Day: March 1, 2022

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.23405-32-5,Methyl 1-oxo-1,3-dihydroisobenzofuran-5-carboxylate,as a common compound, the synthetic route is as follows.

General procedure: Isobenzofuran-1(3H)-one (0.4 mmol), KOH (0.4 mmol), PhSiH3 (1.2 mmol), dried THF (2 mL) were charged in a Schlenk tube(15 mL) under N2 atmosphere. The mixture was refluxed for 4 h. After cooling to rt, the reaction was quenched with EtOH(0.5-1 mL). Solvent was removed under reduced pressure and the crude residue was purified by column chromatography on silica gel with petroleum ether-ethyl acetate as the eluent to afford the desired product.

23405-32-5, 23405-32-5 Methyl 1-oxo-1,3-dihydroisobenzofuran-5-carboxylate 23299433, abenzofuran compound, is more and more widely used in various fields.

Reference：
Article; Liu, Bin; Zhou, Xigeng; Chinese Chemical Letters; vol. 30; 3; (2019); p. 725 – 728;,
Benzofuran – Wikipedia
Benzofuran | C8H6O – PubChem

374706-07-7, 1-(2,3-Dihydrobenzofuran-6-yl)ethanone is a benzofuran compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

The title compound was prepared according to procedures reported in the literature and known by persons skill in the art, using 1-(2,3-dihydrobenzofuran-6-yl)ethan-1-one (0.6 g, 3.7 mmol) as starting material. In a preferred method, to a stirred solution of 1-(2,3-dihydrobenzofuran-6-yl)ethan-1-one (0.6 g, 3.7 mmol) in methanol (10 mL), sodium borohydride (281 mg, 7.4 mmol) was added slowly at 0 C and stirred 1.5 h. The completion of the reaction was monitored by TLC and the solvents were evaporated at 45 C under vacuum. The residue was diluted with EtOAc (25 mL) and washed with water (25 mL), brine solution (25 mL) and dried over Na2SO4. After evaporation of the solvent, the title compound was isolated and used without further purification. Yield: 88.30% (0.53 g, colourless liquid). 1H NMR (400 MHz, DMSO-d6): delta 7.1 1 (d, J = 7.6 Hz, 1H), 6.77-6.75 (m, 1 H), 6.71 (s, 1H), 5.04 (d, J = 4.4 Hz, 1H), 4.63-4.61 (m, 1H), 4.48 (t, J = 8.8 Hz, 2H), 3.1 1 (t, J = 8.8 Hz, 2H), 1 .25 (d, J = 6.4 Hz, 3H). LCMS: (Method A) 147.0 (M-17H), Rt. 2.64 min, 89.95% (Max).

374706-07-7, The synthetic route of 374706-07-7 has been constantly updated, and we look forward to future research findings.

Reference：
Patent; ASCENEURON S. A.; QUATTROPANI, Anna; KULKARNI, Santosh S.; GIRI, Awadut Gajendra; KOEK, Johannes Nicolaas; (64 pag.)WO2017/144635; (2017); A1;,
Benzofuran – Wikipedia
Benzofuran | C8H6O – PubChem

23405-32-5, Methyl 1-oxo-1,3-dihydroisobenzofuran-5-carboxylate is a benzofuran compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Compound 2 was converted to 1,3-dihydro-1-oxoisobenzofuran-5-carbohydrazide (3) by reacting with hydrazine hydrate in methanol. To a mixture of methyl-1,3-dihydro-1-oxoisobenzofuran-5-carboxylate (2, 5.2 mmol) and methanol (5 mL) at 20-25 C, hydrazine hydrate (5 mL) was added. The reaction mass was refluxed for 4 h and the reaction completion was monitored by TLC. The reaction mass was filtered, washed with water followed by methanol and finally dried to get the pure product. White colour solid, yield: 98 %, m.p.: 220-230 C. IR (KBr, numax, cm-1): 3284 (-NH), 3178 (-NH2), 3053 (-CH), 1759 (lactone C=O), 1644 (amide C=O), 1045 (C-O); 1H NMR (400 MHz, DMSO-d6) delta ppm: 5.44 (2H, d, CH2), 7.41 (1H, m, ArH), 7.72 (1H, m, ArH), 8.01 (1H, dd, ArH), 9.81 (1H, s, CONH), 4.50 (2H, -NH2); 13C NMR (100 MHz, DMSO-d6) delta ppm: 170.2, 164.5, 144.8, 134.8, 128.7, 127.6, 126.4, 123.8, 60.6. LC-MS: m/z: 192 [M]+, 193 [M+1]+. Elemental analysis of C9H8N2O3 calcd. (found) %: C, 56.28 (56.23); H, 4.20 (4.20); N, 14.58 (14.58); O, 24.98 (24.99)., 23405-32-5

As the paragraph descriping shows that 23405-32-5 is playing an increasingly important role.

Reference：
Article; Rao, Nunna Madhava; Viveka, Tella Lakshmi; Raju, Koneti Mallikarjuna; Chary, Maringanti Thirumala; Asian Journal of Chemistry; vol. 32; 1; (2020); p. 95 – 100;,
Benzofuran – Wikipedia
Benzofuran | C8H6O – PubChem

57830-14-5, 5-Phenoxyisobenzofuran-1(3H)-one is a benzofuran compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

57830-14-5, 5-phenoxyisobenzofuran-1(3H)-one (1.0g, 4.42mmol), xylene 10mL, benzyl triethyl ammonium chloride (300 mg, 1.32 mmol) and boron trifluoride diethyl ether (200 mg, 1.41 mmol) were added to the reaction flask, and the mixture was heated to 100 C dropwise to add thionyl chloride (5.0 g, 42.03 mmol). The reaction was carried out at 135 C for 5 hours. After the reaction was completed by thin layer chromatography, the filtrate was concentrated under reduced pressure. The filtrate was concentrated to 3 mL of methanol. The mixture was stirred at 55 C for 1 hour, then concentrated to dryness under reduced pressure. The potassium carbonate solution and the sodium chloride solution were washed and concentrated to dryness to give the title compound 2c (1.0 g, 83.0%).Used directly in the next step.

As the paragraph descriping shows that 57830-14-5 is playing an increasingly important role.

Reference：
Patent; Sichuan Kelun Botai Bio-pharmaceutical Co., Ltd.; Cai Jiaqiang; Xie Yinong; You Zejin; Song Changwei; Zhang Jichao; Li Lu; Zhang Qiaoling; Wang Yongqiang; Chen Xing; Jiao Shihu; Li Youqiang; Wang Tao; Zeng Hong; Song Hongmei; Ye Qijun; Su Donghai; Zhou Xin; Zhang Shaohua; Wang Lichun; Wang Jingyi; (122 pag.)CN108341777; (2018); A;,
Benzofuran – Wikipedia
Benzofuran | C8H6O – PubChem

57830-14-5, 5-Phenoxyisobenzofuran-1(3H)-one is a benzofuran compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

57830-14-5, 5-phenoxyisobenzofuran-1(3H)-one (1.0g, 4.42mmol), xylene 10mL, benzyl triethyl ammonium chloride (300 mg, 1.32 mmol) and boron trifluoride diethyl ether (200 mg, 1.41 mmol) were added to the reaction flask, and the mixture was heated to 100 C dropwise to add thionyl chloride (5.0 g, 42.03 mmol). The reaction was carried out at 135 C for 5 hours. After the reaction was completed by thin layer chromatography, the filtrate was concentrated under reduced pressure. The filtrate was concentrated to 3 mL of methanol. The mixture was stirred at 55 C for 1 hour, then concentrated to dryness under reduced pressure. The potassium carbonate solution and the sodium chloride solution were washed and concentrated to dryness to give the title compound 2c (1.0 g, 83.0%).Used directly in the next step.

As the paragraph descriping shows that 57830-14-5 is playing an increasingly important role.

Reference：
Patent; Sichuan Kelun Botai Bio-pharmaceutical Co., Ltd.; Cai Jiaqiang; Xie Yinong; You Zejin; Song Changwei; Zhang Jichao; Li Lu; Zhang Qiaoling; Wang Yongqiang; Chen Xing; Jiao Shihu; Li Youqiang; Wang Tao; Zeng Hong; Song Hongmei; Ye Qijun; Su Donghai; Zhou Xin; Zhang Shaohua; Wang Lichun; Wang Jingyi; (122 pag.)CN108341777; (2018); A;,
Benzofuran – Wikipedia
Benzofuran | C8H6O – PubChem