One of the oldest and most widely used commercial enzyme inhibitors is aspirin, name: Benzofuran-2-carboxylic acid, which selectively inhibits one of the enzymes involved in the synthesis of molecules that trigger inflammation. you can also check out more blogs about 496-41-3
One of the major reasons for studying chemical kinetics is to use measurements of the macroscopic properties of a system, name: Benzofuran-2-carboxylic acid, such as the rate of change in the concentration of reactants or products with time.In a article, mentioned the application of 496-41-3, Name is Benzofuran-2-carboxylic acid, molecular formula is C9H6O3
Tubulin modulating agents such as the taxanes are among the most effective antimitotic cancer drugs, although resistance and toxicity present significant problems in their clinical use. However, most tubulin modulators are derived from complex natural products, which can make modification of their structure to address these problems difficult. Here, we report the discovery of new antimitotic compounds with simple structures that can be rapidly synthesized, through the phenotypic screening of a diverse compound library for the induction of mitotic arrest. We first identified a compound, which induced mitotic arrest in human cells at submicromolar concentrations. Its simple structure enabled rapid exploration of activity, defining a biphenylacetamide moiety required for activity, A family of analogues was synthesized, yielding optimized compounds that caused mitotic arrest and cell death in the low nanomolar range, comparable to clinically used antimitotic agents. These compounds can be synthesized in 1-3 steps and good yields. We show that one such compound targets tubulin, partially inhibiting colchicine but not vinblastine binding, suggesting that it acts allosterically to the known colchicine-binding site. Thus, our results exemplify the use of phenotypic screening to identify novel antimitotic compounds from diverse chemical libraries and characterize a family of biphenylacetamides (biphenabulins) that show promise for further development.
One of the oldest and most widely used commercial enzyme inhibitors is aspirin, name: Benzofuran-2-carboxylic acid, which selectively inhibits one of the enzymes involved in the synthesis of molecules that trigger inflammation. you can also check out more blogs about 496-41-3
Reference:
Benzofuran – Wikipedia,
Benzofuran | C8H1863O – PubChem