Direct construction of 2,3-unsubstituted benzofurans and benzothiophenes via a metal-free catalyzed intramolecular Friedel-Crafts reaction was written by Ma, Weimin;Huang, Jiawei;Huang, Xianyu;Meng, Shulin;Yang, Zhengwei;Li, Chao;Wang, Yue;Qi, Ting;Li, Baolin. And the article was included in Organic Chemistry Frontiers in 2019.Recommanded Product: 7-Fluorobenzofuran This article mentions the following:
A highly effective and straightforward method for the construction of 2,3-unsubstituted benzofurans and benzothiophenes such as I [R = 7-F, 6-Me, 5-OMe, etc.; X = O, S] by the intramol. Friedel-Crafts reaction was developed. This phosphoric acid-catalyzed method exhibited good functional group tolerance for both electron-withdrawing groups and electron-donating groups. Successfully synthesized benzofuran and benzothiophene derivatives with various substituents, and the yield was up to 94%. The development of this reaction provided a simple and efficient strategy for the construction of benzofuran and benzothiophene skeleton compounds In the experiment, the researchers used many compounds, for example, 7-Fluorobenzofuran (cas: 24410-61-5Recommanded Product: 7-Fluorobenzofuran).
7-Fluorobenzofuran (cas: 24410-61-5) belongs to benzofurans derivatives. Benzofurans are compounds with a planar structure having 10 pi electrons that include the lone pair on oxygen atom, which makes it more susceptible to electrophilic attack. Benzofurans have also made significant and distinctive contributions to biology. They exhibit several biological activities that range from antioxidant, antitubercular, antiplasmodial, insecticidal.Recommanded Product: 7-Fluorobenzofuran
Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem