Day: March 15, 2022

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.374706-07-7,1-(2,3-Dihydrobenzofuran-6-yl)ethanone,as a common compound, the synthetic route is as follows.

2-Bromo-l-(2,3-dihydro-benzofuran-6-yl)-ethanoneBr2 (0.36 ml, 7.01 mmol) was added dropwise to a stirring solution of l-(2,3-dihydro- benzofuran-6-yl)-ethanone (1.13 g, 6.97 mmol) in MeOH (20 mL) held at 00C. The reaction mixture was slowly allowed to reach room temperature. After 3 h, the reaction was quenched by the addition of NaHCO3 (aq, saturated)(until pH=8). Most of the methanol was removed under reduced pressure and the residue was extracted twice with EtOAc (2×20 mL). The organic extracts were pooled, washed with brine (10 mL), dried over MgSO4 and concentrated under reduced pressure. The residue was purified by preparative HPLC using a gradient of 40-70% MeCN in a 0.1M ammonium acetate buffer as eluent. The fractions containing the desired product were pooled and most of the MeCN was removed under EPO reduced pressure. The residue was extracted with EtOAc (2×20 mL) and the combined organic layers was washed with brine, dried over MgSO4 and concentrated. The obtained was finely washed MeOH to give the title compound.1H-NMR (CDC13, 400 MHz): delta 3.25 (t, 2H), 4.39 (s, 2H), 4.61 (t, 2H), 7.24-7.36 (m, 2H), 7.45-7.52 (m, IH).-, 374706-07-7

As the paragraph descriping shows that 374706-07-7 is playing an increasingly important role.

Reference：
Patent; ASTRAZENECA AB; WO2006/137796; (2006); A1;,
Benzofuran – Wikipedia
Benzofuran | C8H6O – PubChem

57830-14-5, 5-Phenoxyisobenzofuran-1(3H)-one is a benzofuran compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated,57830-14-5

102351 A reactor was charged with toluene (24 Kg), and stirring was initiated. The reactor was then charged with 5-phenoxyphthalide (56 Kg), thionyl chloride (41 Kg), trimethyl borate (1 Kg), dichlorotriphenylphosphorane (2.5 Kg), and potassium carbonate (77 Kg). The mixture was heated to reflux until reaction completion and solvent was removed leaving 2-chloromethyl-4-phenoxybenzoylchloride. Methanol was charged and the mixture was heated above 50 C until reaction completion. Solvent was removed and replaced with DMF. This solution of the product methyl 2-chloromethyl-4- phenoxybenzoic acid methyl ester in DMF was used directly in the next step (HPLC: 85%).

57830-14-5 5-Phenoxyisobenzofuran-1(3H)-one 44558580, abenzofuran compound, is more and more widely used in various fields.

Reference：
Patent; FIBROGEN, INC.; THOMPSON, Michael D.; PARK, Jung Min; AREND, Michael P.; WO2014/14834; (2014); A1;,
Benzofuran – Wikipedia
Benzofuran | C8H6O – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.374706-07-7,1-(2,3-Dihydrobenzofuran-6-yl)ethanone,as a common compound, the synthetic route is as follows.

2-Bromo-l-(2,3-dihydro-benzofuran-6-yl)-ethanoneBr2 (0.36 ml, 7.01 mmol) was added dropwise to a stirring solution of l-(2,3-dihydro- benzofuran-6-yl)-ethanone (1.13 g, 6.97 mmol) in MeOH (20 mL) held at 00C. The reaction mixture was slowly allowed to reach room temperature. After 3 h, the reaction was quenched by the addition of NaHCO3 (aq, saturated)(until pH=8). Most of the methanol was removed under reduced pressure and the residue was extracted twice with EtOAc (2×20 mL). The organic extracts were pooled, washed with brine (10 mL), dried over MgSO4 and concentrated under reduced pressure. The residue was purified by preparative HPLC using a gradient of 40-70% MeCN in a 0.1M ammonium acetate buffer as eluent. The fractions containing the desired product were pooled and most of the MeCN was removed under EPO reduced pressure. The residue was extracted with EtOAc (2×20 mL) and the combined organic layers was washed with brine, dried over MgSO4 and concentrated. The obtained was finely washed MeOH to give the title compound.1H-NMR (CDC13, 400 MHz): delta 3.25 (t, 2H), 4.39 (s, 2H), 4.61 (t, 2H), 7.24-7.36 (m, 2H), 7.45-7.52 (m, IH).-, 374706-07-7

As the paragraph descriping shows that 374706-07-7 is playing an increasingly important role.

Reference：
Patent; ASTRAZENECA AB; WO2006/137796; (2006); A1;,
Benzofuran – Wikipedia
Benzofuran | C8H6O – PubChem

57830-14-5, 5-Phenoxyisobenzofuran-1(3H)-one is a benzofuran compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

57830-14-5, 5-phenoxyisobenzofuran-1(3H)-one (1.0g, 4.42mmol), xylene 10mL, benzyl triethyl ammonium chloride (300 mg, 1.32 mmol) and boron trifluoride diethyl ether (200 mg, 1.41 mmol) were added to the reaction flask, and the mixture was heated to 100 C dropwise to add thionyl chloride (5.0 g, 42.03 mmol). The reaction was carried out at 135 C for 5 hours. After the reaction was completed by thin layer chromatography, the filtrate was concentrated under reduced pressure. The filtrate was concentrated to 3 mL of methanol. The mixture was stirred at 55 C for 1 hour, then concentrated to dryness under reduced pressure. The potassium carbonate solution and the sodium chloride solution were washed and concentrated to dryness to give the title compound 2c (1.0 g, 83.0%).Used directly in the next step.

As the paragraph descriping shows that 57830-14-5 is playing an increasingly important role.

Reference：
Patent; Sichuan Kelun Botai Bio-pharmaceutical Co., Ltd.; Cai Jiaqiang; Xie Yinong; You Zejin; Song Changwei; Zhang Jichao; Li Lu; Zhang Qiaoling; Wang Yongqiang; Chen Xing; Jiao Shihu; Li Youqiang; Wang Tao; Zeng Hong; Song Hongmei; Ye Qijun; Su Donghai; Zhou Xin; Zhang Shaohua; Wang Lichun; Wang Jingyi; (122 pag.)CN108341777; (2018); A;,
Benzofuran – Wikipedia
Benzofuran | C8H6O – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.23405-32-5,Methyl 1-oxo-1,3-dihydroisobenzofuran-5-carboxylate,as a common compound, the synthetic route is as follows.

General procedure: Isobenzofuran-1(3H)-one (0.4 mmol), KOH (0.4 mmol), PhSiH3 (1.2 mmol), dried THF (2 mL) were charged in a Schlenk tube(15 mL) under N2 atmosphere. The mixture was refluxed for 4 h. After cooling to rt, the reaction was quenched with EtOH(0.5-1 mL). Solvent was removed under reduced pressure and the crude residue was purified by column chromatography on silica gel with petroleum ether-ethyl acetate as the eluent to afford the desired product.

23405-32-5, 23405-32-5 Methyl 1-oxo-1,3-dihydroisobenzofuran-5-carboxylate 23299433, abenzofuran compound, is more and more widely used in various fields.

Reference：
Article; Liu, Bin; Zhou, Xigeng; Chinese Chemical Letters; vol. 30; 3; (2019); p. 725 – 728;,
Benzofuran – Wikipedia
Benzofuran | C8H6O – PubChem