Heterocyclic Building Block-benzofuran

Visible-light-triggered direct benzoyloxylation of electron-rich arenes at room temperature without chelation assistance was written by Rao, Honghua;Wang, Ping;Li, Chao-Jun. And the article was included in European Journal of Organic Chemistry in 2012.Recommanded Product: 3′,6′-Dimethoxy-3H-spiro[isobenzofuran-1,9′-xanthen]-3-one This article mentions the following:

A Ru(II) photocatalytic method was developed for the direct mono-benzoyloxylation of electron-rich aromatic and heteroaromatic systems even with an excess amount of benzoyl peroxide. The reaction was conducted at room temperature under visible light. The direct Ar(C-H) benzoyloxylations occur without the assistance of any directing groups and can also tolerate various functional groups that already showed diverse reactivities in transition-metal catalysis. In the experiment, the researchers used many compounds, for example, 3′,6′-Dimethoxy-3H-spiro[isobenzofuran-1,9′-xanthen]-3-one (cas: 36886-76-7Recommanded Product: 3′,6′-Dimethoxy-3H-spiro[isobenzofuran-1,9′-xanthen]-3-one).

3′,6′-Dimethoxy-3H-spiro[isobenzofuran-1,9′-xanthen]-3-one (cas: 36886-76-7) belongs to benzofurans derivatives. Benzofuran derivatives are one of the most important oxygen-containing heterocycles. Benzofurans are stable towards alkali and readily polymerize on treatment with sulfuric acid, due to which they are useful for the preparation of low cost chemically relatively inert resins.Recommanded Product: 3′,6′-Dimethoxy-3H-spiro[isobenzofuran-1,9′-xanthen]-3-one

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Direct construction of 2,3-unsubstituted benzofurans and benzothiophenes via a metal-free catalyzed intramolecular Friedel-Crafts reaction was written by Ma, Weimin;Huang, Jiawei;Huang, Xianyu;Meng, Shulin;Yang, Zhengwei;Li, Chao;Wang, Yue;Qi, Ting;Li, Baolin. And the article was included in Organic Chemistry Frontiers in 2019.Recommanded Product: 7-Fluorobenzofuran This article mentions the following:

A highly effective and straightforward method for the construction of 2,3-unsubstituted benzofurans and benzothiophenes such as I [R = 7-F, 6-Me, 5-OMe, etc.; X = O, S] by the intramol. Friedel-Crafts reaction was developed. This phosphoric acid-catalyzed method exhibited good functional group tolerance for both electron-withdrawing groups and electron-donating groups. Successfully synthesized benzofuran and benzothiophene derivatives with various substituents, and the yield was up to 94%. The development of this reaction provided a simple and efficient strategy for the construction of benzofuran and benzothiophene skeleton compounds In the experiment, the researchers used many compounds, for example, 7-Fluorobenzofuran (cas: 24410-61-5Recommanded Product: 7-Fluorobenzofuran).

7-Fluorobenzofuran (cas: 24410-61-5) belongs to benzofurans derivatives. Benzofurans are compounds with a planar structure having 10 pi electrons that include the lone pair on oxygen atom, which makes it more susceptible to electrophilic attack. Benzofurans have also made significant and distinctive contributions to biology. They exhibit several biological activities that range from antioxidant, antitubercular, antiplasmodial, insecticidal.Recommanded Product: 7-Fluorobenzofuran

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Comparative Efficacy of Drugs for the Treatment of Chronic Constipation: Quantitative Information for Medication Guidelines was written by Zhang, Yi;Yin, Fang;Xu, Ling;Li, Yun-fei;Chen, Jun-chao;Liu, Hong-xia;Zheng, Qing-shan;Li, Lu-jin. And the article was included in Journal of Clinical Gastroenterology in 2020.Recommanded Product: 4-Amino-5-chloro-N-(1-(3-methoxypropyl)piperidin-4-yl)-2,3-dihydrobenzofuran-7-carboxamide This article mentions the following:

In this study, we used a model-based meta-anal. to quant. estimate deviations from the baseline number of spontaneous bowel movements (SBMs) and complete spontaneous bowel movements (CSBMs) associated with pharmacotherapy for chronic constipation to bridge knowledge gap in guidelines for current medications. A comprehensive survey was conducted using literature databases. In this study, we also included randomized placebo-controlled trials on chronic constipation. Pharmacodynamic models were established to describe the time course of the numbers of SBMs and CSBMs produced by each drug. Data from 20 studies (comprising 9998 participants and 8 drugs) were used to build this model. The results showed that bisacodyl had greatest effect on increasing frequency of bowel movements, whereas plecanatide yielded lowest increase in number of SBMs and CSBMs. After eliminating the placebo effect, the maximal increase in bowel movement frequency associated with bisacodyl was 6.8 for SBMs (95% confidence interval: 6.1-7.6) and 4.7 for CSBMs (95% confidence interval: 4.3-5.1) per wk. These numbers are ∼4 times higher than the number of bowel movements produced by plecanatide. The highest increases in frequency of SBM and CSBM were 2.5 to 4 and 1 to 2.1 per wk, resp. Bisacodyl had most noticeable loss of efficacy between week 1 and week 4; it reduced frequencies of SBMs and CSBMs by 2.3 and 2.2, resp. By contrast, the changes in frequencies of SBMs and CSBMs were not as great with other drugs. In the experiment, the researchers used many compounds, for example, 4-Amino-5-chloro-N-(1-(3-methoxypropyl)piperidin-4-yl)-2,3-dihydrobenzofuran-7-carboxamide (cas: 179474-81-8Recommanded Product: 4-Amino-5-chloro-N-(1-(3-methoxypropyl)piperidin-4-yl)-2,3-dihydrobenzofuran-7-carboxamide).

4-Amino-5-chloro-N-(1-(3-methoxypropyl)piperidin-4-yl)-2,3-dihydrobenzofuran-7-carboxamide (cas: 179474-81-8) belongs to benzofurans derivatives.Benzofuran is one of the most significant oxygen-containing heterocycles consisting of fused benzene and furan ring, which are widely presented in various naturally occurring and synthetically active compounds. They are also prone to polymerisation in the presence of concentrated mineral acids and Lewis acids.Recommanded Product: 4-Amino-5-chloro-N-(1-(3-methoxypropyl)piperidin-4-yl)-2,3-dihydrobenzofuran-7-carboxamide

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Ultraviolet spectra, methoxy, and methylenedioxy groups of some aromatic compounds and alkaloids. II. The effect of methoxy and methylenedioxy groups on the ultraviolet spectra of aromatic compounds with a conjugated carbonyl chromophore was written by Santavy, Frantisek;Hruban, Ladislav;Simanek, Vaclav;Walterova, D.. And the article was included in Collection of Czechoslovak Chemical Communications in 1970.Name: 5-Methoxyisobenzofuran-1(3H)-one This article mentions the following:

Characteristic changes in the location and intensity of absorption bands in the uv region are given and discussed with regard to the nature and position of the electron donating O-containing substituents in numerous derivatives of benzene, indanones, protoochotensimine compounds, phthalic acids, protopine and oxyprotopine alkaloids. In the experiment, the researchers used many compounds, for example, 5-Methoxyisobenzofuran-1(3H)-one (cas: 4741-62-2Name: 5-Methoxyisobenzofuran-1(3H)-one).

5-Methoxyisobenzofuran-1(3H)-one (cas: 4741-62-2) belongs to benzofurans derivatives. Benzofuran is a core structural unit found in many naturally occurring compounds with multidirectional biological activities. They are also prone to polymerisation in the presence of concentrated mineral acids and Lewis acids.Name: 5-Methoxyisobenzofuran-1(3H)-one

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Distribution of oxygenated and unoxygenated aromatics from phenol pyrolysis at low temperatures was written by Yang, Yun;Mulholland, James A.. And the article was included in Organohalogen Compounds in 1997.Recommanded Product: 205-39-0 This article mentions the following:

The gas-phase pyrolysis of phenol was studied to investigate the effect of temperature on the distribution of aromatic products in waste incineration. Experiments were conducted in a flow tube reactor at 400-700° with a residence time of 20 s. Oxygenated and unoxygenated aromatic products were detected. The major oxygenated product was dibenzofuran which peaked at 650°. The major unoxygenated products were benzene, naphthalene, and indene. Yields of these and higher mol. weight polyaromatic hydrocarbons increased with temperature The conversion rate of phenol was <5% at <550°, but >95% at ≥650°. In the experiment, the researchers used many compounds, for example, Naphtho[2,1-b]benzofuran (cas: 205-39-0Recommanded Product: 205-39-0).

Naphtho[2,1-b]benzofuran (cas: 205-39-0) belongs to benzofurans derivatives. Many natural or synthetic compounds containing benzofuran skeletons have been found to possess remarkable activity as agrochemicals and pharmaceuticals. Benzofurans have also made significant and distinctive contributions to biology. They exhibit several biological activities that range from antiviral, antimicrobial, antitumor, anti-inflammatory.Recommanded Product: 205-39-0

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Preparation of organic reversible thermochromatic material and study on its microencapsulation was written by Cui, Xiaoliang;Zhang, Baoyan;Meng, Fanbao;Meng, Hao;Xia, Yan. And the article was included in Hecheng Shuzhi Ji Suliao in 2002.Product Details of 1552-42-7 This article mentions the following:

A kind of organic reversible thermochromatic material was prepared with the crystal violet lactone as leuco dye, cetanol as solvent and benzyl P-hydroxybenzoate as ingrain agent. The optimum ratio of the leuco dye, ingrain agent and solvent was determined as 1:3:30. In the material, the solvent decided the temperature to change color, the ingrain agent decided the color shade and the leuco dye itself decided the properties such as the color and stability of the reversible thermochromatic material. The results indicate that when the reversible thermochromatic material is microcapsuled with urea-formaldehyde resin, its thermal stability is enhanced, its solvent resistance improves, and its loss during usage reduces. In the experiment, the researchers used many compounds, for example, Crystal violet lactone (cas: 1552-42-7Product Details of 1552-42-7).

Crystal violet lactone (cas: 1552-42-7) belongs to benzofurans derivatives. Benzofurans are compounds with a planar structure having 10 pi electrons that include the lone pair on oxygen atom, which makes it more susceptible to electrophilic attack. Benzofurans have also made significant and distinctive contributions to biology. They exhibit several biological activities that range from antiviral, antimicrobial, antitumor, anti-inflammatory.Product Details of 1552-42-7

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Determination of fructose 1,6-bisphosphate using a double-receptor sandwich type fluorescence sensing method based on uranyl-salophen complexes was written by Zhang, Guangliang;Liao, Lifu;Lin, Yingwu;Yang, Miao;Xiao, Xilin;Nie, Changming. And the article was included in Analytica Chimica Acta in 2013.Recommanded Product: 3326-34-9 This article mentions the following:

In this paper, we report a double-receptor sandwich type fluorescence sensing method for the determination of fructose bisphosphates (FBPs) using fructose 1,6-bisphosphate (F-1,6-BP) as a model analyte based on uranyl-salophen complexes. The solid phase receptor is an immobilized uranyl-salophen (IUS) complex which is bound on the surface of glass slides by covalent bonds. The labeled receptor is another uranyl-salophen complex containing a fluorescence group, or uranyl-salophen-fluorescein (USF). In the procedure of determining F-1,6-BP in sample solution, F-1,6-BP is first adsorbed on the surface of the glass slide through the coordination reaction of F-1,6-BP with IUS. It then binds USF through another coordination reaction to form a sandwich-type structure of IUS-F-1,6-BP-USF. The amount of F-1,6-BP is detected by the determination of the fluorescence intensity of IUS-F-1,6-BP-USF bound on the glass slide. Under optimal conditions, the linear range for the detection of F-1,6-BP is 0.05-5.0 nmol mL^-1 with a detection limit of 0.027 nmol mL^-1. The proposed method has been successfully applied for the determination of F-1,6-BP in real samples with satisfactory results. In the experiment, the researchers used many compounds, for example, 5-Amino-3′,6′-dihydroxy-3H-spiro[isobenzofuran-1,9′-xanthen]-3-one (cas: 3326-34-9Recommanded Product: 3326-34-9).

5-Amino-3′,6′-dihydroxy-3H-spiro[isobenzofuran-1,9′-xanthen]-3-one (cas: 3326-34-9) belongs to benzofurans derivatives. Benzofuran is a core structural unit found in many naturally occurring compounds with multidirectional biological activities. Benzofurans are stable towards alkali and readily polymerize on treatment with sulfuric acid, due to which they are useful for the preparation of low cost chemically relatively inert resins.Recommanded Product: 3326-34-9

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Qualitative and quantitative characterization of phenolic and diterpenoid constituents in Danshen (Salvia miltiorrhiza) by comprehensive two-dimensional liquid chromatography coupled with hybrid linear ion trap Orbitrap mass was written by Cao, Ji-Liang;Wei, Jin-Chao;Hu, Yuan-Jia;He, Cheng-Wei;Chen, Mei-Wan;Wan, Jian-Bo;Li, Peng. And the article was included in Journal of Chromatography A in 2016.SDS of cas: 875313-64-7 This article mentions the following:

Danshen is one of the most frequently used traditional Chinese herbs owing to its remarkable and reliable therapeutic effects. Phenolic acids and diterpenoids have proved to be the bioactive substance groups. In order to fully profile its chem. compositions and explore new potential bioactive compounds, a comprehensive two-dimensional liquid chromatog. system coupled to DAD detector and hybrid linear ion trap (LTQ) Orbitrap mass spectrometry (LC × LC-DAD-ESI/HRMS/MSⁿ) was set up in this study based on the column combination of Hypersil gold CN (150 mm × 1 mm, 3 μm) and Accucore C18 (50 mm × 4.6 mm, 2.6 μm). Using the optimal segment gradient program, phenolic acids and diterpenoids were separated into two independent groups and a total of 328 peaks were successfully detected on the contour plot of Danshen. By means of the accurate mass and reliable MSⁿ data, 102 compounds were identified or tentatively identified and 7 of them were discovered from Danshen for the first time. Moreover, the LC × LC-DAD system was validated for the quant. anal. of 14 bioactive analytes using the contour plot, exhibiting satisfactory linearity (r ≥ 0.9976) and high precision for both peak locating (≤1.07%) and peak volume calculating (0.34%-4.11%). The established method could afford powerful separation capability, reliable identification data and accurate quant. results, which is very suitable for anal. of complex herbal samples. In the experiment, the researchers used many compounds, for example, (R)-3-(3,4-Dihydroxyphenyl)-1-methoxy-1-oxopropan-2-yl (2S,3S)-2-(3,4-dihydroxyphenyl)-4-((E)-3-(((R)-3-(3,4-dihydroxyphenyl)-1-methoxy-1-oxopropan-2-yl)oxy)-3-oxoprop-1-en-1-yl)-7-hydroxy-2,3-dihydrobenzofuran-3-carboxylate (cas: 875313-64-7SDS of cas: 875313-64-7).

(R)-3-(3,4-Dihydroxyphenyl)-1-methoxy-1-oxopropan-2-yl (2S,3S)-2-(3,4-dihydroxyphenyl)-4-((E)-3-(((R)-3-(3,4-dihydroxyphenyl)-1-methoxy-1-oxopropan-2-yl)oxy)-3-oxoprop-1-en-1-yl)-7-hydroxy-2,3-dihydrobenzofuran-3-carboxylate (cas: 875313-64-7) belongs to benzofurans derivatives. Many natural or synthetic compounds containing benzofuran skeletons have been found to possess remarkable activity as agrochemicals and pharmaceuticals. They are also prone to polymerisation in the presence of concentrated mineral acids and Lewis acids.SDS of cas: 875313-64-7

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Selective Disruption of Early/Recycling Endosomes: Release of Disulfide-Linked Cargo Mediated by a N-Alkyl-3β-Cholesterylamine-Capped Peptide was written by Sun, Qi;Cai, Sutang;Peterson, Blake R.. And the article was included in Journal of the American Chemical Society in 2008.Category: benzofurans This article mentions the following:

The use of endocytic uptake pathways to deliver poorly permeable mols. into mammalian cells is often plagued by entrapment and degradation of material in late endosomes and lysosomes. As a strategy to prevent the exposure of cargo to these highly hydrolytic membrane-sealed compartments, we synthesized derivatives of the membrane anchor N-alkyl-3β-cholesterylamine that selectively target linked compounds to less hydrolytic early/recycling endosomes. By targeting a pH-dependent membrane-lytic dodecapeptide and a disulfide-linked fluorophore to these compartments in Chinese hamster ovary cells or Jurkat lymphocytes, membranes of early/recycling endosomes were selectively disrupted, resulting in cleavage of the disulfide and escape of the fluorophore into the cytosol and nucleus with low toxicity. The ability of appropriately designed N-alkyl-3β-cholesterylamines to deliver cargo into and release disulfide-linked cargo from relatively nonhydrolytic early/recycling endosomes may be useful for the delivery of a variety of sensitive mols. into living mammalian cells. In the experiment, the researchers used many compounds, for example, 2,5-Dioxopyrrolidin-1-yl 3′,6′-dihydroxy-3-oxo-3H-spiro[isobenzofuran-1,9′-xanthene]-5-carboxylate (cas: 92557-80-7Category: benzofurans).

2,5-Dioxopyrrolidin-1-yl 3′,6′-dihydroxy-3-oxo-3H-spiro[isobenzofuran-1,9′-xanthene]-5-carboxylate (cas: 92557-80-7) belongs to benzofurans derivatives.Benzofuran is one of the most significant oxygen-containing heterocycles consisting of fused benzene and furan ring, which are widely presented in various naturally occurring and synthetically active compounds. They are also prone to polymerisation in the presence of concentrated mineral acids and Lewis acids.Category: benzofurans

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

The hepatotoxic potential of protein kinase inhibitors predicted with Random Forest and Artificial Neural Networks was written by Schoning, Verena;Krahenbuhl, Stephan;Drewe, Jurgen. And the article was included in Toxicology Letters in 2018.SDS of cas: 850879-09-3 This article mentions the following:

Protein kinases (PKs) play a role in many pivotal aspects of cellular function. Dysregulation and mutations of protein kinases are involved in the development of different diseases, which might be treated by inhibition of the corresponding kinase. Protein kinase inhibitors (PKIs) are generally well tolerated, but unexpected and serious adverse events on the heart, lung, kidney and liver were observed clin. In this study, the structure-activity relationship of PKIs in relation to hepatotoxicity was investigated. A dataset of 165 PKIs was compiled and the probability of human hepatotoxicity with two different machine learning algorithms (Random Forest and Artificial Neural Networks) was analyzed. The estimated probability of hepatotoxicity was generally high for single PKIs. However, depending on the target kinase of the PKI, a difference in hepatotoxic potential could be observed The similarity of the PKIs to each other is caused by the conserved site of action of the protein kinases. Hepatotoxicity may therefore always be an issue in PKIs. In the experiment, the researchers used many compounds, for example, N-(Benzo[d][1,3]dioxol-5-ylmethyl)-4-(benzofuro[3,2-d]pyrimidin-4-yl)piperazine-1-carbothioamide (cas: 850879-09-3SDS of cas: 850879-09-3).

N-(Benzo[d][1,3]dioxol-5-ylmethyl)-4-(benzofuro[3,2-d]pyrimidin-4-yl)piperazine-1-carbothioamide (cas: 850879-09-3) belongs to benzofurans derivatives.Benzofuran is one of the most significant oxygen-containing heterocycles consisting of fused benzene and furan ring, which are widely presented in various naturally occurring and synthetically active compounds. Substituted benzofurans find applications such as fluorescent sensors, oxidants, in drug discovery, and in another field of chemistry and agriculture.SDS of cas: 850879-09-3

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem