2c (1.0 g, 83.0%).Used directly in the next step.

As the paragraph descriping shows that 57830-14-5 is playing an increasingly important role.

Reference：
Patent; Sichuan Kelun Botai Bio-pharmaceutical Co., Ltd.; Cai Jiaqiang; Xie Yinong; You Zejin; Song Changwei; Zhang Jichao; Li Lu; Zhang Qiaoling; Wang Yongqiang; Chen Xing; Jiao Shihu; Li Youqiang; Wang Tao; Zeng Hong; Song Hongmei; Ye Qijun; Su Donghai; Zhou Xin; Zhang Shaohua; Wang Lichun; Wang Jingyi; (122 pag.)CN108341777; (2018); A;,
Benzofuran – Wikipedia
Benzofuran | C8H6O – PubChem