Heterocyclic Building Block-benzofuran

Separation, identification, and quantification of active constituents in Fructus Psoraleae by high-performance liquid chromatography with UV, ion trap mass spectrometry, and electrochemical detection was written by Chen, Qinhua;Li, Yuan;Chen, Zilin. And the article was included in Journal of Pharmaceutical Analysis in 2012.Reference of 905954-17-8 This article mentions the following:

The qual. and quant. anal. of active constituents in Fructus Psoraleae is presented by high-performance liquid chromatog. (HPLC) coupled with different detections. Extracts of Fructus Psoraleae were examined by HPLC with ion trap mass spectrometry (IT-MS) and 18 major compounds of coumarins, benzofuran glycosides, flavonoids, and meroterpene were identified. The determination of 4 major constituents including bavachin, isobavachalcone, bavachinin, and bakuchiol was accomplished by HPLC with UV, MS, and electrochem. detection (ECD). These methods were evaluated for a number of validation characteristics (repeatability, LOD, calibration range, and recovery). ECD obtained a high sensitivity for anal. of the 4 components; MS provided a high selectivity and sensitivity for determination of bavachin, isobavachalcone, and bavachinin in neg.-ion mode. After optimization of the methods, separation, identification, and quantification of the 4 components in Fructus Psoraleae were comprehensively tested by HPLC with UV, MS, and ECD. In the experiment, the researchers used many compounds, for example, (Z)-3-(6-(((2S,3R,4S,5S,6R)-3,4,5-Trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)oxy)benzofuran-5-yl)acrylic acid (cas: 905954-17-8Reference of 905954-17-8).

(Z)-3-(6-(((2S,3R,4S,5S,6R)-3,4,5-Trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)oxy)benzofuran-5-yl)acrylic acid (cas: 905954-17-8) belongs to benzofurans derivatives. Benzofurans are only weakly aromatic in nature and they are cleaved by many oxidative and reductive conditions. They are also prone to polymerisation in the presence of concentrated mineral acids and Lewis acids.Reference of 905954-17-8

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Palladium-catalyzed direct C-H arylation of pyridine N-oxides with potassium aryl- and heteroaryltrifluoroborates was written by Li, Mengli;Li, Xing;Chang, Honghong;Gao, Wenchao;Wei, Wenlong. And the article was included in Organic & Biomolecular Chemistry in 2016.Electric Literature of C8H5BF3KO This article mentions the following:

An efficient ligand-free Pd(OAc)₂-catalyzed selective arylation of pyridine N-oxides, e.g. pyridine N-oxide, using potassium (hetero)aryltrifluoroborates as coupling partners via C-H bond activation was achieved in the presence of TBAI to give the corresponding aryl pyridine oxides,, e.g. I. This approach has a broad substrate scope and shows moderate to high yields. In the experiment, the researchers used many compounds, for example, Potassium benzofuran-2-yltrifluoroborate (cas: 929626-27-7Electric Literature of C8H5BF3KO).

Potassium benzofuran-2-yltrifluoroborate (cas: 929626-27-7) belongs to benzofurans derivatives.Benzofuran is one of the most significant oxygen-containing heterocycles consisting of fused benzene and furan ring, which are widely presented in various naturally occurring and synthetically active compounds. Introduction of benzofurans in organic synthesis, particularly drug synthesis, involves generally the use of their metalated species as nucleophiles in addition reactions or in metal-catalysed cross-coupling reactions.Electric Literature of C8H5BF3KO

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Improving peak capacities over 100 in less than 60 seconds: operating above normal peak capacity limits with signal processing was written by Hellinghausen, Garrett;Wahab, M. Farooq;Armstrong, Daniel W.. And the article was included in Analytical and Bioanalytical Chemistry in 2020.Formula: C16H10O This article mentions the following:

A primary focus in liquid chromatog. anal. of complex samples is high peak capacity separations Using advanced instrumentation and optimal small, high-efficiency columns, complex multicomponent mixtures can now be analyzed in relatively short times. Despite these advances, chromatog. peak overlap is still observed Recently, attention has shifted from improvements in chromatog. efficiency and selectivity to enhancing data processing after collection. Curve fitting methods can be used to trace underlying peaks, but do not directly enhance chromatog. resolution Methods based on the properties of derivatives and power transform were recently shown to enhance chromatog. peak resolution while maintaining critical peak information (peak areas and retention times). These protocols have been extensively investigated for their fundamental properties, advantages, and limitations, but they have not been evaluated with complex chromatograms. Herein, we evaluate the use of deconvolution via Fourier transform (FT), even-derivative peak sharpening, and power law with the fast separation (< 60 s) of a 101-component mixture using ultra-high-pressure liquid chromatog. High noise and peak overlap are present in this gradient separation, which is representative of fast chromatog. Chromatog. resolution enhancement is demonstrated and described. Further, accurate quantitation is maintained and shown with representative examples. Enhancements in peak capacity and peak-to-peak resolutions are discussed. Finally, the statistical theory of overlap is used for 101 peaks and predictions are made for the number of singlet, doublet, and multiplets analyte peaks. The effect of increasing peak capacity by FT even derivative sharpening and power laws leads to a decrease in the number of peak overlaps and an increase in total peak number In the experiment, the researchers used many compounds, for example, Naphtho[2,1-b]benzofuran (cas: 205-39-0Formula: C16H10O).

Naphtho[2,1-b]benzofuran (cas: 205-39-0) belongs to benzofurans derivatives. Benzofuran is the “”parent”” of many related compounds with more complex structures. For example, psoralen is a benzofuran derivative that occurs in several plants. As benzofurans are prone to undergo ring opening of the heterocycle, examples of reduction of this type of aromatics by using dissolving metals are rather scarce.Formula: C16H10O

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Phosphopeptides Designed for 5-Methylcytosine Recognition was written by Nomura, Akiko;Okamoto, Akimitsu. And the article was included in Biochemistry in 2011.Formula: C25H15NO9 This article mentions the following:

An artificial phosphopeptide has been developed through rational design of the interaction with 5-methylcytosine in duplex DNA. The peptide consists of two tandem zinc finger motifs, in one of which the glutamate was replaced with a phosphotyrosine, the phosphotyrosine in the peptide being effective for methylcytosine selectivity of DNA binding. The flexible modulation of the target methylated sequence by rearrangement of zinc finger peptides is possible, and the phosphopeptide provided the authors an important hint for expansion of the codes for the interactions of zinc fingers with DNA to methylated DNA sequences. The fluorescence-labeled phosphopeptide provided information on the methylation status of genomic DNA through fluorescence anisotropy after a 10 min incubation. In the experiment, the researchers used many compounds, for example, 2,5-Dioxopyrrolidin-1-yl 3′,6′-dihydroxy-3-oxo-3H-spiro[isobenzofuran-1,9′-xanthene]-5-carboxylate (cas: 92557-80-7Formula: C25H15NO9).

2,5-Dioxopyrrolidin-1-yl 3′,6′-dihydroxy-3-oxo-3H-spiro[isobenzofuran-1,9′-xanthene]-5-carboxylate (cas: 92557-80-7) belongs to benzofurans derivatives. Many natural or synthetic compounds containing benzofuran skeletons have been found to possess remarkable activity as agrochemicals and pharmaceuticals. Benzofurans have also made significant and distinctive contributions to biology. They exhibit several biological activities that range from antiviral, antimicrobial, antitumor, anti-inflammatory.Formula: C25H15NO9

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Dermatologic management of ocular mucous membrane (cicatricial) pemphigoid with mycophenolate mofetil in 38 patients was written by Hrin, Matthew L.;Jorizzo, Joseph L.;Feldman, Steven R.;Shah, Rajiv E.;Huang, William W.. And the article was included in Journal of the American Academy of Dermatology in 2022.Application In Synthesis of (E)-6-(4-Hydroxy-6-methoxy-7-methyl-3-oxo-1,3-dihydroisobenzofuran-5-yl)-4-methylhex-4-enoic acid This article mentions the following:

This article describes about dermatol. management of ocular mucous membrane (cicatricial) pemphigoid with mycophenolate mofetil in 38 patients. In the experiment, the researchers used many compounds, for example, (E)-6-(4-Hydroxy-6-methoxy-7-methyl-3-oxo-1,3-dihydroisobenzofuran-5-yl)-4-methylhex-4-enoic acid (cas: 24280-93-1Application In Synthesis of (E)-6-(4-Hydroxy-6-methoxy-7-methyl-3-oxo-1,3-dihydroisobenzofuran-5-yl)-4-methylhex-4-enoic acid).

(E)-6-(4-Hydroxy-6-methoxy-7-methyl-3-oxo-1,3-dihydroisobenzofuran-5-yl)-4-methylhex-4-enoic acid (cas: 24280-93-1) belongs to benzofurans derivatives. Benzofuran is the “”parent”” of many related compounds with more complex structures. For example, psoralen is a benzofuran derivative that occurs in several plants. As benzofurans are prone to undergo ring opening of the heterocycle, examples of reduction of this type of aromatics by using dissolving metals are rather scarce.Application In Synthesis of (E)-6-(4-Hydroxy-6-methoxy-7-methyl-3-oxo-1,3-dihydroisobenzofuran-5-yl)-4-methylhex-4-enoic acid

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Chemical constituents from aerial part of Rumex patientia was written by Zeng, Yong;Luo, Jian-jun;Li, Chong. And the article was included in Zhongyaocai in 2013.Formula: C22H22O10 This article mentions the following:

The chem. constituents from aerial part of Rumex patientia were studied. The compounds were isolated and purified by silica gels and polyamide column chromatog. Their structures were elucidated by physicochem. and spectroscopic evidences. Twelve compounds were identified as: chrysophanol (1), chrysophanol-8-O-β-D-glucopyranoside (2), physcion (3), emodin (4), emodin-8-O-β-D-glucopyranoside (5), maackiain (6), maackiain-3-O-β-D-glucopyranoside (7), quercetin-3-O-β-D-glucopyranoside (8), quercetin-3-O-β-D-glucuronide(9), 2-O-methylinositol(10), torachrysone-8-O-β-D-glucopyranoside(11) and nepodin-8-O-β-D-glucopyranoside (12). Compounds 6,7,10 are isolated from this genus for the first time, and compound 9 is isolated from this plant for the first time. In the experiment, the researchers used many compounds, for example, (2S,3R,4S,5S,6R)-2-(((6aR,12aR)-6a,12a-Dihydro-6H-[1,3]dioxolo[4′,5′:5,6]benzofuro[3,2-c]chromen-3-yl)oxy)-6-(hydroxymethyl)tetrahydro-2H-pyran-3,4,5-triol (cas: 6807-83-6Formula: C22H22O10).

(2S,3R,4S,5S,6R)-2-(((6aR,12aR)-6a,12a-Dihydro-6H-[1,3]dioxolo[4′,5′:5,6]benzofuro[3,2-c]chromen-3-yl)oxy)-6-(hydroxymethyl)tetrahydro-2H-pyran-3,4,5-triol (cas: 6807-83-6) belongs to benzofurans derivatives. Many natural or synthetic compounds containing benzofuran skeletons have been found to possess remarkable activity as agrochemicals and pharmaceuticals. Benzofurans have also made significant and distinctive contributions to biology. They exhibit several biological activities that range from antiviral, antimicrobial, antitumor, anti-inflammatory.Formula: C22H22O10

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Biomembrane-embedded catalysts for membrane-associated protein labeling on red blood cells was written by Yasueda, Yuki;Tamura, Tomonori;Kuwara, Keiko;Takaoka, Yousuke;Hamachi, Itaru. And the article was included in Chemistry Letters in 2015.Synthetic Route of C25H15NO9 This article mentions the following:

Membrane proteins play crucial roles in fundamental biol. processes. Here, we propose a new chem. strategy to label and characterize membrane proteins on cell surface. In this study, 4-dimethylaminopyridine (DMAP) is embedded and concentrated on plasma membrane surface (biomembrane-embedded DMAP: BeD), allowing to selectively modify membrane proteins with synthetic probes such as a fluorophore and an affinity tag. We applied this strategy to human red blood cells, which demonstrated that membrane proteins such as PAS-1 and Band-3 were selectively labeled. In the experiment, the researchers used many compounds, for example, 2,5-Dioxopyrrolidin-1-yl 3′,6′-dihydroxy-3-oxo-3H-spiro[isobenzofuran-1,9′-xanthene]-5-carboxylate (cas: 92557-80-7Synthetic Route of C25H15NO9).

2,5-Dioxopyrrolidin-1-yl 3′,6′-dihydroxy-3-oxo-3H-spiro[isobenzofuran-1,9′-xanthene]-5-carboxylate (cas: 92557-80-7) belongs to benzofurans derivatives. Benzofuran is a core structural unit found in many naturally occurring compounds with multidirectional biological activities. In nature, benzofurans have occupied an important role among the plant phenols & several pharmacologically active compounds.Synthetic Route of C25H15NO9

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Review article of indications, dose & dosage and use of rifaximin in special population was written by Devadi, Rama Lakshmi. And the article was included in World Journal of Pharmaceutical Research in 2021.SDS of cas: 80621-81-4 This article mentions the following:

Rifaximin, an oral antimicrobial, has many advantages because it is selective intestine, has minimal adverse effects and is used for the treatment of some diseases such as hepatic encephalopathy, irritable bowel syndrome, travelers’ diarrhea, ulcerative colitis, Clostridium difficile and acute diarrhea. Rifaximin in the form of 200 mg tablets is com. available. The crystalline a form is therapeutically safe and effective. In most of the official compendia, rifaximin has no monograph and in none of them is there a monograph for rifaximin tablets. The literature, however, contemplates this gap with varied methods. The literature presents some methods for evaluation of rifaximin in both biol. fluid and pharmaceutical product. High performance liquid chromatog. stands out for the evaluation of rifaximin. Most of the methods reported in the literature are for pharmaceuticals products. In the experiment, the researchers used many compounds, for example, (2S,16Z,18E,20S,21S,22R,23R,24R,25S,26R,27S,28E)-25-(Acetyloxy)-5,6,21,23-tetrahydroxy-27-methoxy-2,4,11,16,20,22,24,26-octamethyl-2,7-(epoxypentadeca[1,11,13]trienimino)benzofuro[4,5-e]pyrido[1,2-a]benzimidazole-1,15(2H)-dione (cas: 80621-81-4SDS of cas: 80621-81-4).

(2S,16Z,18E,20S,21S,22R,23R,24R,25S,26R,27S,28E)-25-(Acetyloxy)-5,6,21,23-tetrahydroxy-27-methoxy-2,4,11,16,20,22,24,26-octamethyl-2,7-(epoxypentadeca[1,11,13]trienimino)benzofuro[4,5-e]pyrido[1,2-a]benzimidazole-1,15(2H)-dione (cas: 80621-81-4) belongs to benzofurans derivatives. Benzofurans are only weakly aromatic in nature and they are cleaved by many oxidative and reductive conditions. In nature, benzofurans have occupied an important role among the plant phenols & several pharmacologically active compounds.SDS of cas: 80621-81-4

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Development of a highly sensitive fluorescence probe for peptidyl arginine deiminase (PAD) activity was written by Kunieda, Kazuki;Kawaguchi, Mitsuyasu;Ieda, Naoya;Nakagawa, Hidehiko. And the article was included in Bioorganic & Medicinal Chemistry Letters in 2019.Recommanded Product: 3326-34-9 This article mentions the following:

Peptidyl arginine deiminases (PADs) catalyze the post-translational deimination of arginine residues to citrulline residues. Aberrant levels of PAD activity are associated with various diseases, such as rheumatoid arthritis, Alzheimer’s disease, and multiple sclerosis, so there is a need for simple and convenient high-throughput screening systems to discover PAD inhibitors as candidate therapeutic agents. Here, we report a highly sensitive off/on-type fluorescence probe for PAD activity based on the donor-excited photoinduced electron transfer (d-PeT) mechanism, utilizing the specific cycloaddition reaction between the benzil group of the probe and the ureido group of the PAD product, citrulline, under acidic conditions. We synthesized and functionally evaluated a series of probes bearing substituents on the benzil Ph group, and found that 4MEBz-FluME could successfully detect citrulline with higher sensitivity and broader dynamic range than our previously reported fluorescence probe, FGME. Moreover, we succeeded in establishing multiple assay systems for PAD subtypes activities, including PAD2 and PAD4, with 4MeBz-FluME thanks to its high sensitivity. We expect that our fluorescence probes will become a powerful tool for discovering PAD inhibitors of several subtypes. Thus, it should be suitable for high-throughput screening of chem. libraries for inhibitors of PADs. In the experiment, the researchers used many compounds, for example, 5-Amino-3′,6′-dihydroxy-3H-spiro[isobenzofuran-1,9′-xanthen]-3-one (cas: 3326-34-9Recommanded Product: 3326-34-9).

5-Amino-3′,6′-dihydroxy-3H-spiro[isobenzofuran-1,9′-xanthen]-3-one (cas: 3326-34-9) belongs to benzofurans derivatives. Benzofurans are compounds with a planar structure having 10 pi electrons that include the lone pair on oxygen atom, which makes it more susceptible to electrophilic attack. Benzofurans have also made significant and distinctive contributions to biology. They exhibit several biological activities that range from antioxidant, antitubercular, antiplasmodial, insecticidal.Recommanded Product: 3326-34-9

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Chemotherapeutic studies on 2-nitrobenzofuran derivatives was written by Kuriyama, Kiyoshi;Matsuzawa, Mikihiko;Uno, Masae;Ohishi, Yoshitaka;Ikemoto, Masahiko. And the article was included in Yakugaku Zasshi in 1978.Related Products of 33094-66-5 This article mentions the following:

Antibacterial activities of 2-nitrobenzofuran derivatives (NBFD) against 8 strains of gram-pos. and -neg. bacteria were comparable to nitrofurantoin. Elongated cells were occasionally observed in the culture medium containing NBFD. When NBFD (12.5-100 mg/kg) was orally administered to rats, the metabolites excreted in urine also showed antibacterial activity. The antibacterial spectrum of the urinary metabolites, however, was different from that of the intact compound The cytotoxicity of NBFD and nitrofurantoin was examined using cultured chick embryo fibroblasts. The inhibition of cell multiplication appeared in the concentration range of 0.39-25 μg/mL. In the case of 7-substituted NBFD, the compound which possessed a high antibacterial activity indicated a low cytotoxicity. A reverse relation between antibacterial activity and cytotoxicity seemed to depend on the size of a substituent in the 7-position of NBFD. In the experiment, the researchers used many compounds, for example, 2-Nitrobenzofuran (cas: 33094-66-5Related Products of 33094-66-5).

2-Nitrobenzofuran (cas: 33094-66-5) belongs to benzofurans derivatives. Benzofurans are only weakly aromatic in nature and they are cleaved by many oxidative and reductive conditions. They are also prone to polymerisation in the presence of concentrated mineral acids and Lewis acids.Related Products of 33094-66-5

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem